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    Depletion-Free MOS using Atomic-Layer Doping
    144.
    发明申请
    Depletion-Free MOS using Atomic-Layer Doping 有权
    消耗MOS的原子层掺杂

    公开(公告)号：US20100068873A1

    公开(公告)日：2010-03-18

    申请号：US12211546

    申请日：2008-09-16

    Applicant: Jing-Cheng Lin ,  Chen-Hua Yu

    Inventor： Jing-Cheng Lin ,  Chen-Hua Yu

    IPC: H01L21/22

    CPC classification number: H01L21/823842 ,  H01L21/2254 ,  H01L21/28035 ,  H01L29/4925 ,  H01L29/6659

    Abstract: A semiconductor device and a method of manufacturing are provided. A dielectric layer is formed over a substrate, and a first silicon-containing layer, undoped, is formed over the dielectric layer. Atomic-layer doping is used to dope the undoped silicon-containing layer. A second silicon-containing layer is formed over first silicon-containing layer. The process may be expanded to include forming a PMOS and NMOS device on the same wafer. For example, the first silicon-containing layer may be thinned in the PMOS region prior to the atomic-layer doping. In the NMOS region, the doped portion of the first silicon-containing layer is removed such that the remaining portion of the first silicon-containing layer in the NMOS is undoped. Thereafter, another atomic-layer doping process may be used to dope the first silicon-containing layer in the NMOS region to a different conductivity type. A third silicon-containing layer may be formed doped to the respective conductivity type.

    Abstract translation: 提供半导体器件和制造方法。 介电层形成在衬底上，并且在介电层上形成未掺杂的第一含硅层。 原子层掺杂用于掺杂未掺杂的含硅层。 在第一含硅层上形成第二含硅层。 该过程可以扩展到包括在同一晶片上形成PMOS和NMOS器件。 例如，在原子层掺杂之前，第一含硅层可以在PMOS区中减薄。 在NMOS区域中，去除第一含硅层的掺杂部分，使得NMOS中的第一含硅层的剩余部分未掺杂。 此后，可以使用另一种原子层掺杂工艺将NMOS区域中的第一含硅层掺杂到不同的导电类型。 可以形成掺杂到相应导电类型的第三含硅层。

    METHODS FOR IDENTIFICATION OF ALLELES
    146.
    发明申请
    METHODS FOR IDENTIFICATION OF ALLELES 有权
    方法识别对象

    公开(公告)号：US20100041563A1

    公开(公告)日：2010-02-18

    申请号：US12305193

    申请日：2007-06-29

    Applicant: Caixia Li ,  Huafang Gao ,  Xiang Liu ,  Bin Cai ,  Di Zhang ,  Jing Cheng

    Inventor： Caixia Li ,  Huafang Gao ,  Xiang Liu ,  Bin Cai ,  Di Zhang ,  Jing Cheng

    IPC: C40B30/04 ,  C40B40/08

    CPC classification number: C12Q1/6883 ,  C12Q1/6858 ,  C12Q2600/156 ,  C12Q2600/16 ,  C12Q2565/501 ,  C12Q2535/125 ,  C12Q2525/161

    Abstract: The invention provides a method for identification of alleles. In this method, genomic DNA is used as target. Multiple allele-specific PCR amplification are carried out with a group of primers comprising one or more allele-specific primers for a target gene, a universal primer, and a common primer; and a DNA polymerase without 5′ to 3′ exonuclease activity. The PCR products are hybridized with tag probes immobilized on a DNA chip. Results are determined based on the signal intensity and the position of the probe immobilized on the array. Each allele-specific primer comprises a unique tag sequence at the 5′ end. Each tag probe immobilized on the DNA chip comprises a sequence identical to its corresponding tag sequence; and each tag probe hybridizes only with the complementary sequence in the PCR amplification product.

    Abstract translation: 本发明提供了一种鉴定等位基因的方法。 在该方法中，使用基因组DNA作为靶。 使用包含靶基因，通用引物和通用引物的一个或多个等位基因特异性引物的引物组进行多重等位基因特异性PCR扩增; 和没有5'至3'外切核酸酶活性的DNA聚合酶。 PCR产物与固定在DNA芯片上的标签探针杂交。 结果基于信号强度和固定在阵列上的探针的位置来确定。 每个等位基因特异性引物包含在5'末端的唯一标签序列。 固定在DNA芯片上的每个标签探针包含与其相应的标签序列相同的序列; 并且每个标签探针仅与PCR扩增产物中的互补序列杂交。

    Capillary electrophoresis chip apparatus for detecting nucleotide polymorphism and single nucleotide polymorphism
    149.
    发明授权
    Capillary electrophoresis chip apparatus for detecting nucleotide polymorphism and single nucleotide polymorphism 有权
    用于检测核苷酸多态性和单核苷酸多态性的毛细管电泳芯片装置

    公开(公告)号：US07527719B2

    公开(公告)日：2009-05-05

    申请号：US10500180

    申请日：2002-11-29

    Applicant: Peng Liu ,  Wanli Xing ,  Dong Liang ,  Jing Cheng

    Inventor： Peng Liu ,  Wanli Xing ,  Dong Liang ,  Jing Cheng

    IPC: G01N27/453

    CPC classification number: G01N27/44791

    Abstract: The present invention provides a capillary electrophoresis chip apparatus for detecting nucleotide polymorphism or single nucleotide polymorphism belonging to capillary electrophoresis apparatuses. The apparatus comprises an upper channel layer comprising a one-, two-, or multi-dimensional microfluid channel and an electrode aperture structure for loading sample, a middle electrode layer for sealing the microfluid channel to form an intact capillary and providing the needed voltage for electrophoresis; and a lower heating layer for providing a stable temperature gradient for electrophoresis. The upper, middle and lower layers are thermal conductive and adhesive to each other.

    Abstract translation: 本发明提供一种用于检测属于毛细管电泳装置的核苷酸多态性或单核苷酸多态性的毛细管电泳芯片装置。 该装置包括上通道层，其包括一维，二维或多维微流体通道和用于装载样品的电极孔结构，用于密封微流体通道以形成完整毛细管的中间电极层，并提供所需电压 电泳; 以及用于提供电泳的稳定温度梯度的较低加热层。 上，中，下层相互导热，粘合。

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