公开(公告)号：US07767588B2

公开(公告)日：2010-08-03

申请号：US11364128

申请日：2006-02-28

Applicant: Tien Ying Luo ,  Rajesh A. Rao

Inventor： Tien Ying Luo ,  Rajesh A. Rao

IPC: H01L21/31 ,  H01L21/461

CPC classification number: H01L21/28282 ,  B82Y10/00 ,  H01L21/02164 ,  H01L21/02271 ,  H01L21/02304 ,  H01L21/02337 ,  H01L21/31612 ,  H01L29/42332 ,  H01L29/7883 ,  H01L29/7885

Abstract: An insulating layer formed by deposition is annealed in the presence of radical oxygen to reduce bond defects. A substrate is provided. An oxide layer is deposited overlying the substrate. The oxide layer has a plurality of bond defects. The oxide layer is annealed in the presence of radical oxygen to modify a substantial portion of the plurality of bond defects by using oxygen atoms. The anneal, in one form, is an in-situ steam generation (ISSG) anneal. In one form, the insulating layer overlies a layer of charge storage material, such as nanoclusters, that form a gate structure of a semiconductor storage device. The ISSG anneal repairs bond defects by oxidizing defective silicon bonds in the oxide layer when the oxide layer is silicon dioxide.

Abstract translation: 通过沉积形成的绝缘层在自由基氧的存在下退火以减少键合缺陷。 提供基板。 沉积在衬底上的氧化物层。 氧化物层具有多个键合缺陷。 氧化层在自由基氧的存在下进行退火，通过使用氧原子来修饰多个键缺陷的大部分。 一种形式的退火是原位蒸汽发生（ISSG）退火。 在一种形式中，绝缘层覆盖形成半导体存储装置的栅极结构的诸如纳米团簇的电荷存储材料层。 当氧化物层是二氧化硅时，ISSG退火通过氧化氧化物层中的有缺陷的硅键来修复接合缺陷。

公开(公告)号：US07741019B2

公开(公告)日：2010-06-22

申请号：US10415222

申请日：2001-11-01

Applicant: Eleftherios P. Diamandis ,  Liu-Ying Luo

Inventor： Eleftherios P. Diamandis ,  Liu-Ying Luo

IPC: C12Q1/00 ,  G01N33/574

CPC classification number: G01N33/57449 ,  G01N2333/96455

Abstract: A method for the diagnosis, prognosis, and monitoring of ovarian cancer in a subject by detecting hK10 in a sample from the subject, preferably a serum sample or tumor tissue extract. hK10 may be measured using a reagent that detects or binds to hK10 preferably antibodies specifically reactive with hK10 or a part thereof. Imaging methods for tumors associated with hK10 are also described using an agent that binds to hK10 which had a label for imaging the tumor.

Abstract translation: 一种通过检测来自受试者的样品中的hK10，优选血清样品或肿瘤组织提取物来诊断，预后和监测受试者的卵巢癌的方法。 可以使用检测或结合hK10的试剂优选hK10，优选与hK10或其一部分特异性反应的抗体。 还使用与hK10结合的试剂描述与hK10相关的肿瘤的成像方法，所述试剂具有用于成像肿瘤的标记。

公开(公告)号：US20080173908A1

公开(公告)日：2008-07-24

申请号：US11655461

申请日：2007-01-19

Applicant: Kurt H. Junker ,  Paul A. Grudowski ,  Xiang-Zheng Bo ,  Tien Ying Luo

Inventor： Kurt H. Junker ,  Paul A. Grudowski ,  Xiang-Zheng Bo ,  Tien Ying Luo

IPC: H01L29/78 ,  H01L21/3105 ,  H01L21/8238

CPC classification number: H01L21/02348 ,  H01L21/0217 ,  H01L21/02274 ,  H01L21/02351 ,  H01L21/3105 ,  H01L21/3185 ,  H01L21/823807 ,  H01L29/7843

Abstract: A method for making a semiconductor device is provided which comprises (a) providing a semiconductor structure equipped with a gate and a channel region, said channel region being associated with the gate; (b) depositing a first sub-layer (131) of a first stressor material over the semiconductor structure, said first stressor material containing silicon-nitrogen bonds and imparting tensile stress to the semiconductor structure; (c) curing the first stressor material through exposure to a radiation source; (d) depositing a second sub-layer (133) of a second stressor material over the first sub-layer, said second stressor material containing silicon-nitrogen bonds and imparting tensile stress to the semiconductor structure; and (e) curing the second sub-layer of stressor material through exposure to a radiation source.

Abstract translation: 提供了制造半导体器件的方法，其包括（a）提供配备有栅极和沟道区域的半导体结构，所述沟道区域与栅极相关联; （b）在半导体结构上沉积第一应力源材料的第一子层（131），所述第一应力源材料含有硅 - 氮键并向半导体结构施加拉伸应力; （c）通过暴露于辐射源固化第一应激物材料; （d）在所述第一子层上沉积第二应力源材料的第二子层（133），所述第二应力源材料含有硅 - 氮键并向所述半导体结构施加拉伸应力; 和（e）通过暴露于辐射源固化应力源材料的第二子层。

公开(公告)号：US07384761B2

公开(公告)日：2008-06-10

申请号：US10220375

申请日：2001-03-02

Applicant: Ying Luo ,  Xiang Xu

Inventor： Ying Luo ,  Xiang Xu

IPC: C12Q1/48 ,  C12N9/16

CPC classification number: C07K14/4738 ,  C12N9/16 ,  C12Y301/03016 ,  G01N33/5011 ,  G01N33/6872 ,  G01N2333/4739 ,  G01N2333/8114

Abstract: The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

Abstract translation: 本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。 本文还提供了与异源多肽序列融合的本发明的载体和宿主细胞多肽，与本发明的多肽结合的抗体和用于产生本发明的多肽的方法。 本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。

公开(公告)号：US20080101662A1

公开(公告)日：2008-05-01

申请号：US11554720

申请日：2006-10-31

Applicant: PETER Z. LO ,  YING LUO

Inventor： PETER Z. LO ,  YING LUO

IPC: G06K9/00

CPC classification number: G06K9/0008 ,  G06K9/00087

Abstract: A method for comparing a search print image comprising a first plurality of minutiae to a file print image comprising a second plurality of minutiae and the apparatus implementing the method is provided. The method includes the steps of: aligning the search and file print images; obtaining the first and second plurality of minutiae, a first plurality of pseudo-ridges generated from a first direction field of the search print image and a second plurality of pseudo-ridges generated from a second direction field of the file print image; for each aligning of the search and file print images, generating a pseudo-ridge score, and determining a minutiae matching score; and providing, based on the pseudo-ridge and minutiae matching scores, an output that indicates a level of similarity between the search and file print images.

Abstract translation: 提供一种将包括第一多个细节的搜索打印图像与包括第二多个细节的文件打印图像和实现该方法的装置进行比较的方法。 该方法包括以下步骤：对齐搜索和文件打印图像; 获取第一和第二多个细节，从搜索打印图像的第一方向域产生的第一多个伪脊和从文件打印图像的第二方向字段产生的第二多个伪脊; 对于搜索和文件打印图像的每个对齐，生成伪脊得分，以及确定细节匹配得分; 并且基于伪脊和细节匹配分数提供指示搜索和文件打印图像之间的相似程度的输出。

公开(公告)号：US20080026526A1

公开(公告)日：2008-01-31

申请号：US11459837

申请日：2006-07-25

Applicant: Rajesh A. Rao ,  Tien Ying Luo ,  Ramachandran Muralidhar ,  Robert F. Steimle ,  Sherry G. Straub

Inventor： Rajesh A. Rao ,  Tien Ying Luo ,  Ramachandran Muralidhar ,  Robert F. Steimle ,  Sherry G. Straub

IPC: H01L21/336 ,  H01L21/3205

CPC classification number: H01L21/28273 ,  H01L21/28282 ,  H01L21/32134 ,  H01L27/11526 ,  H01L27/11531 ,  H01L27/11573 ,  Y10S977/774 ,  Y10S977/779 ,  Y10S977/78 ,  Y10S977/943

Abstract: A method of making a semiconductor device includes a substrate having a semiconductor layer having a first portion for non-volatile memory and a second portion exclusive of the first portion. A first dielectric layer is formed on the semiconductor layer. A plasma nitridation is performed on the first dielectric layer. A first plurality of nanoclusters is formed over the first portion and a second plurality of nanoclusters over the second portion. The second plurality of nanoclusters is removed. A second dielectric layer is formed over the semiconductor layer. A conductive layer is formed over the second dielectric layer.

Abstract translation: 制造半导体器件的方法包括具有半导体层的衬底，该半导体层具有用于非易失性存储器的第一部分和不包括第一部分的第二部分。 在半导体层上形成第一电介质层。 在第一电介质层上进行等离子体氮化。 在第一部分上形成第一多个纳米团簇，并在第二部分上形成第二多个纳米团簇。 第二组纳米团簇被去除。 在半导体层上方形成第二电介质层。 在第二电介质层上形成导电层。

公开(公告)号：US07300780B2

公开(公告)日：2007-11-27

申请号：US10493164

申请日：2002-10-21

Applicant: Cindy Leo ,  Ying Luo ,  Xiang Xu ,  Simon Yu

Inventor： Cindy Leo ,  Ying Luo ,  Xiang Xu ,  Simon Yu

IPC: C12N9/12 ,  C07K1/00

CPC classification number: C12N9/1205 ,  C12Q1/485 ,  G01N33/5041 ,  G01N2500/02

Abstract: The present invention provides compositions and methods for modulating cell proliferation, survival, morphology, and migration. Nucleic adds encoding proteins and proteins so encoded which are capable of modulating proliferation, survival, morphology and migration in mammalian cells are provided. Compositions and methods for the treatment of disorders related to cell proliferation, survival, morphology and migration are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating proliferation, survival, morphology and migration in mammalian cells.

Abstract translation: 本发明提供调节细胞增殖，存活，形态和迁移的组合物和方法。 核酸添加编码蛋白质和如此编码的蛋白质，其能够调节哺乳动物细胞中的增殖，存活，形态和迁移。 还提供了用于治疗与细胞增殖，存活，形态和迁移相关的病症的组合物和方法。 还提供了预防和预防这种疾病的方法。 还提供了用于诊断和预测这些疾病的组合物和方法。 还提供了用于鉴定能够调节哺乳动物细胞中增殖，存活，形态和迁移的生物活性剂的测定。

公开(公告)号：US07122630B1

公开(公告)日：2006-10-17

申请号：US10088960

申请日：2000-09-25

Applicant: Ying Luo ,  Helena Mancebo

Inventor： Ying Luo ,  Helena Mancebo

IPC: C07K14/00 ,  C12N15/00 ,  C12N15/12 ,  C12N15/63 ,  C07H21/04

CPC classification number: C07K14/47

Abstract: The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

Abstract translation: 本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。

公开(公告)号：US20060228761A1

公开(公告)日：2006-10-12

申请号：US11295841

申请日：2005-12-06

Applicant: Ying Luo ,  Pei Yu ,  Mary Shen ,  Betty Huang

Inventor： Ying Luo ,  Pei Yu ,  Mary Shen ,  Betty Huang

IPC: G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C40B30/06 ,  C07K14/82 ,  C07K16/30

CPC classification number: C12N9/1205 ,  C07K14/4738 ,  C07K16/18

Abstract: The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

公开(公告)号：US07001852B2

公开(公告)日：2006-02-21

申请号：US10836149

申请日：2004-04-30

Applicant: Tien-Ying Luo ,  Olubunmi O. Adetutu ,  Hsing-Huang Tseng

Inventor： Tien-Ying Luo ,  Olubunmi O. Adetutu ,  Hsing-Huang Tseng

IPC: H01L21/31

CPC classification number: H01L21/02255 ,  H01L21/02299 ,  H01L21/28185 ,  H01L21/28194 ,  H01L21/28202 ,  H01L21/28211 ,  H01L21/3141 ,  H01L21/31645 ,  H01L29/513

Abstract: A method of making a high quality thin dielectric layer includes annealing a substrate and a base oxide layer overlying a top surface of the substrate at a first temperature in a first ambient and annealing the substrate and base oxide layer at a second temperature in a second ambient subsequent to the first anneal. The first ambient includes an inert gas ambient selected from the group consisting of a nitrogen, argon, and helium ambient. Prior to the first anneal, the base oxide layer has an initial thickness and an initial density. The first anneal causes a first density and thickness change in the base oxide layer from the initial thickness and density to a first thickness and density, with no incorporation of nitrogen, argon, or helium of the ambient within the base oxide layer. The first thickness is less than the initial thickness and the first density is greater than the initial density. The second anneal causes a second density and thickness change in the base oxide layer from the first thickness and density to a second thickness and density. The second thickness is larger than the first thickness and the second density is on the order of the greater than or equal to the first density.

Abstract translation: 制造高品质薄介电层的方法包括在第一环境中的第一温度下对衬底和覆盖在衬底的顶表面上的基底氧化物层进行退火，并在第二环境中的第二温度退火衬底和基底氧化物层 在第一退火之后。 第一环境包括选自氮，氩和氦环境的惰性气体环境。 在第一退火之前，基底氧化物层具有初始厚度和初始密度。 第一次退火使基底氧化物层中的初始密度和厚度变化从初始厚度和密度到第一厚度和密度，而不会在基底氧化物层内引入环境的氮，氩或氦。 第一厚度小于初始厚度，第一密度大于初始密度。 第二退火导致基础氧化物层中的第二密度和厚度从第一厚度和密度变化到第二厚度和密度。 第二厚度大于第一厚度，第二密度大于或等于第一密度。