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公开(公告)号：US07566538B2
公开(公告)日：2009-07-28
申请号：US12017859
申请日：2008-01-22
申请人： J. Wallace Parce , Theo T. Nikiforov , Tammy Burd Mehta , Anne R. Kopf-Sill , Andrea W. Chow , Michael R. Knapp
发明人： J. Wallace Parce , Theo T. Nikiforov , Tammy Burd Mehta , Anne R. Kopf-Sill , Andrea W. Chow , Michael R. Knapp
CPC分类号： C12Q1/6874 , B01F13/0059 , B01J2219/00317 , B01J2219/00459 , B01J2219/00468 , B01L3/5027 , B01L3/502715 , B01L3/502761 , B01L2200/0668 , B01L2400/0409 , B01L2400/0415 , B01L2400/043 , B01L2400/0487 , C07H21/02 , C07H21/04 , C12Q1/6869 , C40B60/14 , G01N27/44756 , G01N35/0098 , G01N2035/00574 , Y10T436/143333 , C12Q2565/629 , C12Q2535/101 , C12Q2563/173 , C12Q2525/186 , C12Q2527/125
摘要： Nucleotides and nucleotide analogs are used in various sequencing by incorporation/sequencing by synthesis methods. Nucleotide analogs comprising 3′-blocking groups are used to provide reversible chain-termination for sequencing by synthesis. Typical blocking groups include phosphate groups and carbamate groups. Fluorescent nucleotides are used to perform sequencing by synthesis with detection by incorporation of the fluorescently labeled nucleotide, optionally followed by photobleaching and intercalating dyes are used to detect addition of a non-labeled nucleotide in sequencing by synthesis with detection by intercalation. Microfluidic devices, including particle arrays, are used in the sequencing methods.
摘要翻译： 核苷酸和核苷酸类似物通过合成方法的并入/测序用于各种测序。 包含3'-封闭基团的核苷酸类似物用于提供可逆的链终止，用于通过合成进行测序。 典型的封闭基团包括磷酸基和氨基甲酸酯基。 使用荧光核苷酸进行测序，通过掺入荧光标记的核苷酸进行检测，任选地随后进行光漂白，并使用嵌入染料检测通过插入检测合成测序中的未标记核苷酸的添加。 微流控器件，包括粒子阵列，用于测序方法。
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公开(公告)号：US20090017363A1
公开(公告)日：2009-01-15
申请号：US12234104
申请日：2008-09-19
IPC分类号： H01M4/86
CPC分类号： H01M4/8605 , B82Y30/00 , H01M4/881 , H01M4/8846 , H01M4/8853 , H01M4/8867 , H01M4/90 , H01M4/9075 , H01M4/921 , H01M4/925 , H01M4/926 , H01M8/023 , H01M8/0232 , H01M8/0234 , H01M8/0236 , H01M8/0241 , H01M8/1004 , H01M8/1007 , H01M8/1011 , H01M8/1086 , Y02E60/523 , Y02P70/56 , Y10S977/762 , Y10S977/948
摘要： The present invention discloses nanowires for use in a fuel cell comprising a metal catalyst deposited on a surface of the nanowires. A membrane electrode assembly for a fuel cell is disclosed which generally comprises a proton exchange membrane, an anode electrode, and a cathode electrode, wherein at least one or more of the anode electrode and cathode electrode comprise an interconnected network of the catalyst supported nanowires. Methods are also disclosed for preparing a membrane electrode assembly and fuel cell based upon an interconnected network of nanowires.
摘要翻译： 本发明公开了一种用于燃料电池的纳米线，其包括沉积在纳米线表面上的金属催化剂。 公开了一种用于燃料电池的膜电极组件，其通常包括质子交换膜，阳极电极和阴极电极，其中阳极电极和阴极电极中的至少一个或多个包括催化剂负载的纳米线的互连网络。 还公开了基于互连的纳米线网络来制备膜电极组件和燃料电池的方法。
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公开(公告)号：US20080257407A1
公开(公告)日：2008-10-23
申请号：US12132967
申请日：2008-06-04
申请人： J. Wallace Parce , Calvin Y.H. Chow , Andreas P. Meisel , Linh Nguyen , Erik C. Scher , Jeffery A. Whiteford
发明人： J. Wallace Parce , Calvin Y.H. Chow , Andreas P. Meisel , Linh Nguyen , Erik C. Scher , Jeffery A. Whiteford
IPC分类号： H01L31/00
CPC分类号： H01L51/447 , H01L27/302 , H01L31/0384 , H01L31/056 , H01L51/0007 , H01L51/0036 , H01L51/0037 , H01L51/4213 , H01L51/424 , H01L51/4253 , H01L51/426 , Y02E10/52 , Y02E10/549 , Y02P70/521
摘要： Devices, compositions and methods for producing photoactive devices, systems and compositions that have improved conversion efficiencies relative to previously described devices, systems and compositions. This improved efficiency is generally obtained by one or both of improving the efficiency of light absorption into the photoactive component, and improving the efficiency of energy extraction from that active component.
摘要翻译： 相对于先前描述的装置，系统和组合物，具有提高的转换效率的用于生产光活性装置，系统和组合物的装置，组合物和方法。 这种提高的效率通常通过提高光活性组分的光吸收效率之一或两者获得，并且提高从该活性组分提取能量的效率。
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94.发明授权公开(公告)号：US07364704B2
公开(公告)日：2008-04-29
申请号：US11493997
申请日：2006-07-27
CPC分类号： G01N27/44791 , B01J19/0093 , B01J2219/00783 , B01J2219/00826 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00891 , B01J2219/00909 , B01L3/0244 , B01L3/0262 , B01L3/5025 , B01L3/50255 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502753 , B01L2200/027 , B01L2300/0681 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2400/0406 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , B01L2400/0688 , G01N27/44743 , G01N2035/00237 , G01N2035/1037 , Y10T436/25125 , Y10T436/25375 , Y10T436/2575
摘要： Fluid introduction is facilitated through the use of a port which extends entirely through a microfluidic substrate. Capillary forces can be used to retain the fluid within the port, and a series of samples or other fluids may be introduced through a single port by sequentially blowing the fluid out through the substrate and replacing the removed fluid with an alternate fluid, or by displacing the fluid in part with additional fluid. In another aspect, microfluidic substrates have channels which varying in cross-sectional dimension so that capillary action spreads a fluid only within a limited portion of the channel network. In yet another aspect, the introduction ports may include a multiplicity of very small channels leading from the port to a fluid channel, so as to filter out particles or other contaminants which might otherwise block the channel at the junction between the channel and the introduction port.
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公开(公告)号：US07276330B2
公开(公告)日：2007-10-02
申请号：US10418008
申请日：2003-04-17
IPC分类号： C12Q1/00
CPC分类号： B01L3/5027 , B01L2200/0621 , B01L2300/0816 , B01L2300/0867 , B01L2400/0415 , B01L2400/049 , B01L2400/084
摘要： Time dependent iterative reactions are carried out in microscale fluidic channels by configuring the channels such that reagents from different sources are delivered to a central reaction zone at different times during the analysis, allowing for the performance of a variety of time dependent, and/or iterative reactions in simplified microfluidic channels. Exemplary analyses include the determination of dose responses for biological and biochemical systems.
摘要翻译： 时间依赖性迭代反应在微量流体通道中进行，通过配置通道使得来自不同来源的试剂在分析期间的不同时间被递送到中央反应区，允许执行各种时间依赖性和/或迭代 简化微流体通道中的反应。 示例性分析包括确定生物和生化系统的剂量反应。
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公开(公告)号：US07192559B2
公开(公告)日：2007-03-20
申请号：US09922224
申请日：2001-08-02
CPC分类号： B01D61/18 , B01L3/5025 , B01L3/502707 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L2200/027 , B01L2300/0861 , B01L2300/0867 , B01L2400/0406 , B01L2400/0415 , B01L2400/043 , B01L2400/0457 , Y10T137/2496 , Y10T137/2499 , Y10T137/2501 , Y10T137/2514 , Y10T137/2516 , Y10T436/11 , Y10T436/2575
摘要： Methods and devices for delivering fluids into microfluidic device body structures are described. The methods and devices include the use of fluid manifolds which are integrated or interchangeable with device body structures. Methods of fabricating manifolds are also provided.
摘要翻译： 描述了将流体输送到微流体装置体结构中的方法和装置。 所述方法和装置包括使用与装置主体结构集成或可互换的流体歧管。 还提供了制造歧管的方法。
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公开(公告)号：US07160423B2
公开(公告)日：2007-01-09
申请号：US10386900
申请日：2003-03-04
申请人： Ring-Ling Chien , J. Wallace Parce , Michael Spaid
发明人： Ring-Ling Chien , J. Wallace Parce , Michael Spaid
IPC分类号： G01N27/447
CPC分类号： B01F13/0076 , B01L3/502746 , B01L3/502784 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , F04B19/006 , G01N27/44791 , H02N11/006
摘要： Methods and systems that employ hybrid fluid flow profiles for optimized movement of materials through channel networks. These systems employ hybrid pressure-based and electrokinetic based flow systems for moving materials through interconnected channel networks while maintaining interconnection among the various channel segments. In particular, the invention is generally directed to channel networks where flow in a first channel segment is driven by pressure flow with its consequent parabolic flow profile, while flow in an interconnected channel segment is dominated by electrokinetic flow with its consequent plug flow profile. The invention also provides channel networks wherein fluid flow in channel segments is driven by both pressure and electric field and the multiple species contained in a fluid plug are separated by altering the applied pressure and electric fields in the various channel segments of the channel networks.
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公开(公告)号：US07155344B1
公开(公告)日：2006-12-26
申请号：US09361478
申请日：1999-07-26
申请人： J. Wallace Parce , Morten J. Jensen
发明人： J. Wallace Parce , Morten J. Jensen
IPC分类号： G01N33/48
CPC分类号： B01L3/5027 , B01L2200/143 , G01N35/0092 , G01N2035/0093 , Y10T436/115831 , Y10T436/25375 , Y10T436/2575
摘要： Techniques for controlling analytical instruments are provided. A sequence of steps can be utilized to specify wells of a microfluidic device, mobility to be applied to fluid in the wells, and the duration to apply the mobility. For example, fluids can be sequentially run past down a main channel to a detection zone of the microfluidic device in order to analyze the fluids. In order to increase the efficiency of the analysis, fluids can be processed in parallel by running one fluid down the main channel while another fluid is loaded to the main channel.
摘要翻译： 提供了控制分析仪器的技术。 可以使用一系列步骤来指定微流体装置的孔，将要施加到井中的流体的移动性以及施加移动性的持续时间。 例如，为了分析流体，流体可以顺序地沿主通道向下流动到微流体装置的检测区域。 为了提高分析效率，可以通过在主通道下方运行一个流体同时将另一个流体加载到主通道来并行处理流体。
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99.发明授权公开(公告)号：US07087832B2
公开(公告)日：2006-08-08
申请号：US11007916
申请日：2004-12-09
申请人： Erik C. Scher , Mihai Buretea , Calvin Y. H. Chow , Stephen A. Empedocles , Andreas P. Meisel , J. Wallace Parce
发明人： Erik C. Scher , Mihai Buretea , Calvin Y. H. Chow , Stephen A. Empedocles , Andreas P. Meisel , J. Wallace Parce
IPC分类号： H01L31/04 , H01L31/0264 , H01L31/036
CPC分类号： H01L31/04 , B82Y10/00 , B82Y20/00 , B82Y30/00 , H01L31/0384 , H01L51/0036 , H01L51/0037 , H01L51/4213 , H01L51/4226 , H01L51/426 , Y02E10/549 , Y02P70/521
摘要： Nanocomposite photovoltaic devices are provided that generally include semiconductor nanocrystals as at least a portion of a photoactive layer. Photovoltaic devices and other layered devices that comprise core-shell nanostructures and/or two populations of nanostructures, where the nanostructures are not necessarily part of a nanocomposite, are also features of the invention. Varied architectures for such devices are also provided including flexible and rigid architectures, planar and non-planar architectures and the like, as are systems incorporating such devices, and methods and systems for fabricating such devices. Compositions comprising two populations of nanostructures of different materials are also a feature of the invention.
摘要翻译： 提供纳米复合光伏器件，其通常包括作为光活性层的至少一部分的半导体纳米晶体。 包含核 - 壳纳米结构和/或两组纳米结构的光伏器件和其它分层器件，其中纳米结构不一定是纳米复合材料的一部分，也是本发明的特征。 还提供了用于这种装置的各种架构，包括柔性和刚性架构，平面和非平面架构等，以及结合这种装置的系统，以及用于制造这种装置的方法和系统。 包含两种不同材料的纳米结构群的组合物也是本发明的特征。
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公开(公告)号：US07037416B2
公开(公告)日：2006-05-02
申请号：US09760009
申请日：2001-01-11
申请人： J. Wallace Parce , Claudia B. Jaffe
发明人： J. Wallace Parce , Claudia B. Jaffe
CPC分类号： G01F1/7086 , B01L3/502746 , B01L2200/0673 , B01L2200/143 , B01L2300/0816 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487 , B01L2400/082 , G01N27/44704
摘要： Microfluidic methods, devices, and systems are provided for monitoring and controlling flow rates in response to one or more marker signals. The marker signals are used to provide an indication of flow rate in the various channels of the devices. Signals obtained from the markers are deconvoluted and used in a feedback loop to make flow rate adjustments.
摘要翻译： 微流控方法，装置和系统被提供用于响应于一个或多个标记信号来监测和控制流速。 标记信号用于提供装置的各种通道中的流量的指示。 从标记获得的信号被去卷积并用于反馈回路以进行流量调节。
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