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    BIODEGRADABLE POLY(BETA-AMINO ESTERS) AND USES THEREOF
    34.
    发明申请
    BIODEGRADABLE POLY(BETA-AMINO ESTERS) AND USES THEREOF 有权
    生物可降解聚（氨基甲酸酯）及其用途

    公开(公告)号：US20100036084A1

    公开(公告)日：2010-02-11

    申请号：US12507999

    申请日：2009-07-23

    申请人： Robert S. Langer ,  David M. Lynn ,  David Putnam ,  Mansoor M. Amiji ,  Daniel G. Anderson

    发明人： Robert S. Langer ,  David M. Lynn ,  David Putnam ,  Mansoor M. Amiji ,  Daniel G. Anderson

    IPC分类号： C08G63/685

    CPC分类号： A61K47/34 ,  A61K9/5146 ,  A61K31/711 ,  A61K31/713 ,  A61K47/59 ,  A61K47/593 ,  A61K47/6929 ,  B82Y5/00 ,  C08G63/685 ,  C08G73/02 ,  C08G73/0273 ,  C08G73/06 ,  C08G73/0611 ,  C08G73/0616 ,  C12N15/88

    摘要： Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

    摘要翻译： 描述了从双（仲胺）或伯胺向双（丙烯酸酯）共轭加成制备的聚（β-氨基酯）。 还提供了从市售的原料制备这些聚合物的方法。 这些含叔胺的聚合物优选是可生物降解的和生物相容的并且可以用于各种药物递送系统中。 鉴于这些聚合物的聚（胺）性质，它们特别适用于递送多核苷酸。 已经制备了含有聚合物/多核苷酸复合物的纳米颗粒。 本发明的聚合物也可以用于包封待递送的其它试剂。 考虑到缓冲其周围环境的pH值，它们特别适用于提供不稳定剂。

    CROSSLINKED, DEGRADABLE POLYMERS AND USES THEREOF
    39.
    发明申请
    CROSSLINKED, DEGRADABLE POLYMERS AND USES THEREOF 有权
    交联，可降解的聚合物及其用途

    公开(公告)号：US20080145338A1

    公开(公告)日：2008-06-19

    申请号：US11758078

    申请日：2007-06-05

    申请人： Daniel Griffith Anderson ,  Jason Alan Burdick ,  Robert S. Langer

    发明人： Daniel Griffith Anderson ,  Jason Alan Burdick ,  Robert S. Langer

    IPC分类号： A61K47/32 ,  C08G73/00 ,  C08F2/48 ,  A61K35/00

    CPC分类号： C08L79/02 ,  C08F283/00 ,  C08F290/06 ,  C08F290/061 ,  C08F290/065 ,  C08F299/024 ,  C08F299/0485 ,  C08G63/6858 ,  C08G73/02

    摘要： Acrylate-terminated poly(beta-amino esters) are cross-linked to form materials useful in the medical as well as non-medical field. The polymeric starting material is combined with a free radical initiator, either a thermal initiator or a photoinitiator, and the mixture for cross-linking is heated or exposed to light depending on the initiator used. The resulting materials due to the hydrolysable ester bond in the polymer backbone are biodegradable under physiological conditions. These cross-linked materials are particular useful as drug delivery vehicles, tissue engineering scaffolds, and in fabricating microdevices. The materials may also be used as plastics, coating, adhesives, inks, etc. The cross-linked materials prepared exhibit a wide range of degradation times, mass loss profiles, and mechanical properties. Therefore, the properties of the material may be tuned for the desired use. The high-throughput approach to preparing a library of cross-linked poly(beta-amino esters) allows for the rapid screening and design of degradable polymers for a variety of applications.

    摘要翻译： 丙烯酸酯封端的聚（β-氨基酯）被交联以形成用于医疗和非医学领域的材料。 将聚合起始材料与自由基引发剂，热引发剂或光引发剂组合，并且根据所使用的引发剂将用于交联的混合物加热或暴露于光。 由于聚合物骨架中的可水解的酯键导致的所得材料在生理条件下是可生物降解的。 这些交联材料特别用作药物递送载体，组织工程支架和制造微型装置。 这些材料也可以用作塑料，涂料，粘合剂，油墨等。制备的交联材料表现出广泛的降解时间，质量损失曲线和机械性能。 因此，可以调整材料的性质以达到期望的用途。 制备交联聚（β-氨基酯）文库的高通量方法允许快速筛选和设计可降解聚合物用于各种应用。

    Highly convertible endolumenal prostheses and methods of manufacture
    40.
    发明授权
    Highly convertible endolumenal prostheses and methods of manufacture 失效
    高度可转换的腔内假体和制造方法

    公开(公告)号：US07377939B2

    公开(公告)日：2008-05-27

    申请号：US10988814

    申请日：2004-11-15

    申请人： Michael S. Williams ,  Robert S. Langer ,  Yadong Wang

    发明人： Michael S. Williams ,  Robert S. Langer ,  Yadong Wang

    IPC分类号： A61F2/06

    CPC分类号： A61F2/06 ,  A61L31/04 ,  A61L31/041 ,  A61L31/14 ,  A61L2400/16

    摘要： Endolumenal prostheses that readily and extensively convert from a delivery configuration to a deployed configuration are disclosed. Endolumenal prostheses may be fabricated from one or more shape memory polymers, a high modulus elastomer, a polymer that is both elastomeric and exhibits shape memory behavior, a hydrogel, or some combination thereof. Polymers used to fabricate the prostheses are selectively synthesized to exhibit desired characteristics such as crystallinity, strain fixity rate, strain recovery rate, elasticity, tensile strength, mechanical strength, cross-linking density, extent physical cross-linking, extent of covalent cross-linking, extent of interpenetrating networks, rate of erosion, heat of fusion, crystallization temperature, and acidity during erosion. The endolumenal prostheses convert to the deployed configuration following delivery to a treatment site, upon exposure to an initiator either present within the body naturally or introduced into the body.

    摘要翻译： 公开了容易且广泛地从输送配置转换成展开构型的腔内假体。 腔内假体可以由一种或多种形状记忆聚合物，高模量弹性体，弹性体和表现出形状记忆行为的聚合物，水凝胶或其某些组合制成。 用于制造假体的聚合物被选择性地合成以显示所需的特性，例如结晶度，应变固定率，应变恢复速率，弹性，拉伸强度，机械强度，交联密度，物理交联程度，共价交联程度 互穿网络的程度，侵蚀速率，熔化热，结晶温度和侵蚀过程中的酸度。 在暴露于身体内自然存在或引入体内的引发剂之后，腔内假体转化为部署构型。