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公开(公告)号：US5965001A
公开(公告)日：1999-10-12
申请号：US888064
申请日：1997-07-03
IPC分类号： G01N27/26 , G01N27/447 , G01N37/00
CPC分类号： G01N27/44791 , G01N27/44713 , G01N27/44752 , G01N27/44773 , Y10S366/02 , Y10T29/49002
摘要： In a microfluidic system using electrokinetic forces, the present invention uses electrical current or electrical parameters, other than voltage, to control the movement of fluids through the channels of the system. Time-multiplexed power supplies also provide further control over fluid movement by varying the voltage on an electrode connected to a fluid reservoir of the microfluidic system, by varying the duty cycle during which the voltage is applied to the electrode, or by a combination of both. A time-multiplexed power supply can also be connected to more than one electrode for a savings in cost.
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公开(公告)号：US20020123133A1
公开(公告)日：2002-09-05
申请号：US09925285
申请日：2001-08-09
IPC分类号： C12M001/34 , G01N033/561 , C12Q001/68
CPC分类号： G01N27/44791 , B01J19/0093 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00909 , B01J2219/00912 , B01J2219/00961 , B01J2219/00986 , B01L3/5027 , B01L3/502784 , B01L7/52 , B01L2200/0673 , B01L2200/10 , B01L2300/0816 , B01L2300/0867 , B01L2300/1827 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , Y10S435/814
摘要： Multiphasic microfluidic apparatus for performing product fluid manipulation and separation in a single continuous unit are provided. Related methods, kits, and compositions are also provided.
摘要翻译： 提供了用于在单个连续单元中执行产品流体操纵和分离的多相微流体装置。 还提供了相关方法，试剂盒和组合物。
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公开(公告)号：US5942443A
公开(公告)日：1999-08-24
申请号：US671987
申请日：1996-06-28
IPC分类号： B01J19/00 , B01L3/00 , B01L9/00 , G01N27/447 , G01N33/50 , G01N33/53 , G01N33/574 , G01N35/08 , G01N33/558
CPC分类号： G01N33/5091 , B01J19/0093 , B01L3/5025 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L3/502784 , G01N27/44791 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5044 , G01N33/5064 , G01N33/5094 , G01N33/5304 , G01N33/57415 , B01L2200/0605 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2200/0689 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B01L9/527 , G01N35/08 , Y10S366/02 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/806 , Y10S436/807 , Y10S436/809
摘要： Microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.
摘要翻译： 用于进行高通量筛选测定的微流控装置和方法。 特别地，本发明的装置和方法可用于筛选大量不同的化合物，因为它们对多种化学品，优选生物化学体系的影响。
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公开(公告)号：US5842787A
公开(公告)日：1998-12-01
申请号：US948194
申请日：1997-10-09
IPC分类号： B01J19/00 , B01L3/00 , G01N27/447 , B01F5/00
CPC分类号： G01N27/44791 , B01J19/0093 , B01L3/502746 , B01F13/0059 , B01J2219/00783 , B01J2219/0086 , B01J2219/00889 , B01L2300/0816 , B01L2300/0867 , B01L2400/0415 , B01L2400/084 , B01L3/502707 , B01L3/502776 , Y10S366/01 , Y10S366/02 , Y10S366/03 , Y10T436/2575
摘要： The present invention is generally directed to improved microfluidic devices, systems and methods of using same, which incorporate channel profiles that impart significant benefits over previously described systems. In particular, the presently described devices and systems employ channels having, at least in part, depths that are varied over those which have been previously described. These varied channel depths provide numerous beneficial and unexpected results.
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公开(公告)号：US5779868A
公开(公告)日：1998-07-14
申请号：US671986
申请日：1996-06-28
申请人： J. Wallace Parce , Michael R. Knapp
发明人： J. Wallace Parce , Michael R. Knapp
IPC分类号： B01F13/00 , B01J19/00 , B01L3/00 , B01L3/02 , F04B17/00 , F04B19/00 , G01N27/447 , H02N11/00 , G01N27/26
CPC分类号： B01F13/0071 , B01J19/0093 , B01L3/502715 , B01L3/50273 , B01L3/502784 , F04B17/00 , F04B19/006 , G01N27/44704 , G01N27/44743 , G01N27/44791 , H02N11/006 , B01F13/0084 , B01F13/0086 , B01L2200/027 , B01L2200/0673 , B01L2300/0816 , B01L2400/0415 , B01L3/021 , B01L3/502753
摘要： The present invention provides for techniques for transporting materials using electrokinetic forces through the channels of a microfluidic system. The materials are transported in slug regions of high ionic concentration, next to buffer material regions of high ionic concentration, which are separated by buffer material regions of low ionic concentration. Such arrangements allow the materials to remain localized for the transport transit time to avoid mixing of the materials. Using these techniques, an electropipettor which is compatible with the microfluidic system is created so that materials can be easily introduced into the microfluidic system. The present invention also compensates for electrophoretic bias as materials are transported through the channels of the microfluidic system by splitting a channel into portions with positive and negative surface charges and a third electrode between the two portions, or by diffusion of the electrophoresing materials after transport along a channel.
摘要翻译： 本发明提供了使用电动力通过微流体系统的通道输送材料的技术。 材料以高离子浓度的块状区域运输，靠近高离子浓度的缓冲材料区域，其由低离子浓度的缓冲材料区域分离。 这种布置允许材料在运输通过时间内保持局部化，以避免混合材料。 使用这些技术，产生与微流体系统相容的电吸移器，使得材料可以容易地引入到微流体系统中。 本发明还补偿电泳偏压，因为材料通过将通道分成具有正表面电荷和负表面电荷的部分，以及两部分之间的第三电极，或者通过在运输之后电泳材料的扩散而传输通过微流体系统的通道 一个频道
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公开(公告)号：US6132685A
公开(公告)日：2000-10-17
申请号：US132096
申请日：1998-08-10
申请人： Joseph E. Kercso , Steven A. Sundberg , Jeffrey A. Wolk , Andrew W. Toth , Calvin Y. H. Chow , J. Wallace Parce
发明人： Joseph E. Kercso , Steven A. Sundberg , Jeffrey A. Wolk , Andrew W. Toth , Calvin Y. H. Chow , J. Wallace Parce
CPC分类号： G01N35/028 , G01N2035/00148 , Y10T436/11 , Y10T436/113332 , Y10T436/119163 , Y10T436/25625 , Y10T436/2575
摘要： The invention provides improved systems, devices, and methods for analyzing a large number of sample compounds contained in standard multiwell microtiter plates or other array structures. The multiwell plates travel along a conveyor system to a test station having a microfluidic device. At the test station, each plate is removed from the conveyor and the wells of the multiwell plate are sequentially aligned with an input port of the microfluidic device. After at least a portion of each sample has been input into the microfluidic channel system, the plate is returned to the conveyor system. Pre and/or post testing stations may be disposed along the conveyor system, and the use of an X-Y-Z robotic arm and novel plate support bracket allows each of the samples in the wells to be input into the microfluidic network through a probe affixed to a microfluidic chip. A clamshell structure having a hinged lid can releasably support the chip while providing and/or accommodating the electrical, optical, structural, and other interface connections between the microfluidic device and the surrounding system.
摘要翻译： 本发明提供用于分析标准多孔微量滴定板或其它阵列结构中所含的大量样品化合物的改进的系统，装置和方法。 多孔板沿传送系统行进到具有微流体装置的测试台。 在试验台，每个板从输送机上取出，多孔板的孔依次与微流体装置的输入端对准。 在每个样品的至少一部分已经被输入到微流体通道系统中之后，板返回到输送系统。 可以沿输送机系统布置前后测试站，并且使用XYZ机器人臂和新的板支撑支架允许孔中的每个样品通过固定在微流体上的探针输入微流体网络 芯片。 具有铰接盖的蛤壳结构可以可释放地支撑芯片，同时提供和/或容纳微流体装置和周围系统之间的电，光学，结构和其它界面连接。
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公开(公告)号：US6046056A
公开(公告)日：2000-04-04
申请号：US761575
申请日：1996-12-06
IPC分类号： B01J19/00 , B01L3/00 , B01L9/00 , G01N27/447 , G01N33/50 , G01N33/53 , G01N33/574 , G01N35/08 , G01N33/558 , G01N33/543
CPC分类号： G01N33/5091 , B01J19/0093 , B01L3/5025 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L3/502784 , G01N27/44791 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5044 , G01N33/5064 , G01N33/5094 , G01N33/5304 , G01N33/57415 , B01L2200/0605 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2200/0689 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B01L9/527 , G01N35/08 , Y10S366/02 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/806 , Y10S436/807 , Y10S436/809
摘要： The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.
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公开(公告)号：US5959291A
公开(公告)日：1999-09-28
申请号：US104813
申请日：1998-06-25
申请人： Morten J. Jensen
发明人： Morten J. Jensen
摘要： A method and apparatus for measuring very low light signals including integrating a signal from a photo diode, avalanche photo diode, photomultiplier tube or the like, digitally sampling the integrator output more than two times during each integration period, fitting a curve to the multiple digitized readings to calculate the integration slope for each integration period and determining the original signal from the calculated integration slope.
摘要翻译： 一种用于测量非常低的光信号的方法和装置，包括积分来自光电二极管，雪崩光电二极管，光电倍增管等的信号，在每个积分周期期间对积分器输出进行数字采样两次以上，将曲线拟合到多个数字化 读数计算每个积分周期的积分斜率，并从计算的积分斜率确定原始信号。
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公开(公告)号：US5885470A
公开(公告)日：1999-03-23
申请号：US843212
申请日：1997-04-14
IPC分类号： B01J19/00 , B01L3/00 , G01N27/447 , B44C1/22
CPC分类号： B01L3/502707 , B01J19/0093 , B01L3/50273 , G01N27/44791 , B01J2219/00783 , B01J2219/00833 , B01J2219/00853 , B01J2219/00952 , B01J2219/00995 , B01L2200/0689 , B01L2200/12 , B01L2200/147 , B01L2300/0816 , B01L2300/0887 , B01L2300/12 , B01L2400/0418 , Y10S366/03 , Y10T137/2224 , Y10T29/49229
摘要： Microfluidic devices are provided for the performance of chemical and biochemical analyses, syntheses and detection. The devices of the invention combine precise fluidic control systems with microfabricated polymeric substrates to provide accurate, low cost miniaturized analytical devices that have broad applications in the fields of chemistry, biochemistry, biotechnology, molecular biology and numerous other fields.
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公开(公告)号：US5880071A
公开(公告)日：1999-03-09
申请号：US760446
申请日：1996-12-06
申请人： J. Wallace Parce , Michael R. Knapp
发明人： J. Wallace Parce , Michael R. Knapp
IPC分类号： B01F13/00 , B01J19/00 , B01L3/00 , B01L3/02 , F04B17/00 , F04B19/00 , G01N27/447 , H02N11/00 , G01N27/26
CPC分类号： B01F13/0071 , B01J19/0093 , B01L3/502715 , B01L3/50273 , B01L3/502784 , F04B17/00 , F04B19/006 , G01N27/44704 , G01N27/44743 , G01N27/44791 , H02N11/006 , B01F13/0084 , B01F13/0086 , B01L2200/027 , B01L2200/0673 , B01L2300/0816 , B01L2400/0415 , B01L3/021 , B01L3/502753
摘要： The present invention provides for techniques for transporting materials using electrokinetic forces through the channels of a microfluidic system. The subject materials materials are transported in regions of high ionic concentration, next to spacer material regions of high ionic concentration, which are separated by spacer material regions of low ionic concentration. Such arrangements allow the materials to remain localized for the transport transit time to avoid mixing of the materials. Using these techniques, an electropipettor which is compatible with the microfluidic system is created so that materials can be easily introduced into the microfluidic system. The present invention also compensates for electrophoretic bias as materials are transported through the channels of the microfluidic system by splitting a channel into portions with positive and negative surface charges and a third electrode between the two portions, or by diffusion of the electrophoresing materials after transport along a channel.
摘要翻译： 本发明提供了使用电动力通过微流体系统的通道输送材料的技术。 主体材料在高离子浓度的区域内运输，靠近高离子浓度的间隔物材料区域，其由具有低离子浓度的间隔物材料区域分离。 这种布置允许材料在运输通过时间内保持局部化，以避免混合材料。 使用这些技术，产生与微流体系统相容的电吸移器，使得材料可以容易地引入到微流体系统中。 本发明还补偿电泳偏压，因为材料通过将通道分成具有正表面电荷和负表面电荷的部分，以及两部分之间的第三电极，或者通过在运输之后电泳材料的扩散而传输通过微流体系统的通道 一个频道
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