公开(公告)号：US07088143B2

公开(公告)日：2006-08-08

申请号：US10847018

申请日：2004-05-17

Applicant: Li Ding ,  Pinaki Mazumder

Inventor： Li Ding ,  Pinaki Mazumder

IPC: H03K19/096 ,  H03K19/00 ,  H03K19/20 ,  H03K19/094

CPC classification number: H03K19/0963

Abstract: A number of different dynamic circuits having improved noise tolerance and a method for designing same are provided. The circuits include a power supply node and a precharge node. Keeper circuitry is connected to the nodes and has a current-voltage characteristic that exhibits a negative differential resistance property to improve noise tolerance of the circuits.

Abstract translation: 提供了许多具有改进的噪声容限的不同动态电路及其设计方法。 电路包括电源节点和预充电节点。 Keeper电路连接到节点，并具有呈现负差分电阻特性的电流 - 电压特性，以改善电路的噪声容限。

公开(公告)号：US06927056B2

公开(公告)日：2005-08-09

申请号：US10363937

申请日：2001-09-06

Applicant: Stephen Todd ,  Angelo M. Delegeane ,  Ameena R. Gandhi ,  Danniel B. Nguyen ,  April J. A. Hafalia ,  Liam Kearney ,  Yan Lu ,  Ernestine A. Lee ,  Narinder K. Chawla ,  Debopriya Das ,  Chandra S. Arvizu ,  Monique G. Yao ,  Deborah A. Kallick ,  Vicki S. Elliott ,  Li Ding ,  Henry Yue ,  Roopa M. Reddy ,  Dyung Aina M. Lu ,  Jayalaxmi Ramkumar ,  Junming Yang ,  Catherine M. Tribouley ,  Neil Burford ,  Mariah R. Baughn ,  Preeti G. Lal ,  Mark L. Borowsky ,  Farrah A. Khan ,  Rajagopal Gururajan ,  Y. Tom Tang ,  Janice K. Au-Young ,  Bridget A. Warren ,  Roberto Hernandez ,  Brendan M. Duggan

Inventor： Stephen Todd ,  Angelo M. Delegeane ,  Ameena R. Gandhi ,  Danniel B. Nguyen ,  April J. A. Hafalia ,  Liam Kearney ,  Yan Lu ,  Ernestine A. Lee ,  Narinder K. Chawla ,  Debopriya Das ,  Chandra S. Arvizu ,  Monique G. Yao ,  Deborah A. Kallick ,  Vicki S. Elliott ,  Li Ding ,  Henry Yue ,  Roopa M. Reddy ,  Dyung Aina M. Lu ,  Jayalaxmi Ramkumar ,  Junming Yang ,  Catherine M. Tribouley ,  Neil Burford ,  Mariah R. Baughn ,  Preeti G. Lal ,  Mark L. Borowsky ,  Farrah A. Khan ,  Rajagopal Gururajan ,  Y. Tom Tang ,  Janice K. Au-Young ,  Bridget A. Warren ,  Roberto Hernandez ,  Brendan M. Duggan

IPC: A01K67/00 ,  C07H21/04 ,  C12N9/64 ,  C12N15/09 ,  C12P21/06 ,  C12Q1/68 ,  C12N1/20 ,  C12N15/00 ,  C12N15/63

CPC classification number: C12N9/6421 ,  A01K2217/05 ,  A01K2217/075 ,  C07H21/04 ,  C12N9/6472 ,  C12Q1/6837 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  Y02A50/52

Abstract: The invention provides a human cysteine proteases and polynucleotides which encode those proteases. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists, as well as methods for diagnosing, treating, or preventing disorders associated with aberrant expression of cysteine proteases.

Abstract translation: 本发明提供编码这些蛋白酶的人半胱氨酸蛋白酶和多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂，以及用于诊断，治疗或预防与半胱氨酸蛋白酶异常表达相关的紊乱的方法。

公开(公告)号：US20050135974A1

公开(公告)日：2005-06-23

申请号：US10739784

申请日：2003-12-18

Applicant: Michael Harvey ,  Lara Dowland ,  Breck Parker ,  Stephen Sherman ,  To Cheung ,  Bin Li ,  Yong Peng ,  Qi- Cai ,  Ke Liu ,  Hai Ge ,  Fu Deng ,  Li Ding

Inventor： Michael Harvey ,  Lara Dowland ,  Breck Parker ,  Stephen Sherman ,  To Cheung ,  Bin Li ,  Yong Peng ,  Qi- Cai ,  Ke Liu ,  Hai Ge ,  Fu Deng ,  Li Ding

IPC: B01L3/00 ,  B01L9/00 ,  G01N1/31 ,  G01N31/22

CPC classification number: B01L3/50855 ,  B01L9/52 ,  B01L2200/025 ,  B01L2300/0822 ,  B01L2300/0829 ,  G01N1/312

Abstract: The present invention relates to a device for preparing assay samples using a number of microscope slides. Each slide has a number of assay reaction surface locations spaced on the planar surface of the slide. In preferred embodiments, the device comprises, in part, a microscope slide holder that has the exterior dimensions of a SBS standard microplate, such as a 96 well plate. The device accepts conventional microscope slides equipped with sixteen microarray surfaces spaced nine millimeters apart on center, or four for a 96 well plate. Individual chamber plates are placed on top of the slides, creating an individual well above each assay reaction surface location. In preferred embodiments, each assay reaction surface location can comprise a microarray of multiple reactive sites. Thus, parallel processing can be done of samples for genomic or proteomic profiling. An advantage of the present invention is that one can use the conventional high throughput assaying equipment for SBS standard microplates while using conventional microscope slides, thereby allowing the use of robotic assay reading equipment designed for slides.

Abstract translation: 本发明涉及使用多个显微镜幻灯片制备测定样品的装置。 每个载片具有在载玻片平面上间隔开的多个测定反应表面位置。 在优选实施例中，该装置部分地包括具有诸如96孔板的SBS标准微板的外部尺寸的显微镜载玻片保持器。 该装置接受传统的显微镜载玻片，其中装有十六个微阵列表面，中心隔开9毫米，或四个96孔板。 单独的室板放置在载玻片的顶部，在每个测定反应表面位置之上产生单个孔。 在优选实施方案中，每个测定反应表面位置可以包含多个反应性位点的微阵列。 因此，可以对基因组或蛋白质组图谱的样品进行并行处理。 本发明的一个优点是可以使用传统的高通量测定设备用于SBS标准微孔板，同时使用传统的显微镜载玻片，从而允许使用为幻灯片设计的机器人测定读数设备。

公开(公告)号：US20050118582A1

公开(公告)日：2005-06-02

申请号：US10483505

申请日：2002-07-10

Applicant: Anita Swarnakar ,  Thomas Richardson ,  Bridget Warren ,  Jennifer Griffin ,  Y Tang ,  Henry Yue ,  Mariah Baughn ,  Brooke Emerling ,  Preeti Lal ,  Dyung Lu ,  Ian Forsythe ,  Jayalaxmi Ramkumar ,  Joana Li ,  Shanya Becha ,  Brendan Duggan ,  Madhusudan Sanjanwala ,  Ernestine Lee ,  Neil Burford ,  Vicki Elliott ,  Craig Ison ,  Li Ding ,  Mark Borowsky ,  Monique Yao ,  Ines Barroso ,  Bao Tran ,  Narinder Chawla ,  April Hafalia ,  Danniel Nguyen ,  Yan Lu ,  Chandra Arvizu

Inventor： Anita Swarnakar ,  Thomas Richardson ,  Bridget Warren ,  Jennifer Griffin ,  Y Tang ,  Henry Yue ,  Mariah Baughn ,  Brooke Emerling ,  Preeti Lal ,  Dyung Lu ,  Ian Forsythe ,  Jayalaxmi Ramkumar ,  Joana Li ,  Shanya Becha ,  Brendan Duggan ,  Madhusudan Sanjanwala ,  Ernestine Lee ,  Neil Burford ,  Vicki Elliott ,  Craig Ison ,  Li Ding ,  Mark Borowsky ,  Monique Yao ,  Ines Barroso ,  Bao Tran ,  Narinder Chawla ,  April Hafalia ,  Danniel Nguyen ,  Yan Lu ,  Chandra Arvizu

IPC: C07K14/47 ,  C12N15/12 ,  C12Q1/68 ,  C07H21/04 ,  C12M1/34 ,  C12N9/22

CPC classification number: C07K14/4702

Abstract: Various embodiments of the invention provide human nucleic acid-associated proteins (NAAP) and polynucleotides which identify and encode NAAP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of NAAP.

Abstract translation: 本发明的各种实施方案提供了识别和编码NAAP的人核酸相关蛋白（NAAP）和多核苷酸。 本发明的实施方案还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 其他实施方案提供用于诊断，治疗或预防与NAAP异常表达相关的紊乱的方法。

公开(公告)号：US20050112745A1

公开(公告)日：2005-05-26

申请号：US10976440

申请日：2004-10-29

Applicant: Preeti Lal ,  Y. Tang ,  Henry Yue ,  Neil Burford ,  Ameena Gandhi ,  Bridget Warren ,  Monique Yao ,  Catherine Tribouley ,  Mariah Baughn ,  Ernestine Lee ,  April Hafalia ,  Yan Lu ,  Jennifer Griffin ,  Madhusudan Sanjanwala ,  Li Ding

Inventor： Preeti Lal ,  Y. Tang ,  Henry Yue ,  Neil Burford ,  Ameena Gandhi ,  Bridget Warren ,  Monique Yao ,  Catherine Tribouley ,  Mariah Baughn ,  Ernestine Lee ,  April Hafalia ,  Yan Lu ,  Jennifer Griffin ,  Madhusudan Sanjanwala ,  Li Ding

IPC: A61K38/00 ,  A61K48/00 ,  C12N9/10 ,  C40B40/10 ,  A61K38/48 ,  C07H21/04

CPC classification number: C12N9/10 ,  A61K38/00 ,  A61K48/00 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01J2219/00725 ,  C40B40/10

Abstract: The invention provides human transferases (TRNFR) and polynucleotides which identify and encode TRNFR. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of TRNFR.

Abstract translation: 本发明提供鉴定和编码TRNFR的人转移酶（TRNFR）和多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供用于诊断，治疗或预防与TRNFR异常表达相关的紊乱的方法。

公开(公告)号：US5961990A

公开(公告)日：1999-10-05

申请号：US850167

申请日：1997-05-02

Applicant: Pascal Delrieu ,  Li Ding

Inventor： Pascal Delrieu ,  Li Ding

IPC: A61K8/02 ,  A61K8/00 ,  A61K8/04 ,  A61K8/11 ,  A61K8/29 ,  A61K8/33 ,  A61K8/36 ,  A61K8/49 ,  A61K8/64 ,  A61K8/65 ,  A61K8/66 ,  A61K8/73 ,  A61P17/16 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q1/10 ,  A61Q1/12 ,  A61Q17/04 ,  A61Q19/00 ,  A61K9/14

CPC classification number: A61K8/042 ,  A61K8/0287 ,  A61K8/73 ,  A61K8/737 ,  A61Q17/04 ,  A61Q19/00 ,  A61K2800/56 ,  A61K2800/654 ,  Y10S514/937 ,  Y10S514/944

Abstract: A protective cosmetic particulate gel delivery system for a topically applied active agent employs an agar gel and a restraining polymer to retain the actve agent in the gel. The particles have an average particle diameter of at least 0.05 mm while the restraining polymer has a molecular weight of at least 50,000 daltons and has retention groups to bind the active agent. The restraining polymers can be selected from the group consisting of polyquaternium 24, laurdimonium hydroxyethylcellulose, cocodimonium hydroxyethylcellulose, steardimonium hydroxyethylcellulose, quaternary ammonium substituted water-soluble polysaccharides, alleyl quaternary celluloses and polypeptides having or provided with retention groups to retain the active agent. The gel particles of the invention are manually crushable on the skin to increase the surface area of the gel particle material and expose the restraining polymer to the skin or other body surface for release of the active agent. The delivery system can be incorporated in multiphase cosmetic formulations such as gels, creams and lotions.

Abstract translation: 用于局部施用的活性剂的保护性化妆品颗粒状凝胶递送系统使用琼脂凝胶和约束聚合物将活性剂保留在凝胶中。 颗粒的平均粒径至少为0.05mm，而抑制聚合物的分子量至少为50,000道尔顿，并具有结合活性剂的保留基团。 约束聚合物可以选自聚季铵盐24，月桂基二甲基羟乙基纤维素，椰子二甲基羟乙基纤维素，聚对苯二甲酸羟乙基纤维素，季铵取代的水溶性多糖，等位基季铵纤维素和具有或具有保留活性剂的保留基团的多肽。 本发明的凝胶颗粒可手动压碎在皮肤上以增加凝胶颗粒材料的表面积，并将约束聚合物暴露于皮肤或其他身体表面以释放活性剂。 递送系统可以并入多相化妆品配方如凝胶，乳膏和洗剂中。

公开(公告)号：US10776725B2

公开(公告)日：2020-09-15

申请号：US12815375

申请日：2010-06-14

Applicant: Li Ding ,  Diana H. Lau ,  Elena H. Litani ,  Joanna W. Ng ,  Leho Nigul

Inventor： Li Ding ,  Diana H. Lau ,  Elena H. Litani ,  Joanna W. Ng ,  Leho Nigul

IPC: G06F9/44 ,  G06Q10/04 ,  G06Q10/10

Abstract: A method for implementing a graphical modeling tool in a web-based environment is disclosed herein. In one embodiment, such a method may include enabling a user to import, into a web-based environment, a domain meta model comprising a number of meta model elements. The method may further enable the user to associate the meta model elements with graphical representations in the web-based environment, thereby allowing the user to create palette elements. The user may then assemble the palette elements on a canvas to create a diagram. This diagram may be converted into an instance of the domain meta model. This instance may be validated for conformance with the rules and constraints associated with the domain meta model. A corresponding apparatus and computer program product are also disclosed and claimed herein.

公开(公告)号：US20150378879A1

公开(公告)日：2015-12-31

申请号：US14319786

申请日：2014-06-30

Applicant: Li Ding

Inventor： Li Ding

IPC: G06F11/36

CPC classification number: G06F11/3688 ,  G06F11/3684

Abstract: An embodiment of a method of testing software can include, as performed by at least one computing device, evaluating a first criterion for a plurality of software components, selecting a subset of the plurality of software components based on the evaluated first criterion, evaluating a second criterion for a plurality of test cases each defining a respective test to evaluate functionality of at least one of the software components, selecting a subset of the plurality of test cases based on the evaluated second criterion, and testing the selected subset of the plurality of software components utilizing the selected subset of the plurality of test cases.

Abstract translation: 测试软件的方法的实施例可以包括如由至少一个计算设备执行的评估多个软件组件的第一标准，基于所评估的第一标准来选择所述多个软件组件的子集，评估第二标准 多个测试用例的标准，每个测试用例定义相应的测试以评估软件组件中的至少一个的功能，基于所评估的第二标准来选择多个测试用例的子集，以及测试所选择的多个软件的子集 使用多个测试用例的所选子集的组件。

公开(公告)号：US09060847B2

公开(公告)日：2015-06-23

申请号：US12380892

申请日：2009-03-04

Applicant: Thomas Smith ,  Wayne H. Knox ,  Li Ding ,  Dharmendra Jani ,  Jeffrey G. Linhardt

Inventor： Thomas Smith ,  Wayne H. Knox ,  Li Ding ,  Dharmendra Jani ,  Jeffrey G. Linhardt

IPC: B05D3/06 ,  A61L27/50 ,  A61L27/52 ,  A61F9/008 ,  B29D11/00 ,  A61F2/16

CPC classification number: A61F9/00804 ,  A61F2/1451 ,  A61F2/1627 ,  A61F2/1635 ,  A61L27/50 ,  A61L27/52 ,  A61L2430/16 ,  B29D11/00009 ,  G02C2202/14

Abstract: A method for modifying the refractive index of an optical, hydrogel polymeric material. The method comprises irradiating predetermined regions of an optical, polymeric material with a laser to form refractive structures. To facilitate the formation of the refractive structures the optical, hydrogel polymeric material comprises a photosensitizer. The presence of the photosensitizer permits one to set a scan rate to a value that is at least fifty times greater than a scan rate without the photosensitizer in the material, yet provides similar refractive structures in terms of the observed change in refractive index. Alternatively, the photosensitizer in the polymeric material permits one to set an average laser power to a value that is at least two times less than an average laser power without the photosensitizer in the material, yet provide similar refractive structures.

公开(公告)号：US08759759B2

公开(公告)日：2014-06-24

申请号：US13079740

申请日：2011-04-04

Applicant: Li Ding ,  Tao Lin ,  Gongyu Jiang ,  Hui Mu

Inventor： Li Ding ,  Tao Lin ,  Gongyu Jiang ,  Hui Mu

IPC: H01J49/00

CPC classification number: H01J49/423

Abstract: The present invention relates generally to the field of ion storage and analysis, in particular to a linear ion trap mass analyzer comprised by multiple columnar electrodes. High frequency voltages are applied on at least one of the columnar electrodes to form ion confining space, which mainly consists of two-dimensional quadrupole electric radial trapping field, and there is at least one through slot for ion ejection in at least one direction perpendicular to the axis of the ion trap, wherein an AC electric field superposition is applied to invoke dipole excitation. Opposite to the through slot, there is an elongated electrode for field adjusting between two columnar electrodes or inside the slit of one of the columnar electrodes mentioned above. The potential on the elongated electrode for field adjusting is set as the sum of a portion of the high frequency voltage which applied on one adjacent columnar electrode and a DC offset, which can be adjusted freely. Through adjusting the portion of the high frequency potential and DC potential on this electrode, one or more objectives, including field optimization inside the ion trap as well as ion motion characteristics of resonant ejection, can be realized.

Abstract translation: 本发明一般涉及离子存储和分析领域，特别涉及由多个柱状电极组成的线性离子阱质量分析仪。 在至少一个柱状电极上施加高频电压以形成主要由二维四极电子径向捕获场组成的离子限制空间，并且至少有一个通孔用于在至少一个垂直于 离子阱的轴线，其中施加AC电场叠加以调用偶极子激发。 与通孔相对，有一个用于在两个柱状电极之间进行现场调节的细长电极或者在上述一个柱状电极的狭缝内部。 用于场调整的细长电极上的电位被设置为施加在一个相邻柱状电极上的高频电压的一部分和可以自由调节的DC偏移之和。 通过调节该电极上的高频电位和直流电位的一部分，可以实现一个或多个目标，包括离子阱内的场优化以及共振喷射的离子运动特性。