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公开(公告)号：US20090264618A1
公开(公告)日：2009-10-22
申请号：US12370886
申请日：2009-02-13
CPC分类号： G01N33/6845 , C07K1/1075 , C07K1/1077 , C07K14/001 , G01N33/5306 , G01N33/531 , G01N33/532 , G01N33/533 , G01N33/68
摘要： Disclosed herein are branched linkers of the formula: Zn-Y-Xm Wherein X, Y, Z, m, and n are as defined herein. The branched linkers are useful for producing conjugates that are used in diagnostic or therapeutic methods. Methods of producing the branched linkers are also described.
摘要翻译： 本文公开了下式的支链接头：Zn-Y-Xm，其中X，Y，Z，m和n如本文所定义。 支链接头可用于制备用于诊断或治疗方法的缀合物。 还描述了生产支化接头的方法。
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公开(公告)号：US07897404B2
公开(公告)日：2011-03-01
申请号：US10381941
申请日：2001-08-26
申请人： Eva Hoess , Herbert Andres , Frederic Donie , Rudolf Vogel , Hans-Peter Josel , Rupert Hermann , Herbert Von Der Eltz
发明人： Eva Hoess , Herbert Andres , Frederic Donie , Rudolf Vogel , Hans-Peter Josel , Rupert Hermann , Herbert Von Der Eltz
IPC分类号： G01N30/02
CPC分类号： C07K1/1077 , A61K47/643 , A61K47/6889 , G01N33/5306 , G01N33/531 , G01N33/68 , G01N33/6845 , Y10S435/961 , Y10S435/962
摘要： The invention relates to a process for the production of a biomolecule-linker conjugate of uniform stochiometry. It especially relates to a conjugate consisting of a biomolecule of a molecular weight between 5 kD and 500 kD and a hydrophilic linker molecule said linker having a molecular weight between 1 and 15 kD and between 4 and 60 charged residues, characterized in that said conjugate comprises at least one biomolecule-linker product of uniform stoichiometry in a pre-selected amount.
摘要翻译： 本发明涉及一种制备均匀化学计量学的生物分子 - 接头共轭物的方法。 它特别涉及由分子量在5kD至500kD之间的生物分子和亲水性连接分子之间的共轭物，所述亲水性连接分子的所述连接体具有1至15kD的分子量和4至60个带电荷的残基，其特征在于所述共轭物包含 至少一种具有预选量的均匀化学计量的生物分子 - 接头产物。
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3.发明授权Heterocyclic dioxethane substrates, process for their preparation and their use 失效杂环二恶烷基质，其制备方法及其用途
公开(公告)号：US06107036A
公开(公告)日：2000-08-22
申请号：US051487
申请日：1998-04-20
申请人： Dieter Heindl , Hans-Peter Josel , Herbert Von Der Eltz , Rupert Herrmann , Hans-Joachim Holtke , Rainer Beckert , Dieter Weiss , Waldemar Adam
发明人： Dieter Heindl , Hans-Peter Josel , Herbert Von Der Eltz , Rupert Herrmann , Hans-Joachim Holtke , Rainer Beckert , Dieter Weiss , Waldemar Adam
IPC分类号： C07D321/00 , C07D491/113 , C07D493/10 , C07F7/18 , C07F9/38 , C07F9/6561 , C07J1/00 , C07J17/00 , C07J21/00 , C07J51/00 , G01N33/533 , G01N33/58 , C12Q1/68 , C12Q1/44 , C07D263/52 , C07D305/00
CPC分类号： C07D493/10 , C07D321/00 , C07F7/1856 , C07F9/6561 , C07J17/00 , C07J21/00 , C07J51/00 , G01N33/582
摘要： Compounds of the general formula Ia and Ib are described ##STR1## in which R.sup.1 and R.sup.2 are the same or different and represent hydrogen, straight-chain or branched C.sub.1 to C.sub.6 lower alkyl or an aryl group optionally substituted by electron-withdrawing groups, R.sup.3 denotes a cleavable group, W is hydrogen, halogen or a pseudohalogen and at least one of the groups R.sup.4 or R.sup.5 is a group stabilizing the dioxetane structure and at most one of the groups R.sup.4 or R.sup.5 represents hydrogen and X or Y represents oxygen, N-R or C(R).sub.2 in which R has the meanings stated for R.sup.1 and R.sup.2 or represents a mesomeric double bond or a carbonyl group and n denotes the number 0 or 1 and m denotes the number 1 or 2, as well as a process for their production. These compounds are new and can be used as substrates in immunological assays and in DNA diagnostics using activating agents for colour formation.
摘要翻译： PCT No.PCT / EP96 / 04506 Sec。 371日期：1998年4月20日 102（e）1998年4月20日PCT PCT 1996年10月17日PCT公布。 公开号WO97 / 14696 日本1997年4月24日描述了通式Ia和Ib的化合物，其中R 1和R 2相同或不同，表示氢，直链或支链C 1至C 6低级烷基或任选被吸电子基团取代的芳基 ，R3表示可裂解基团，W表示氢，卤素或假卤素，R 4或R 5中的至少一个是稳定二氧杂环丁烷结构的基团，R4或R5中至少一个表示氢，X或Y表示氧 ，NR或C（R）2，其中R具有R 1和R 2所述的含义或表示中间双键或羰基，n表示数字0或1，m表示数字1或2，以及a 他们的生产过程。 这些化合物是新的，可用作免疫学测定中的底物和使用活化剂进行染色形成的DNA诊断。
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公开(公告)号：US07335401B2
公开(公告)日：2008-02-26
申请号：US10774325
申请日：2004-07-12
申请人： Andreas Finke , Ursula Klause , Federic Donie , Rupert Herrmann , Herbert Von Der Eltz , Peter Sluka , Wolfgang Jona
发明人： Andreas Finke , Ursula Klause , Federic Donie , Rupert Herrmann , Herbert Von Der Eltz , Peter Sluka , Wolfgang Jona
IPC分类号： B05D7/00 , G01N33/553 , G01N33/546
CPC分类号： G01N33/54326 , A61K9/1676 , G01N33/54353 , G01N33/545
摘要： The present invention concerns a method for producing microparticles loaded with proteins which is characterized in that the microparticles are loaded in suspension under strongly alkaline conditions. The invention also concerns microparticles which can be produced using this method and their use in a binding test e.g. in an immunoassay.
摘要翻译： 本发明涉及一种负载蛋白质的微粒的制造方法，其特征在于，在强碱性条件下将微粒负载在悬浮液中。 本发明还涉及可以使用该方法生产的微粒及其在结合试验中的用途，例如， 在免疫测定中。
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公开(公告)号：US20050079545A1
公开(公告)日：2005-04-14
申请号：US10774325
申请日：2004-07-12
申请人： Andreas Finke , Ursula Klause , Frederic Donie , Rupert Herrmann , Herbert Von Der Eltz , Peter Sluka , Wolfgang Jona
发明人： Andreas Finke , Ursula Klause , Frederic Donie , Rupert Herrmann , Herbert Von Der Eltz , Peter Sluka , Wolfgang Jona
IPC分类号： A61K9/14 , A61K9/16 , G01N33/48 , G01N33/53 , G01N33/543 , G01N33/545 , A61L2/00 , C12M1/34
CPC分类号： G01N33/54326 , A61K9/1676 , G01N33/54353 , G01N33/545
摘要： The present invention concerns a method for producing microparticles loaded with proteins which is characterized in that the microparticles are loaded in suspension under strongly alkaline conditions. The invention also concerns microparticles which can be produced using this method and their use in a binding test e.g. in an immunoassay.
摘要翻译： 本发明涉及一种负载蛋白质的微粒的制造方法，其特征在于，在强碱性条件下将微粒负载在悬浮液中。 本发明还涉及可以使用该方法生产的微粒及其在结合试验中的用途，例如， 在免疫测定中。
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6.发明授权N-acyldihydroresorufin derivatives, processes for their preparation, reagents containing them and the use thereof for determining hydrogen peroxide, peroxidate-acting compounds or peroxidase 失效N-酰基二氢代芬芬衍生物，其制备方法，含有它们的试剂及其用于测定过氧化氢，过氧化物作用化合物或过氧化物酶
公开(公告)号：US4737466A
公开(公告)日：1988-04-12
申请号：US884372
申请日：1986-07-11
CPC分类号： C07D265/38 , C12Q1/28 , C12Q2326/00 , Y10S436/904 , Y10T436/206664
摘要： The present invention provides N-acylidihydroresorufin derivatives of the general formula: ##STR1## wherein R.sup.1 is a lower alkyl, aryl or aralkyl radical, which can be substituted by carboxyl or sulphonic acid residues, R.sup.2, R.sup.3 and R.sup.4, which can be the same or different, are hydrogen or halogen atoms or lower alkyl or lower alkoxy radicals, Y is an --NR.sup.5 R.sup.6 or --OR.sup.7 group, wherein R.sup.5 and R.sup.6 are, in each case, hydrogen atoms or lower alkyl radicals, which can be substituted by carboxyl or sulphonic acid residues, or together represent a hydrocarbon bridge optionally interrupted by hereto atoms and R.sup.7 is a lower alkyl radical which can be substituted by a lower alkoxy or poly-lower alkoxy radical.
摘要翻译： 本发明提供以下通式的N-酰基二氢代芬芬衍生物：其中R 1是低级烷基，芳基或芳烷基，其可以被羧基或磺酸残基取代，R 2，R 3和R 4，其可以 相同或不同，为氢或卤素原子或低级烷基或低级烷氧基，Y为-NR5R6或-OR7基团，其中R5和R6各自为氢原子或低级烷基，可取代 或者一起代表任选被该原子间隔的烃桥，并且R7是可被低级烷氧基或多 - 低级烷氧基取代的低级烷基。
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![Nucleic acid binding compounds containing pyrazolo[3,4-D]pyrimidine analogues of purin-2,6-diamine and their uses](/abs-image/US/2011/11/15/US08057997B2/abs.jpg.150x150.jpg)
7.发明授权Nucleic acid binding compounds containing pyrazolo[3,4-D]pyrimidine analogues of purin-2,6-diamine and their uses 有权含有嘌呤-2,6-二胺的吡唑并[3,4-D]嘧啶类似物的核酸结合化合物及其用途公开(公告)号：US08057997B2
公开(公告)日：2011-11-15
申请号：US11742416
申请日：2007-04-30
申请人： Frank Seela , Frank Bergmann , Herbert Von Der Eltz , Dieter Heindl , Christoph Seidel , Georg Becher
发明人： Frank Seela , Frank Bergmann , Herbert Von Der Eltz , Dieter Heindl , Christoph Seidel , Georg Becher
CPC分类号： C07H21/00 , C07H19/16 , Y10T436/143333
摘要： The present invention is in the field of nucleic acid binding compounds comprising 7-substituted 7-deaza-8aza-2,6-diamino-purine bases, compounds useful for the preparation of such compounds, various uses thereof and methods for the determination of nucleic acids using said compounds in the field of diagnostics.
摘要翻译： 本发明涉及包含7-取代的7-脱氮-8-氮杂-2,6-二氨基嘌呤碱基的核酸结合化合物领域，可用于制备这些化合物的化合物，其各种用途和用于测定核酸的方法 在诊断领域使用所述化合物的酸。
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8.发明授权Nucleotides labelled with an infrared dye and their use in nucleic acid detection 失效用红外染料标记的核苷酸及其在核酸检测中的用途公开(公告)号：US06573374B1
公开(公告)日：2003-06-03
申请号：US08411761
申请日：1995-03-28
IPC分类号： C07H1904
CPC分类号： C07H19/10 , C07F9/5728 , C07H19/20 , C07H21/00
摘要： Nucleoside-5′-triphosphates and phosphoramidites which carry a residue absorbing in the long wavelength region, preferably a carbocyanine group of the general formula (I), on the base portion or on the phosphorus atom in which R1 and R2 each denote hydrogen or together form a phenyl residue; R3 denotes hydrogen if linkage with the nucleotide is via the R4 position or it denotes a —NHCS— group if linkage with the nucleotide is via the R3 position; both R4 and R5, or R5, alone denote an alkylsulfonyl group with n being a number from 3 to 5 or R4 represents a —NHCS— group with n being a number from 3 to 8, as well as the use of the compounds to label, detect and sequence nucleic acids.
摘要翻译： 核苷-5'-三磷酸和亚磷酰胺，其在碱性部分或磷原子上具有在长波长区域吸收的残基，优选为通式（I）的碳菁基团，其中R1和R2各自表示氢或一起形成 苯基残基; 如果与核苷酸的连接通过R4位置，R3表示氢，如果与核苷酸的连接通过R3位置，则表示-NHCS-基团; R4和R5或R5独立地表示烷基磺酰基，n为3至5的数，或R4表示-NHCS-基，n为3至8的数，以及该化合物用于标记 ，检测和序列核酸。
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9.发明授权2-deoxy-isoguanosines isoteric analogues and isoguanosine containing oligonucleotides 失效2-脱氧 - 异鸟嘌呤等同类似物和含有异鸟苷酸的寡核苷酸
公开(公告)号：US6147199A
公开(公告)日：2000-11-14
申请号：US86910
申请日：1998-05-29
IPC分类号： C12P19/34 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7056 , A61K31/7076 , A61P31/12 , C07H19/04 , C07H19/052 , C07H19/16 , C07H19/20 , C07H19/23 , C07H21/00 , C07H21/02 , C07H21/04 , C12Q1/68
摘要： 2'-Deoxyisoguanosine, isosteric analogues and isoguanosine derivatives of formulae I-V, processes for their production via compounds of the general formulae a or b and reaction with aroyl isocyanates or from compounds of the general formulae VI-IX by photochemical irradiation. A further production process is the conversion of deoxyguanosines or guanosines by means of persilylation, reaction with ammonia and deamination in the 2 position. The compounds are suitable as pharmaceutical agents with antiviral efficacy.
摘要翻译： 2-脱氧异鸟苷，式I-V的异构体类似物和异鸟嘌呤衍生物，其通过通式a或b的化合物生产并通过光化学辐射与芳酰基异氰酸酯或通式VI-IX的化合物反应。 进一步的生产过程是通过去硅藻土或鸟氨酸的转化，通过与二氨基反应和脱氨作用。 该化合物适合作为具有抗病毒功效的药剂。
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10.发明授权Cationic and polycationic amphiphiles, reactives containing the same and their use 失效阳离子和阳离子两亲物，含有相同的反应物及其用途
公开(公告)号：US6060455A
公开(公告)日：2000-05-09
申请号：US952970
申请日：1997-12-05
IPC分类号： C12N15/09 , A61K9/127 , A61K48/00 , C07C215/10 , C07C219/08 , C07C237/08 , C07C271/22 , C07C309/04 , C07K5/023 , C07K14/775 , C12N15/88
CPC分类号： A61K9/1272 , C07C219/08 , C07C237/08 , C07C271/22 , C12N15/88
摘要： The invention concerns new cationic or polycationic amphiphiles which are capable of forming aggregates with macromolecules, in particular with DNA or RNA, and it concerns their delivery into prokaryotic or eukaryotic cells. Compounds with spermyl-dioleoyloxypropyl structure have proven to be particularly preferable.
摘要翻译： PCT No.PCT / EP96 / 02541 Sec。 371 1997年12月5日第 102（e）1997年12月5日PCT PCT 1996年6月12日PCT公布。 出版物WO97 / 00241 日期1997年1月3日本发明涉及能够与大分子，特别是与DNA或RNA形成聚集体的新的阳离子或阳离子两亲物，并且涉及它们递送到原核或真核细胞中。 已经证明具有精 - 二烯酰氧基丙基结构的化合物是特别优选的。
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