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    System and method for automating association of retail items to support shopping proposals
    56.
    发明授权
    System and method for automating association of retail items to support shopping proposals 有权
    自动化零售商品协会支持购物建议的系统和方法

    公开(公告)号：US07865407B2

    公开(公告)日：2011-01-04

    申请号：US11953232

    申请日：2007-12-10

    申请人： Reiner Kraft ,  Joerg Meyer

    发明人： Reiner Kraft ,  Joerg Meyer

    IPC分类号： G06F17/30

    CPC分类号： G06Q30/02 ,  G06Q30/0613 ,  G06Q30/0623 ,  G06Q30/0625 ,  G06Q30/0631 ,  G06Q40/04

    摘要： A shopping server proposal system includes a mechanism that enhances the online retailer's existing database system with the necessary information to provide the desired services. The existing catalog of items is analyzed based on a set of predefined rules for a given retail store. This analysis determines which of the items in the catalog are related to other items in the catalog. The result of this analysis includes new relations of the catalog items that are written into the retailer's existing database system. The mechanism for assembling this information, based on a set of predefined rules, is independent of the retailer or the retailer's industry. The provides retail businesses with a competitive edge by enabling them to offer automated shopping advice to solve the shoppers' problems of finding related and matching items, and by providing a list of related items based on the selected item's properties.

    摘要翻译： 购物服务器提议系统包括一种增强在线零售商现有数据库系统的机制，并具有提供所需服务的必要信息。 根据给定零售商店的一组预定义规则分析现有的商品目录。 此分析确定目录中的哪些项目与目录中的其他项目相关。 该分析的结果包括写入零售商现有数据库系统的目录项目的新关系。 基于一组预定义规则组装此信息的机制独立于零售商或零售商的行业。 通过使零售企业能够提供自动购物建议来解决购物者查找相关和匹配项目的问题，并通过根据所选项目的属性提供相关项目列表，为零售企业提供竞争优势。

    Peptide and peptide mimetic conjugates with integrin-inhibitor properties
    59.
    发明授权
    Peptide and peptide mimetic conjugates with integrin-inhibitor properties 有权
    具有整合素抑制剂性质的肽和肽模拟物缀合物

    公开(公告)号：US07655624B2

    公开(公告)日：2010-02-02

    申请号：US10344669

    申请日：2001-08-02

    申请人： Joerg Meyer ,  Berthold Nies ,  Michel Dard ,  Guenter Hoelzemann ,  Horst Kessler ,  Martin Kantlehner ,  Ulrich Hersel ,  Christoph Gibson ,  Gabor Sulyok

    发明人： Joerg Meyer ,  Berthold Nies ,  Michel Dard ,  Guenter Hoelzemann ,  Horst Kessler ,  Martin Kantlehner ,  Ulrich Hersel ,  Christoph Gibson ,  Gabor Sulyok

    IPC分类号： A61K38/12 ,  A61F2/02

    CPC分类号： A61K47/6435 ,  A61K47/6425

    摘要： The invention relates to compounds of formula (1) B-Q-X1, wherein B is bioactive cell adhesive mediating molecule. Q is absent or is an inorganic spacer molecule and X1 is an anchor molecule, selected from the group Lys-(CO—CH2—(CH2)n—PO3H2)2(I), -Lys-[-Lys-(CO—CH2—(CH2)a—PO3H2)2]2(ii) or -Lys-(Lys[-Lys-(CO—CH2—(CH2)n—PO3H2]2 (iii), and n independently represents 0, 1, 2 or 3, wherein a free amino group of group B is linked in peptide form to a free carboxyl group of the spacer molecule Q or of the anchor molecule X1, or a free amino group of the radical Q is linked in peptide form to a free carboxyl group of the radical X1. The invention also relates to the salts thereof. The inventive compounds can be used as integrin inhibitors for the treatment of illnesses, deficiencies, inflammations caused by implants and osteolytic illnesses such as osteoporosis, thrombosis, cardiac infarction and arteriosclerosis, in addition to the acceleration and strengthening of the integration process of implants or the biocompatible surface in tissue.

    摘要翻译： 本发明涉及式（1）B-Q-X1的化合物，其中B是生物活性细胞粘附介导分子。 Q不存在或是无机间隔分子，X1是选自Lys-（CO-CH 2 - （CH 2）n -PO 3 H 2）2（I），-Lys - [ - Lys-（CO-CH 2） - （CH 2）a-PO 3 H 2）2] 2（ⅱ）或-Lys-（Lys [-Lys-（CO-CH 2 - （CH 2）n -PO 3 H 2] 2（ⅲ），n独立地表示0,1,2 或3，其中B族的游离氨基以间隔分子Q或锚分子X1的游离羧基形式连接，或者基团Q的游离氨基以肽形式连接至游离氨基 本发明还涉及其盐。本发明化合物可用作整联蛋白抑制剂，用于治疗由植入物引起的疾病，缺血性和溶骨性疾病如骨质疏松症，血栓形成，心肌梗塞和动脉硬化 ，除了加速和加强植入物或组织中生物相容性表面的整合过程。