专利检索 ap:"James L. Winkler" 第 3 页

21.

发明授权
Computer-aided engineering system for design of sequence arrays and lithographic masks 失效
标题翻译：用于设计序列阵列和光刻掩模的计算机辅助工程系统

公开(公告)号：US5856101A

公开(公告)日：1999-01-05

申请号：US721689

申请日：1996-09-27

申请人： Earl A. Hubbell , MacDonald S. Morris , James L. Winkler

发明人： Earl A. Hubbell , MacDonald S. Morris , James L. Winkler

IPC分类号： B01J19/00 , C07B61/00 , C07K1/04 , C40B40/06 , C40B60/14 , G03F1/00 , C12Q1/68 , C12M1/34 , C12M3/04

CPC分类号： B82Y30/00 , B01J19/0046 , C07K1/04 , C07K1/045 , B01J2219/00432 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00693 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , C40B40/06 , C40B60/14

摘要： An improved set of computer tools for forming arrays. According to one aspect of the invention, a computer system (100) is used to select probes and design the layout of an array of DNA or other polymers with certain beneficial characteristics. According to another aspect of the invention, a computer system uses chip design files (104) to design and/or generate lithographic masks (110).

摘要翻译： 一组改进的用于形成阵列的计算机工具。根据本发明的一个方面，计算机系统（100）用于选择探针并设计具有某些有益特征的DNA或其它聚合物阵列的布局。根据本发明的另一方面，计算机系统使用芯片设计文件（104）来设计和/或生成光刻掩模（110）。

22.

发明授权
Printing molecular library arrays using deprotection agents solely in the vapor phase 失效
标题翻译：使用去保护剂仅在气相中印刷分子库阵列

公开(公告)号：US5599695A

公开(公告)日：1997-02-04

申请号：US395604

申请日：1995-02-27

申请人： R. Fabian Pease , Glenn McGall , Martin J. Goldberg , Richard P. Rava , Stephen P. A. Fodor , Virginia Goss , Lubert Stryer , James L. Winkler

发明人： R. Fabian Pease , Glenn McGall , Martin J. Goldberg , Richard P. Rava , Stephen P. A. Fodor , Virginia Goss , Lubert Stryer , James L. Winkler

IPC分类号： B01J19/00 , B41M3/00 , C07H21/00 , C40B40/06 , C40B50/14 , C40B60/14 , G03F7/00 , C12P19/34 , C07H21/02 , C07K5/00 , G01N33/543

CPC分类号： C07H21/00 , B01J19/0046 , G03F7/00 , B01J2219/00378 , B01J2219/00382 , B01J2219/00385 , B01J2219/00427 , B01J2219/00454 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00639 , B01J2219/00659 , B01J2219/00722 , B41M3/00 , C40B40/06 , C40B50/14 , C40B60/14

摘要： A method and apparatus for selectively applying a print material onto a substrate for the synthesis of an array of oligonucleotides at selected regions of a substrate. The print material includes a barrier material, a monomer sequence, a nucleoside, a deprotection agent, a carrier material, among other materials. The method and apparatus also relies upon standard DMT based chemistry, and a vapor phase deprotection agent such as solid TCA and the like.

摘要翻译： 一种用于选择性地将印刷材料施加到基底上以在基底的选定区域合成寡核苷酸阵列的方法和装置。印刷材料包括阻挡材料，单体序列，核苷，去保护剂，载体材料等。该方法和装置还依赖于基于标准的基于DMT的化学，以及气相脱保护剂如固体TCA等。

23.

发明授权
Computer-aided engineering system for design of sequence arrays and lithographic masks 失效
标题翻译：用于设计序列阵列和光刻掩模的计算机辅助工程系统

公开(公告)号：US5593839A

公开(公告)日：1997-01-14

申请号：US460411

申请日：1995-06-02

申请人： Earl A. Hubbell , Robert J. Lipshutz , Macdonald S. Morris , James L. Winkler

发明人： Earl A. Hubbell , Robert J. Lipshutz , Macdonald S. Morris , James L. Winkler

IPC分类号： B01J19/00 , C07B61/00 , C07K1/04 , C40B40/06 , C40B60/14 , G03F1/00 , C12Q1/68 , C07H21/04 , G03F9/00

CPC分类号： B82Y30/00 , B01J19/0046 , C07K1/04 , C07K1/045 , B01J2219/00432 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00693 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , C40B40/06 , C40B60/14

摘要： An improved set of computer tools for forming arrays. According to one aspect of the invention, a computer system is used to select probes and design the layout of an array of DNA or other polymers with certain beneficial characteristics. According to another aspect of the invention, a computer system uses chip design files to design and/or generate lithographic masks.

摘要翻译： 一组改进的用于形成阵列的计算机工具。根据本发明的一个方面，计算机系统用于选择探针并设计具有某些有益特征的DNA或其它聚合物阵列的布局。根据本发明的另一方面，计算机系统使用芯片设计文件来设计和/或生成光刻掩模。

24.

发明授权
Computer-aided engineering system for design of sequence arrays and lithographic masks 失效

公开(公告)号：US5571639A

公开(公告)日：1996-11-05

申请号：US249188

申请日：1994-05-24

申请人： Earl A. Hubbell , MacDonald S. Morris , James L. Winkler

发明人： Earl A. Hubbell , MacDonald S. Morris , James L. Winkler

IPC分类号： B01J19/00 , C07B61/00 , C07K1/04 , C40B40/06 , C40B60/14 , G03F1/00 , G03F7/26 , C12Q1/68 , G03C5/00

CPC分类号： B82Y30/00 , B01J19/0046 , C07K1/04 , C07K1/045 , B01J2219/00432 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00693 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , C40B40/06 , C40B60/14

摘要： An improved set of computer tools for forming arrays. According to one aspect of the invention, a computer system (100) is used to select probes and design the layout of an array of DNA or other polymers with certain beneficial characteristics. According to another aspect of the invention, a computer system uses chip design files (104) to design and/or generate lithographic masks (110).

25.

发明申请
BIOARRAY CHIP REACTION APPARATUS AND ITS MANUFACTURE 审中-公开
标题翻译：生物芯片反应装置及其制造

公开(公告)号：US20090143249A1

公开(公告)日：2009-06-04

申请号：US12265048

申请日：2008-11-05

申请人： Donald M. Besemer , Virginia W. Goss , James L. Winkler

发明人： Donald M. Besemer , Virginia W. Goss , James L. Winkler

IPC分类号： C40B50/08

CPC分类号： B01L3/502715 , B01F13/0059 , B01F13/02 , B01F13/08 , B01J19/0046 , B01J2219/00371 , B01J2219/00432 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/0054 , B01J2219/00547 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00662 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L3/5027 , B01L3/502707 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2200/12 , B01L2300/0636 , B01L2300/0816 , B01L2300/0825 , B01L2300/0877 , B01L2400/0487 , B82Y30/00 , C07H21/00 , C12Q1/6874 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C40B70/00 , G01N33/543 , G01N33/54366 , G01N2035/00158 , Y10S435/97 , Y10S435/973 , Y10S436/809 , Y10T436/112499

摘要： A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the cavity to contact the probes. Accordingly, a commercially feasible device for use in high throughput assay systems is provided.

摘要翻译： 具有空腔310的主体300，其具有根据美国专利No. 提供了第5,143,854号和PCT WO 92/10092等。空腔包括用于将选定流体引入空腔中以接触探针的入口350和360。因此，提供了用于高通量测定系统的商业上可行的装置。

26.

发明授权
System for microvolume laser scanning cytometry 失效
标题翻译：微体积激光扫描细胞计数系统

公开(公告)号：US07336812B2

公开(公告)日：2008-02-26

申请号：US10771585

申请日：2004-02-03

申请人： Louis J Dietz , Ian Walton , Chih-Hua Chung , Scott Norton , James L Winkler , Aaron B Kantor , Byron Lee , Shalom Tsur

发明人： Louis J Dietz , Ian Walton , Chih-Hua Chung , Scott Norton , James L Winkler , Aaron B Kantor , Byron Lee , Shalom Tsur

IPC分类号： G06K9/00 , G06K9/46 , G06K99/66 , G06K9/38

CPC分类号： G01N15/1475

摘要： The present invention provides an improved integrated system for biological marker identification. The system uses Microvolume Laser Scanning Microscopy (MLSC) in order to measure patterns of expression of biological markers in biological fluids. The system includes improved instrumentation for performing MLSC, and also includes improved particle detection and analysis methods. The system further comprises an informatics architecture for the analysis of data obtained from the MLSC in tandem with other medical information.

摘要翻译： 本发明提供了用于生物标志物鉴定的改进的集成系统。该系统使用微量激光扫描显微镜（MLSC）来测量生物液体中生物标志物的表达模式。该系统包括用于执行MLSC的改进仪器，还包括改进的粒子检测和分析方法。该系统还包括用于分析从MLSC获得的数据与其他医疗信息的信息架构。

27.

发明授权
Methods for mixing fluid in a rotating container 有权
标题翻译：将流体混合在旋转容器中的方法

公开(公告)号：US07125161B2

公开(公告)日：2006-10-24

申请号：US10727877

申请日：2003-12-03

申请人： James L. Winkler , Mark Chee , David Lockhart

发明人： James L. Winkler , Mark Chee , David Lockhart

IPC分类号： B01F11/00

CPC分类号： B01J19/28 , B01F9/0021 , B01J2219/00488 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/00659 , B01J2219/00722 , C40B40/06 , C40B60/14 , Y10S435/809

摘要： The invention provides exemplary devices, systems and methods for mixing of fluids, such as biological fluids. One exemplary device comprises is particularly adapted for holding at least one cartridge having a chamber containing a biological fluid, with the chamber having a generally planar face. The device comprises a rotatable body having a rotational axis. The rotatable body includes at least one mounting element which is adapted to mount the rotatable body such that the face of the chamber is generally perpendicular to the rotational axis.

摘要翻译： 本发明提供了用于混合流体例如生物流体的示例性装置，系统和方法。一个示例性装置包括特别适用于保持具有包含生物流体的腔室的至少一个筒，该腔室具有大致平坦的面。该装置包括具有旋转轴线的可转动体。可旋转主体包括至少一个安装元件，该安装元件适于安装可旋转主体，使得腔室的表面大致垂直于旋转轴线。