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1.发明授权公开(公告)号：US06650102B2
公开(公告)日：2003-11-18
申请号：US09938994
申请日：2001-08-24
申请人： Damian A. Hajduk , Eric D. Carlson , J. Christopher Freitag , Oleg Kolosov , James R. Engstrom , Adam Safir , Ravi Srinivasan , Leonid Matsiev
发明人： Damian A. Hajduk , Eric D. Carlson , J. Christopher Freitag , Oleg Kolosov , James R. Engstrom , Adam Safir , Ravi Srinivasan , Leonid Matsiev
IPC分类号： G01N2700
CPC分类号： B01J19/0046 , B01J2219/00315 , B01J2219/00364 , B01J2219/00369 , B01J2219/00376 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00621 , B01J2219/00659 , B01J2219/00677 , B01J2219/00689 , B01J2219/00691 , B01J2219/00698 , B01J2219/00704 , B01J2219/00722 , B01J2219/00725 , B01J2219/00736 , B01J2219/00756 , G01N3/10 , G01N3/18 , G01N2203/0016 , G01N2203/0051 , G01N2203/0252 , G01N2203/0254 , G01N2203/0258 , G01N2203/0617 , G01N2203/0623 , G01N2203/0641
摘要： The present invention provides instruments and methods for screening combinatorial libraries that addresses many of the problems encountered when using conventional instruments. For example, the disclosed instruments can measure mechanical properties of library members in rapid serial or parallel test format, and can perform tests on small amounts of material, which are easily prepared or dispensed using art-disclosed liquid or solid handling techniques. Compared to conventional instruments, the disclosed instruments afford faster sample loading and unloading, for example, through the use of disposable libraries of material samples.
摘要翻译： 本发明提供了用于筛选组合文库的仪器和方法，其解决了使用常规仪器时遇到的许多问题。 例如，所公开的仪器可以以快速的串联或并行测试形式测量文库成员的机械性能，并且可以使用本领域公开的液体或固体处理技术容易地制备或分配的少量材料进行测试。 与常规仪器相比，所公开的仪器例如通过使用材料样品的一次性库来提供更快的样品加载和卸载。
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2.发明授权公开(公告)号：US06772642B2
公开(公告)日：2004-08-10
申请号：US09939404
申请日：2001-08-24
申请人： Damian A. Hajduk , Eric D. Carlson , J. Christopher Freitag , Oleg Kolosov , James R. Engstrom , Adam Safir , Ravi Srinivasan , Leonid Matsiev
发明人： Damian A. Hajduk , Eric D. Carlson , J. Christopher Freitag , Oleg Kolosov , James R. Engstrom , Adam Safir , Ravi Srinivasan , Leonid Matsiev
IPC分类号： G01N308
CPC分类号： G01N3/18 , B01J2219/00274 , G01N3/10 , G01N2203/0016 , G01N2203/0051 , G01N2203/0252 , G01N2203/0254 , G01N2203/0258 , G01N2203/0617 , G01N2203/0623 , G01N2203/0641
摘要： A method for high throughput mechanical property and bulge testing of materials libraries. A plurality of samples on a substrate are monitored for their response to a force from a fluid.
摘要翻译： 一种材料库高通量机械性能和凸起试验方法。 监测基板上的多个样品对来自流体的力的响应。
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3.发明授权High throughput mechanical property testing of materials libraries using capacitance 失效使用电容的材料库的高通量机械性能测试公开(公告)号：US06690179B2
公开(公告)日：2004-02-10
申请号：US09939263
申请日：2001-08-24
申请人： Damian A. Hajduk , Eric D. Carlson , J. Christopher Freitag , Oleg Kolosov , James R. Engstrom , Adam Safir , Ravi Srinivasan , Leonid Matsiev
发明人： Damian A. Hajduk , Eric D. Carlson , J. Christopher Freitag , Oleg Kolosov , James R. Engstrom , Adam Safir , Ravi Srinivasan , Leonid Matsiev
IPC分类号： G01R2726
CPC分类号： G01N3/10 , B01J2219/00274 , B01J2219/00315 , B01J2219/00364 , B01J2219/00373 , B01J2219/00477 , B01J2219/00495 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00621 , B01J2219/00653 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00689 , B01J2219/00691 , B01J2219/00707 , B01J2219/00716 , B01J2219/00722 , B01J2219/00745 , B01J2219/0075 , B01J2219/00754 , B82Y30/00 , C40B40/14 , C40B40/18 , C40B50/14 , C40B60/14 , G01N3/18 , G01N2203/0016 , G01N2203/0252 , G01N2203/0254 , G01N2203/0258 , G01N2203/0617 , G01N2203/0623 , G01N2203/0641
摘要： One aspect of the present invention provides instruments for measuring mechanical properties of a combinatorial library of materials. The instruments include at least one capacitor to which a member of a library of material samples is removably secured for testing; at least one voltage source for delivering one or more forces to each library member; and at least one sensing device for monitoring the response each library member to the one or more forces. Another aspect of the present invention provides methods of screening a combinatorial library of materials where the method monitors the responses of a plurality of samples on a substrate to a force induced by a capacitor.
摘要翻译： 本发明的一个方面提供用于测量材料组合库的机械特性的仪器。 这些仪器包括至少一个电容器，材料样品库的成员可拆卸地固定到其上进行测试; 至少一个电压源，用于将一个或多个力递送到每个库构件; 以及至少一个感测装置，用于监视每个库成员对一个或多个力的响应。 本发明的另一方面提供了筛选材料的组合文库的方法，其中该方法将衬底上的多个样品的响应监测到由电容器引起的力。
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公开(公告)号：US06881363B2
公开(公告)日：2005-04-19
申请号：US10291108
申请日：2002-11-08
申请人： Eric D. Carlson , Damian A. Hajduk , Leonid Matsiev , Adam Safir , Paul Mansky
发明人： Eric D. Carlson , Damian A. Hajduk , Leonid Matsiev , Adam Safir , Paul Mansky
IPC分类号： B01F5/10 , B01F7/00 , B01F7/08 , B01F13/10 , B01J19/00 , B01L3/00 , G01N1/28 , G01N35/00 , G01N35/02 , G01B1/00
CPC分类号： B01L3/5085 , B01F5/104 , B01F7/00341 , B01F7/00416 , B01F7/082 , B01F13/1013 , B01F13/1022 , B01J19/0046 , B01J2219/00274 , B01J2219/00756 , B01L2200/12 , B01L2300/0812 , B01L2300/0829 , G01N1/286 , G01N35/00 , G01N35/00009 , G01N35/021 , G01N2001/2866 , G01N2035/00495 , G01N2035/00534
摘要： A rapid throughput method for the preparation, analysis or both of libraries of material samples is provided. According to the method, a plurality of samples is provided. Providing the plurality of samples can include a variety of sample formation techniques including, but not limited to, extruding, milling, compression preparation, rotary mixing, microcentrifugation, molding and casting. Preferably, the samples are solidified into a near net shape configuration appropriate for testing of properties or characteristics of the samples.
摘要翻译： 提供了用于材料样品库的制备，分析或两者的快速通量方法。 根据该方法，提供多个样品。 提供多个样品可以包括各种样品形成技术，包括但不限于挤出，研磨，压缩制备，旋转混合，微量离心，模塑和铸造。 优选地，样品被固化成适合于测试样品的性质或特性的近净形状构型。
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公开(公告)号：US06818183B2
公开(公告)日：2004-11-16
申请号：US10134556
申请日：2002-04-29
申请人： Damian A. Hajduk , Ralph B. Nielsen , Adam Safir , Leonid Matsiev , Eric McFarland , Paul Mansky
发明人： Damian A. Hajduk , Ralph B. Nielsen , Adam Safir , Leonid Matsiev , Eric McFarland , Paul Mansky
IPC分类号： G01N3348
CPC分类号： B01F15/00207 , B01F13/065 , B01F13/08 , B01F15/00357 , B01F15/00396 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00745 , B01L3/50851 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , F28D15/00 , F28D2021/0077 , F28F27/00 , G01K13/00 , G01N21/253 , Y10T436/10 , Y10T436/11 , Y10T436/25
摘要： An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.
摘要翻译： 公开了一种用于实施和监测多重反应的进展和性质的装置和方法。 该方法和装置对于组合文库的合成，筛选和表征特别有用，但是与常规实验反应器相比也具有显着的优点。 该装置通常包括用于容纳反应混合物的多个容器和用于控制各个反应混合物或反应混合物组的搅拌速率和温度的系统。 此外，该装置可以包括用于独立地控制每个容器中的压力的装置。 单独反应混合物的原位监测为过程控制器提供反馈，并提供了确定反应速率，产物产率和反应产物各种性质（包括粘度和分子量）的数据。
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公开(公告)号：US06528026B2
公开(公告)日：2003-03-04
申请号：US09417125
申请日：1998-11-19
申请人： Damian A. Hajduk , Ralph B. Nielsen , Adam Safir , Leonid Matsiev , Eric McFarland , Paul Mansky
发明人： Damian A. Hajduk , Ralph B. Nielsen , Adam Safir , Leonid Matsiev , Eric McFarland , Paul Mansky
IPC分类号： G01N3300
CPC分类号： B01F15/00207 , B01F13/065 , B01F13/08 , B01F15/00357 , B01F15/00396 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00745 , B01L3/50851 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , F28D15/00 , F28D2021/0077 , F28F27/00 , G01K13/00 , G01N21/253 , Y10T436/10 , Y10T436/11 , Y10T436/25
摘要： An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.
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公开(公告)号：US06890492B1
公开(公告)日：2005-05-10
申请号：US09724276
申请日：2000-11-28
申请人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. Van Beek , Damian A. Hajduk , Ralph B. Nielsen , Paul Mansky , Leonid Matsiev , Pei Wang , Eric McFarland
发明人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. Van Beek , Damian A. Hajduk , Ralph B. Nielsen , Paul Mansky , Leonid Matsiev , Pei Wang , Eric McFarland
IPC分类号： B01F15/00 , B01J19/00 , B01L3/00 , B01L7/00 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/10 , B01F7/00
CPC分类号： B01L3/50851 , B01F13/0818 , B01F13/0827 , B01F15/00201 , B01F15/00207 , B01F15/00246 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00736 , B01J2219/00738 , B01J2219/00745 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/1079 , Y10T436/11 , Y10T436/115831 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/25875
摘要： Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.
摘要翻译： 公开了用于控制和监测多个反应的进展和性质的装置和方法。 该方法和装置对于组合文库的合成，筛选和表征特别有用，但是与常规实验反应器相比也具有显着的优点。 该装置通常包括用于容纳反应混合物的多个容器和用于控制各个反应混合物或反应混合物组的搅拌速率和温度的系统。 此外，该装置可以包括用于独立地控制每个容器中的压力的装置，以及用于以不同于环境压力的压力将液体注入容器的系统。 单独反应混合物的原位监测为过程控制器提供反馈，并提供了确定反应速率，产物产率和反应产物各种性质（包括粘度和分子量）的数据。 公开了基于计算机的方法，用于过程监控和控制，以及数据显示和分析。
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公开(公告)号：US07112443B2
公开(公告)日：2006-09-26
申请号：US10274184
申请日：2002-10-18
申请人： Damian A. Hajduk , Oleg Kolosov
发明人： Damian A. Hajduk , Oleg Kolosov
CPC分类号： G01N33/442 , G01N7/10 , G01N15/0826 , G01N2015/086 , Y10T436/11 , Y10T436/20 , Y10T436/207497 , Y10T436/209163 , Y10T436/25875
摘要： A library of material samples is screened for properties such as permeability. A library of material samples is provided. A stimulus such as an exposure to a permeate fluid is provided to each member of the library. A response of each of the material samples due to the stimulus is measured and the response, the stimulus or both are recorded and related to provide data. Thereafter, the data is analyzed to reach conclusions regarding the properties of the material samples.
摘要翻译： 对材料样品库进行筛选，例如渗透性等。 提供材料样本库。 向图书馆的每个成员提供诸如暴露于渗透液的刺激。 测量由于刺激引起的每个材料样品的响应，并记录响应，刺激或两者以提供数据。 此后，分析数据以得出关于材料样品的性质的结论。
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公开(公告)号：US07013709B2
公开(公告)日：2006-03-21
申请号：US10313477
申请日：2002-12-06
申请人： Damian A. Hajduk , Oleg Kolosov
发明人： Damian A. Hajduk , Oleg Kolosov
IPC分类号： G01N3/10
CPC分类号： B01J19/0046 , C40B40/00
摘要： A rapid throughput method for the preparation, analysis or both of libraries of material samples is provided. According to the method, a plurality of samples is provided. The plurality of samples is then formed into a plurality of films. Thereafter, the plurality of films is plastically deformed. Preferably, the plurality of films is deformed into a configuration appropriate for testing of properties or characteristics of the samples.
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公开(公告)号：US06864092B1
公开(公告)日：2005-03-08
申请号：US09723926
申请日：2000-11-28
申请人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. VanBeek , Damian A. Hajduk , Ralph B. Nielsen , Paul Mansky , Leonid Matsiev , Pei Wang , Eric McFarland
发明人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. VanBeek , Damian A. Hajduk , Ralph B. Nielsen , Paul Mansky , Leonid Matsiev , Pei Wang , Eric McFarland
IPC分类号： B01F15/00 , B01J19/00 , B01L3/00 , B01L7/00 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/10 , G01N31/10
CPC分类号： B01L3/50851 , B01F13/0818 , B01F13/0827 , B01F15/00201 , B01F15/00207 , B01F15/00246 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00736 , B01J2219/00738 , B01J2219/00745 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/1079 , Y10T436/11 , Y10T436/115831 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/25875
摘要： Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.
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