公开(公告)号：US20020176807A1

公开(公告)日：2002-11-28

申请号：US10192905

申请日：2002-07-10

Applicant: COMBICHEM, INC.

Inventor： Klaus M. Gubernator ,  Joseph L. Cohen ,  Robert A. Zambias

IPC: B01J019/00

CPC classification number: B01L3/5025 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00315 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00364 ,  B01J2219/00373 ,  B01J2219/00484 ,  B01J2219/0049 ,  B01J2219/00495 ,  C40B60/14

Abstract: A microtiter reaction system (15), comprising, a support rack (16) having an array of reaction wells (18) disposed therein, each reaction well (18) having an open top end (30) and a closed bottom end (32); a plurality of generally funnel shaped reactor caps (20) with each of reactor cap (20) being received into open top end (30) of each reaction well (18); a porous gas-permeable layer (22) positioned over support rack (16), gas-permeable layer (22) having an array of holes (23) therein with each hole (23) being positioned over open top end (30) of each of the plurality of reaction wells (18); gasket (24) positioned over porous gas-permeable layer (22); and a top cover (26) positioned over gasket (22).

Abstract translation: 一种微量滴定反应系统（15），包括：具有布置在其中的反应孔阵列（18）的支撑架（16），每个反应井（18）具有敞开的顶端（30）和封闭的底端（32） ; 多个大致漏斗形的反应器盖（20），其中每个反应器盖（20）被接纳到每个反应井（18）的开放顶端（30）中; 位于支撑架（16）上方的多孔透气层（22），具有孔阵列（23）的透气层（22），其中每个孔（23）位于每个孔（23）的开口顶端（30）上， 的多个反应孔（18）; 位于多孔透气层（22）之上的垫圈（24）; 和位于垫圈（22）之上的顶盖（26）。

公开(公告)号：US20020155036A1

公开(公告)日：2002-10-24

申请号：US10134556

申请日：2002-04-29

Applicant: Symyx Technologies, Inc.

Inventor： Damian A. Hajduk ,  Ralph B. Nielsen ,  Adam Safir ,  Leonid Matsiev ,  Eric McFarland ,  Paul Mansky

IPC: B01J019/00

CPC classification number: B01F15/00207 ,  B01F13/065 ,  B01F13/08 ,  B01F15/00357 ,  B01F15/00396 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50851 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  F28D15/00 ,  F28D2021/0077 ,  F28F27/00 ,  G01K13/00 ,  G01N21/253 ,  Y10T436/10 ,  Y10T436/11 ,  Y10T436/25

Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.

Abstract translation: 公开了一种用于实施和监测多重反应的进展和性质的装置和方法。 该方法和装置对于组合文库的合成，筛选和表征特别有用，但是与常规实验反应器相比也具有显着的优点。 该装置通常包括用于容纳反应混合物的多个容器和用于控制各个反应混合物或反应混合物组的搅拌速率和温度的系统。 此外，该装置可以包括用于独立地控制每个容器中的压力的​​装置。 单独反应混合物的原位监测为过程控制器提供反馈，并提供了确定反应速率，产物产率和反应产物各种性质（包括粘度和分子量）的数据。

公开(公告)号：US20020127146A1

公开(公告)日：2002-09-12

申请号：US10092364

申请日：2002-03-06

Applicant: Symyx Technologies, Inc.

Inventor： H. Sam Bergh ,  Daniel M. Pinkas

IPC: B01J019/00 ,  G01N030/02 ,  B01L003/00

CPC classification number: F16K99/0001 ,  F15C5/00 ,  F16K7/14 ,  F16K27/003 ,  F16K99/0015 ,  F16K99/0059 ,  F16K2099/0076 ,  F16K2099/008 ,  F16K2099/0084 ,  G01N30/20 ,  G01N2030/205 ,  Y10T436/2575

Abstract: A novel gas injection valve for injecting discrete charges of gas into a mobile phase or carrier stream is provided. Injection valves of the invention comprise a plurality of microvalves capable of receiving gas at different pressures and emitting discrete charges of gas at approximately the same pressure. The invention further provides for parallel injection valve arrays capable of injecting multiple samples substantially simultaneously and a method of injecting discrete gas samples at a controlled pressure to a high-resolution gas chromatograph.

Abstract translation: 提供了一种用于将离散的气体注入流动相或载流子的新颖的气体注入阀。 本发明的注射阀包括能够接收不同压力的气体并以大致相同的压力发射离散的气体的多个微型阀。 本发明还提供了能够基本上同时喷射多个样品的平行喷射阀阵列以及将受控压力的离散气体样品注入高分辨率气相色谱仪的方法。

公开(公告)号：US20020119578A1

公开(公告)日：2002-08-29

申请号：US10116085

申请日：2002-04-03

Inventor： Alejandro C. Zaffaroni ,  Christopher J. Buchko ,  Douglas N. Modlin

IPC: B01J019/00

CPC classification number: B01L3/5085 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00367 ,  B01J2219/00378 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00635 ,  B01J2219/00659 ,  B01J2219/0072 ,  B01L2300/0893 ,  C40B60/14 ,  G01N2035/1039 ,  Y10T436/111666 ,  Y10T436/143333 ,  Y10T436/2575

Abstract: An apparatus and method is provided for preparing and using a very large and diverse array of compounds on a substrate having rapidly accessible locations. The substrate contains cells in which the compounds of the array are located. Surrounding the cells is a non-wetable surface that prevents the solution in one cell from moving to adjacent cells. The compounds are delivered to the individual cells of the array by a micropipette attached to an X-Y translation stage.

公开(公告)号：US20020106311A1

公开(公告)日：2002-08-08

申请号：US09991377

申请日：2001-11-15

Applicant: Cellular Process Chemistry, Inc.

Inventor： Klaus Golbig ,  Volker Autze ,  Peter Born ,  Christian Drescher

IPC: B01J019/00

CPC classification number: B01F5/0604 ,  B01F13/0059 ,  B01F13/0064 ,  B01F13/0066 ,  B01F13/0093 ,  B01F13/0094 ,  B01F13/1013 ,  B01F13/1022 ,  B01F15/06 ,  B01J19/0093 ,  B01J19/248 ,  B01J19/249 ,  B01J2219/00783 ,  B01J2219/00804 ,  B01J2219/00835 ,  B01J2219/00869 ,  B01J2219/00871 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00961 ,  B01J2219/00995 ,  B01J2219/00997 ,  B01J2219/2453 ,  B01J2219/2456 ,  B01J2219/246 ,  B01J2219/2462 ,  B01J2219/2464 ,  B01J2219/247 ,  B01J2219/2485 ,  B01J2219/2486 ,  B01J2219/2487 ,  B01J2219/2488 ,  B01J2219/249 ,  B01J2219/2493 ,  B01J2219/2495 ,  B01J2219/2496 ,  B01J2219/2497 ,  F28D9/0093 ,  F28F2210/02 ,  F28F2260/02

Abstract: A stacked plate chemical reactor in which simple plates are stacked together to form the reactor. When openings in adjacent plates are properly aligned, fluid pathways and processing volumes are defined for chemical reactants, heat transfer medium, and a product. In one embodiment of the invention, an n-fold internal array is achieved by providing a first group of simple plates defining a reaction unit that includes bypass fluid channels and reaction fluid channels for each reactant, such that a portion of each reactant is directed to subsequent groups of simple plates defining additional reaction units. A chemical reactor with variable output is obtained in a preferred embodiment by reversibly joining reactor stacks comprising irreversibly joined reaction units, these reaction units consisting of a plurality of simple plates. Other embodiments employ at least one of an array of parallel fluid channels having different widths, bifurcated fluid distribution channels to achieve a substantially even flow equipartition for fluids with varying viscosities flowing within the fluid channels of each reaction unit.

Abstract translation: 堆叠板式化学反应器，其中简单的板堆叠在一起以形成反应器。 当相邻板中的开口正确对准时，为化学反应物，传热介质和产品定义流体路径和加工体积。 在本发明的一个实施例中，通过提供限定反应单元的第一组简单板来实现n折内部阵列，所述反应单元包括每个反应物的旁路流体通道和反应流体通道，使得每个反应物的一部分被引导到 随后的简单板组定义了额外的反应单元。 通过可逆地连接包括不可逆连接的反应单元的反应堆，在优选的实施方案中获得具有可变输出的化学反应器，这些反应单元由多个简单的板组成。 其他实施例采用具有不同宽度的平行流体通道的阵列中的至少一个，分叉的流体分配通道，以实现在每个反应单元的流体通道内流动的具有变化的粘度的流体的基本均匀的流量均分。

公开(公告)号：US20020032356A1

公开(公告)日：2002-03-14

申请号：US09878540

申请日：2001-06-11

Inventor： Peter Gideon Gelblum ,  Norman Herron ,  Charles Joseph Noelke ,  Velliyur Nott Mallikarjuna Rao

IPC: C07C021/18 ,  B01J019/00

CPC classification number: C07C17/269 ,  B01J19/0053 ,  B01J19/02 ,  B01J2219/00058 ,  B01J2219/00123 ,  B01J2219/00132 ,  B01J2219/00159 ,  B01J2219/00166 ,  B01J2219/0236 ,  C07C17/00 ,  C07C17/361 ,  C07C21/18 ,  C07C21/185

Abstract: A gold-lined pyrolysis reactor is used to pyrolyze compounds to form fluoroolefins like tetrafluoroethylene and hexafluoropropylene in high yield, with minimum to no formation of perfluoroisobutylene, chlorotrifluoroethylene, coke, salts, or polymer.

Abstract translation: 使用金衬里的热解反应器以高产率热解化合物以形成氟烯烃如四氟乙烯和六氟丙烯，最少不形成全氟异丁烯，三氟氯乙烯，焦炭，盐或聚合物。

公开(公告)号：US20020028160A1

公开(公告)日：2002-03-07

申请号：US09791410

申请日：2001-02-22

Inventor： Jianming Xiao ,  Shiping Chen ,  Yuling Luo ,  Anthony Chen

IPC: B01J019/00

CPC classification number: G01N21/6452 ,  B01J19/0046 ,  B01J2219/00369 ,  B01J2219/00382 ,  B01J2219/00385 ,  B01J2219/00418 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/00585 ,  B01J2219/00587 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00725 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N2021/6484

Abstract: Disclosed are systems and methods involved in ultra high throughput screening of chemical compounds which have an affinity for or interact with a biological target. The invention utilizes an apparatus for ultra high throughput screening of chemical compounds for a biological target. The system is based on a capillary bundle that has two distinguishable ends. Capillaries on one end are connected to chemical compounds stored in discrete reservoirs such as micro titer plate wells; capillaries on the other end are tightly bound and then processed to form a two dimensional array that enable the parallel reactions of a target and many different compounds.

Abstract translation: 公开了涉及对生物靶具有亲和性或与之相互作用的化学化合物的超高通量筛选的系统和方法。 本发明利用用于生物靶的化合物的超高通量筛选装置。 该系统基于具有两个可区分端部的毛细管束。 一端的毛细管连接到储存在离散储层（如微量滴定板孔）中的化学化合物; 另一端的毛细血管紧密结合，然后加工成形成二维阵列，使阵列和许多不同化合物的平行反应。

公开(公告)号：US20040258584A1

公开(公告)日：2004-12-23

申请号：US10802926

申请日：2004-03-18

Applicant: Samsung Electronics Co., Ltd.

Inventor： Jin-hyuk Choi ,  Do-young Kam ,  Jung-wook Kim ,  Suk-chan Lee

IPC: B01J019/00

CPC classification number: H01L21/67126 ,  B01J3/03 ,  H01L21/6719 ,  Y10T16/532 ,  Y10T16/5323

Abstract: A reaction apparatus including: a main body having a reaction chamber with an upper opening thereof, a lid hinge, and a lid combined to the lid hinge, rotationally opening and closing the upper opening; a lifting member having a first end part separated from a rotation axis of the lid and rotatably combined with the lid, and a second end part rotatably combined to the main body, that moves in opening and closing directions; and a driver activating the lifting member. With this configuration, the present invention provides a reaction apparatus, with a lid that is opened and closed readily, and in which the lid parallelly contacts a sealing member, and thereby creating a vacuum in the reaction chamber with ease.

Abstract translation: 一种反应装置，包括：主体，具有其上开口的反应室，盖铰链和与盖铰链组合的盖，可旋转地打开和关闭上开口; 提升构件，其具有与所述盖的旋转轴线分离并与所述盖可旋转地组合的第一端部，以及可旋转地组合到所述主体的第二端部，其沿打开和关闭方向移动; 以及激活升降构件的驾驶员。 采用这种结构，本发明提供了一种反应装置，其具有容易打开和关闭的盖，并且其中盖平行地接触密封构件，从而容易地在反应室中产生真空。

公开(公告)号：US20040228774A1

公开(公告)日：2004-11-18

申请号：US10732210

申请日：2003-12-11

Applicant: Hitachi, Ltd.

Inventor： Taro Ogawa ,  Masaru Izawa ,  Nobuyuki Negishi ,  Kaoru Umemura ,  Hiroshi Kakibayashi

IPC: B01J019/00

CPC classification number: B01L3/5085 ,  B01L2300/0645 ,  B01L2300/0819 ,  C12M23/12 ,  C12M23/20

Abstract: Disclosed is a technology associated with a microreactor, which realizes convenient introduction of a sample biological cell such as an animal culture cell in the microcell, and enables further reduction in the size as well as higher integration of the microcells, thereby realizing a highly improved efficiency in the drug efficacy screening experiments. In the present invention, interior of the of the microreactor has been treated to impart higher affinity such as hydrophilicity for the sample such as cell while the surface near the microreactor has been treated to impart non-affinity such as water repellency. A mechanical vibration, oscillation, or shaking in either a defined pattern or in a random motion may be applied to the microreactor and the surface near the microreactor cavity by a motion generator or oscillator or the like. As a result, the cell or other sample that has been dropped near the microreactor can freely migrate along the surface without being adsorbed to the surface where it was first dropped, and the cell or other sample that has been once introduced in the interior of the microreactor will stay in the microreactor without moving out of the microreactor.

Abstract translation: 公开了与微反应器相关的技术，其实现了在微细胞中方便地引入样品生物细胞如动物培养细胞，并且能够进一步减小微细胞的尺寸以及更高的集成度，从而实现高效率的效率 在药物疗效筛选实验中。 在本发明中，微反应器的内部已经被处理以赋予样品如细胞亲水性更高的亲和性，而微反应器附近的表面已被处理以赋予非亲和性，例如拒水性。 可以通过运动发生器或振荡器等将微型反应器和微反应器腔附近的表面施加在限定的模式或随机运动中的机械振动，振荡或振动。 结果，在微反应器附近滴落的电池或其他样品可以沿着表面自由迁移，而不会被吸附到首先掉下的表面，并且已经被引入到内部的电池或其它样品 微反应器将停留在微反应器中而不移出微反应器。

公开(公告)号：US20040180450A1

公开(公告)日：2004-09-16

申请号：US10810074

申请日：2004-03-26

Inventor： Jay K. Bass ,  John F. McEntee ,  Tim J. Lazaruk ,  Maryam Mobed-Miremadi

IPC: B01J019/00

CPC classification number: B82Y30/00 ,  B01J19/0046 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00657 ,  B01J2219/00659 ,  B01J2219/00664 ,  B01J2219/00675 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B50/14 ,  Y10T436/11 ,  Y10T436/2575

Abstract: Devices and methods are disclosed for synthesizing compounds on the surface of supports. The devices are flow devices, which include a housing comprising a housing chamber. The housing has an opening adapted for insertion of a support into the housing chamber. A sealing member is movably mounted in the housing chamber and adapted to engage the support to form a reagent chamber between a surface of the support and a surface of the sealing member. A mechanism is included for moving the sealing member within the housing chamber. The device has both an inlet and an outlet, which are both in fluid communication with the reagent chamber. In the methods of the invention a support is placed into a chamber of a device such as described above. The mechanism adapted to engage the support on a surface opposite the surface engaged by the sealing member is activated to urge the support toward the sealing member. The pressure-activated mechanism is activated to urge the support against the aforesaid mechanism and against an interior wall of the housing chamber to form the reagent chamber. A fluid reagent for conducting the reaction step is introduced into the reagent chamber by means of the inlet. Thereafter, the fluid reagent is removed from the reagent chamber. The pressure-activated mechanism is deactivated and the support is removed from the housing chamber. In this way the reagent chamber is formed and un-formed in situ.