公开(公告)号：US09884853B2

公开(公告)日：2018-02-06

申请号：US14392304

申请日：2014-09-23

Applicant: CHDI Foundation, Inc.

Inventor： Leticia M. Toledo-Sherman ,  Celia Dominguez ,  Michael Prime ,  William Mitchell ,  Naomi Went

IPC: C07D413/00 ,  C07D263/00 ,  C07D307/00 ,  C07D277/60 ,  C07D231/56 ,  C07D209/04 ,  C07D237/26 ,  C07D239/72 ,  C07D217/00 ,  C07D215/00 ,  C07D413/12 ,  C07D215/18 ,  C07D319/18 ,  C07D333/06 ,  C07D241/42 ,  C07D277/24 ,  C07D277/64 ,  C07D213/46 ,  C07D307/79 ,  C07D209/08 ,  C07D217/02 ,  C07D235/08 ,  C07D237/28 ,  C07D239/74 ,  C07D261/20 ,  C07D263/56 ,  C07D333/10 ,  C07D333/28 ,  C07D407/12

CPC classification number: C07D413/12 ,  C07D209/08 ,  C07D213/46 ,  C07D215/18 ,  C07D217/02 ,  C07D231/56 ,  C07D235/08 ,  C07D237/28 ,  C07D239/74 ,  C07D241/42 ,  C07D261/20 ,  C07D263/56 ,  C07D277/24 ,  C07D277/64 ,  C07D307/79 ,  C07D319/18 ,  C07D333/06 ,  C07D333/10 ,  C07D333/28 ,  C07D407/12

Abstract: Certain compounds, or pharmaceutically acceptable salts or prodrugs thereof, are provided herein. Also provided are pharmaceutical compositions comprising at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein as a single active agent or administering at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.

公开(公告)号：US09822058B2

公开(公告)日：2017-11-21

申请号：US14390190

申请日：2013-03-13

Applicant: CHDI FOUNDATION, INC.

Inventor： Leticia M. Toledo-Sherman ,  Celia Dominguez ,  Michael Prime ,  William Leonard Mitchell ,  Peter Johnson ,  Naomi Went

IPC: C07C62/38 ,  C07D307/94 ,  C07D309/10 ,  C07D215/18 ,  C07D311/58 ,  C07D317/46 ,  C07D317/60 ,  C07D319/18 ,  C07D233/64 ,  C07D235/26 ,  C07D403/10 ,  C07D405/08 ,  C07D405/10 ,  C07D405/12 ,  C07C317/44 ,  C07D413/08 ,  C07D413/10 ,  C07C323/62 ,  C07C229/22 ,  C07C229/46 ,  C07C229/48 ,  C07D257/04 ,  C07D203/08 ,  C07D263/58 ,  C07C235/82 ,  C07D207/08 ,  C07D271/07 ,  C07D207/337 ,  C07D295/155 ,  C07D305/06 ,  C07D305/08 ,  C07D307/54 ,  C07D307/80 ,  C07C69/757 ,  C07D203/10 ,  C07D307/79 ,  C07D413/12 ,  C07H15/20

CPC classification number: C07C62/38 ,  C07C69/757 ,  C07C229/22 ,  C07C229/46 ,  C07C229/48 ,  C07C235/82 ,  C07C317/44 ,  C07C323/62 ,  C07C2601/02 ,  C07C2602/50 ,  C07D203/08 ,  C07D203/10 ,  C07D207/08 ,  C07D207/337 ,  C07D215/18 ,  C07D233/64 ,  C07D235/26 ,  C07D257/04 ,  C07D263/58 ,  C07D271/07 ,  C07D295/155 ,  C07D305/06 ,  C07D305/08 ,  C07D307/54 ,  C07D307/79 ,  C07D307/80 ,  C07D307/94 ,  C07D309/10 ,  C07D311/58 ,  C07D317/46 ,  C07D317/60 ,  C07D319/18 ,  C07D403/10 ,  C07D405/08 ,  C07D405/10 ,  C07D405/12 ,  C07D413/08 ,  C07D413/10 ,  C07D413/12 ,  C07H15/20

Abstract: Certain compounds, or pharmaceutically acceptable salts or prodrugs thereof, are provided herein. Also provided are pharmaceutical compositions comprising at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein as a single active agent or administering at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.

公开(公告)号：US20170283436A1

公开(公告)日：2017-10-05

申请号：US15507208

申请日：2015-08-28

Applicant: Celia DOMINGUEZ ,  John WITYAK ,  Jonathan BARD ,  Alex KISELYOV ,  Christopher John BROWN ,  Sebastien Rene Gabriel GALAN ,  Michael Edward PRIME ,  Paul Richard GILES ,  Elise Luciennen Paulette GADOULEAU ,  Thomas Martin KRÜLLE ,  Daniel CLARKFREW ,  Peter David JOHNSON ,  Sabinc SCHAERTI ,  Steffen Kaspar GRIMM ,  Jan Dirk KAHMANN ,  Christoph SCHEICH ,  Samuel COE ,  Sarah HAYES ,  CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  John Wityak ,  Jonathan Bard ,  Alex Kiselyov ,  Christopher John Brown ,  Sébastien René Gabriel Galan ,  Michael Edward Prime ,  Paul Richard Giles ,  Elise Luciennen Paulette Gadouleau ,  Thomas Martin Krülle ,  Daniel Clark-Frew ,  Peter David Johnson ,  Samuel Coe ,  Sarah Hayes

IPC: C07D513/04 ,  C07D413/04 ,  C07D413/14 ,  A61K51/04 ,  C07D498/04 ,  C07D405/14 ,  C07D471/04 ,  C07D263/57 ,  C07D413/12

CPC classification number: C07D513/04 ,  A61K51/0455 ,  A61K51/0459 ,  A61K51/0463 ,  C07D263/57 ,  C07D405/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D498/04

Abstract: Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US20160326124A1

公开(公告)日：2016-11-10

申请号：US15148907

申请日：2016-05-06

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Michel C. Maillard ,  Alan F. Haughan ,  Amanda Van de Poël ,  Andrew J. Stott ,  Christopher A. Luckhurst ,  Elizabeth A. Saville-Stones ,  Grant Wishart ,  Michael Wall ,  Perla Breccia ,  Rebecca E. Jarvis

IPC: C07D271/06 ,  C07D471/04 ,  C07D413/12

CPC classification number: C07D271/06 ,  C07D413/12 ,  C07D471/04

Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.

公开(公告)号：US20160039745A1

公开(公告)日：2016-02-11

申请号：US14776280

申请日：2014-03-10

Applicant: CHDI FOUNDATION, INC.

Inventor： Celia Dominguez ,  Ignacio Muñoz-San Juan ,  Michel Maillard ,  Gilles Raphy ,  Alan F. Haughan ,  Christopher A. Luckhurst ,  Rebecca E. Jarvis ,  Roland W. Burli ,  Grant Wishart ,  Samantha J. Hughes ,  Daniel R. Allen ,  Stephen D. Penrose ,  Perla Breccia

IPC: C07C233/60 ,  C07D413/06 ,  C07D239/26 ,  C07D471/04 ,  C07D401/12 ,  C07D213/58 ,  C07D231/12 ,  C07D209/46 ,  C07D307/81 ,  C07D235/06 ,  C07D277/66 ,  C07D215/06 ,  C07D311/96 ,  C07D263/57 ,  C07D231/56 ,  C07D265/30 ,  C07D265/36

CPC classification number: C07C233/60 ,  C07C259/08 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07D209/46 ,  C07D213/54 ,  C07D213/56 ,  C07D213/58 ,  C07D215/06 ,  C07D215/14 ,  C07D231/12 ,  C07D231/56 ,  C07D235/06 ,  C07D235/08 ,  C07D239/26 ,  C07D263/56 ,  C07D263/57 ,  C07D265/30 ,  C07D265/36 ,  C07D277/64 ,  C07D277/66 ,  C07D295/073 ,  C07D307/79 ,  C07D307/81 ,  C07D311/96 ,  C07D333/54 ,  C07D401/12 ,  C07D413/06 ,  C07D471/04

Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.

公开(公告)号：US20160031863A1

公开(公告)日：2016-02-04

申请号：US14776058

申请日：2014-03-10

Applicant: CHDI FOUNDATION, INC.

Inventor： Celia Dominguez ,  Ignacio Muñoz-Sanjuán ,  Michel Maillard ,  Huw D. Vater ,  Rebecca E. Jarvis ,  Christopher A. Luckhurst ,  Roland W. Bürli ,  Grant Wishart ,  Andrew J. Stott

IPC: C07D409/04 ,  C07D207/34 ,  C07D231/14 ,  C07D401/04 ,  C07D403/04

CPC classification number: C07D409/04 ,  C07D207/34 ,  C07D231/14 ,  C07D231/22 ,  C07D401/04 ,  C07D403/04

Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.

公开(公告)号：US20150203468A1

公开(公告)日：2015-07-23

申请号：US14414149

申请日：2013-07-16

Applicant: CHDI FOUNDATION, INC.

Inventor： Celia Dominguez ,  Christopher A. Luckhurst ,  Roland W. Bürli ,  Andrew J. Stott ,  Perla Breccia

IPC: C07D319/18 ,  C07D277/30 ,  C07D263/32 ,  C07D239/26 ,  C07D213/56

CPC classification number: A61K31/505 ,  A61K31/165 ,  A61K31/357 ,  A61K31/421 ,  A61K31/426 ,  A61K31/4418 ,  C07B2200/07 ,  C07C259/08 ,  C07C2601/02 ,  C07D213/56 ,  C07D213/61 ,  C07D213/74 ,  C07D215/18 ,  C07D237/08 ,  C07D239/26 ,  C07D239/30 ,  C07D239/34 ,  C07D241/12 ,  C07D263/32 ,  C07D263/56 ,  C07D277/30 ,  C07D277/64 ,  C07D295/155 ,  C07D311/58 ,  C07D319/18 ,  C07D401/04 ,  C07D417/04

Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.

Abstract translation: 提供式I的组蛋白脱乙酰酶（HDAC）抑制剂，其组合物及其使用方法。

公开(公告)号：US12281116B2

公开(公告)日：2025-04-22

申请号：US17988340

申请日：2022-11-16

Applicant: CHDI Foundation, Inc.

Inventor： Longbin Liu ,  Celia Dominguez ,  Nikolay V. Plotnikov ,  Alan Haughan ,  Andrew Stott ,  Brett Cosgrove ,  Cole Clissold ,  Huw Vater ,  Jonathan Spencer ,  William Esmieu ,  Karine Malagu ,  Mark Chambers

IPC: C07D471/10 ,  A61K45/06 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04

Abstract: Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.

公开(公告)号：US12036291B2

公开(公告)日：2024-07-16

申请号：US17353611

申请日：2021-06-21

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  John Wityak ,  Jonathan Bard ,  Christopher John Brown ,  Thomas Martin Krülle ,  Daniel Clark-Frew ,  Sarah Hayes

IPC: A61K51/04 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D487/04 ,  C07D513/04 ,  C07D513/14

CPC classification number: A61K51/0455 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D487/04 ,  C07D513/04 ,  C07D513/14 ,  C07B2200/05

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

公开(公告)号：US11992535B2

公开(公告)日：2024-05-28

申请号：US17125905

申请日：2020-12-17

Applicant: CHDI Foundation, Inc.

Inventor： Longbin Liu ,  Matthew Lee ,  Celia Dominguez ,  Peter David Johnson ,  Christopher John Brown ,  Sarah Hayes ,  Adrian Kotey ,  Matthew Robert Mills ,  Michael Edward Prime

IPC: A61K51/04 ,  C07B59/00 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/107

CPC classification number: A61K51/0455 ,  A61K51/0459 ,  A61K51/0468 ,  C07B59/00 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/107 ,  C07B2200/05

Abstract: Provided herein are certain compounds and imaging agents useful for detecting a condition or disorder associated with protein aggregation, compositions thereof, and methods of their use.