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公开(公告)号：US09623081B2
公开(公告)日：2017-04-18
申请号：US14873847
申请日：2015-10-02
申请人： Ntercept, LLC
发明人： Louis Hawthorne
CPC分类号： A61K38/191 , A61K38/195 , A61K38/2013 , A61K47/10 , A61K47/60 , A61K47/61 , A61K47/62 , A61K47/642 , A61K47/6923 , A61K47/6929 , A61K47/6937 , B82Y5/00 , B82Y30/00
摘要： The disclosure provides, among other things, compositions that bind to and inhibit the biological activity of soluble biomolecules, as well as pharmaceutical compositions thereof. Also provided herein are a number of applications (e.g., therapeutic applications) in which the compositions are useful.
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公开(公告)号：US09616104B2
公开(公告)日：2017-04-11
申请号：US14744941
申请日：2015-06-19
发明人： Francois Binette
CPC分类号： A61K38/191 , A61K9/0019 , A61K9/5031 , A61K45/06
摘要： Effective methods of treating a spinal disorder or osteoarthritis associated with a proinflammatory agent in a patient in need of such treatment, the method comprising administering an effective amount of DN-TNF (e.g., XPro®-1595) to a target tissue site at or near the spine or osteoarthritic joint to reduce pain and/or inflammation.
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公开(公告)号：US20170080030A1
公开(公告)日：2017-03-23
申请号：US15126460
申请日：2015-03-17
CPC分类号： A61K35/28 , A61K9/0019 , A61K9/0048 , A61K9/0051 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/19 , A61K38/191 , A61K38/204 , C12N5/0667 , C12N2533/74 , A61K2300/00
摘要： The present invention encompasses the use of adipose tissue derived cells, or conditioned medium of such cells, to treat and prevent vascular related injuries, diseases, disorders, and conditions such as diabetic retinopathy, where, in one aspect, pericytes such as retinal pericytes have been lost or damaged. The present application further discloses compositions and methods useful for enhancing the function and activity of the adipose tissue derived cells in the treatment and prevention of injuries, diseases, disorders, and conditions including the use of TGFβ to condition the cells to enhance their activity.
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公开(公告)号：US09597431B2
公开(公告)日：2017-03-21
申请号：US14274897
申请日：2014-05-12
IPC分类号： A61K35/28 , A61K38/16 , A61K38/17 , A61K38/18 , A61K38/19 , A61K38/22 , A61L27/54 , A61K9/00 , A61K35/32 , A61K38/29 , A61L27/12 , A61K38/20 , A61K31/573 , A61K33/42 , A61L27/36 , A61L27/38 , A61F2/28
CPC分类号： A61L27/54 , A61F2/28 , A61F2002/2817 , A61F2310/00359 , A61K9/0024 , A61K31/573 , A61K33/42 , A61K35/32 , A61K38/177 , A61K38/1866 , A61K38/191 , A61K38/193 , A61K38/2006 , A61K38/202 , A61K38/29 , A61L27/12 , A61L27/3608 , A61L27/3821 , A61L2300/258 , A61L2300/412 , A61L2300/414 , A61L2300/426 , A61L2300/428 , A61L2300/43 , A61L2300/45 , A61L2400/18 , A61L2430/02 , A61K2300/00
摘要： A method for promoting bone formation is provided. More specifically, a method for promoting bone formation by promoting osteoclast formation is provided. In one embodiment, an implant comprising an implantable material and an osteoclast stimulating substance is provided.
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45.发明申请METHODS AND COMPOSITIONS FOR PRODUCING AN ADENOVIRUS VECTOR FOR USE WITH MULTIPLE VACCINATIONS 审中-公开用于生产用于多种疫苗的腺病毒载体的方法和组合物公开(公告)号：US20170065706A1
公开(公告)日：2017-03-09
申请号：US15265723
申请日：2016-09-14
申请人： Etubics Corporation
IPC分类号： A61K39/12 , C07K14/71 , A61K39/21 , C07K14/705 , A61K39/00 , C07K14/005 , C12N15/86
CPC分类号： A61K39/12 , A61K38/191 , A61K38/193 , A61K38/2013 , A61K38/2026 , A61K38/2033 , A61K38/204 , A61K38/2046 , A61K38/2066 , A61K38/208 , A61K38/217 , A61K39/00 , A61K39/0011 , A61K39/21 , A61K39/235 , A61K2039/5256 , A61K2039/54 , A61K2039/545 , A61K2039/55555 , A61K2039/57 , A61K2039/575 , A61P35/00 , C07K14/005 , C07K14/70503 , C07K14/71 , C12N15/86 , C12N2710/10034 , C12N2710/10321 , C12N2710/10334 , C12N2710/10343 , C12N2710/10371 , C12N2710/20034 , C12N2740/15034 , C12N2740/16234 , C12N2800/24
摘要： Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided.
摘要翻译： 提供了使用允许使用相同腺病毒载体进行多次疫苗接种的腺病毒载体产生免疫反应的方法，并且在具有预先存在的腺病毒免疫的个体中接种疫苗。
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46.发明授权Modified polynucleotides for the production of oncology-related proteins and peptides 有权用于产生肿瘤学相关蛋白和肽的修饰多核苷酸公开(公告)号：US09587003B2
公开(公告)日：2017-03-07
申请号：US15015684
申请日：2016-02-04
发明人： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Sayda M. Elbashir , Matthias John , Atanu Roy , Susan Whoriskey , Kristy M. Wood , Paul Hatala , Jason P. Schrum , Kenechi Ejebe , Jeff Lynn Ellsworth , Justin Guild
IPC分类号： C07K14/535 , C07K14/505
CPC分类号： C07K14/535 , A61K9/0019 , A61K9/1271 , A61K9/1272 , A61K9/1277 , A61K9/14 , A61K9/5031 , A61K31/7088 , A61K38/1767 , A61K38/1816 , A61K38/1866 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/215 , A61K38/36 , A61K38/363 , A61K38/44 , A61K38/4833 , A61K38/4846 , A61K39/3955 , A61K47/10 , A61K47/54 , A61K47/542 , A61K48/00 , A61K48/0033 , A61K48/0066 , A61K48/0075 , C07K14/47 , C07K14/475 , C07K14/505 , C07K14/525 , C07K14/56 , C07K14/565 , C07K14/745 , C07K14/75 , C07K16/2887 , C07K16/32 , C07K19/00 , C12N9/0069 , C12N9/644 , C12N15/85 , C12N15/88 , C12N2840/00 , C12Y113/12007 , C12Y304/21005 , C12Y304/21022
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules.
摘要翻译： 本发明涉及用于制备，制造和治疗使用肿瘤学相关多核苷酸，肿瘤学相关的初级转录物和肿瘤相关的mmRNA分子的组合物和方法。
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47.发明授权Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins 有权用于产生细胞质和细胞骨架蛋白的修饰多核苷酸公开(公告)号：US09572897B2
公开(公告)日：2017-02-21
申请号：US15042173
申请日：2016-02-12
发明人： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Sayda M. Elbashir , Matthias John , Atanu Roy , Susan Whoriskey , Kristy M. Wood , Paul Hatala , Jason P. Schrum , Kenechi Ejebe , Jeff Lynn Ellsworth , Justin Guild
IPC分类号： A61K48/00 , A61K31/7115 , A61K9/127 , C12N9/64 , C07K14/515 , C07K16/00 , C07K14/535 , C07K14/47 , A61K38/17 , A61K38/45 , C07K14/005 , C07K14/435 , C07K14/485 , C07K14/505 , C07K14/62 , C07K14/705 , C12N9/10 , C12N9/16 , C12N9/24 , C12N9/42 , C12N9/88 , C12N9/00 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , A61K9/51 , A61K38/18 , A61K38/19 , A61K38/21 , A61K38/48 , A61K47/48 , C07K14/525 , C07K14/56 , A61K9/14 , A61K38/00
CPC分类号： A61K48/0066 , A61K9/0019 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/48046 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07K14/005 , C07K14/435 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/485 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/56 , C07K14/62 , C07K14/705 , C07K16/00 , C12N9/1051 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/644 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y304/21022 , C12Y603/02019
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
摘要翻译： 本发明涉及多核苷酸，初级转录物和mmRNA分子的制备，制备和治疗用途的组合物和方法。
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48.发明授权公开(公告)号：US09545507B2
公开(公告)日：2017-01-17
申请号：US13641507
申请日：2011-04-27
CPC分类号： A61M37/0015 , A61B17/205 , A61K9/0021 , A61K9/7023 , A61K38/1793 , A61K38/191 , A61M2037/0023 , A61M2037/003 , A61M2037/0038 , A61M2037/0053 , A61M2037/0061 , B29C59/002 , B29C59/026 , B29C2059/023 , B29K2995/0056 , B29L2031/7544 , B29L2031/756 , Y10T156/10 , Y10T156/1039 , Y10T156/1057
摘要： Disclosed are injection molded devices including microneedles on a substrate base. The microneedles may include a plurality of nano-sized structures fabricated thereon. The molds used to form the microneedles are assembled from a plurality of mold segments, each defining portions of the microneedles. Upon assembly of the multiple mold segments, microneedle negative cavities are formed. The molds may be used in an injection molding process to form microneedle arrays. Devices may be utilized for interacting with a component of the dermal connective tissue.
摘要翻译： 本发明公开了一种注射成型装置，其包括在基底上的微针。 微针可以包括在其上制造的多个纳米尺寸结构。 用于形成微针的模具由多个模具段组装，每个模具段限定微针的部分。 在组装多个模具段时，形成微针负空腔。 模具可以用于注射成型工艺以形成微针阵列。 装置可用于与真皮结缔组织的组分相互作用。
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49.发明申请公开(公告)号：US20160361388A1
公开(公告)日：2016-12-15
申请号：US15246789
申请日：2016-08-25
申请人： Ahmed H. Al-Qahtani
发明人： Ahmed H. Al-Qahtani
IPC分类号： A61K38/20 , A61K31/7036 , A61K38/12 , A61K47/38 , A61K31/07 , A45C11/00 , A61K31/19 , A61K38/17 , A61K38/19 , A61K38/18 , C12N5/079 , A61K9/00 , A61K47/18
CPC分类号： A61K38/2086 , A45C11/005 , A61K9/0048 , A61K31/07 , A61K31/165 , A61K31/19 , A61K31/341 , A61K31/351 , A61K31/382 , A61K31/4178 , A61K31/7036 , A61K33/10 , A61K33/14 , A61K35/30 , A61K38/12 , A61K38/1735 , A61K38/1793 , A61K38/18 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/19 , A61K38/191 , A61K38/193 , A61K38/195 , A61K38/2006 , A61K38/2013 , A61K38/2026 , A61K38/204 , A61K38/2046 , A61K38/2053 , A61K47/183 , A61K47/38 , C12N5/0621 , C12N2500/84 , C12N2501/734 , C12N2501/999 , C12N2502/085 , C12Y304/21004 , A61K2300/00
摘要： The present invention relates to topical ophthalmic compositions for treating or preventing epithelial lesions or ophthalmic disorders, including dry eye or keratoconjunctivitis sicca.
摘要翻译： 本发明涉及用于治疗或预防上皮损伤或眼科疾病的局部用眼用组合物，其包括干眼症或角结膜结膜炎。
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50.发明申请公开(公告)号：US20160354333A1
公开(公告)日：2016-12-08
申请号：US15172372
申请日：2016-06-03
发明人： Undurti N. Das
CPC分类号： A61K31/202 , A61K9/0019 , A61K9/08 , A61K38/1709 , A61K38/191 , A61K38/21 , A61K45/06 , A61K47/02 , A61K47/10 , A61K47/542
摘要： Pharmaceutical compositions with selective tumoricial activity comprising polyunsaturated fatty acids or a pharmaceutically acceptable salt or derivative thereof, in an aqueous solution or emulsion are provided. Methods associated with preparation and use of such compositions and methods to selectively cause tumoricial and/or anti-angiogenic action in a neoplastic region, such as cancer, are also provided.
摘要翻译： 提供了在水溶液或乳液中包含多不饱和脂肪酸或其药学上可接受的盐或衍生物的具有选择性肿瘤活性的药物组合物。 还提供了与这样的组合物的制备和使用相关的方法，以及在肿瘤区域如癌症中选择性地引起肿瘤和/或抗血管生成作用的方法。
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