公开(公告)号：US20230343569A1

公开(公告)日：2023-10-26

申请号：US18298327

申请日：2023-04-10

Applicant: Protein Metrics, LLC

Inventor： Marshall BERN ,  Yong Joo KIL

IPC: H01J49/00 ,  G01N33/68 ,  G01N33/58

CPC classification number: H01J49/0036 ,  G01N33/6848 ,  G01N33/58

Abstract: This invention relates to graphical user-interactive displays for use in MS-based analysis of protein impurities, as well as methods and software for generating and using such. One aspect provides a user-interactive display comprising interactive and dynamic selection of one or more masses and concurrent display of peaks (points) corresponding to that predicted mass value across other displays (MS1, deconvolved mass spectrum, mass extracted ion chromatogram, etc.).

公开(公告)号：US20230341411A1

公开(公告)日：2023-10-26

申请号：US18214988

申请日：2023-06-27

Applicant: NATIONAL CHUNG CHENG UNIVERSITY

Inventor： Lai-Kwan CHAU ,  Chang-Yue CHIANG

IPC: G01N33/68 ,  G01N33/543 ,  G01N33/74 ,  G01N33/53 ,  G01N21/77

CPC classification number: G01N33/6848 ,  G01N33/54346 ,  G01N33/6887 ,  G01N33/74 ,  G01N33/5308 ,  G01N21/7703 ,  G01N2333/585 ,  G01N2333/4712 ,  G01N2470/04

Abstract: A method of measuring a concentration of an analyte is provided, including: reacting a test solution including an analyte with a nanoparticle solution including a plurality of nanoparticles and an optical waveguide element to form a sandwich-like structure; and measuring evanescent wave energy of the optical waveguide element absorbed and/or scattered by the plurality of nanoparticles after the plurality of nanoparticles forming the sandwich-like structure by using a photodetector to obtain a first signal, and calculating the concentration of the analyte based on the first signal. Wherein, a detection recognition element is conjugated on a surface of each of the plurality of nanoparticles, and a capture recognition element is conjugated on a waveguide surface of the optical waveguide element.

公开(公告)号：US11786584B2

公开(公告)日：2023-10-17

申请号：US17320929

申请日：2021-05-14

Applicant: Immatics Biotechnologies GmbH

Inventor： Andrea Mahr ,  Toni Weinschenk ,  Oliver Schoor ,  Jens Fritsche ,  Harpreet Singh ,  Phillip Mueller ,  Julia Leibold ,  Valentina Goldfinger

IPC: A61K39/00 ,  C07K14/47 ,  C07K14/725 ,  C07K16/30 ,  C12N5/0783 ,  C12N15/115 ,  C12Q1/6886 ,  G01N33/574 ,  G01N33/68 ,  A61K38/00

CPC classification number: A61K39/0011 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/7051 ,  C07K16/30 ,  C12N5/0636 ,  C12N15/115 ,  C12Q1/6886 ,  G01N33/5748 ,  G01N33/6848 ,  A61K38/00 ,  A61K2039/5158 ,  A61K2039/572 ,  C07K2319/00 ,  C12N2310/16 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57407 ,  G01N2570/00 ,  G01N2800/52

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor associated T-cell peptide epitopes, alone or in combination with other tumor associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：US20230324409A1

公开(公告)日：2023-10-12

申请号：US18096447

申请日：2023-01-12

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Ching-Hsuan CHANG ,  Pi-Ju FU ,  Fang-Hsin LIN ,  Kuan-Hung LIU ,  Bin HSU

IPC: G01N33/68 ,  G01N1/34 ,  G01N15/14 ,  G01N35/00

CPC classification number: G01N33/6872 ,  G01N33/6848 ,  G01N1/34 ,  G01N15/1434 ,  G01N35/0099 ,  G01N2333/70539 ,  G01N2015/1486

Abstract: A beta2-microglobulin concentration analyzing method includes: preparing a sample with dialysate, and putting the sample into a differential mobility analyzing device for analysis to obtain a beta2-microglobulin concentration. The present invention further provides a beta2-microglobulin concentration analyzing system, which includes: a preparation device and a differential mobility analyzing device, wherein the preparation device is configured to prepare a sample with dialysate, and the differential mobility analyzing device is configured to analyze the sample to obtain a beta2-microglobulin concentration.

公开(公告)号：US20230324400A1

公开(公告)日：2023-10-12

申请号：US18079578

申请日：2022-12-12

Applicant: The General Hospital Corporation

Inventor： Wilhelm Haas ,  Cyril Benes

IPC: G01N33/68 ,  C12Q1/48 ,  G16B25/00 ,  G16B5/00 ,  G16B25/10

CPC classification number: G01N33/6845 ,  G01N33/6848 ,  C12Q1/485 ,  G16B25/00 ,  G16B5/00 ,  G16B25/10 ,  G01N2570/00

Abstract: The disclosure features methods of identifying protein-protein deregulation that include: generating a basal protein-protein interaction network for a plurality of biological samples, the network featuring a set of proteins expressed in the biological samples and concentrations of each member of the set of expressed proteins in each of the biological samples; identifying two associated expressed proteins in the network; for the two associated expressed proteins, comparing correlated relative concentration values of the two proteins in each of the biological samples to identify outliers among a distribution of the relative concentration values; and identifying members of the plurality of biological samples in which deregulation of the two associated expressed proteins occurs based on the outliers.

公开(公告)号：US20230314444A1

公开(公告)日：2023-10-05

申请号：US18328104

申请日：2023-06-02

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Samir Karaca ,  Nicole Pirkl ,  Martin Rempt

IPC: G01N33/68 ,  H01J49/16

CPC classification number: G01N33/6848 ,  H01J49/165 ,  G01N33/743

Abstract: The present invention relates to a method, a diagnostic system, a dopand and the use thereof for the enhancement of detection of an analyte of interest by Cross Spray ESI mass spectrometry.

公开(公告)号：US20230296631A1

公开(公告)日：2023-09-21

申请号：US18014376

申请日：2021-07-05

Applicant: IN OVO HOLDING B.V.

Inventor： Wil Marijn STUTTERHEIM ,  Wouter Sebastiaan BRUINS ,  Sebastiaan Frans TEUNISSEN ,  Thomas HANKEMEIER ,  Nicolas Francois Pierre DROUIN

IPC: G01N33/74 ,  G01N35/10 ,  G01N33/68 ,  G01N33/08

CPC classification number: G01N33/74 ,  G01N35/1009 ,  G01N35/1065 ,  G01N33/6848 ,  G01N33/08

Abstract: The present invention relates to a method for determining a characteristic of one or more eggs in an automated manner, comprising the steps of: a. extracting a sample from one or more eggs in an automated manner; i. holding and transferring the sample through one or more instruments to a unit for holding one or more samples; ii. ejecting an aliquot from the sample by applying sound or light energy to at least an amount of the sample; iii. entraining the ejected aliquot in a gas or liquid stream; and iv. transporting the ejected aliquot to a mass spectrometer using the gas or liquid stream; and b. analyzing the sample or an aliquot thereof in an automated manner in a mass spectrometer for the absence or presence and the amount of one or more molecules, to determine one or more characteristics of the egg.

公开(公告)号：US20230287040A1

公开(公告)日：2023-09-14

申请号：US17776478

申请日：2020-11-13

Applicant: AMUNIX PHARMACEUTICALS, INC.

Inventor： Volker SCHELLENBERGER ,  Eric JOHANSEN ,  Angela HENKENSIEFKEN

IPC: C07K1/13 ,  C07K14/00 ,  G01N33/68 ,  C12N15/70

CPC classification number: C07K1/13 ,  C07K14/001 ,  G01N33/6848 ,  C12N15/70 ,  G01N2333/95 ,  C12N2800/101

Abstract: Disclosed herein are polypeptides comprising an extended recombinant polypeptide (XTEN) comprised of a plurality of overlapping sequence motifs and one or more barcode fragments releasable upon protease digestion and detectable from ail other proteolytic-ally releasable fragments. Certain embodiments of these polypeptides further comprise a biologically active polypeptide, wherein advantageous embodiments thereof comprise a releasable segment capable of proteolytic cleavage that cleaves the linkage between the XTEN polypeptide and the biologically active polypeptide. Methods of making and methods of using said polypeptides are also disclosed.

公开(公告)号：US11756778B2

公开(公告)日：2023-09-12

申请号：US17566192

申请日：2021-12-30

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Livia Schiavinato Eberlin ,  Thomas Milner ,  Jialing Zhang ,  John Lin ,  John Rector ,  Nitesh Katta ,  Aydin Zahedivash

IPC: H01J49/00 ,  H01J49/04 ,  A61B10/00 ,  G01N33/487 ,  B01L3/00 ,  G01N33/68 ,  G01N1/02 ,  G01N30/72 ,  G01N33/574 ,  B01L3/02 ,  G01N1/40

CPC classification number: H01J49/0431 ,  A61B10/0045 ,  B01L3/502 ,  G01N1/02 ,  G01N30/72 ,  G01N33/487 ,  G01N33/574 ,  G01N33/6848 ,  H01J49/0031 ,  H01J49/04 ,  B01L3/0293 ,  B01L2200/0605 ,  B01L2400/0655 ,  G01N2001/028 ,  G01N2001/4061 ,  G01N2560/00

Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.

公开(公告)号：US11754573B2

公开(公告)日：2023-09-12

申请号：US17349840

申请日：2021-06-16

Applicant: Genzyme Corporation

Inventor： Christopher Morgan ,  Xiaokui Zhang

IPC: G01N7/00 ,  G01N33/68

CPC classification number: G01N33/6857 ,  G01N33/6848 ,  G01N33/6854

Abstract: Provided are methods for quantitating an amount of a polypeptide that comprises a portion of an antibody present in a sample (e.g., a plasma or serum sample) wherein the antibody comprises a constant region (e.g., a heavy chain or light chain constant region) that comprises an engineered mutation.