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公开(公告)号：US10138453B2
公开(公告)日：2018-11-27
申请号：US15163368
申请日：2016-05-24
Applicant: EMD Millipore Corporation
Inventor： Paul J. Hung , Philip J. Lee
Abstract: A number of novel improved microfluidic configurations and systems and methods of manufacture and operation. In one embodiment, three wells are used for independent cell culture systems in a cell culture array. In a second aspect, artificial sinusoids with artificial epithelial barriers are provided with just one (optionally shared or multiplexed) fluidic inlet and one (optionally shared or multiplexed) fluidic output, where the medium output also functions as a cellular input. A pneumatic cell loader combined with other components provides a fully automated cell culture system. Magnetic alignment of plate molds provides advantages and ease of molded manufacture.
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公开(公告)号：US10054536B2
公开(公告)日：2018-08-21
申请号：US15163398
申请日：2016-05-24
Applicant: EMD Millipore Corporation
Inventor： Philip Janmin Lee , Paul Ju-Sung Hung , Narendra Maheshri
IPC: G01N15/14 , B01L3/00 , G01N33/487 , G01N33/543 , G01N15/00
CPC classification number: G01N15/1484 , B01L3/502707 , B01L3/502761 , B01L2200/0668 , B01L2300/0867 , B01L2300/123 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , G01N15/1459 , G01N15/1463 , G01N15/147 , G01N15/1475 , G01N33/487 , G01N33/54366 , G01N2015/0065 , G01N2015/1493
Abstract: The device and method relate to microfluidic particle analysis. The device is designed for trapping particles for solution analysis. Exemplary particles include beads and cells. The device has a microfluidics body, and a microfluidics channel formed in the body for receiving particles at an upstream region thereof. The channel has a deformable wall portion that defines a particle-capture region, and is responsive to a change in fluid pressure applied thereto, to selectively vary the particle-flow dimensions of the capture region. In this way, particles having a given size may be selectively retained in the capture region. In one embodiment, the deformable wall portion is expandable in response to a positive fluid pressure applied within the channel. In another embodiment, the deformable wall portion is expandable in response to a negative pressure applied to a cavity communicating with the wall portion, external to the channel.
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公开(公告)号：US09999568B2
公开(公告)日：2018-06-19
申请号：US15005118
申请日：2016-01-25
Applicant: EMD Millipore Corporation
Inventor： James Hobson , James Austin , Boris Pesakovich , Elias G. Noukas , Thomas Janko , Shaun McMahon
CPC classification number: A61J1/10 , B65B69/0091 , B65D88/20 , B65D90/046 , B65D2203/10 , B65D2303/00 , B65F1/06 , Y10T29/49826
Abstract: The present invention is an alignment device for a bag containing one or more ports. The alignment device is attached to either the one or more ports or to the bag adjacent the one or more ports. The plate has an indicator or a unique outer edge shape that is designed to fit into a corresponding unique opening in a holder to ensure proper alignment of the bag and its port(s) in the holder. The plate is has a series of holes equal to and in alignment with the one or more ports of the bag and the port(s) extend through the holes of the plate.
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公开(公告)号：US09926210B2
公开(公告)日：2018-03-27
申请号：US14125412
申请日：2012-06-20
Applicant: Yves Gaignet , Didier Meyer , Julien Bole
Inventor： Yves Gaignet , Didier Meyer , Julien Bole
Abstract: The invention concerns a treated water purification system (18) comprising a closed water flow loop (107) said loop comprising at least one treated water supply point (A), at least one point of use (U) of purified water, a pump means (101), a sterilization means (106) and a filtration means (103), characterized in that the zone (106) comprises the supply point (A) and a water extraction point (P), situated upstream of the supply point (A), and in that the extraction point (P) and the supply point (A) are both situated in a sector (106B) of the sterilization zone (106) that is isolated from the two connection points (RM, RV) of the loop (107) to the zone (106) by two other sectors (106A, 106C) of the zone (106). Method for use of such a system.
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公开(公告)号：US09897520B2
公开(公告)日：2018-02-20
申请号：US14974334
申请日：2015-12-18
Applicant: EMD Millipore Corporation
Inventor： Christopher A. Scott , Timothy K. Nadler , Kurt Greenizen , Louis Bonhomme , Sara D. Gutierrez , Masaharu Mabuchi , David Briggs , Phillip Clark , Ralph T. Scaduto
CPC classification number: G01N1/34 , B01D61/18 , B01D63/06 , B01D63/16 , B01D2315/02 , B01L3/5021 , B01L3/5085 , B01L2300/0618 , B01L2300/0681 , C07K1/16 , C07K1/22 , G01N1/405 , G01N1/4077 , G01N2001/4088 , Y10T436/25375
Abstract: Sample preparation device that allows for a complete bind, wash, elute, buffer-exchange and concentration process to be carried out without sample transfer between multiple devices. The device includes a reservoir, a column for holding chromatography media, a holder region for holding a filtration device, and an outlet. The filtration device plugs into the holder region of the centrifugal device, and the assembly can be placed in an optional holder. The assembly, with or without the optional holder, can be placed in a conventional centrifuge tube for centrifugation. The entire bind, wash, elute, buffer exchange and concentration steps can be carried out with the apparatus without any pipette transfers (and the associated sample losses. The sample preparation device also can be used for binding and washing steps, in which case the filtration device is not needed, and for buffer exchange and concentration steps, in which case the media is not needed.
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Patent Agency Ranking
公开(公告)号：US09833784B2
公开(公告)日：2017-12-05
申请号：US12818754
申请日：2010-06-18
Applicant: Dennis Wong , Elias Noukas , Kristin Prescott , Brian Pereira , John Saragosa
Inventor： Dennis Wong , Elias Noukas , Kristin Prescott , Brian Pereira , John Saragosa
CPC classification number: B01L3/523 , B01L3/502 , B01L3/505 , B01L2200/0689 , B01L2200/087 , B01L2300/042 , B01L2400/0633 , B65D33/00 , C12M99/00
Abstract: A feed bag construction is provided comprising a feed bag, a first conduit sealed to the feed bag, a second conduit sealed to the interior of the feed bag for supplying wash reagent to the feed bag and a one piece cap that is removably mounted on the first conduit. The first conduit is provided with a hand operated butterfly valve to open or close the conduit.
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公开(公告)号：US09777847B2
公开(公告)日：2017-10-03
申请号：US14413556
申请日：2013-07-18
Applicant: EMD Millipore Corporation
Inventor： Ronald Tuccelli , Sebastien Cirou , Virginie Buisson , Christine Abouayad El Idrissi , Jim Kelly
CPC classification number: F16K7/06 , B01L3/502753 , B01L3/561 , B01L3/565 , B01L3/567 , B01L99/00 , B01L2200/0689 , B01L2300/0816 , B01L2300/0861 , B01L2300/0887 , B01L2400/0655 , B29C49/0047 , B29L2031/14 , F16K7/123 , Y10T137/85954
Abstract: The invention concerns a circuit comprising a bag (11) comprising two flexible films (45, 46) and a press (10) comprising a first (14) and a second (13) shell clamping the bag to form pipes having a passage and edges (41); the first shell comprising a valve (20) which comprises a movable member (24) and a pad (31), which pad has a resting configuration in which a second face (33) of the pad is concave and locally delimits a channel (18) and a pinching configuration in which the second face (33) is convex; said movable member and said pad being configured so that, when said valve is in closed position and said pad in pinching configuration, said passage is pinched by said movable member against said second shell channel and said edges (41) are pinched flat by said movable member against said second shell (13).
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公开(公告)号：US09739424B2
公开(公告)日：2017-08-22
申请号：US14493858
申请日：2014-09-23
Applicant: EMD Millipore Corporation
Inventor： Sebastien Cirou , Rene Reinbigler , Virginie Buisson , Jean-Louis Weissenbach
IPC: B01D61/20 , B01D61/30 , B30B7/00 , B30B9/22 , C12M1/12 , C12M3/06 , F17D1/00 , B01D61/18 , F04B43/08 , C12M1/00
CPC classification number: F17D1/00 , B01D61/18 , B01D61/20 , B01D61/30 , B01D2313/105 , B01D2313/125 , B01D2313/58 , B30B7/00 , B30B9/22 , C12M47/12 , F04B43/08 , Y10T137/0318 , Y10T137/8593
Abstract: The invention concerns a device comprising: a base (2); a moveable or removable door (20), said device having a closed door position; and in the closed door position, a circuit (8) comprising a bag comprising two flexible films and conveying network connectors, and a press (9) comprising a first shell (16) disposed on said front face (5) of said base (2) and a second shell (17) disposed in said door (20); said bag being clamped between said first shell (16) and said second shell (17) in a state in which conduits of said network for conveying liquid are formed between said films.
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公开(公告)号：US09594007B2
公开(公告)日：2017-03-14
申请号：US14309051
申请日：2014-06-19
Applicant: EMD Millipore Corporation
Inventor： Chris Scott , Rob Colonna , Christopher Barmore , Todd Taylor , Daniel Morgan
CPC classification number: G01N1/28 , B01D61/18 , B01J20/281 , B01L3/50255 , G01N1/4077 , G01N30/14 , G01N2030/146
Abstract: Sample preparation device for receiving in sealing relation one or more filter assemblies and one or more sample containers, each container uniquely positioned within the device to receive filtered sample from a designated filter. The device includes a body, a lid disposed on the body, a container tray, a base, an integrated seal on the body, a valve and a valve actuator. The tray can be disposed in a vacuum chamber defined by the lid and the body, and one or more sample containers can be disposed in the tray. When properly positioned in the tray in the vacuum chamber, each container is in fluid communication with a single respective filter assembly disposed in sealing relation in a respective aperture in the lid. A single actuation of a valve to place the vacuum chamber under vacuum causes the lid to seal to the base and drives the simultaneous filtration of a plurality of samples.
Abstract translation: 用于以密封关系接收一个或多个过滤器组件和一个或多个样品容器的样品制备装置，每个容器唯一地定位在装置内以从指定的过滤器接收经过滤的样品。 该装置包括主体，设置在主体上的盖，容器托盘，基座，主体上的集成密封件，阀和阀致动器。 托盘可以设置在由盖和主体限定的真空室中，并且一个或多个样品容器可以设置在托盘中。 当适当地定位在真空室中的托盘中时，每个容器与在盖中的相应孔中以密封关系设置的单个相应的过滤器组件流体连通。 将真空室置于真空下的阀的单次致动导致盖子密封到基座并驱动多个样品的同时过滤。
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公开(公告)号：US09592577B2
公开(公告)日：2017-03-14
申请号：US14311395
申请日：2014-06-23
Applicant: EMD Millipore Corporation
Inventor： Sebastien Cirou , Jean-Louis Weissenbach , Rene Reinbigler , Jean-Luc Beulay , Frans Mels , Cecile Delbos
IPC: B01D25/12 , B01D25/127 , B01D25/164 , B01D25/19 , B01D61/18 , B01D61/20 , B01D63/08 , B23P19/04
CPC classification number: B23P19/04 , B01D25/127 , B01D25/14 , B01D25/164 , B01D25/19 , B01D61/18 , B01D61/20 , B01D63/082 , B01D2313/02 , B01D2313/06 , B01D2313/105 , B01D2313/125 , Y10T29/49826
Abstract: The invention concerns a filtration device comprising a providing fluid connection and mechanical connection comprising a clamping plate movably mounted relative to the manifold and adapted to compress at least one cassette against the manifold, means for driving and guiding the clamping plate comprising a rod extending between the manifold and the plate, an actuator provided with a body and a member moveable relative to the body, which member is adapted to move through a predetermined travel between an extended position and a retracted position, the body being carried by the manifold, and the member carrying the rod and driving the plate via the rod to a clamped position in which the member is in an intermediate retracted position in which it has moved through a shorter travel than the predetermined travel relative to its extended position.
Abstract translation: 本发明涉及一种过滤装置，包括提供流体连接和机械连接，其包括可相对于歧管可移动地安装的夹板，并且适于将至少一个盒体压靠在歧管上，用于驱动和引导夹板的装置， 歧管和板，致动器，其设置有主体和可相对于主体移动的构件，该构件适于在延伸位置和缩回位置之间移动通过预定行程，所述主体由歧管承载，并且构件 承载杆并经由杆驱动板到夹紧位置，在夹紧位置中，构件处于中间缩回位置，在夹紧位置中，其已经相对于其延伸位置移动经过比预定行程更短的行程。
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