公开(公告)号：US20070178516A1

公开(公告)日：2007-08-02

申请号：US11726520

申请日：2007-03-22

申请人： Ronald Sosnowski ,  William Butler ,  Eugene Tu ,  Michael Nerenberg ,  Michael Heller ,  Carl Edman

发明人： Ronald Sosnowski ,  William Butler ,  Eugene Tu ,  Michael Nerenberg ,  Michael Heller ,  Carl Edman

IPC分类号： C12Q1/68

CPC分类号： H01L29/7834 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00713 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502761 ,  B01L3/5085 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2400/0415 ,  B01L2400/0421 ,  B82Y5/00 ,  B82Y10/00 ,  C07B2200/11 ,  C07H21/00 ,  C07K1/04 ,  C07K1/045 ,  C07K1/047 ,  C12Q1/6825 ,  C12Q1/6832 ,  C12Q1/6837 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B60/14 ,  G11C13/0014 ,  G11C13/0019 ,  G11C13/04 ,  G11C19/00 ,  H01L25/50 ,  H01L29/6656 ,  H01L29/6659 ,  H01L29/66628 ,  H01L2224/95145 ,  H01L2224/95147 ,  H01L2924/01019 ,  H01L2924/01025 ,  H01L2924/01046 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/10253 ,  C12Q2565/515 ,  C12Q2565/607 ,  H01L2924/00

摘要： A method for electronically stabilizing hybridization of nucleic acids bound at a test site of a microelectronic device is described. First and second negatively charged nucleic acids are provided, the second nucleic acid being bound to the test site. A zwitterionic buffer having a conductance of less than 100 mS/cm is applied to the microelectronic device. A current is applied to the test site to positively bias the test site, such that the first negatively charged nucleic acid is transported to the positively biased test site having the bound the second negatively charged nucleic acid. At the test site, the first and second negatively charged nucleic acids hybridize. The zwitterionic buffer acquires a net positive charge under influence of the current, such that the positively charged zwitterionic buffer stabilizes the hybridization by reducing the repulsion between the first and second negatively charged nucleic acids

摘要翻译： 描述了用于电子稳定在微电子器件的测试位点处结合的核酸杂交的方法。 提供第一和第二带负电荷的核酸，第二核酸与测试部位结合。 将具有小于100mS / cm 2的电导的两性离子缓冲液施加到微电子器件。 将电流施加到测试部位以使测试部位正偏置，使得将第一带负电荷的核酸转运到具有结合第二带负电荷核酸的正偏压测试位点。 在测试位点，第一和第二带负电荷的核酸杂交。 两性离子缓冲液在电流影响下获得净正电荷，使得带正电的两性离子缓冲液通过降低第一和第二带负电的核酸之间的排斥来稳定杂交

公开(公告)号：US20050207940A1

公开(公告)日：2005-09-22

申请号：US10928650

申请日：2004-08-27

申请人： William Butler ,  Mirianas Chachisvilis ,  Robert Dees ,  Norbert Hagen ,  Philippe Marchand ,  Daniel Raymond ,  Eugene Tu ,  Mark Wang ,  Joon Yang ,  Rong Yang ,  Haichuan Zhang

发明人： William Butler ,  Mirianas Chachisvilis ,  Robert Dees ,  Norbert Hagen ,  Philippe Marchand ,  Daniel Raymond ,  Eugene Tu ,  Mark Wang ,  Joon Yang ,  Rong Yang ,  Haichuan Zhang

IPC分类号： B01L3/00 ,  G01N15/14 ,  G01N21/64 ,  G01N33/53

CPC分类号： G01N15/1459 ,  B01L3/502707 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0454 ,  B01L2400/0487 ,  G01N2015/149 ,  Y10T436/2575

摘要： Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on an optical switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000-100,000 cells). The invention includes packaging of the microfluidic channel network in a self-contained plastic cartridge that enables microfluidic channel network to macro-scale instrument interconnect, in a sterile, disposable format.

摘要翻译： 为微型荧光激活细胞分选器提供基于光学开关的装置和方法，用于通过微流体通道网络快速，主动地控制细胞路由。 该分选机能够对小数量细胞群体（即1000-100,000个细胞）进行低应激，高效分选。 本发明包括将微流体通道网络包装在独立的塑料盒中，使得微流体通道网络能够以无菌的一次性格式进行大规模的仪器互连。

公开(公告)号：US20060060767A1

公开(公告)日：2006-03-23

申请号：US11272593

申请日：2005-11-11

申请人： Mark Wang ,  Eugene Tu ,  Luis Pestana ,  Andrew Senyei ,  James O'Connell ,  Tina Nova ,  Kristie Lykstad ,  Jeffrey Hall ,  William Butler

发明人： Mark Wang ,  Eugene Tu ,  Luis Pestana ,  Andrew Senyei ,  James O'Connell ,  Tina Nova ,  Kristie Lykstad ,  Jeffrey Hall ,  William Butler

IPC分类号： H05H3/02

CPC分类号： G01N15/1463 ,  B07C5/34 ,  G01N15/1459 ,  G01N30/02 ,  G01N2015/1486 ,  G01N2015/149 ,  H05H3/04 ,  B01D2015/3895

摘要： Apparatus and methods are provided for interacting light with particles, including but not limited to biological matter such as cells, in unique and highly useful ways. Optophoresis consists of subjecting particles to various optical forces, especially optical gradient forces, and more particularly moving optical gradient forces, so as to obtain useful results. In biology, this technology represents a practical approach to probing the inner workings of a living cell, preferably without any dyes, labels or other markers. In one aspect, a particle may be characterized by determining its optophoretic constant or signature. For example, a diseased cell has a different optophoretic constant from a healthy cell, thereby providing information, or the basis for sorting. In the event of physical sorting, various forces may be used for separation, including fluidic forces, such as through the use of laminar flow, or optical forces, or mechanical forces, such as through adhesion. Various techniques for measuring the dielectric constant of particles are provided.

公开(公告)号：US20100016655A1

公开(公告)日：2010-01-21

申请号：US12506661

申请日：2009-07-21

申请人： Lon S. Annest ,  Claudio Argento ,  William Butler ,  Ernest Heflin

发明人： Lon S. Annest ,  Claudio Argento ,  William Butler ,  Ernest Heflin

IPC分类号： A61F2/00 ,  A61M25/09 ,  A61B1/32 ,  A61B17/08

CPC分类号： A61M25/04 ,  A61B17/00234 ,  A61B17/0401 ,  A61B17/0467 ,  A61B17/0487 ,  A61B50/30 ,  A61B2017/00243 ,  A61B2017/00469 ,  A61B2017/00473 ,  A61B2017/0404 ,  A61B2017/0409 ,  A61B2017/0417 ,  A61B2017/0456 ,  A61B2017/0464 ,  A61B2017/048 ,  A61B2017/0488 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2017/06176 ,  A61F2/2487

摘要： Medical devices, systems, and methods reduce the distance between two points in tissue, often for treatment of congestive heart failure and often in a minimally invasive manner. An anchor is inserted along an insertion path through a first wall of the heart. An arm of the anchor is deployed and rotationally positioned according to a desired alignment. Application of tension to the anchor may draw the first and second walls of the heart into contact along a desired contour so as to effect a desired change in the geometry of the heart. Additional anchors may be inserted and aligned with the first anchor to close off a portion of a ventricle such that the ventricle is geometrically remodeled and disease progression is reversed, halted, and/or slowed.

摘要翻译： 医疗设备，系统和方法减少组织中两点之间的距离，通常用于治疗充血性心力衰竭，并且通常以微创方式。 沿着穿过心脏的第一壁的插入路径插入锚。 根据期望的对准，锚定器的臂部署并旋转定位。 向锚定器施加张力可以使心脏的第一和第二壁沿期望的轮廓接触，以便实现心脏几何形状的所需变化。 另外的锚可以被插入并与第一锚定件对准以封闭心室的一部分，使得心室几何地被改造并且疾病进展被颠倒，停止和/或减慢。

公开(公告)号：US20080066479A1

公开(公告)日：2008-03-20

申请号：US11941673

申请日：2007-11-16

申请人： William Butler ,  Steven Carey ,  Hung Pham ,  Nagaraj Jayanth

发明人： William Butler ,  Steven Carey ,  Hung Pham ,  Nagaraj Jayanth

IPC分类号： F25B39/04 ,  G05B13/02

CPC分类号： F25B49/02 ,  F24F11/30 ,  F24F11/52 ,  F24F11/54 ,  F25B2600/025 ,  F25B2600/111 ,  F25B2700/151 ,  F25B2700/2104 ,  F25B2700/2106 ,  F25B2700/21152 ,  Y02B30/743

摘要： An interactive system for controlling the operation of an HVAC system is provide that comprises a thermostat for initiating the operation of the HVAC system in either a full capacity mode of operation or at least one reduced capacity mode of operation, and a controller for an outside condenser unit having a condenser fan motor and a compressor motor, the controller being capable of operating the compressor in a full capacity mode and at least one reduced capacity mode. The system also comprises a controller for an indoor blower unit having a blower fan motor, the controller being capable of operating the blower fan motor in a full capacity mode an at least one reduced capacity mode. The system further includes a communication means for transmitting information between the outside condenser unit controller and at least the indoor blower controller, where the information relates to the operation of the indoor blower and the outdoor condenser unit. The indoor blower controller responsively controls the operation of the blower fan motor in a full capacity mode or a reduced capacity mode based on the information received from the outdoor unit controller, and the outdoor unit controller responsively controls the operation of the compressor in a full capacity mode or a reduced capacity mode based on the information received from the indoor blower controller.

摘要翻译： 提供一种用于控制HVAC系统的操作的交互式系统，其包括用于在全容量操作模式或至少一个简化容量操作模式中启动HVAC系统的操作的恒温器，以及用于外部冷凝器的控制器 具有冷凝器风扇电动机和压缩机电动机的单元，所述控制器能够以全容量模式和至少一种减小容量模式来操作所述压缩机。 该系统还包括具有鼓风机风扇马达的室内鼓风机单元的控制器，该控制器能够以全容量模式操作鼓风机风扇马达，并具有至少一个减小容量的模式。 该系统还包括用于在外部冷凝器单元控制器和至少室内鼓风机控制器之间传送信息的通信装置，其中该信息涉及室内鼓风机和室外冷凝器单元的操作。 室内鼓风机控制器基于从室外机控制器接收到的信息，以全容量模式或减容模式响应地控制鼓风机电动机的运行，并且室外机控制器响应于全压控制压缩机的运行 模式或基于从室内鼓风机控制器接收的信息的减小容量模式。

公开(公告)号：US20060142694A1

公开(公告)日：2006-06-29

申请号：US11023667

申请日：2004-12-28

申请人： Michael Bednarek ,  Eric Wilkowske ,  Richard Stehr ,  William Butler

发明人： Michael Bednarek ,  Eric Wilkowske ,  Richard Stehr ,  William Butler

IPC分类号： A61M31/00

CPC分类号： A61M25/0147 ,  A61B5/042 ,  A61B5/0422 ,  A61M25/0136

摘要： The present invention is a handle for controlling the deflection of a distal end of a catheter body. The catheter body includes first and second deflection wires that extend through the catheter body from the distal end of the catheter body. The handle comprises a slide base, an adjustment knob, a first slide and a second slide. The slide base includes a first end, a second end, and a slide compartment longitudinally extending through at least a portion of the slide base. The adjustment knob is rotateably connected to the first end of the slide base and includes a hole extending through the knob, wherein at least a portion of an inner diameter of the hole includes an internal right thread and an internal left thread. The first slide is located in the slide compartment, is adapted to be coupled to the first deflection wire, and includes an external right thread. The second slide is located in the slide compartment, is adapted to be coupled to the second deflection wire, and includes an external left thread. The internal threads of the knob engage the threads of the slides. Consequently, in operation, rotation of the adjustment knob causes the slides to displace in opposite directions within the slide compartment and the distal end of the catheter body to deflect accordingly.

摘要翻译： 本发明是用于控制导管主体的远端的偏转的手柄。 导管主体包括从导管主体的远端延伸穿过导管主体的第一和第二偏转线。 手柄包括滑动底座，调节旋钮，第一滑块和第二滑块。 滑动底座包括第一端，第二端和纵向延伸穿过滑动底座的至少一部分的滑动隔间。 调节旋钮可旋转地连接到滑动基座的第一端并且包括延伸穿过该旋钮的孔，其中孔的内径的至少一部分包括内部右螺纹和内部左螺纹。 第一滑块位于滑动隔室中，适于联接到第一偏转线，并且包括外部右螺纹。 第二滑块位于滑动隔室中，适于联接到第二偏转线，并且包括外部左螺纹。 旋钮的内螺纹与滑块的螺纹啮合。 因此，在操作中，调节旋钮的旋转使得滑动件在滑动隔间内的相反方向移动，并且导管主体的远端相应地偏转。

公开(公告)号：US20090093670A1

公开(公告)日：2009-04-09

申请号：US12245040

申请日：2008-10-03

申请人： Lon S. Annest ,  Claudio Argento ,  William Butler ,  Ernest Heflin

发明人： Lon S. Annest ,  Claudio Argento ,  William Butler ,  Ernest Heflin

IPC分类号： A61F2/24 ,  A61N1/362 ,  A61B17/03

CPC分类号： A61F2/2487 ,  A61B17/00234 ,  A61B17/0057 ,  A61B17/0401 ,  A61B17/0467 ,  A61B17/0469 ,  A61B17/0487 ,  A61B17/06066 ,  A61B50/30 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/00469 ,  A61B2017/00561 ,  A61B2017/00601 ,  A61B2017/00867 ,  A61B2017/0237 ,  A61B2017/0404 ,  A61B2017/0408 ,  A61B2017/0417 ,  A61B2017/0464 ,  A61B2017/048 ,  A61B2017/0488 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2017/0608 ,  A61B2017/061 ,  A61B2017/06176 ,  A61F2002/249 ,  A61M25/0138 ,  A61M25/0147 ,  A61M25/09 ,  A61M29/02

摘要： Medical devices, systems, and methods reduce the distance between two points in tissue, often for treatment of congestive heart failure and often in a minimally invasive manner. An anchor is inserted along an insertion path through a first wall of the heart. An arm of the anchor is deployed and rotationally positioned according to a desired alignment. Application of tension to the anchor may draw the first and second walls of the heart into contact along a desired contour so as to effect a desired change in the geometry of the heart. Additional anchors may be inserted and aligned with the first anchor to close off a portion of a ventricle such that the ventricle is geometrically remodeled and disease progression is reversed, halted, and/or slowed.

摘要翻译： 医疗设备，系统和方法减少组织中两点之间的距离，通常用于治疗充血性心力衰竭，并且通常以微创方式。 沿着穿过心脏的第一壁的插入路径插入锚。 根据期望的对准，锚定器的臂部署并旋转定位。 向锚定器施加张力可以使心脏的第一和第二壁沿期望的轮廓接触，以便实现心脏几何形状的所需变化。 另外的锚可以被插入并与第一锚定件对准以封闭心室的一部分，使得心室几何地被改造并且疾病进展被颠倒，停止和/或减慢。

公开(公告)号：US20080073440A1

公开(公告)日：2008-03-27

申请号：US11941669

申请日：2007-11-16

申请人： William Butler ,  Steven Carey ,  Hung Pham ,  Nagaraj Jayanth

发明人： William Butler ,  Steven Carey ,  Hung Pham ,  Nagaraj Jayanth

IPC分类号： G05D23/19 ,  G05B11/01

CPC分类号： F25B49/02 ,  F24F11/30 ,  F24F11/52 ,  F24F11/54 ,  F25B2600/025 ,  F25B2600/111 ,  F25B2700/151 ,  F25B2700/2104 ,  F25B2700/2106 ,  F25B2700/21152 ,  Y02B30/743

摘要： An interactive system for controlling the operation of an HVAC system is provide that comprises a thermostat for initiating the operation of the HVAC system in either a full capacity mode of operation or at least one reduced capacity mode of operation, and a controller for an outside condenser unit having a condenser fan motor and a compressor motor, the controller being capable of operating the compressor in a full capacity mode and at least one reduced capacity mode. The system also comprises a controller for an indoor blower unit having a blower fan motor, the controller being capable of operating the blower fan motor in a full capacity mode an at least one reduced capacity mode. The system further includes a communication means for transmitting information between the outside condenser unit controller and at least the indoor blower controller, where the information relates to the operation of the indoor blower and the outdoor condenser unit. The indoor blower controller responsively controls the operation of the blower fan motor in a full capacity mode or a reduced capacity mode based on the information received from the outdoor unit controller, and the outdoor unit controller responsively controls the operation of the compressor in a full capacity mode or a reduced capacity mode based on the information received from the indoor blower controller.

公开(公告)号：US20070016164A1

公开(公告)日：2007-01-18

申请号：US11170550

申请日：2005-06-28

申请人： Joshua Dudney ,  Donald Goblish ,  William Butler

发明人： Joshua Dudney ,  Donald Goblish ,  William Butler

IPC分类号： A61M25/00

CPC分类号： A61M25/0136

摘要： The present invention is a catheter actuation handle for deflecting a distal end of a tubular catheter body including first, second and third actuation wires extending from a proximal end of the body. The handle comprises a grip portion, a first actuator, first and second stationary gear racks, first and second moveable gear racks, first and second pinion gears, and a second actuator. The grip portion is coupled to the proximal end of the body. The first actuator is pivotally coupled to the grip portion. The first and second stationary gear racks are fixed relative to the grip portion. The first and second moveable gear racks are moveable relative to the grip portion and couple to the first and second actuation wires, respectively. The first pinion gear is coupled to the first actuator and located between, and engaged with, the first stationary gear rack and the first moveable gear rack. Similarly, the second pinion gear is coupled to the first actuator and located between, and engaged with, the second stationary gear rack and the second moveable gear rack. The second actuator is slideably coupled to the grip portion and adapted to displace the third actuation wire.

摘要翻译： 本发明是用于偏转管状导管主体的远端的导管致动手柄，包括从主体的近端延伸的第一，第二和第三致动线。 手柄包括握持部分，第一致动器，第一和第二固定齿条，第一和第二可移动齿条，第一和第二小齿轮以及第二致动器。 抓握部分联接到主体的近端。 第一致动器枢转地联接到把手部分。 第一和第二固定齿条相对于把手部分是固定的。 第一和第二可移动齿条相对于把手部分可移动，并且分别耦合到第一和第二致动丝线。 第一小齿轮联接到第一致动器并且位于第一固定齿条和第一可移动齿条之间并与其接合。 类似地，第二小齿轮联接到第一致动器并且位于第二固定齿条和第二可移动齿条之间并与其啮合。 第二致动器可滑动地联接到把手部分并且适于移动第三致动线。

公开(公告)号：US20060185373A1

公开(公告)日：2006-08-24

申请号：US11063806

申请日：2005-02-23

申请人： William Butler ,  Steven Carey ,  Hung Pham ,  Nagaraj Jayanth

发明人： William Butler ,  Steven Carey ,  Hung Pham ,  Nagaraj Jayanth

IPC分类号： F25B13/00 ,  F25D17/00 ,  F25B1/00 ,  F25B49/00

CPC分类号： F25B49/02 ,  F24F11/30 ,  F24F11/52 ,  F24F11/54 ,  F25B2600/025 ,  F25B2600/111 ,  F25B2700/151 ,  F25B2700/2104 ,  F25B2700/2106 ,  F25B2700/21152 ,  Y02B30/743

摘要： An interactive system for controlling the operation of an HVAC system is provide that comprises a thermostat for initiating the operation of the HVAC system in either a full capacity mode of operation or at least one reduced capacity mode of operation, and a controller for an outside condenser unit having a condenser fan motor and a compressor motor, the controller being capable of operating the compressor in a full capacity mode and at least one reduced capacity mode. The system also comprises a controller for an indoor blower unit having a blower fan motor, the controller being capable of operating the blower fan motor in a full capacity mode an at least one reduced capacity mode. The system further includes a communication means for transmitting information between the outside condenser unit controller and at least the indoor blower controller, where the information relates to the operation of the indoor blower and the outdoor condenser unit. The indoor blower controller responsively controls the operation of the blower fan motor in a full capacity mode or a reduced capacity mode based on the information received from the outdoor unit controller, and the outdoor unit controller responsively controls the operation of the compressor in a full capacity mode or a reduced capacity mode based on the information received from the indoor blower controller.