Discontinuous atmospheric pressure interface
    41.
    发明授权
    Discontinuous atmospheric pressure interface 有权
    不连续的大气压力界面

    公开(公告)号:US09058967B2

    公开(公告)日:2015-06-16

    申请号:US14478529

    申请日:2014-09-05

    Abstract: A method of interfacing atmospheric pressure ion sources, including electrospray and desorption electrospray ionization sources, to mass spectrometers, for example miniature mass spectrometers, in which the ionized sample is discontinuously introduced into the mass spectrometer. Discontinuous introduction improves the match between the pumping capacity of the instrument and the volume of atmospheric pressure gas that contains the ionized sample. The reduced duty cycle of sample introduction is offset by operation of the mass spectrometer under higher performance conditions and by ion accumulation at atmospheric pressure.

    Abstract translation: 将大气压力离子源(包括电喷雾和解吸电喷雾离子源)与将其离子化样品不连续地引入质谱仪的质谱仪(例如微型质谱仪)进行接口的方法。 不连续的介绍改善了仪器的抽吸能力与含有电离样品的大气压气体的体积之间的匹配。 样品引入的减少的占空比通过质谱仪在较高性能条件下的操作和大气压下的离子积聚来抵消。

    ION GENERATION USING MODIFIED WETTED POROUS MATERIALS
    43.
    发明申请
    ION GENERATION USING MODIFIED WETTED POROUS MATERIALS 有权
    使用改性润湿多孔材料进行离子生成

    公开(公告)号:US20140183351A1

    公开(公告)日:2014-07-03

    申请号:US14119548

    申请日:2012-06-01

    Abstract: The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.

    Abstract translation: 本发明一般涉及使用改进的润湿多孔材料的离子产生。 在某些方面,本发明一般涉及使用基本上防止样品扩散到基底中的润湿多孔基质进行离子生成的系统和方法。 在其它方面,本发明一般涉及使用润湿多孔材料和干燥剂的离子产生。 在其它方面,本发明一般涉及使用改性润湿多孔基材的离子产生,其中多孔基材的至少一部分包括改变样品和基底之间的相互作用的材料。

    Systems and methods for quantifying an analyte extracted from a sample

    公开(公告)号:US11875983B2

    公开(公告)日:2024-01-16

    申请号:US17979972

    申请日:2022-11-03

    CPC classification number: H01J49/167 C12Q1/6806 Y10T436/24 Y10T436/255

    Abstract: The invention generally relates to systems and methods for quantifying an analyte extracted from a sample. In certain embodiments, the invention provides methods that involve introducing a solvent into a capillary, introducing the capillary into a vessel including a sample such that a portion of the sample is introduced into the capillary, moving the sample and the solvent within the capillary to induce circulation within the sample and the solvent, thereby causing the analyte to be extracted from the sample and into the solvent, analyzing the analyte that has been extracted from the sample, and quantifying the analyte. In certain embodiments, the quantifying step is performed without knowledge of a volume of the sample and/or solvent.

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