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公开(公告)号：US20150375173A1
公开(公告)日：2015-12-31
申请号：US14750838
申请日：2015-06-25
Applicant: EMD Millipore Corporation
Inventor： Jonathan Steen
CPC classification number: B01D63/12 , B01D61/025 , B01D61/145 , B01D61/147 , B01D63/10 , B01D63/103 , B01D67/0086 , B01D71/68 , B01D2313/14 , B01D2313/143 , B01D2313/146 , B01D2313/50 , B01D2315/10 , B01D2315/16 , B01D2317/02 , C02F1/44 , C02F1/441 , C02F1/442 , C02F1/444 , D06C15/02
Abstract: The present invention provides compact spiral-wound filter elements having cassette-like performance. The invention further provides filtration systems (e.g., TFF systems) and processes (e.g., SPTFF processes) employing compact spiral-wound filter elements having cassette-like performance.
Abstract translation: 本发明提供具有盒状性能的紧凑型螺旋缠绕式过滤元件。 本发明进一步提供使用具有盒状性能的紧凑型螺旋缠绕过滤器元件的过滤系统（例如，TFF系统）和工艺（例如SPTFF工艺）。
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公开(公告)号：US09181941B2
公开(公告)日：2015-11-10
申请号：US14080826
申请日：2013-11-15
Applicant: EMD Millipore Corporation
Inventor： Sebastien Cirou , Jean-Louis Weissenbach
CPC classification number: F04B43/14 , B01L3/502738 , B01L3/502753 , B01L2400/0655 , F04B43/043 , Y10T137/85978
Abstract: The invention concerns a circuit comprising a bag (111) comprising two flexible films (145, 146) and routing network connectors, and a press (110) comprising a first shell (114) and a second shell (113) clamping the bag to form pipes (104) between the films, the first shell comprising a pinch valve (120) which comprises an actuator (121) comprising a movable member (124) and in register with the moveable member an elastically compressible pad (131) which, when the valve is in an open position, has a resting configuration in which a second face (33) of the pad is concave and locally delimits a shaping channel (118), and, when the valve is in a closed position, has a pinching configuration in which the second face (133) is convex, with the pipe and the pad sandwiched between a shaping channel (116) and the moveable member.
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公开(公告)号：US20150298077A1
公开(公告)日：2015-10-22
申请号：US14440373
申请日：2013-11-05
Applicant: EMD MILLIPORE CORPORATION
Inventor： Martin Morrissey , Brian Pereira
CPC classification number: B01F7/00241 , B01F7/162 , B01F7/1635 , B01F13/0827 , B01F13/0872 , B01F15/0085
Abstract: A disposable container, such as a deformable bag, for a fluid, having one or more inlets and one or more outlets and an impeller assembly within the container to cause mixing, dispersing, homogenizing and/or circulation of one or more ingredients contained or added to the container. The impeller assembly has a protective hood surrounding at least a portion of the moveable blades or vanes of the impeller assembly and being above at least a portion of the blades or vanes. The hood surrounds the blades or vanes and arcs over the height of the blades or vanes. The hood is shaped in a dome shape or semi-spherical shape that is around and above the impeller blades and acts as a protector for the container surface against the impeller assembly both during shipping and storage as well as when in use, particularly at lower liquid levels.
Abstract translation: 用于流体的一次性容器，例如可变形袋，具有一个或多个入口和一个或多个出口以及容器内的叶轮组件，用于引起包含或添加的一种或多种成分的混合，分散，均化和/或循环 到容器 叶轮组件具有围绕叶轮组件的可移动叶片或叶片的至少一部分并且在叶片或叶片的至少一部分上方的保护罩。 发动机罩围绕叶片或叶片并在叶片或叶片的高度上弧形。 发动机罩形成为圆顶形或半球形，其在叶轮叶片周围和上方，并且在运输和储存期间以及在使用时特别是在较低液体下作为用于容器表面抵靠叶轮组件的保护器 水平。
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公开(公告)号：US20150291349A1
公开(公告)日：2015-10-15
申请号：US14745770
申请日：2015-06-22
Applicant: EMD Millipore Corporation
Inventor： James Hobson , James Austin , Boris Pesakovich , Elias G. Noukas , Thomas Janko , Shaun McMahon
CPC classification number: A61J1/10 , B65B69/0091 , B65D88/20 , B65D90/046 , B65D2203/10 , B65D2303/00 , B65F1/06 , Y10T29/49826
Abstract: The present invention is an alignment device for a bag containing one or more ports. The alignment device is attached to either the one or more ports or to the bag adjacent the one or more ports. The plate has an indicator or a unique outer edge shape that is designed to fit into a corresponding unique opening in a holder to ensure proper alignment of the bag and its port(s) in the holder. The plate is has a series of holes equal to and in alignment with the one or more ports of the bag and the port(s) extend through the holes of the plate.
Abstract translation: 本发明是一种用于包含一个或多个端口的袋的对准装置。 对准装置附接到一个或多个端口或邻近一个或多个端口的袋。 该板具有指示器或独特的外边缘形状，其被设计成装配在保持器中相应的独特开口中，以确保袋和其端口在保持器中的适当对准。 板具有与袋的一个或多个端口相等并且对准的一系列孔，并且该端口延伸穿过板的孔。
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公开(公告)号：US09150825B2
公开(公告)日：2015-10-06
申请号：US14032211
申请日：2013-09-20
Applicant: EMD Millipore Corporation
Inventor： Pierre Guedon
CPC classification number: C12M33/07 , B01L3/567 , G01N1/10 , G01N35/1097 , G01N2001/022
Abstract: The device for the transfer of a medium comprises a magazine having two main faces (17) of which one is adapted to cooperate with a container and a lateral face (18) extending between said main faces (17) as well as at least one sliding valve (3) housed in a cavity of said magazine (2) and in which there is formed a transfer duct (59) for said medium which issues on said face (17) adapted to cooperate with said container, said valve (3) having a closed position in which it sealingly isolates said duct (59) from said container and an open position in which said duct (59) is placed in communication with said container; said valve (3) comprising a valve member (40), an isolation sleeve (41) surrounding at least partially said valve member (40) as well as spring means (58) adapted to be compressed by said valve member (40) when said valve (3) is in its open position.
Abstract translation: 用于传送介质的装置包括具有两个主表面（17）的盒，其中一个适于与容器配合，以及在所述主面（17）之间延伸的侧面（18）以及至少一个滑动 阀（3）容纳在所述盒（2）的空腔中，其中形成有用于所述介质的传送管道（59），所述传送管道（59）适于与所述容器协作的所述面（17）上，所述阀（3）具有 关闭位置，其中密封地将所述管道（59）与所述容器隔离，并且所述管道（59）放置成与所述容器连通的打开位置; 所述阀（3）包括阀构件（40），至少部分地围绕所述阀构件（40）的隔离套（41）以及适于在所述阀构件（40）被所述阀构件（40）压缩时的弹簧装置 阀（3）处于其打开位置。
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Patent Agency Ranking
公开(公告)号：US09103756B2
公开(公告)日：2015-08-11
申请号：US14031458
申请日：2013-09-19
Applicant: EMD Millipore Corporation
Inventor： Christopher A. Scott , Timothy K. Nadler , Kurt Greenizen , Louis Bonhomme , Sara D. Gutierrez , Masaharu Mabuchi , David Briggs , Phillip Clark , Ralph T. Scaduto
CPC classification number: G01N1/34 , B01D61/18 , B01D63/06 , B01D63/16 , B01D2315/02 , B01L3/5021 , B01L3/5085 , B01L2300/0618 , B01L2300/0681 , C07K1/16 , C07K1/22 , G01N1/405 , G01N1/4077 , G01N2001/4088 , Y10T436/25375
Abstract: Sample preparation device that allows for a complete bind, wash, elute, buffer-exchange and concentration process to be carried out without sample transfer between multiple devices. The device includes a reservoir, a column for holding chromatography media, a holder region for holding a filtration device, and an outlet. The filtration device plugs into the holder region of the centrifugal device, and the assembly can be placed in an optional holder. The assembly, with or without the optional holder, can be placed in a conventional centrifuge tube for centrifugation. The entire bind, wash, elute, buffer exchange and concentration steps can be carried out with the apparatus without any pipette transfers (and the associated sample losses. The sample preparation device also can be used for binding and washing steps, in which case the filtration device is not needed, and for buffer exchange and concentration steps, in which case the media is not needed.
Abstract translation: 允许完全结合，洗涤，洗脱，缓冲交换和浓缩过程的样品制备装置，在多个装置之间没有样品转移的情况下进行。 该装置包括储存器，用于保持色谱介质的柱，用于保持过滤装置的保持器区域和出口。 过滤装置插入到离心装置的保持器区域中，并且组件可以放置在可选的保持器中。 具有或不具有任选的保持器的组件可以放置在用于离心的常规离心管中。 整个结合，洗涤，洗脱，缓冲液交换和浓缩步骤可以在没有任何移液管转移（和相关样品损失）的情况下进行，样品制备装置也可用于结合和洗涤步骤，在这种情况下，过滤 设备不需要，并且用于缓冲区交换和集中步骤，在这种情况下不需要介质。
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公开(公告)号：US20150217882A1
公开(公告)日：2015-08-06
申请号：US14684510
申请日：2015-04-13
Applicant: EMD Millipore Corporation
Inventor： Stephane Olivier
IPC: B65B3/26
CPC classification number: B65B3/26 , G01N1/18 , G01N35/1079 , G01N2001/1037 , G01N2001/2085
Abstract: The device for the transfer of a medium comprises a magazine (2) and at least one transfer element (3) for transfer of said medium, said transfer element (3) comprising a duct (45) for transfer of said medium provided at one end with a needle (31), a septum (32), and a maneuvering unit (33) of said needle (31), said transfer element (3) also comprising means for locking (61, 65) adapted to cooperate with complementary locking means (15) of said magazine (2) to lock said needle (31) in a waiting position, said locking means (61, 62, 65) belonging to said maneuvering unit (33) and cooperating with said complementary locking means (15) at a location of said magazine (2) distinct from the location through which said duct (45) issues from the cavity (20), at the opposite end from the needle (31).
Abstract translation: 用于传送介质的装置包括用于传送所述介质的盒（2）和至少一个传送元件（3），所述传送元件（3）包括用于传送在一端设置的所述介质的导管（45） 与所述针（31）的针（31），隔膜（32）和操纵单元（33）相连，所述传送元件（3）还包括用于锁定（61,65）的装置，所述装置适于与互补锁定装置 （3）的所述锁定装置（61,62,65）与所述互补锁定装置（15）配合，所述锁定装置（61,62,65）在所述弹匣（2）的所述锁定装置（15） 所述盒（2）的位置不同于所述管道（45）在与所述针（31）相对的端部从所述腔（20）发出的位置。
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公开(公告)号：US20150204450A1
公开(公告)日：2015-07-23
申请号：US14413556
申请日：2013-07-18
Applicant: EMD Millipore Corporation
Inventor： Ronald Tuccelli , Sebastien Cirou , Virginie Buisson , Christine Abouayad El Idrissi , Jim Kelly
CPC classification number: F16K7/06 , B01L3/502753 , B01L3/561 , B01L3/565 , B01L3/567 , B01L99/00 , B01L2200/0689 , B01L2300/0816 , B01L2300/0861 , B01L2300/0887 , B01L2400/0655 , B29C49/0047 , B29L2031/14 , F16K7/123 , Y10T137/85954
Abstract: The invention concerns a circuit comprising a bag (11) comprising two flexible films (45, 46) and a press (10) comprising a first (14) and a second (13) shell clamping the bag to form pipes having a passage and edges (41); the first shell comprising a valve (20) which comprises a movable member (24) and a pad (31), which pad has a resting configuration in which a second face (33) of the pad is concave and locally delimits a channel (18) and a pinching configuration in which the second face (33) is convex; said movable member and said pad being configured so that, when said valve is in closed position and said pad in pinching configuration, said passage is pinched by said movable member against said second shell channel and said edges (41) are pinched flat by said movable member against said second shell (13).
Abstract translation: 本发明涉及一种电路，其包括包括两个柔性膜（45,46）的袋（11）和包括第一（14）和第二（13）壳的压力机（10），所述第一（14）和第二（13）壳夹紧所述袋以形成具有通道和边缘 （41）; 所述第一壳体包括阀（20），所述阀（20）包括可动构件（24）和垫（31），所述垫具有静止构型，其中所述垫的第二面（33）是凹入的并且局部地限定通道（18 ）和第二面（33）是凸起的夹持构造; 所述可动构件和所述衬垫构造成使得当所述阀处于关闭位置并且所述衬垫处于夹持构造时，所述通道被所述可动构件夹住所述第二壳体通道，并且所述边缘（41）被所述可移动的 构件抵靠所述第二壳体（13）。
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公开(公告)号：US09067976B2
公开(公告)日：2015-06-30
申请号：US14083590
申请日：2013-11-19
Applicant: EMD Millipore Corporation
Inventor： Kwok-Shun Cheng , Senthilkumar Ramaswamy , Chen Wang , Nanying Bian , Brian Gagnon , Joaquin A. Umana , Dennis Aquino , Neil Soice , Andrew Lyddiatt
IPC: C07K16/00 , B01J20/26 , B01J20/28 , B01J20/285 , B01J20/286 , B01J20/32 , B01J39/26
CPC classification number: C07K16/00 , B01J20/262 , B01J20/265 , B01J20/267 , B01J20/28019 , B01J20/28092 , B01J20/285 , B01J20/286 , B01J20/3212 , B01J20/3244 , B01J20/3274 , B01J20/328 , B01J20/3285 , B01J20/3293 , B01J39/26 , Y10T428/2982
Abstract: The present invention relates to an asymmetric chromatography media suitable for separations applications, particularly as packed bed, fluidized bed or magnetized bed chromatography media. In certain embodiments, the asymmetric chromatography media comprises asymmetric particles, preferably beads, having at least two distinct, controlled pore size distributions. Preferably one of the distinct pore size distributions is in an internal region of the particle, and the other is in an external region or coating on the particle. These distinct pore size distributions can be modified with uniform or alternatively unique functional groups or mixtures of functional groups. The present invention allows for the control over pore size distribution within an asymmetric porous particle by providing a distinct internal region, preferably in the form of a bead, and a distinct external region, preferably in the form of a coating on the bead.
Abstract translation: 本发明涉及适用于分离应用的非对称色谱介质，特别是作为填充床，流化床或磁化床层析介质。 在某些实施方案中，不对称色谱介质包含具有至少两个不同的，受控的孔径分布的不对称颗粒，优选珠粒。 优选地，不同孔径分布中的一个在颗粒的内部区域中，另一个位于颗粒的外部区域或涂层中。 这些不同的孔径分布可以用均匀的或替代地独特的官能团或官能团的混合物进行改性。 本发明允许通过提供不同的内部区域，优选以珠粒的形式和不同的外部区域，优选以珠粒上的涂层的形式来控制不对称多孔颗粒内的孔径分布。
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公开(公告)号：US09050565B2
公开(公告)日：2015-06-09
申请号：US13739008
申请日：2013-01-11
Applicant: EMD Millipore Corporation
Inventor： Louis Bonhomme , John Doyle , Kurt Greenizen , George Gagne , Sean Devin , Gerard Lombard , Vincent Smith
CPC classification number: B01D63/16 , B01D61/145 , B01D61/18 , B01D63/08 , B01D2313/08 , B01L3/502 , B01L3/5021 , B01L3/5635 , B01L2300/0681
Abstract: Filtration device suited for concentration of liquid samples, particularly biomolecules, and a method of concentrating, desalting, purifying and/or fractionating liquid samples. In certain embodiments the device includes a housing having a sample reservoir, and two substantially vertically oriented and spaced apart membranes disposed in the housing. An underdrain is associated with each membrane such that fluid passing through each membrane flows through a respective underdrain into a filtrate collection chamber. The fluid that does not pass through the membrane is collected in the retentate collection chamber, and can be recovered such as by a reverse spinning step, achieving recoveries greater than about 90%. The substantially vertical orientation of the membranes increases the available membrane area by at least 2.7 times the area available in a conventional filter device. The two-panel configuration also maintains more available membrane area in use during the last stages of filtration than a one-panel configuration.
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