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    BIOCOMPATIBLE IMPLANTS AND METHODS OF MAKING AND ATTACHING THE SAME
    2.
    发明申请
    BIOCOMPATIBLE IMPLANTS AND METHODS OF MAKING AND ATTACHING THE SAME 有权
    生物可塑性植入物及其制备方法

    公开(公告)号：US20080306611A1

    公开(公告)日：2008-12-11

    申请号：US12041651

    申请日：2008-03-03

    申请人： Adrian P. Rowley ,  Lucien D. Laude ,  Mark S. Humayun ,  James D. Weiland ,  Atoosa Lotfi

    发明人： Adrian P. Rowley ,  Lucien D. Laude ,  Mark S. Humayun ,  James D. Weiland ,  Atoosa Lotfi

    IPC分类号： A61F2/02

    CPC分类号： A61F2/148 ,  A61L27/34 ,  A61L27/50 ,  A61L2400/18 ,  A61N1/0543 ,  A61N1/36 ,  A61N1/36046 ,  C08L89/00

    摘要： The invention provides a biocompatible silicone implant that can be securely affixed to living tissue through interaction with integral membrane proteins (integrins). A silicone article containing a laser-activated surface is utilized to make the implant. One example is an implantable prosthesis to treat blindness caused by outer retinal degenerative diseases. The device bypasses damaged photoreceptors and electrically stimulates the undamaged neurons of the retina. Electrical stimulation is achieved using a silicone microelectrode array (MEA). A safe, protein adhesive is used in attaching the MEA to the retinal surface and assist in alleviating focal pressure effects. Methods of making and attaching such implants are also provided.

    摘要翻译： 本发明提供了一种生物相容的硅氧烷植入物，其通过与整合的蛋白质（整联蛋白）的相互作用可靠地固定在生物体组织上。 使用含有激光激活表面的硅胶制品来制造植入物。 一个例子是用于治疗由视网膜外变性疾病引起的失明的可植入假体。 该装置绕过受损的光感受器并电刺激视网膜的未损伤的神经元。 使用硅微电极阵列（MEA）实现电刺激。 使用安全的蛋白质粘合剂将MEA附着到视网膜表面并有助于减轻焦点压力的影响。 还提供了制造和附接这种植入物的方法。

    Polymer layer comprising silicone and at least one metal trace and a process of manufacturing the same
    3.
    发明授权
    Polymer layer comprising silicone and at least one metal trace and a process of manufacturing the same 有权
    包含硅氧烷和至少一种金属痕迹的聚合物层及其制造方法

    公开(公告)号：US08771805B2

    公开(公告)日：2014-07-08

    申请号：US11270907

    申请日：2005-11-10

    申请人： Lucien D. Laude ,  Robert J. Greenberg

    发明人： Lucien D. Laude ,  Robert J. Greenberg

    IPC分类号： B05D1/18 ,  B05D3/00 ,  B05D3/06

    CPC分类号： H05K3/185 ,  C08J7/12 ,  C08J2383/04 ,  C23C18/1608 ,  C23C18/1612 ,  C23C18/1657 ,  C23C18/204 ,  C23C18/206 ,  H05K3/28 ,  H05K3/387 ,  H05K2201/0133 ,  H05K2201/0162 ,  H05K2201/0209 ,  H05K2201/0236 ,  H05K2203/107 ,  H05K2203/1105 ,  Y10T428/26 ,  Y10T428/31663

    摘要： The present invention provides a process for embedding at least one layer of at least one metal trace in a silicone-containing polymer, comprising: a) applying a polymer layer on a substrate; b) thermally treating the polymer; c) irradiating at least one surface area of the polymer with a light beam emitted by an excimer laser; d) immersing the irradiated polymer in at least one autocatalytic bath containing ions of at least one metal, and metallizing the polymer; e) thermally treating the metallized polymer; f) applying a polymer layer covering the thermally treated metallized polymer; and g) thermally treating the metallized covered polymer. The present invention further provides a polymer layer comprising silicone containing oxide particles of SiO2, TiO2, Sb2O3, SnO2, Al2O3, ZnO, Fe2O3, Fe3O4, talc, hydroxyapatite or mixtures thereof and at least one metal trace embedded in said polymer layer.The present invention further provides a flexible electrode array comprising silicone containing oxide particles of SiO2, TiO2, Sb2O3, SnO2, Al2O3, ZnO, Fe2O3, Fe3O4, talc, hydroxyapatite or mixtures thereof and at least one metal trace embedded in said polymer layer.

    摘要翻译： 本发明提供了一种在含硅酮聚合物中嵌入至少一层至少一种金属痕迹的方法，包括：a）在基底上施加聚合物层; b）热处理聚合物; c）用由准分子激光器发射的光束照射所述聚合物的至少一个表面积; d）将经辐射的聚合物浸入至少一种含有至少一种金属的离子的自催化浴中，并对聚合物进行金属化; e）热处理金属化聚合物; f）涂覆覆盖热处理的金属化聚合物的聚合物层; 和g）热处理金属化被覆聚合物。 本发明还提供一种聚合物层，其包含含硅氧烷的SiO 2，TiO 2，Sb 2 O 3，SnO 2，Al 2 O 3，ZnO，Fe 2 O 3，Fe 3 O 4，滑石，羟基磷灰石或其混合物的氧化物颗粒，以及嵌入所述聚合物层中的至少一种金属迹线。 本发明还提供一种柔性电极阵列，其包括含硅氧烷的SiO 2，TiO 2，Sb 2 O 3，SnO 2，Al 2 O 3，ZnO，Fe 2 O 3，Fe 3 O 4，滑石，羟基磷灰石或其混合物的氧化物颗粒和嵌入所述聚合物层中的至少一种金属迹线。

    Process for the metallization of plastic materials and products thereto obtained
    7.
    发明授权
    Process for the metallization of plastic materials and products thereto obtained 失效
    获得的塑料材料及其制品的金属化方法

    公开(公告)号：US5599592A

    公开(公告)日：1997-02-04

    申请号：US530315

    申请日：1995-09-29

    申请人： Lucien D. Laude

    发明人： Lucien D. Laude

    IPC分类号： C23C18/22 ,  H05K1/03 ,  H05K3/18 ,  B05D3/06

    CPC分类号： H05K3/185 ,  C23C18/22 ,  H05K1/0373

    摘要： A positive metallization process for metallizing a plastic composite piece containing a polymer and grains of one or more oxides, includes three successive steps. The first step consists of irradiating the plastic piece surface to be metallized with a light beam emitted by an excimer laser. The second step consists of immersing the irradiated piece into at least one autocatalytic bath containing metal ions and without palladium. This immersion induces the deposit of the metal ions onto the irradiated surface to form a metal film onto the surface. The third step consists of thermally processing the metallized plastic piece to induce the diffusion of the deposited metal into the plastic piece.

    摘要翻译： PCT No.PCT / EP95 / 00346 Sec。 371 1995年9月29日第 102（e）1995年9月29日PCT PCT 1995年1月31日PCT公布。 公开号WO95 / 20689 日期1995年8月3日用于金属化含有聚合物和一种或多种氧化物的颗粒的塑料复合片的正金属化方法包括三个连续步骤。 第一步包括用准分子激光器发射的光束照射待金属化的塑料片表面。 第二步是将被照射的片浸入含有金属离子和不含钯的至少一个自催化浴中。 这种浸渍引起金属离子沉积到被照射的表面上以在表面上形成金属膜。 第三步包括热处理金属化的塑料件以引起沉积的金属扩散到塑料件中。

    Method for preparing composite or elementary semi-conducting polycrystalline films
    8.
    发明授权
    Method for preparing composite or elementary semi-conducting polycrystalline films 失效
    制备复合或半导体多晶薄膜的方法

    公开(公告)号：US4463028A

    公开(公告)日：1984-07-31

    申请号：US289695

    申请日：1981-08-03

    申请人： Lucien D. Laude

    发明人： Lucien D. Laude

    IPC分类号： C30B1/02 ,  C30B1/08 ,  B05D5/12

    CPC分类号： C30B1/08 ,  C30B1/023 ,  Y10S148/093 ,  Y10S148/094

    摘要： There is described a method for preparing polycrystalline semi-conducting films comprised of two elements respectively from Groups III and V, or Groups II and VI of the Periodic Table, by irradiating with a laser beam a film which is comprised of at least two layers from elements selected with a stoichiometric ratio, said film being deposited over a non-crystalline substrate and being coated with a protective layer, which method is comprised of irradiating said film with a structured laser beam to cause crystallizing into crystallites which are regularly aligned and with a size at least equal to the thickness of the resulting film.

    摘要翻译： 描述了通过用激光束照射由两个元素组成的多晶半导体膜，该多晶半导体膜由分别来自元素周期表的III和V族或II族和VI族的元素组成，该膜由至少两层 所述膜以非化学计量比选择，所述膜沉积在非晶体衬底上并涂覆有保护层，该方法包括用结构化的激光束照射所述膜以使结晶成规则排列的微晶，并且与 尺寸至少等于所得膜的厚度。

    Method for crystallizing films
    10.
    发明授权
    Method for crystallizing films 失效
    使膜结晶的方法

    公开(公告)号：US4469551A

    公开(公告)日：1984-09-04

    申请号：US302753

    申请日：1981-09-16

    申请人： Lucien D. Laude

    发明人： Lucien D. Laude

    IPC分类号： H01L31/04 ,  B23K26/00 ,  C30B1/02 ,  C30B1/08 ,  C30B21/02 ,  C30B29/02 ,  C30B29/40 ,  C30B29/48 ,  H01L21/20 ,  H01L21/268 ,  C30B1/04

    CPC分类号： C30B29/40 ,  C30B1/02 ,  C30B1/023 ,  C30B1/08 ,  C30B21/02 ,  C30B29/48 ,  Y10S117/904

    摘要： There is described a method for crystallizing films selected from the group comprising the amorphous elementary semi-conducting films and the polymetallic films comprised of two elements belonging respectively to Groups III and V, or Groups II and VI of the Periodic Table, which comprises irradiating the film surface with a laser beam guided by an assembly from optic fibers which are arranged in parallel relationship with one another, each fiber having a diameter which is not larger than 50.mu., said irradiating causing crystallizing into crystallites which are regularly distributed and closely confined.

    摘要翻译： 描述了选自包括非晶元件半导电膜和由分别属于元素周期表III和V族或II族和VI族的两种元素组成的组的膜结晶的方法，其中包括将 膜表面具有由彼此平行关系的光纤的组件引导的激光束，每根纤维的直径不大于50微米，所述照射导致结晶成规则分布和紧密限制的微晶。