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公开(公告)号：US20170217663A1
公开(公告)日：2017-08-03
申请号：US15418003
申请日：2017-01-27
Applicant: Beckman Coulter, Inc.
Inventor： Stephen Otts , Stefan Rückl
IPC: B65D83/04 , A47B88/483 , A47B88/969 , B65D25/10
CPC classification number: B65D83/0481 , A47B88/969 , A47B2088/4015 , A47B2210/07 , B65D43/20 , B65D47/286 , B65D90/60 , B65G69/0441 , G01N35/04 , G01N2035/0405
Abstract: A storage system for storing material such as sample tube caps comprises a drawer with a reservoir, the drawer being movable between a first position and a second position. A storage container is arranged below the reservoir of the drawer when the drawer is arranged in the first position. A transport device is configured to retrieve material from the storage container and to transport the material out of the storage container. Therein, the reservoir of the drawer comprises a bottom with at least one closable opening.
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公开(公告)号：US09610583B2
公开(公告)日：2017-04-04
申请号：US14723286
申请日：2015-05-27
Applicant: Beckman Coulter, Inc. , DHR Technologies Ireland Limited
Inventor： Hiroyuki Onishi , Masato Kayahara , Hiroshi Suzuki , Ryusuke Furuya , Naoki Mukaiyama , Michael Cooney , Marcus O'Neill , Sean O'Mahony
IPC: B01L3/00 , B29C49/04 , G01N35/10 , B29C49/42 , B29K105/00 , B29L31/00 , B29C49/20 , B29C65/08 , B29C65/48 , B29C65/58 , B29C65/02 , B29C65/06
CPC classification number: B01L3/523 , B01L2200/026 , B01L2200/0684 , B01L2200/12 , B01L2200/16 , B01L2300/042 , B01L2300/08 , B01L2300/0809 , B01L2300/0848 , B01L2300/0851 , B01L2300/0858 , B29C49/04 , B29C49/20 , B29C49/4205 , B29C49/4273 , B29C65/02 , B29C65/06 , B29C65/08 , B29C65/48 , B29C65/4895 , B29C65/58 , B29C2049/2047 , B29K2105/258 , B29L2031/712 , B29L2031/7158 , G01N35/1002 , Y10T29/49828
Abstract: An embodiment of a reagent container includes a bottle with a pipe to reduce the effects of reagent sloshing. The bottle has an elongated base and an opposed cover connected by side walls and an end wall. A flat platform surrounded by a raised rim lies in the base opposite an opening in the cover. A ribbed pipe frictionally fits within the bottle opening and may attach to the anchor region leaving vent passages around the pipe. The pipe includes an aperture adjacent to the anchor region and oriented toward the end wall so that sloshed fluid has only a small effect on the level of reagent in the pipe during transfers. A modified blow molding process produces the anchor region by extending a pin a predetermined distance into a mold while the molded material is still plastic.
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183.发明授权公开(公告)号：US09567622B2
公开(公告)日：2017-02-14
申请号：US14730963
申请日：2015-06-04
Applicant: Beckman Coulter, Inc.
Inventor： Wayne Goldson , Sandra Socarras
CPC classification number: C12Q1/06 , G01N33/5002
Abstract: The present invention discloses multi-purpose metering fluid/rinse reagents for use in automated cellular analyzers that use liquid volumetric metering. The compositions contain a chelating agent, an ionizing salt, optionally a stabilizing ion, a buffer, a non-hemolytic surfactant, and optionally an antimicrobial agent. Advantageously, the compositions produce less than one part-per-million of formaldehyde over the course of one year. Methods for using the compositions are also described.
Abstract translation: 本发明公开了用于使用液体体积计量的自动细胞分析仪中的多用途计量流体/漂洗剂。 组合物含有螯合剂，电离盐，任选的稳定离子，缓冲液，非溶血性表面活性剂和任选的抗微生物剂。 有利地，组合物在一年的时间内产生少于百万分之一百万的甲醛。 还描述了使用组合物的方法。
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184.发明申请公开(公告)号：US20170010204A1
公开(公告)日：2017-01-12
申请号：US15263133
申请日：2016-09-12
Applicant: Beckman Coulter, Inc.
Inventor： William H. Gutierrez , Cheng Qian , John S. Riley
CPC classification number: G01N15/1429 , G01N15/12 , G01N15/1209 , G01N15/147 , G01N2015/0073 , G01N2015/008 , G01N2015/1037 , G01N2015/1497
Abstract: The present invention provides methods and systems to combine the capabilities of a hematology analyzer with those of a flow cytometer to yield a far more powerful analytical system than either device alone. In one embodiment, a method of analyzing a cell sample includes receiving a first data generated by an analysis of a first aliquot of the sample on a first particle analyzer having a fluorescence measurement device such as a flow cytometer, detecting at least one unresolved cell population in the first data, and accessing a second data stored on a storage device wherein the second data was previously generated by interrogating a second aliquot of the sample using at least one of a cell volume measurement device and a cell conductivity measurement device in a second particle analyzer such as a hematology analyzer. The unresolved cell population in the first data is then resolved using the second data. Corresponding system embodiments are also disclosed.
Abstract translation: 本发明提供了将血液分析仪的能力与流式细胞仪的能力相结合的方法和系统，以产生比任何一种装置更强大的分析系统。 在一个实施方案中，分析细胞样品的方法包括通过在具有荧光测量装置例如流式细胞仪的第一粒子分析仪上接收样品的第一等分试样生成的第一数据，检测至少一个未解析的细胞群 并且访问存储在存储设备上的第二数据，其中先前通过使用第二粒子中的细胞体积测量装置和细胞电导率测量装置中的至少一个询问样品的第二等分试样来生成第二数据 分析仪如血液分析仪。 然后使用第二数据来解析第一数据中的未解析细胞群。 还公开了相应的系统实施例。
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公开(公告)号：USD774205S1
公开(公告)日：2016-12-13
申请号：US29505633
申请日：2015-12-24
Applicant: Beckman Coulter, Inc.
Designer： Eric M. Grace , Thys Müller
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Patent Agency Ranking
公开(公告)号：US09519000B2
公开(公告)日：2016-12-13
申请号：US13747945
申请日：2013-01-23
Applicant: Beckman Coulter, Inc.
Inventor： Brian D. Wilson , Alan N. Johnson , Charles S. Kraihanzel , Joshua D. Wiltsie
IPC: B01L3/00 , G01N35/04 , G01N35/10 , G01N35/00 , C12P19/34 , G05B13/02 , B01L7/00 , C12Q3/00 , G01F23/24 , G01F23/26 , G06F19/10 , C12M1/34 , C12Q1/68 , G01N1/38 , G01N1/31 , B01L3/02
CPC classification number: G01N35/04 , B01L3/021 , B01L3/0275 , B01L3/50825 , B01L3/5085 , B01L3/50851 , B01L3/52 , B01L3/545 , B01L7/52 , B01L2200/025 , B01L2200/0642 , B01L2200/0668 , B01L2200/12 , B01L2200/147 , B01L2300/021 , B01L2300/022 , B01L2300/024 , B01L2300/042 , B01L2300/044 , B01L2300/045 , B01L2300/046 , B01L2300/0654 , B01L2300/0851 , B01L2300/123 , B01L2300/18 , B01L2300/1822 , B01L2300/1827 , B01L2400/043 , C12M41/12 , C12P19/34 , C12Q1/68 , C12Q1/686 , C12Q3/00 , G01F23/24 , G01F23/26 , G01N1/31 , G01N1/38 , G01N35/00732 , G01N35/0092 , G01N35/0098 , G01N35/1002 , G01N35/1011 , G01N35/1016 , G01N35/1081 , G01N2035/00435 , G01N2035/00752 , G01N2035/00851 , G01N2035/0413 , G01N2035/0415 , G01N2035/0436 , G01N2035/0465 , G01N2035/0475 , G01N2035/1013 , G01N2035/1025 , G01N2035/1048 , G01N2035/1051 , G01N2035/1076 , G05B13/02 , G05B13/0205 , G06F19/10 , Y10T436/113332
Abstract: Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples.
Abstract translation: 公开了用于处理和分析样品的系统和方法。 该系统可以使用可在不同处理位置处理的测定盒来处理样品，例如生物流体。 在某些情况下，该系统可用于PCR处理。 不同的处理位置可以包括可以准备样品的准备位置和可以分析样品的分析位置。 为了帮助准备样品，系统还可以包括可以包括加工车道的多个处理站。 在样品分析期间，在某些情况下，可以使用热循环仪模块和适当的光学检测系统来检测样品中某些核酸序列的存在或不存在。 该系统可用于准确快速地处理样品。
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公开(公告)号：US20160290915A1
公开(公告)日：2016-10-06
申请号：US15036712
申请日：2014-11-14
Applicant: BECKMAN COULTER, INC.
Inventor： Antao Chen , Juan J. Fernandez De Castro , Paul K. Church
CPC classification number: G01N15/1436 , G01N15/1459 , G01N21/53 , G01N21/645 , G01N2015/0065 , G01N2021/6421 , G01N2021/6463 , G01N2021/6478 , G01N2021/6484 , G01N2201/0637
Abstract: High numerical aperture collection optics for particle analyzers may include an ellipsoidal reflector or an ellipsoidal reflector in combination with a spherical reflector, and may efficiently collect light scattered or emitted by particles in a sample stream and then couple that collected light into a lower numerical aperture portion of the instrument's optical detection system, such as into an optical fiber for example. The reflectors may be integrated with a flow cell through which the sample stream passes, or may be separate components arranged around a flow cell or, in instruments not employing a flow cell, arranged around a sample stream in air. Refractive beam steering optics may allow multiple closely spaced excitation beams to be directed into the sample stream at low angles of incidence. The collection optics and refractive beam steering optics may be employed separately or in combination with each other.
Abstract translation: 用于粒子分析器的高数值孔径采集光学器件可以包括椭球反射器或与球形反射器组合的椭圆反射器，并且可以有效地收集由样品流中的颗粒散射或发射的光，然后将收集的光耦合到较低的数值孔径部分 的仪器的光学检测系统，例如成为光纤。 反射器可以与样品流通过的流动池一体化，或者可以是布置在流动池周围的分离的组件，或者在不使用流动池的仪器中，布置在空气中的样品流周围。 折射光束转向光学器件可以允许多个紧密间隔的激发光束以低入射角被引导到样品流中。 收集光学器件和折射光束转向光学元件可以单独使用或者彼此组合使用。
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188.发明申请公开(公告)号：US20160002698A1
公开(公告)日：2016-01-07
申请号：US14730963
申请日：2015-06-04
Applicant: Beckman Coulter, Inc.
Inventor： Wayne Goldson , Sandra Socarras
IPC: C12Q1/06
CPC classification number: C12Q1/06 , G01N33/5002
Abstract: The present invention discloses multi-purpose metering fluid/rinse reagents for use in automated cellular analyzers that use liquid volumetric metering. The compositions contain a chelating agent, an ionizing salt, optionally a stabilizing ion, a buffer, a non-hemolytic surfactant, and optionally an antimicrobial agent. Advantageously, the compositions produce less than one part-per-million of formaldehyde over the course of one year. Methods for using the compositions are also described.
Abstract translation: 本发明公开了用于使用液体体积计量的自动细胞分析仪中的多用途计量流体/漂洗剂。 组合物含有螯合剂，电离盐，任选的稳定离子，缓冲液，非溶血性表面活性剂和任选的抗微生物剂。 有利地，组合物在一年的时间内产生少于百万分之一百万的甲醛。 还描述了使用组合物的方法。
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公开(公告)号：US09176112B2
公开(公告)日：2015-11-03
申请号：US14145608
申请日：2013-12-31
Applicant: Beckman Coulter, Inc.
Inventor： Shuliang Zhang , Mark Rossman , Jiuliu Lu , John Riley
CPC classification number: G01N33/49 , G01N15/1031 , G01N15/12 , G01N15/1459 , G01N33/4915 , G01N2015/0084 , G01N2015/1006 , G01N2015/1037 , G01N2015/1402 , G01N2015/1486 , G01N2015/1493
Abstract: Embodiments of the present invention encompass automated systems and methods for analyzing platelet parameters in an individual based on a biological sample obtained from blood of the individual. Exemplary techniques involve correlating aspects of direct current (DC) impedance and/or light measurement data obtained from the biological sample with an evaluation of platelet conditions in the individual.
Abstract translation: 本发明的实施方案包括基于从个体的血液获得的生物样品来分析个体血小板参数的自动化系统和方法。 示例性技术涉及将从生物样品获得的直流（DC）阻抗和/或光测量数据的方面与个体中的血小板状况的评估相关联。
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公开(公告)号：US20150238978A1
公开(公告)日：2015-08-27
申请号：US14699734
申请日：2015-04-29
Applicant: Beckman Coulter, Inc.
Inventor： Martin MÜLLER , Andreas WEIHS , Gerhard GUNZER , Michael EBERHARDT
CPC classification number: G01N35/0099 , B01D21/262 , B01L3/5021 , B04B7/02 , B04B7/08 , B04B9/14 , B04B9/146 , B04B11/04 , B04B13/00 , B04B15/00 , B04B2009/143 , B04B2011/046 , B04B2013/006 , B25J11/00 , B65D51/24 , B65G47/28 , G01B11/02 , G01B11/08 , G01B11/10 , G01B11/24 , G01F23/00 , G01L19/08 , G01M1/14 , G01N21/27 , G01N35/00584 , G01N35/00732 , G01N35/04 , G01N35/10 , G01N35/1009 , G01N2035/00495 , G01N2035/0405 , G01N2035/0462 , G01N2035/0491 , G01N2035/1025 , G01N2035/1032 , Y10T29/49826
Abstract: A system is disclosed. The system includes at least one image acquisition device configured to obtain one or more images of sample containers in a sample container holder. It also includes an image analysis device coupled to the at least one image acquisition device. The image analysis device is configured to analyze, by a processor, the one or more images of the sample containers in the sample container holder, to determine (a) a presence or absence of sample containers at sample container holder locations in the sample container holder, and (b) sample container characteristics of the sample containers in the sample container holder, wherein the sample container characteristics include one or more of cap color, cap shape, labels and markers associated with the sample containers, or one or more sample container holder characteristics.
Abstract translation: 公开了一种系统。 该系统包括至少一个图像采集装置，其被配置为获得样品容器支架中的样品容器的一个或多个图像。 它还包括耦合到至少一个图像采集装置的图像分析装置。 图像分析装置被配置为通过处理器分析样品容器保持器中的样品容器的一个或多个图像，以确定（a）样品容器保持器中的样品容器保持器位置处的样品容器的存在或不存在 ，和（b）样品容器保持器中的样品容器的样品容器特性，其中样品容器特性包括帽样颜色，帽形，与样品容器相关联的标签和标记物，或一个或多个样品容器容器 特点
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