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公开(公告)号：US10065920B2
公开(公告)日：2018-09-04
申请号：US15885387
申请日：2018-01-31
IPC分类号： C07C215/42
摘要： The present invention is generally directed to novel crystalline forms of the acetate salt of (1S,3S,4R)-4-((3aS,4R,5S,7aS)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1H-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol and processes for their preparation.
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公开(公告)号：US10053415B2
公开(公告)日：2018-08-21
申请号：US15411863
申请日：2017-01-20
IPC分类号： C07C209/30
CPC分类号： C07C209/30 , C07B2200/07 , C07C213/00 , C07C249/12 , C07C2601/14 , C07C2602/02 , C07C2602/24 , C07D307/77 , C07D317/70 , C07D317/72 , C07J1/0011 , C07J1/0022 , C07J13/007 , C07J21/008 , C07J31/006 , C07J51/00 , C07J71/0026 , C07J73/003 , C07J73/005 , C07C215/42
摘要： This invention is directed to methods of preparing AQX-1125 having the formula: This invention is also directed to intermediates utilized in the methods of preparing AQX-1125.
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公开(公告)号：US20170253596A2
公开(公告)日：2017-09-07
申请号：US14772737
申请日：2014-02-27
IPC分类号： C07D473/34 , C07C215/42 , C07C233/23 , C07D207/335 , C07C311/04 , C07C225/10 , C07D207/06 , C07D213/38 , C07C233/74 , C07D231/12 , C07D249/08 , C07D233/60 , C07D209/08 , C07D317/46 , C07D295/096 , C07D213/64 , C07D239/34 , C07D241/18 , C07C255/31 , C07C275/24 , C07C279/08
CPC分类号： C07D473/34 , C07C35/21 , C07C35/32 , C07C59/46 , C07C62/32 , C07C215/42 , C07C215/50 , C07C215/52 , C07C225/10 , C07C233/18 , C07C233/23 , C07C233/60 , C07C233/74 , C07C235/30 , C07C235/44 , C07C235/46 , C07C235/48 , C07C255/31 , C07C261/04 , C07C275/10 , C07C275/24 , C07C275/34 , C07C279/08 , C07C291/04 , C07C311/04 , C07C335/10 , C07C2602/24 , C07C2603/14 , C07D207/06 , C07D207/08 , C07D207/335 , C07D207/416 , C07D209/08 , C07D213/04 , C07D213/30 , C07D213/36 , C07D213/38 , C07D213/64 , C07D213/81 , C07D213/82 , C07D231/12 , C07D233/60 , C07D233/72 , C07D235/06 , C07D235/14 , C07D239/34 , C07D241/18 , C07D241/28 , C07D249/08 , C07D295/096 , C07D307/68 , C07D317/46 , C07D317/58
摘要： Compounds of formula (I): where R1, R2, R3, R4a, R4b, R5, R6 and R7 are defined herein, or stereoisomers or pharmaceutically acceptable salts thereof, are described herein. Such compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.
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公开(公告)号：US20180085460A1
公开(公告)日：2018-03-29
申请号：US15716322
申请日：2017-09-26
IPC分类号： A61K45/00 , C07C211/60
CPC分类号： A61K45/00 , A61K31/133 , C07C211/60
摘要： This invention is directed to the use of a SHIP1 activator, preferably AQX-1125, to treat prostatitis.
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公开(公告)号：US09765085B2
公开(公告)日：2017-09-19
申请号：US14772731
申请日：2014-02-27
发明人： Lloyd F. Mackenzie , Thomas B. MacRury , Curtis Harwig , David Bogucki , Jeffery R. Raymond , Jeremy D. Pettigrew
IPC分类号： C07D231/54 , A61K31/416 , C07D493/10 , C07D213/75 , C07D213/82 , C07D215/227 , C07C275/22 , C07D221/18 , C07C215/26 , C07C215/38 , C07C335/10 , C07C233/23 , C07D261/20 , C07D277/24 , C07D277/28 , C07C255/30 , C07D211/58 , C07D213/30 , C07D307/42 , C07D333/16 , C07D231/56 , C07D277/64 , C07C35/21 , C07C35/23 , C07D213/38 , C07D221/16 , C07D307/52 , C07D333/20
CPC分类号： C07D493/10 , A61K31/416 , C07C35/21 , C07C35/23 , C07C215/26 , C07C215/38 , C07C233/23 , C07C255/30 , C07C275/22 , C07C335/10 , C07C2601/14 , C07C2602/24 , C07D211/58 , C07D213/30 , C07D213/38 , C07D213/75 , C07D213/82 , C07D215/227 , C07D221/16 , C07D221/18 , C07D231/54 , C07D231/56 , C07D261/20 , C07D277/24 , C07D277/28 , C07D277/64 , C07D307/42 , C07D307/52 , C07D333/16 , C07D333/20
摘要： Compounds of formula (II): wherein A, R1, R2, R5 and R13 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds have activity as SHIP1 modulators, and thus may be useful in treating a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of the invention are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.
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公开(公告)号：US20170247389A2
公开(公告)日：2017-08-31
申请号：US14772731
申请日：2014-02-27
发明人： Lloyd F. Mackenzie , Thomas B. MacRury , Curtis Harwig , David Bogucki , Jeffery R. Raymond , Jeremy D. Pettigrew
IPC分类号： C07D493/10 , C07D211/58 , C07C255/30 , C07D213/75 , C07C275/22 , C07C335/10 , C07D231/54 , C07D215/227 , C07D221/16 , C07C215/38 , C07D307/52 , C07D333/20 , C07D213/38 , C07D277/28 , C07D231/56 , C07D261/20 , C07D277/64 , C07C35/21 , C07C35/23 , C07D307/42 , C07C233/23 , C07D213/82
CPC分类号： C07D493/10 , A61K31/416 , C07C35/21 , C07C35/23 , C07C215/26 , C07C215/38 , C07C233/23 , C07C255/30 , C07C275/22 , C07C335/10 , C07C2601/14 , C07C2602/24 , C07D211/58 , C07D213/30 , C07D213/38 , C07D213/75 , C07D213/82 , C07D215/227 , C07D221/16 , C07D221/18 , C07D231/54 , C07D231/56 , C07D261/20 , C07D277/24 , C07D277/28 , C07D277/64 , C07D307/42 , C07D307/52 , C07D333/16 , C07D333/20
摘要： Compounds of formula (II): wherein R1, R2, R5 and R13 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds have activity as SHIP1 modulators, and thus may be useful in treating a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of the invention are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.
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公开(公告)号：US09540353B2
公开(公告)日：2017-01-10
申请号：US14759622
申请日：2014-01-07
发明人： Lloyd F. Mackenzie , Thomas B. Macrury , Curtis Harwig , David Bogucki , Jeffery R. Raymond , Jeremy D. Pettigrew , Vladimir Khlebnikov , Rudong Shan
IPC分类号： C07D213/82 , C07C49/83 , C07C43/205 , A61K31/44 , A61K31/05 , C07D405/12 , C07C49/835 , C07C43/215 , C07C62/34 , C07D241/24 , C07D213/81 , C07D249/08 , C07D295/112 , C07D213/75 , C07D295/215 , C07D211/66 , C07C311/18 , C07D213/89 , C07D233/64 , C07D401/12 , C07C233/76 , C07D213/38 , C07C39/17 , C07C43/21 , C07C43/23 , C07C49/84 , C07C62/32 , C07C255/47 , C07C275/26 , C07C275/64 , C07C279/16 , C07C311/07 , C07C311/17 , C07C317/22 , C07C217/84 , C07C323/20 , C07C225/20 , C07C233/26 , C07C233/28 , C07C233/31 , C07C233/32 , C07C233/60 , C07C235/82 , C07C237/08
CPC分类号： A61K31/4965 , A61K31/05 , A61K31/085 , A61K31/09 , A61K31/095 , A61K31/10 , A61K31/12 , A61K31/122 , A61K31/135 , A61K31/155 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/192 , A61K31/277 , A61K31/4164 , A61K31/4196 , A61K31/4402 , A61K31/4406 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4465 , A61K31/495 , A61K31/496 , C07B2200/07 , C07C39/17 , C07C43/21 , C07C43/215 , C07C43/23 , C07C49/83 , C07C49/835 , C07C49/84 , C07C62/32 , C07C62/34 , C07C217/84 , C07C225/20 , C07C233/26 , C07C233/28 , C07C233/31 , C07C233/32 , C07C233/60 , C07C233/76 , C07C235/82 , C07C237/08 , C07C255/47 , C07C275/26 , C07C275/64 , C07C279/16 , C07C311/07 , C07C311/17 , C07C311/18 , C07C317/22 , C07C323/20 , C07C2602/28 , C07D211/66 , C07D213/38 , C07D213/75 , C07D213/81 , C07D213/82 , C07D213/89 , C07D233/64 , C07D241/24 , C07D249/08 , C07D295/112 , C07D295/215 , C07D401/12 , C07D405/12
摘要： Compounds of formula (I): where, n, R1, R4a, R4b, R5, R7 and R8 are defined herein, or pharmaceutically acceptable salts thereof, are described herein. The disclosed compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.
摘要翻译： 本文描述式（I）的化合物：其中，n，R1，R4a，R4b，R5，R7和R8如本文所定义，或其药学上可接受的盐。 所公开的化合物具有作为SHIP1调节剂的活性，因此可用于治疗将受益于SHIP1调节的各种疾病，障碍或病症中的任何一种。 还公开了包含式（I）化合物与药学上可接受的载体或稀释剂的组合物，以及通过将这些化合物施用于有此需要的动物的SHIP1调节方法。
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公开(公告)号：US20190023709A1
公开(公告)日：2019-01-24
申请号：US16129586
申请日：2018-09-12
IPC分类号： C07D473/34 , C07C261/04 , C07D233/60 , C07D213/64 , C07C225/10 , C07C233/23 , C07C233/74 , C07D207/06 , C07D213/38 , C07C35/21 , C07C62/32 , C07C59/46 , C07D307/68 , C07D213/36 , C07D213/30 , C07D213/04 , C07D295/096 , C07C255/31 , C07D209/08 , C07D207/416 , C07D207/335 , C07D207/08 , C07C235/48 , C07C235/46 , C07C235/44 , C07C235/30 , C07C233/60 , C07C233/18 , C07C335/10 , C07D249/08 , C07D241/28 , C07D241/18 , C07C215/52 , C07C215/50 , C07C215/42 , C07D239/34 , C07D235/14 , C07D235/06 , C07C311/04 , C07D233/72 , C07D231/12 , C07C291/04 , C07D317/58 , C07D317/46 , C07C279/08 , C07C275/34 , C07C275/24 , C07C275/10 , C07C35/32 , C07D213/82 , C07D213/81
摘要： Compounds of formula (I): where R1, R2, R3, R4a, R4b, R5, R6 and R7 are defined herein, or stereoisomers or pharmaceutically acceptable salts thereof, are described herein. Such compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.
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公开(公告)号：US20180290964A1
公开(公告)日：2018-10-11
申请号：US16008952
申请日：2018-06-14
IPC分类号： C07C215/42
摘要： The present invention is generally directed to methods of using novel crystalline forms of the acetate salt of (1S,3S,4R)-4-((3aS,4R,5S,7aS)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1H-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol and pharmaceutical compositions comprising same.
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公开(公告)号：US20180155273A1
公开(公告)日：2018-06-07
申请号：US15885387
申请日：2018-01-31
IPC分类号： C07C215/42
CPC分类号： C07C215/42 , C07B2200/13 , C07C2601/14 , C07C2602/08 , C07C2602/24
摘要： The present invention is generally directed to novel crystalline forms of the acetate salt of (1S,3S,4R)-4-((3aS,4R,5S,7aS)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1H-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol and processes for their preparation.
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