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    DNA sample preparation and sequencing
    602.
    发明授权
    DNA sample preparation and sequencing 有权

    公开(公告)号：US09617590B2

    公开(公告)日：2017-04-11

    申请号：US14347690

    申请日：2012-09-28

    Applicant: STC.UNM

    Inventor： Jeremy Edwards ,  Payman Zarkesh-Ha ,  Steven R. J. Brueck

    IPC: C12Q1/68 ,  G01N27/414

    CPC classification number: C12Q1/6869 ,  C12Q1/6806 ,  C12Q1/6874 ,  G01N27/414 ,  G01N27/4145 ,  Y10T436/143333 ,  C12Q2531/125 ,  C12Q2535/122

    Abstract: This disclosure describes, in one aspect, a method for preparing DNA molecule for sequencing. Generally, the method includes fragmenting the DNA molecule into double-stranded fragments; amplifying at least a portion of the double-stranded fragments; circularizing the fragments so that the first end of the fragment comprises a first loop connecting the strands and the second end of the fragment comprises a second loop connecting the strands; annealing a first sequencing primer to the first loop oriented to sequence at least a portion of one strand of the fragment; and annealing a second sequencing primer to the second loop oriented to sequence at least a portion of the other strand of the fragment. In another aspect, this disclosure describes a method for sequencing a DNA molecule. Generally, the method includes fragmenting the DNA molecule into double-stranded fragments; amplifying at least a portion of the double-stranded fragments; circularizing the fragments so that the first end of the fragment comprises a first loop connecting the strands and the second end of the fragment comprises a second loop connecting the strands; and sequencing at least one of the DNA strands.

    Method for atomic layer deposition
    603.
    发明授权
    Method for atomic layer deposition 有权

    公开(公告)号：US09605344B2

    公开(公告)日：2017-03-28

    申请号：US14917566

    申请日：2014-09-12

    Applicant: STC.UNM

    Inventor： Ying-Bing Jiang ,  Joseph L. Cecchi ,  Yaqin Fu ,  C. Jeffrey Brinker

    IPC: C23C16/455 ,  C23C16/46

    CPC classification number: C23C16/45525 ,  C23C16/45534 ,  C23C16/46

    Abstract: An atomic layer deposition method is disclosed for preparing polypeptides. The method comprises providing a solid-phase support comprising a reactive amine monolayer in an atomic layer deposition (ALD) chamber. The solid-phase support is contacted with a first protected amino acid substituted with a protecting group by atomic layer deposition, wherein the protecting group is bonded to a non-side chain amino group of the protected amino acid. A carboxylic acid group of the first protected amino acid is reacted with the reactive amine monolayer, thereby coupling the first protected amino acid to the solid-phase support to produce a coupled-product.

    Patient controlled analgesia device
    607.
    发明授权
    Patient controlled analgesia device 有权
    患者控制止痛装置

    公开(公告)号：US09592349B2

    公开(公告)日：2017-03-14

    申请号：US14544047

    申请日：2014-11-19

    Applicant: STC.UNM

    Inventor： Mark Hauswald

    IPC: A61M5/178 ,  A61M5/315 ,  A61M5/31 ,  A61M5/142 ,  A61M5/14

    CPC classification number: A61M5/3158 ,  A61M5/141 ,  A61M5/14216 ,  A61M5/1424 ,  A61M5/3148 ,  A61M5/31535 ,  A61M2005/1405 ,  A61M2005/3115 ,  A61M2202/048

    Abstract: A mechanical patient-controlled analgesia device for injecting medicine into a patient's IV, includes an IV reservoir and a syringe communicated to the IV reservoir and having a syringe plunger. A mechanical biasing element is provided for exerting bias on the syringe plunger in a first syringe-filling direction to draw medicine from the IV reservoir into the syringe. An injection plunger is operable by the patient to move the syringe plunger in a second injection direction against the bias to inject the medicine in the syringe into a patient's IV. The injection plunger is movable independently of the syringe plunger and is engaged with but unconnected to the syringe plunger when the patient moves the injection plunger to inject the medicine. The patient can inject only a calibrated amount of medicine drawn into the syringe as determined by calibration of the biasing element and a metering element for a given viscosity of the medication.

    Abstract translation: 用于将药物注射到患者IV中的机械患者控制的止痛装置包括连接到IV储液器并具有注射器柱塞的IV储液器和注射器。 提供了一种机械偏置元件，用于在第一注射器填充方向上在注射器柱塞上施加偏压，以将药物从IV储液器吸入注射器。 注射柱塞可由患者操作，以抵抗偏压在第二注射方向上移动注射器柱塞，以将注射器中的药物注入患者体内。 注射柱塞可以独立于针筒柱塞移动，并且当患者移动注射柱塞以注射药物时，注射柱塞可以与注射器柱塞接合但不连接。 患者可以仅注射被注入注射器中的校准量的药物，其通过偏置元件的校准和用于给定粘度的药物的计量元件来确定。

    System and methods of photon-based radiotherapy and radiosurgery delivery
    610.
    发明授权
    System and methods of photon-based radiotherapy and radiosurgery delivery 有权
    光子放射治疗和放射外科手术的系统和方法

    公开(公告)号：US09561389B2

    公开(公告)日：2017-02-07

    申请号：US15179289

    申请日：2016-06-10

    Applicant: STC.UNM

    Inventor： Shuang Luan ,  Lijun Ma ,  Zhe Chen

    IPC: A61N5/00 ,  A61N5/10

    CPC classification number: A61N5/1084 ,  A61B6/4085 ,  A61N5/10 ,  A61N5/1031 ,  A61N5/1065 ,  A61N5/1067 ,  A61N5/1071 ,  A61N5/1081 ,  A61N2005/1074

    Abstract: Photon-based radiosurgery is widely used for treating local and regional tumors. The key to improving the quality of radiosurgery is to increase the dose falloff rate from high dose regions inside the tumor to low dose regions of nearby healthy tissues and structures. Dynamic photon painting (DPP) further increases dose falloff rate by treating a target by moving a beam source along a dynamic trajectory, where the speed, direction and even dose rate of the beam source change constantly during irradiation. DPP creates dose gradient that rivals proton Bragg Peak and outperforms Gamma Knife® radiosurgery.

    Abstract translation: 基于光子的放射外科手术广泛用于治疗局部和局部肿瘤。 提高放射外科手术质量的关键是提高肿瘤内部高剂量区域到附近健康组织和结构的低剂量区域的剂量衰减率。 动态光子绘画（DPP）通过沿着动态轨迹移动光束源来处理目标物体进一步增加剂量衰减速率，其中光束源的速度，方向和均匀剂量率在照射期间不断变化。 DPP产生与质子Bragg峰值相当的剂量梯度，并优于GammaKnife®放射外科手术。

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