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公开(公告)号:US09058967B2
公开(公告)日:2015-06-16
申请号:US14478529
申请日:2014-09-05
Applicant: Purdue Research Foundation
Inventor: Zheng Ouyang , Liang Gao , Robert Graham Cooks
CPC classification number: H01J49/24 , H01J49/00 , H01J49/0013 , H01J49/0027 , H01J49/0031 , H01J49/004 , H01J49/04 , H01J49/0404 , H01J49/0422 , H01J49/0495 , H01J49/10 , H01J49/165 , H01J49/26
Abstract: A method of interfacing atmospheric pressure ion sources, including electrospray and desorption electrospray ionization sources, to mass spectrometers, for example miniature mass spectrometers, in which the ionized sample is discontinuously introduced into the mass spectrometer. Discontinuous introduction improves the match between the pumping capacity of the instrument and the volume of atmospheric pressure gas that contains the ionized sample. The reduced duty cycle of sample introduction is offset by operation of the mass spectrometer under higher performance conditions and by ion accumulation at atmospheric pressure.
Abstract translation: 将大气压力离子源(包括电喷雾和解吸电喷雾离子源)与将其离子化样品不连续地引入质谱仪的质谱仪(例如微型质谱仪)进行接口的方法。 不连续的介绍改善了仪器的抽吸能力与含有电离样品的大气压气体的体积之间的匹配。 样品引入的减少的占空比通过质谱仪在较高性能条件下的操作和大气压下的离子积聚来抵消。
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公开(公告)号:US20140299764A1
公开(公告)日:2014-10-09
申请号:US14277191
申请日:2014-05-14
Applicant: Purdue Research Foundation
Inventor: Zheng Ouyang , Jason David Harper , Nicholas Alan Charipar , Robert Graham Cooks
CPC classification number: H01J37/32009 , H01J27/022 , H01J37/00 , H01J37/32348 , H01J49/02 , H01J49/105 , H01J49/142 , H01J2237/0044 , H05H1/24 , H05H1/2406 , H05H1/30 , H05H2001/2412 , H05H2001/2443 , H05H2240/10 , H05H2240/20 , Y10T436/145555 , Y10T436/147777 , Y10T436/173076 , Y10T436/203332 , Y10T436/24
Abstract: The present invention generally relates to a low temperature plasma probe for desorbing and ionizing at least one analyte in a sample material and methods of use thereof. In one embodiment, the invention generally relates to a low temperature plasma probe including: a housing having a discharge gas inlet port, a probe tip, two electrodes, and a dielectric barrier, in which the two electrodes are separated by the dielectric barrier, in which application of voltage from a power supply generates a low temperature plasma, and in which the low temperature plasma is propelled out of the discharge region by the electric field and/or the discharge gas flow.
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43.
公开(公告)号:US20140183351A1
公开(公告)日:2014-07-03
申请号:US14119548
申请日:2012-06-01
Applicant: PURDUE RESEARCH FOUNDATION
Inventor: Robert G. Cooks , Zheng Ouyang , Ryan Espy
CPC classification number: G01N30/95 , G01N30/91 , G01N33/49 , H01J49/0031 , H01J49/0404 , H01J49/0409 , H01J49/0431 , H01J49/167 , H01J49/168
Abstract: The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.
Abstract translation: 本发明一般涉及使用改进的润湿多孔材料的离子产生。 在某些方面,本发明一般涉及使用基本上防止样品扩散到基底中的润湿多孔基质进行离子生成的系统和方法。 在其它方面,本发明一般涉及使用润湿多孔材料和干燥剂的离子产生。 在其它方面,本发明一般涉及使用改性润湿多孔基材的离子产生,其中多孔基材的至少一部分包括改变样品和基底之间的相互作用的材料。
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公开(公告)号:US08710437B2
公开(公告)日:2014-04-29
申请号:US14023851
申请日:2013-09-11
Applicant: Purdue Research Foundation
Inventor: Robert Graham Cooks , Ahmed Mohamed Hamid , Alan Keith Jarmusch , Zheng Ouyang
IPC: B01D59/44
CPC classification number: H01J49/0036 , C12Q1/04 , G01N2560/00 , H01J49/04 , H01J49/0409 , H01J49/0422 , H01J49/10 , H01J49/16 , H01J49/26
Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.
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45.
公开(公告)号:US20140011282A1
公开(公告)日:2014-01-09
申请号:US14010130
申请日:2013-08-26
Applicant: Purdue Research Foundation
Inventor: Zheng Ouyang , Jason Harper , Nicholas Charipar , Robert Graham Cooks
IPC: H01J27/02
CPC classification number: H01J37/32009 , H01J27/022 , H01J37/00 , H01J37/32348 , H01J49/02 , H01J49/105 , H01J49/142 , H01J2237/0044 , H05H1/24 , H05H1/2406 , H05H1/30 , H05H2001/2412 , H05H2001/2443 , H05H2240/10 , H05H2240/20 , Y10T436/145555 , Y10T436/147777 , Y10T436/173076 , Y10T436/203332 , Y10T436/24
Abstract: The present invention generally relates to a low temperature plasma probe for desorbing and ionizing at least one analyte in a sample material and methods of use thereof. In one embodiment, the invention generally relates to a low temperature plasma probe including: a housing having a discharge gas inlet port, a probe tip, two electrodes, and a dielectric barrier, in which the two electrodes are separated by the dielectric barrier, in which application of voltage from a power supply generates a low temperature plasma, and in which the low temperature plasma is propelled out of the discharge region by the electric field and/or the discharge gas flow.
Abstract translation: 本发明一般涉及用于解吸和电离样品中至少一种分析物的低温等离子体探针及其使用方法。 在一个实施方案中,本发明一般涉及一种低温等离子体探针,其包括:壳体,其具有放电气体入口端口,探针尖端,两个电极和介电屏障,其中两个电极由电介质屏障隔开, 来自电源的电压的施加产生低温等离子体,其中通过电场和/或放电气体流将低温等离子体推出排出区域。
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公开(公告)号:US11903707B2
公开(公告)日:2024-02-20
申请号:US17692613
申请日:2022-03-11
Applicant: Purdue Research Foundation
Inventor: Robert Graham Cooks , Zheng Ouyang , Chien-hsun Chen , Ziqing Lin , Livia Schiavinato Eberlin
IPC: A61B5/1477 , A61B10/00 , H01J49/04 , A61M11/00 , A61M25/00 , H01J49/00 , H01J49/16 , H01J49/34 , G01N33/483 , A61B5/145 , A61B5/15 , A61B5/157 , G01N1/02
CPC classification number: A61B5/1477 , A61B10/0045 , A61M11/00 , A61M25/00 , G01N33/4833 , H01J49/0022 , H01J49/0404 , H01J49/0445 , H01J49/167 , H01J49/34 , A61B5/145 , A61B5/1405 , A61B5/157 , A61B5/150015 , A61B5/150992 , A61M2202/0468 , G01N2001/028
Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.
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公开(公告)号:US11875983B2
公开(公告)日:2024-01-16
申请号:US17979972
申请日:2022-11-03
Applicant: Purdue Research Foundation
Inventor: Zheng Ouyang , Yue Ren , Ziqing Lin
IPC: H01J49/16 , H01J49/04 , C12Q1/6806
CPC classification number: H01J49/167 , C12Q1/6806 , Y10T436/24 , Y10T436/255
Abstract: The invention generally relates to systems and methods for quantifying an analyte extracted from a sample. In certain embodiments, the invention provides methods that involve introducing a solvent into a capillary, introducing the capillary into a vessel including a sample such that a portion of the sample is introduced into the capillary, moving the sample and the solvent within the capillary to induce circulation within the sample and the solvent, thereby causing the analyte to be extracted from the sample and into the solvent, analyzing the analyte that has been extracted from the sample, and quantifying the analyte. In certain embodiments, the quantifying step is performed without knowledge of a volume of the sample and/or solvent.
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公开(公告)号:US11830716B2
公开(公告)日:2023-11-28
申请号:US17841141
申请日:2022-06-15
Applicant: Purdue Research Foundation
Inventor: Robert Graham Cooks , Ahmed Mohamed Hamid , Alan Keith Jarmusch , Zheng Ouyang
CPC classification number: H01J49/0445 , C12N13/00 , C12Q1/04 , G01N2560/00 , H01J49/16
Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.
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公开(公告)号:US20230154737A1
公开(公告)日:2023-05-18
申请号:US17841141
申请日:2022-06-15
Applicant: Purdue Research Foundation
Inventor: Robert Graham Cooks , Ahmed Mohamed Hamid , Alan Keith Jarmusch , Zheng Ouyang
CPC classification number: H01J49/0445 , C12N13/00 , C12Q1/04 , H01J49/16
Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.
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50.
公开(公告)号:US11060959B2
公开(公告)日:2021-07-13
申请号:US16302379
申请日:2017-06-02
Applicant: Purdue Research Foundation
Inventor: Zheng Ouyang , Wenpeng Zhang
Abstract: Systems and methods for analyzing an analyte extracted from a sample using an adsorbent material.
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