公开(公告)号：US09833506B2

公开(公告)日：2017-12-05

申请号：US14366602

申请日：2012-12-21

Applicant: RETROSCREEN VIROLOGY LTD ,  UNIVERSITY OF SOUTHAMPTON

Inventor： Robert Lambkin-Williams ,  John S. Oxford ,  Thomas Wilkinson

IPC: A61K39/145 ,  A61K39/12 ,  G01N33/50 ,  C07K14/005

CPC classification number: A61K39/145 ,  A61K39/12 ,  C07K14/005 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16171 ,  G01N33/505 ,  G01N2500/10

Abstract: The present invention provides screening methods which may be regarded as in vitro or ex vivo methods of interrogating the immune system to understand what viral antigens are “seen” and responded to by T cells of the immune systems during viral infection. The screening methods further link in vitro or ex vivo responses to progression of infection in subjects.

公开(公告)号：US20170175294A1

公开(公告)日：2017-06-22

申请号：US15316555

申请日：2015-06-05

Applicant: University of Southampton

Inventor： Frederic Yannick Gardes ,  Graham Trevor Reed ,  Callum George Johns

IPC: C30B29/52 ,  C30B13/14 ,  C30B29/08 ,  C30B13/34 ,  C30B29/06 ,  C30B29/18 ,  H01L21/02 ,  C30B13/22

CPC classification number: C30B29/52 ,  C30B11/002 ,  C30B13/14 ,  C30B13/22 ,  C30B13/34 ,  C30B29/06 ,  C30B29/08 ,  C30B29/18 ,  H01L21/02381 ,  H01L21/0245 ,  H01L21/02488 ,  H01L21/02532 ,  H01L21/02546 ,  H01L21/02587 ,  H01L21/02625 ,  H01L21/02647 ,  H01L21/02667 ,  H01L21/02675

Abstract: A method of fabricating at least one single-crystal alloy semiconductor structure, comprising: forming at least one seed on a substrate for growth of at least one single-crystal alloy semiconductor structure, the at least one seed containing an alloying material; providing at least one structural form on the substrate which is crystallized to form the at least one single-crystal alloy semiconductor structure, the at least one structural form being formed of a host material and comprising a main body which extends from the at least one seed and a plurality of elements which are connected in spaced relation to the main body; heating the at least one structural form such that the material of the at least one structural form has a liquid state; and cooling the at least one structural form, such that the material of the at least one structural form nucleates at the least one seed and crystallizes as a single crystal to provide at least one single-crystal alloy semiconductor structure, with a growth front of the single crystal propagating in the main body of the respective structural form away from the respective seed; wherein the plurality of elements of each structural form provide reservoirs of the alloying material in liquid state, such that successive ones of the plurality of elements act to maintain, in liquid state, an available supply of the alloying material to the growth front of the single crystal in the main body of the respective structural form.

公开(公告)号：US20170158771A1

公开(公告)日：2017-06-08

申请号：US15128781

申请日：2015-03-24

Applicant: UNIVERSITY OF SOUTHAMPTON

Inventor： Martin J. Glennie ,  Ann White

IPC: C07K16/28 ,  C07K16/30

CPC classification number: C07K16/2878 ,  A61K2039/505 ,  C07K16/2818 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/522 ,  C07K2317/53 ,  C07K2317/70 ,  C07K2317/75 ,  C07K2317/76

Abstract: Through a combination of in vitro and in vivo approaches, the inventors show that human IgG2 (h2) delivers unique FcγR-independent agonistic activity to anti-CD40 antibodies and to antibodies specific to other immunostimulatory receptors, including 4-1BB and CD28. Investigation of an anti-human CD40 mAb, LOB7.4, revealed that the unique activity of h2 was dependent upon the precise arrangement of hinge and CH1 disulfide bonds. Chemical ‘shuffling’ or mutagenesis to ‘lock’ LOB7.4 into either a more flexible ‘h2A’ or more compact ‘h2B’ conformation endowed antagonistic and agonistic properties, respectively. Engineering of h2 in this way allows development of reagents with either immunostimulatory or immunosuppressive characteristics, with direct implication for the design of therapeutic mAb agents and fusion proteins.

公开(公告)号：US09594262B2

公开(公告)日：2017-03-14

申请号：US14388261

申请日：2013-03-12

Applicant: University of Southampton

Inventor： Nikolay Ivanovich Zheludev ,  Kevin Francis MacDonald ,  Jianfa Zhang ,  David John Richardson

IPC: G02B26/00 ,  G02F1/00 ,  G02F1/01 ,  G02B1/00 ,  G02F3/00 ,  G02B5/00

CPC classification number: G02F1/0126 ,  G02B1/002 ,  G02B5/008 ,  G02F3/00 ,  G02F2202/30 ,  G02F2202/36 ,  G02F2203/10 ,  G02F2203/15

Abstract: First and second coherent light beams of the same wavelength are propagated in opposite directions to interact on a sub-wavelength thickness metallic metamaterial layer which is structured with a periodicity such that there is a resonance matched to the wavelength of the coherent beams. The first beam is then able to modulate the intensity of the second beam by modulating the phase and/or intensity of the first beam. The interference of the counter- propagating beams can eliminate or substantially reduce Joule loss of light energy in the metamaterial layer or, on the contrary, can lead to a near total absorption of light, depending on the mutual phase and/or intensity of the interacting beams. A modulation is thus provided without using a non-linear effect.

Abstract translation: 相同波长的第一和第二相干光束以相反的方向传播，以在亚波长厚度的金属超材料层上相互作用，所述亚波长厚度的金属超材料层被构造为具有与相干光束的波长匹配的谐振周期。 第一光束然后能够通过调制第一光束的相位和/或强度来调制第二光束的强度。 反向传播光束的干涉可以消除或显着减少超材料层中焦耳的焦耳损失，相反，可能导致光的接近全部吸收，这取决于相互作用的相互作用和/或强度 梁。 因此提供了不使用非线性效应的调制。

公开(公告)号：US20170056481A1

公开(公告)日：2017-03-02

申请号：US15120007

申请日：2015-02-19

Applicant: University of Southampton ,  University of Cape Town

Inventor： Howard William Clark ,  William Horsnell

IPC: A61K38/17 ,  G01N33/68 ,  A61K45/06 ,  A61K35/62 ,  C07K14/785

CPC classification number: A61K38/395 ,  A61K35/62 ,  A61K45/06 ,  C07K14/785 ,  G01N33/5308 ,  G01N33/6896 ,  G01N2333/43526 ,  G01N2333/785 ,  G01N2800/122 ,  G01N2800/26

Abstract: The present invention relates to Surfactant Protein D (SP-D) or nucleic acids encoding SP-D or variants thereof such as surfactant protein A or mannan binding lectin for use in the treatment and/or prevention of a parasitic infection. Methods for determining the presence of a parasitic infection by determining levels of SP-D in a sample are also disclosed. Also disclosed are helminths for treating allergy, inflammation or infection.

Abstract translation: 本发明涉及用于治疗和/或预防寄生虫感染的表面活性蛋白D（SP-D）或编码SP-D的核酸或其变体，例如表面活性蛋白A或甘露聚糖结合凝集素。 还公开了通过确定样品中SP-D水平来确定寄生虫感染存在的方法。 还公开了用于治疗过敏，炎症或感染的蠕虫。

公开(公告)号：US09448200B2

公开(公告)日：2016-09-20

申请号：US14392031

申请日：2013-09-19

Applicant: University of Southampton

Inventor： Hywel Morgan ,  Matthew Charles Mowlem ,  Xi Huang ,  Robin William Pascal

IPC: G01N27/327 ,  G01N27/416 ,  G01N27/49 ,  G01N33/18

CPC classification number: G01N27/4163 ,  G01N27/49 ,  G01N33/18

Abstract: Apparatus (2) for sensing at least one parameter in water, which apparatus (2) comprises: (i) a dissolved oxygen sensor (4) for sensing dissolved oxygen in the water; and which apparatus (2) is such that: (ii) the dissolved oxygen sensor (4) has a working electrode and a reference electrode; and (iii) a voltage signal is applied between the working electrode and the reference electrode, and the voltage signal provides a conditioning waveform, then a wait time, and then a measurement function.

Abstract translation: 用于感测水中的至少一个参数的装置（2），所述装置（2）包括：（i）用于感测水中的溶解氧的溶解氧传感器（4） 以及（ii）溶解氧传感器（4）具有工作电极和参考电极的装置（2） 和（iii）在工作电极和参考电极之间施加电压信号，并且电压信号提供调理波形，然后是等待时间，然后进行测量功能。

公开(公告)号：US20160018601A1

公开(公告)日：2016-01-21

申请号：US14392048

申请日：2013-12-03

Applicant: University of Southampton

Inventor： Frederic Yannick Gardes ,  David John Thomson ,  Graham Trevor Reed ,  Harold Meng Hoon Chong ,  Scott Ashley Reynolds

IPC: G02B6/30 ,  G02B6/34 ,  G02B6/12 ,  G02B6/36

CPC classification number: G02B6/30 ,  G02B6/12 ,  G02B6/34 ,  G02B6/3636 ,  G02B6/3652 ,  G02B6/3692 ,  G02B6/4214 ,  G02B6/4224 ,  G02B6/423 ,  G02B6/4269 ,  G02B2006/12107

Abstract: Apparatus comprising at least one optical device (106) optically coupled to at least one waveguide (111) on an optical chip (100), characterised in that: (i) the optical device (106) is optically aligned with the waveguide (111) by aligning means (114, 116); (ii) the aligning means (114, 116) comprises at least one male member (114) and at least one female (116) member which locate together; (iii) one of the male member (114) and the female member (116) is positioned on the optical chip (100); (iv) the other one of the male member (114) and the female member (116) is positioned on a capping chip (102); and (v) the apparatus includes a mirror (108) for reflecting light from the optical device (106) to the waveguide (111).

Abstract translation: 包括光学耦合到光学芯片（100）上的至少一个波导（111）的至少一个光学器件（106）的装置，其特征在于：（i）光学器件（106）与波导（111）光学对准， 通过对准装置（114,116）; （ii）对准装置（114,116）包括位于一起的至少一个阳构件（114）和至少一个阴（116）构件; （iii）阳构件（114）和阴构件（116）中的一个位于光学芯片（100）上; （iv）阳构件（114）和阴构件（116）中的另一个定位在封盖芯片（102）上; 和（v）该装置包括用于将来自光学装置（106）的光反射到波导（111）的反射镜（108）。

公开(公告)号：US20160015796A1

公开(公告)日：2016-01-21

申请号：US14774304

申请日：2014-03-11

Applicant: ICON GENETICS GMBH ,  UNIVERSITY OF SOUTHAMPTON

Inventor： Natalia Savelyeva ,  Franziska Jarczowski ,  Romy Kandzia ,  Anja Nickstadt ,  Frank Thieme ,  Victor Klimyuk ,  Yuri Gleba ,  Duc Bui-Minh ,  Freda K. Stevenson ,  Warayut Chotprakaikiat

IPC: A61K39/00 ,  C12N9/12 ,  A61K47/48

CPC classification number: A61K39/0011 ,  A61K47/646 ,  A61K2039/55588 ,  A61K2039/6037 ,  C12N9/12 ,  C12Y207/10001

Abstract: Protein conjugate comprising a protein antigen for generating an immune response against the HER2/neu protein and an immunogenic carrier covalently bonded to said protein antigen, wherein said protein antigen (i) has a sequence segment of 300 or more contiguous amino acids of the amino acid sequence of SEQ ID NO: 1; or (ii) has a variant sequence segment of 300 or more amino acid residues, wherein the amino acid sequence of said variant sequence segment has at least 85% sequence identity to a sequence portion from SEQ ID: 1; or (iii) has a variant sequence segment of 300 or more amino acid residues and has from 1 to 10 substitutions, deletions or additions in said variant sequence segment compared to a sequence segment of 300 or more amino acid residues of the amino acid sequence of SEQ ID NO: 1 or 2.

Abstract translation: 包含用于产生针对HER2 / neu蛋白的免疫应答的蛋白质抗原的蛋白质缀合物和与所述蛋白质抗原共价结合的免疫原性载体，其中所述蛋白质抗原（i）具有氨基酸的300个或更多个连续氨基酸的序列片段 SEQ ID NO：1的序列; 或（ii）具有300个或更多个氨基酸残基的变体序列片段，其中所述变体序列片段的氨基酸序列与SEQ ID：1的序列部分具有至少85％的序列同一性; 或（iii）具有300个或更多个氨基酸残基的变体序列片段，并且与所述变体序列片段中的氨基酸序列的300个或更多个氨基酸残基的序列片段相比，具有1至10个取代，缺失或添加 SEQ ID NO：1或2。

公开(公告)号：US20150329983A1

公开(公告)日：2015-11-19

申请号：US14392013

申请日：2013-07-24

Applicant: UNIVERSITY OF SOUTHAMPTON

Inventor： Gillian Reid ,  Philip Nigel Bartlett ,  Andrew Lee Hector

IPC: C25D7/12 ,  C25D3/56 ,  C25D3/44 ,  C25D5/02 ,  C25D3/02 ,  H01L45/00 ,  C25D3/54

CPC classification number: C25D7/12 ,  C25D3/02 ,  C25D3/26 ,  C25D3/30 ,  C25D3/32 ,  C25D3/34 ,  C25D3/36 ,  C25D3/44 ,  C25D3/54 ,  C25D3/56 ,  C25D3/60 ,  C25D5/02 ,  C25D5/18 ,  C25D9/08 ,  H01L21/02381 ,  H01L21/02491 ,  H01L21/02549 ,  H01L21/02628 ,  H01L45/06 ,  H01L45/1253 ,  H01L45/144 ,  H01L45/1608 ,  H01L45/1683

Abstract: A process for the electrochemical deposition of a semiconductor material, which process comprises: (i) providing a non-aqueous solvent; (ii) providing at least one precursor salt which forms a source of the constituent elements within the semiconductor material to be deposited; and (iii) electrodepositing the semiconductor material onto an electrode substrate using the precursor salt in the non-aqueous solvent, characterised in that: (iv) the semiconductor material is a p-block or a post-transition metal semiconductor material containing at least one p-block element or post-transition metal; and (v) the non-aqueous solvent is a halocarbon non-aqueous solvent.

Abstract translation: 一种用于半导体材料的电化学沉积的方法，该方法包括：（i）提供非水溶剂; （ii）提供至少一种在待沉积的半导体材料内形成组成元素源的前体盐; 以及（iii）使用所述前体盐在所述非水溶剂中将所述半导体材料电沉积到电极基板上，其特征在于：（iv）所述半导体材料是含有至少一个的p块或后过渡金属半导体材料 p-块元素或过渡后金属; 和（v）非水溶剂是卤代烃非水溶剂。

公开(公告)号：US20150192535A1

公开(公告)日：2015-07-09

申请号：US14392030

申请日：2013-09-19

Applicant: UNIVERSITY OF SOUTHAMPTON

Inventor： Hywel Morgan ,  Matthew Charles Mowlen ,  Xi Huang

IPC: G01N27/06 ,  G01F23/00 ,  G01K13/00 ,  G01N33/18

CPC classification number: G01N27/06 ,  G01F23/00 ,  G01K13/00 ,  G01N33/18 ,  G01N33/1806

Abstract: Apparatus (2) for sensing at least one parameter in water, which apparatus (2) comprises: (i) a conductivity sensor (6) for sensing conductivity in water; (ii) the conductivity sensor (6) is an electrode-based conductivity sensor having bare electrodes (12) which contact the water; (iii) there are at least four of the electrodes (12); (iv) the conductivity sensor (6) is fabricated on a substrate (14) using photolithography and etching; (v) the conductivity sensor (6) is an open cell sensor having a physically unconstrained electric field; (vi) the conductivity sensor (6) is of a dot construction comprising a dot and a surrounding formation; (vii) the conductivity sensor (6) has two electrodes which are for current stimulation and which geometrically bound and enclose another two electrodes which are for voltage sensing; and (viii) the conductivity sensor (6) is a laminar construction on the substrate (14).

Abstract translation: 用于感测水中的至少一个参数的装置（2），所述装置（2）包括：（i）用于感测水中的电导率的电导率传感器（6） （ii）电导率传感器（6）是具有与水接触的裸露电极（12）的基于电极的电导率传感器; （iii）至少有四个电极（12）; （iv）使用光刻和蚀刻在基板（14）上制造电导率传感器（6）; （v）电导率传感器（6）是具有物理无约束电场的开放式电池传感器; （vi）电导率传感器（6）是点状结构，其包括点和周围地层; （vii）电导率传感器（6）具有两个用于电流刺激的电极，并且几何结合并且包围用于电压感测的另外两个电极; 和（viii）电导率传感器（6）是衬底（14）上的层状结构。