公开(公告)号：US08220985B2

公开(公告)日：2012-07-17

申请号：US12278311

申请日：2007-02-07

Applicant: Mark Alan Barger ,  Parvinder Singh Walia ,  Matthew T. Bishop ,  Anthony Charles Neubauer ,  Joseph Dooley ,  Shih-Yaw Lai ,  Luciana Rudolph

Inventor： Mark Alan Barger ,  Parvinder Singh Walia ,  Matthew T. Bishop ,  Anthony Charles Neubauer ,  Joseph Dooley ,  Shih-Yaw Lai ,  Luciana Rudolph

IPC: B01F11/00

CPC classification number: G01N1/38 ,  B01F3/10 ,  B01F7/00258 ,  B01F11/0082 ,  B01F11/0085 ,  B01F15/00019 ,  B01F15/00058 ,  B01F15/0279 ,  B01F2015/0009 ,  B01F2015/00103 ,  B01J2219/00315 ,  B01J2219/00353 ,  B01J2219/0036 ,  B01J2219/00418 ,  B01J2219/00481 ,  B01J2219/00486 ,  G01N2011/0046

Abstract: The invention is a device for processing materials comprising a mixing chamber having a valve for removal of the material from the mixing chamber and a piston which fits within the mixing chamber in a manner such that the piston can be moved to remove substantially all material from the mixing chamber via the valve; at least one, preferably at least two, retractable mixing element(s) wherein each of such elements is movable in and out of the mixing chamber through a port wherein the element and port are configured such that during mixing and when the element is withdrawn from the mixing chamber substantially no material is removed from the mixing chamber via the port. The invention is also a method of using such a device and a system comprising use of such devices in an automated or partially automated array.

Abstract translation: 本发明是用于处理材料的装置，其包括具有用于从混合室移除材料的阀的混合室和以这样的方式装配在混合室内的活塞，使得可以移动活塞以将基本上所有的材料从 混合室通过阀门; 至少一个，优选至少两个，可缩回的混合元件，其中每个这样的元件可以通过端口移动和移出混合室，其中元件和端口构造成使得在混合期间以及当元件从 混合室基本上没有材料通过端口从混合室中移出。 本发明还是一种使用这种装置和系统的方法，所述装置和系统包括在自动化或部分自动化的阵列中使用这种装置。

公开(公告)号：US07521023B2

公开(公告)日：2009-04-21

申请号：US10777014

申请日：2004-02-11

Applicant: James A. Laugharn, Jr. ,  Brevard S. Garrison

Inventor： James A. Laugharn, Jr. ,  Brevard S. Garrison

IPC: B06B1/00 ,  B01F11/02

CPC classification number: B01F13/0277 ,  B01F11/02 ,  B01F11/0283 ,  B01F13/0059 ,  B01F13/0222 ,  B01F15/00175 ,  B01F15/00285 ,  B01F2215/0427 ,  B01F2215/0431 ,  B01F2215/045 ,  B01F2215/0454 ,  B01F2215/0468 ,  B01F2215/0477 ,  B01J2219/00317 ,  B01J2219/00486 ,  B01J2219/00659 ,  C12M35/04 ,  C40B60/14 ,  G01N2035/00554 ,  G01N2291/02836 ,  G01N2291/02872 ,  G01N2291/02881

Abstract: Apparatus and methods are disclosed for treating a sample by selectively controlling sonic energy and/or selectively controlling the location of the sample relative to the sonic energy.

Abstract translation: 公开了用于通过选择性地控制声能和/或选择性地控制样品相对于声能的位置来处理样品的装置和方法。

公开(公告)号：US07311885B2

公开(公告)日：2007-12-25

申请号：US10861628

申请日：2004-06-04

Applicant: Anton John Nagy ,  Peter John van den Brink ,  Bashir Husein Harji

Inventor： Anton John Nagy ,  Peter John van den Brink ,  Bashir Husein Harji

IPC: B01J8/04

CPC classification number: B01J19/0046 ,  B01J2219/00038 ,  B01J2219/00283 ,  B01J2219/00337 ,  B01J2219/00389 ,  B01J2219/00477 ,  B01J2219/00479 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00486 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00698 ,  B01J2219/0072 ,  C40B60/14

Abstract: A batch reaction system for simultaneously conducting reactions in at least two separate reactors (CSTR reactors), is provided wherein the at least two batch reactors, containing mixing means and a fluid inlet, a fluid feed common conduit is present for feed fluid to the reactors, which is connected to the inlet of each reactor of a fluid inlet conduits, and further includes a fluid discharge common conduit which is connected to the outlet of each reactor wherein in each fluid inlet conduit and/or in each fluid outlet conduit a non-return valve is arranged to prevent contamination but can provide simultaneous reactions wherein the reactors can be easily isolated from one another during reaction.

Abstract translation: 提供了用于在至少两个分离的反应器（CSTR反应器）中同时进行反应的间歇反应系统，其中存在含有混合装置和流体入口的至少两个间歇反应器，用于将流体馈送到反应器 ，其连接到流体入口管道的每个反应器的入口，并且还包括流体排放公共管道，其连接到每个反应器的出口，其中在每个流体入口管道和/或每个流体出口管道中， 排气阀布置成防止污染，但可以提供同时的反应，其中反应器可以在反应期间彼此容易地彼此分离。

公开(公告)号：US07108970B2

公开(公告)日：2006-09-19

申请号：US09994585

申请日：2001-11-27

Applicant: Douglas Levinson

Inventor： Douglas Levinson

IPC: C12Q1/68

CPC classification number: C12Q1/18 ,  B01J2219/00315 ,  B01J2219/00351 ,  B01J2219/00484 ,  B01J2219/00486 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00698 ,  B01J2219/00707 ,  B01J2219/0072 ,  B01J2219/00756 ,  G01N33/543

Abstract: The invention concerns arrays comprising hundreds, thousands, to hundreds of thousands of samples and methods for screening thereof. These methods are useful to optimize, select, and discover compounds, compositions, or conditions that prevent, inhibit, induce, modify, or reverse physical-state transitions, particularly in-vivo physical-state transitions relating to disease causing processes. Such compounds, compositions, or conditions can be exploited to treat (e.g., reverse) or prevent the disease itself, the cause of the disease, or the symptoms of the disease.

公开(公告)号：US20050142664A1

公开(公告)日：2005-06-30

申请号：US11017095

申请日：2004-12-20

Applicant: Gregory Loney

Inventor： Gregory Loney

IPC: B01F11/02 ,  B01F13/00 ,  B01L3/00 ,  C40B60/14 ,  G01N33/543 ,  G01N35/00 ,  G01N1/00

CPC classification number: B01F11/0266 ,  B01F11/004 ,  B01F13/0059 ,  B01J2219/00484 ,  B01J2219/00486 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01L3/50273 ,  B01L2300/022 ,  B01L2300/0636 ,  B01L2400/0484 ,  C40B60/14 ,  G01N33/54373 ,  G01N2035/00158 ,  G01N2035/00524 ,  Y10T436/25

Abstract: In one embodiment a method of mixing fluid is described that comprises providing a vibration comprising a resonant frequency; sympathetically amplifying the vibration in response to the resonant frequency; and modulating the resonant frequency, to cause the amplified vibration to generate turbulent flow in a fluid that influences the likelihood of interaction between a target molecule in the fluid with a probe on a biological probe array.

Abstract translation: 在一个实施例中，描述了混合流体的方法，其包括提供包括谐振频率的振动; 响应谐振频率同时放大振动; 并调制谐振频率，使放大的振动在流体中产生湍流，这影响流体中的目标分子与生物探针阵列上的探针之间的相互作用的可能性。

公开(公告)号：US20020098518A1

公开(公告)日：2002-07-25

申请号：US09994585

申请日：2001-11-27

Inventor： Douglas Levinson

IPC: G01N033/53 ,  C12M001/34

CPC classification number: C12Q1/18 ,  B01J2219/00315 ,  B01J2219/00351 ,  B01J2219/00484 ,  B01J2219/00486 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00698 ,  B01J2219/00707 ,  B01J2219/0072 ,  B01J2219/00756 ,  G01N33/543

Abstract: The invention concerns arrays comprising hundreds, thousands, to hundreds of thousands of samples and methods for screening thereof. These methods are useful to optimize, select, and discover compounds, compositions, or conditions that prevent, inhibit, induce, modify, or reverse physical-state transitions, particularly in-vivo physical-state transitions relating to disease causing processes. Such compounds, compositions, or conditions can be exploited to treat (e.g., reverse) or prevent the disease itself, the cause of the disease, or the symptoms of the disease.

Abstract translation: 本发明涉及包括数百个，数千个到数十万个样品的阵列和用于筛选的样品。 这些方法可用于优化，选择和发现预防，抑制，诱导，改变或逆转物理状态转换，特别是与疾病引发过程相关的体内物理状态转换的化合物，组合物或病症。 可以利用这些化合物，组合物或病症来治疗（例如逆转）或预防疾病本身，疾病的病因或疾病的症状。

公开(公告)号：US06277332B1

公开(公告)日：2001-08-21

申请号：US09049245

申请日：1998-03-27

Applicant: Irving Sucholeiki

Inventor： Irving Sucholeiki

IPC: B01F1102

CPC classification number: B01F11/0283 ,  B01F13/0809 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00328 ,  B01J2219/00351 ,  B01J2219/00414 ,  B01J2219/00454 ,  B01J2219/00459 ,  B01J2219/00486 ,  B01J2219/00495 ,  B01J2219/005 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00686 ,  B01J2219/00691 ,  B01J2219/0072 ,  B01J2219/00725 ,  B06B3/02 ,  C07K1/042 ,  C07K1/045 ,  C40B40/10 ,  C40B50/14 ,  C40B60/14 ,  Y10T436/113332

Abstract: The inventive apparatus is comprised of a means for producing cavitation in a complex reaction mixture to enhance the yield of the selected reaction product, a means for controlling the temperature of the complex reaction mixture, especially during cavitation, and a means for affecting magnetic separation of paramagnetic beads to which the selected reaction product is attached from the complex reaction mixture. In one embodiment, the compound(s) or molecule(s) is synthesized in situ, and isolated using the inventive apparatus. The apparatus finds use in the fields of solid phase organic synthesis, and for isolation and purification of a selected compound(s) or molecule (s), especially where automation is desired.

Abstract translation: 本发明的装置包括用于在复合反应混合物中产生空化以提高所选择的反应产物的产率的装置，特别是在空化期间控制复合反应混合物的温度的手段和用于影响磁分离的装置 选择的反应产物从复合反应混合物连接到其上的顺磁珠。 在一个实施方案中，化合物或分子原位合成，并使用本发明的装置分离。 该装置用于固相有机合成领域，并用于选择的化合物或分子的分离和纯化，特别是在需要自动化的情况下。

公开(公告)号：US20150166979A1

公开(公告)日：2015-06-18

申请号：US14634042

申请日：2015-02-27

Applicant: Covaris, Inc.

Inventor： James A. Laugharn, JR.

IPC: C12N13/00

CPC classification number: C12N13/00 ,  B01F11/0283 ,  B01J2219/00308 ,  B01J2219/00344 ,  B01J2219/00486 ,  B01J2219/00722 ,  B01J2219/0074 ,  G01N1/286 ,  G01N2035/00554

Abstract: Method and apparatus for controlling acoustic treatment of a sample including a liquid. A processing volume in which the sample is acoustically treated may be controlled, e.g., by positioning a suitable element so as to reduce and/or eliminate a headspace size at a sample/gas interface. An interaction between the acoustic energy and the sample may be controlled, e.g., by using a headspace control element positioned at least partially in the sample that helps to reduce splashing or other sample ejection that would otherwise occur.

Abstract translation: 用于控制包括液体的样品的声学处理的方法和装置。 可以例如通过定位合适的元件来控制样品进行声学处理的处理体积，以减少和/或消除样品/气体界面处的顶空尺寸。 可以例如通过使用至少部分定位在样品中的顶空控制元件来控制声能和样品之间的相互作用，所述顶空控制元件有助于减少否则会发生的飞溅或其它样品喷射。

公开(公告)号：US08691723B2

公开(公告)日：2014-04-08

申请号：US10567029

申请日：2004-07-30

Applicant: Hartmut Hibst ,  Frieder Borgmeier ,  Martin Dieterle

Inventor： Hartmut Hibst ,  Frieder Borgmeier ,  Martin Dieterle

IPC: C01B31/08

CPC classification number: B01J19/2415 ,  B01J19/0046 ,  B01J19/10 ,  B01J19/18 ,  B01J23/002 ,  B01J27/0576 ,  B01J2219/00033 ,  B01J2219/0004 ,  B01J2219/00126 ,  B01J2219/00128 ,  B01J2219/00286 ,  B01J2219/00353 ,  B01J2219/00391 ,  B01J2219/00479 ,  B01J2219/00486 ,  B01J2219/00495 ,  B01J2219/0059 ,  B01J2219/00599 ,  B01J2219/00689 ,  B01J2219/00707 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2523/00 ,  C40B30/08 ,  C40B40/18 ,  C40B50/08 ,  C40B60/14 ,  B01J2523/55 ,  B01J2523/56 ,  B01J2523/64 ,  B01J2523/68

Abstract: The sequential production of a library of N different solids, in particular heterogeneous catalysts, where N within a day is an integer of at least 2, is performed by a) producing at least two different sprayable solutions, emulsions and/or dispersions of elements and/or element compounds of the chemical elements present in the catalyst and optionally of dispersions of inorganic support materials, b) continuously metering the at least two different solutions, emulsions and/or dispersions in a predefined ratio into a mixing apparatus in which the solutions, emulsions and/or dispersions are homogeneously mixed, c) continuously drying the mixture removed from the mixing apparatus and recovering the dried mixture, d) changing the ratios in step b) and repeating steps b), c) and d) (N−1) times until N different dried mixtures are obtained, e) optionally shaping and optionally calcining the mixtures to give the solids.

Abstract translation: 通过a）产生N种不同固体，特别是非均相催化剂的文库，其中N在一天内是至少2的整数，其通过a）产生至少两种不同的可喷雾溶液，元素的乳液和/或分散体，以及 存在于催化剂中的化学元素的元素化合物和任选的无机载体材料的分散体，b）将预定比例的至少两种不同溶液，乳液和/或分散体连续计量成混合设备，其中溶液， 乳液和/或分散体均匀混合，c）连续干燥从混合装置中除去的混合物并回收干燥的混合物，d）改变步骤b）中的比例并重复步骤b），c）和d）（N-1 ），直到获得N种不同的干燥混合物，e）任选地成型和任选地煅烧混合物以得到固体。

公开(公告)号：US08449171B2

公开(公告)日：2013-05-28

申请号：US11910420

申请日：2006-04-07

Applicant: Paul Mun Foo Tho ,  Richard Manasseh ,  Yonggang Zhu ,  Guy Metcalfe

Inventor： Paul Mun Foo Tho ,  Richard Manasseh ,  Yonggang Zhu ,  Guy Metcalfe

IPC: B01F11/02

CPC classification number: B01F11/02 ,  B01F11/0266 ,  B01F13/0059 ,  B01J2219/00486 ,  B01J2219/00889 ,  B01L3/5085

Abstract: A method of mixing (10), including: providing a fluid (10) in a well (6) so as to establish an acoustic field gradient; and applying an acoustic signal to cause mixing within a fluid (3).

Abstract translation: 一种混合（10）的方法，包括：在井（6）中提供流体（10）以便建立声场梯度; 以及施加声信号以在流体（3）内引起混合。