Method of chemical analysis using microwells patterned from self-assembled monolayers and substrates
    94.
    发明申请
    Method of chemical analysis using microwells patterned from self-assembled monolayers and substrates 审中-公开
    使用从自组装单层和底物图案化的微孔的化学分析方法

    公开(公告)号:US20040258832A1

    公开(公告)日:2004-12-23

    申请号:US10463174

    申请日:2003-06-17

    Abstract: A method for chemical analysis is provided comprising using a substrate that includes a hydrophilic silicon oxide surface and a hydrophobic self-assembled silane monolayer overlying and covalently bonded to portions of the silicon oxide surface to form a pattern defining a plurality of microwells, forming a solution comprising at least one chemical analyte in at least one of the microwells, and performing a chemical analysis on the solution.

    Abstract translation: 提供了一种用于化学分析的方法,其包括使用包含亲水性氧化硅表面和疏水性自组装硅烷单层的衬底,覆盖并共价结合到氧化硅表面的部分,以形成限定多个微孔的图案,形成溶液 在至少一个微孔中包含至少一种化学分析物,并对溶液进行化学分析。

    SAMPLE PLATE FOR MATRIX-ASSISTED LASER DESORPTION AND IONIZATION MASS SPECTROMETRY
    96.
    发明申请
    SAMPLE PLATE FOR MATRIX-ASSISTED LASER DESORPTION AND IONIZATION MASS SPECTROMETRY 有权
    用于矩阵辅助激光解吸和离子质谱的样品板

    公开(公告)号:US20040217276A1

    公开(公告)日:2004-11-04

    申请号:US10426599

    申请日:2003-04-30

    Abstract: A sample plate for mass spectrometric analysis of a specimen is provided comprising a substrate having an electrically conductive surface, a mask applied to the electrically conductive surface. The mask is applied to the substrate with a rough surface to form at least one sample site. The sample site comprises a central portion formed from the electrically conductive surface and a marginal portion formed from the mask where the marginal portion is more hydrophobic than the central portion.

    Abstract translation: 提供了用于样本的质谱分析的样品板,其包括具有导电表面的基底,施加到导电表面的掩模。 将掩模以粗糙表面施加到基底上以形成至少一个样品位点。 样品位置包括由导电表面形成的中心部分和由掩模形成的边缘部分,其边缘部分比中心部分更疏水。

    Kit For Microcontact Printing
    98.
    发明授权
    Kit For Microcontact Printing 失效
    微接触印刷套件

    公开(公告)号:US06776094B1

    公开(公告)日:2004-08-17

    申请号:US09164733

    申请日:1998-10-01

    Abstract: Improved methods of forming a patterned self-assembled monolayer on a surface and derivative articles are provided. According to one method, an elastomeric stamp is deformed during and/or prior to using the stamp to print a self-assembled molecular monolayer on a surface. According to another method, during monolayer printing the surface is contacted with a liquid that is immiscible with the molecular monolayer-forming species to effect controlled reactive spreading of the monolayer on the surface. Methods of printing self-assembled molecular monolayers on nonplanar surfaces and derivative articles are provided, as are methods of etching surfaces patterned with self-assembled monolayers, including methods of etching silicon. Optical elements including flexible diffraction gratings, mirrors, and lenses are provided, as are methods for forming optical devices and other articles using lithographic molding. A method for controlling the shape of a liquid on the surface of an article is provided, involving applying the liquid to a self-assembled monolayer on the surface, and controlling the electrical potential of the surface.

    Abstract translation: 提供了在表面和衍生物品上形成图案化自组装单层的改进方法。 根据一种方法,弹性印模在使用印模期间和/或之前变形,以在表面上印刷自组装分子单层。 根据另一种方法,在单层印刷过程中,表面与与分子单层形成物质不混溶的液体接触,以实现单层在表面上的受控的反应性扩散。 提供了在非平面表面和衍生物上印刷自组装分子单层的方法,以及用自组装单层蚀刻表面的方法,包括蚀刻硅的方法。 提供包括柔性衍射光栅,反射镜和透镜的光学元件,以及用于使用光刻成型形成光学器件和其它制品的方法。 提供了一种用于控制制品表面上的液体形状的方法,包括将液体施加到表面上的自组装单层,并控制表面的电位。

    Raised surface assay plate
    100.
    发明申请
    Raised surface assay plate 失效
    升高的表面测定板

    公开(公告)号:US20040101953A1

    公开(公告)日:2004-05-27

    申请号:US10439943

    申请日:2003-05-16

    CPC classification number: B01L3/5088 B01L2300/0829

    Abstract: The assay plate includes a substrate having an substrate surface and at least one raised pad extending from the substrate surface. The raised pad includes a substantially planar sample receiving surface configured for holding a sample thereon for in-situ experimentation. The sample receiving surface preferably has at least one sharp edge at the junction between a sidewall coupling the sample receiving surface to the substrate surface. The sample receiving surface is preferably a circle, oval, square, rectangle, triangle, pentagon, hexagon, or octagon shape that is sized to hold a predetermined volume of the sample. A method of using the above described assay plate is also provided. Once a raised pad extending from a substrate is formed, a sample is deposited on the raised pad. Experiments are subsequently performed using the sample on the raised pad.

    Abstract translation: 测定板包括具有基底表面的基底和从基底表面延伸的至少一个凸起垫。 凸起垫包括被配置用于将样品保持在其上以用于现场实验的基本平坦的样品接收表面。 样品接收表面优选在将样品接收表面耦合到衬底表面的侧壁之间的接合处具有至少一个尖锐边缘。 样品接收表面优选为圆形,椭圆形,正方形,矩形,三角形,五边形,六边形或八边形,其尺寸适于保持样品的预定体积。 还提供了使用上述测定板的方法。 一旦形成了从衬底延伸的凸起垫,则将样品沉积在凸起垫上。 随后使用凸起垫上的样品进行实验。

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