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1.发明授权Computer-aided engineering system for design of sequence arrays and lithographic masks 失效用于设计序列阵列和光刻掩模的计算机辅助工程系统
公开(公告)号：US5856101A
公开(公告)日：1999-01-05
申请号：US721689
申请日：1996-09-27
IPC分类号： B01J19/00 , C07B61/00 , C07K1/04 , C40B40/06 , C40B60/14 , G03F1/00 , C12Q1/68 , C12M1/34 , C12M3/04
CPC分类号： B82Y30/00 , B01J19/0046 , C07K1/04 , C07K1/045 , B01J2219/00432 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00693 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , C40B40/06 , C40B60/14
摘要： An improved set of computer tools for forming arrays. According to one aspect of the invention, a computer system (100) is used to select probes and design the layout of an array of DNA or other polymers with certain beneficial characteristics. According to another aspect of the invention, a computer system uses chip design files (104) to design and/or generate lithographic masks (110).
摘要翻译： 一组改进的用于形成阵列的计算机工具。 根据本发明的一个方面，计算机系统（100）用于选择探针并设计具有某些有益特征的DNA或其它聚合物阵列的布局。 根据本发明的另一方面，计算机系统使用芯片设计文件（104）来设计和/或生成光刻掩模（110）。
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2.发明授权Computer-aided engineering system for design of sequence arrays and lithographic masks 失效用于设计序列阵列和光刻掩模的计算机辅助工程系统
公开(公告)号：US5593839A
公开(公告)日：1997-01-14
申请号：US460411
申请日：1995-06-02
IPC分类号： B01J19/00 , C07B61/00 , C07K1/04 , C40B40/06 , C40B60/14 , G03F1/00 , C12Q1/68 , C07H21/04 , G03F9/00
CPC分类号： B82Y30/00 , B01J19/0046 , C07K1/04 , C07K1/045 , B01J2219/00432 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00693 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , C40B40/06 , C40B60/14
摘要： An improved set of computer tools for forming arrays. According to one aspect of the invention, a computer system is used to select probes and design the layout of an array of DNA or other polymers with certain beneficial characteristics. According to another aspect of the invention, a computer system uses chip design files to design and/or generate lithographic masks.
摘要翻译： 一组改进的用于形成阵列的计算机工具。 根据本发明的一个方面，计算机系统用于选择探针并设计具有某些有益特征的DNA或其它聚合物阵列的布局。 根据本发明的另一方面，计算机系统使用芯片设计文件来设计和/或生成光刻掩模。
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公开(公告)号：US5571639A
公开(公告)日：1996-11-05
申请号：US249188
申请日：1994-05-24
IPC分类号： B01J19/00 , C07B61/00 , C07K1/04 , C40B40/06 , C40B60/14 , G03F1/00 , G03F7/26 , C12Q1/68 , G03C5/00
CPC分类号： B82Y30/00 , B01J19/0046 , C07K1/04 , C07K1/045 , B01J2219/00432 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00693 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , C40B40/06 , C40B60/14
摘要： An improved set of computer tools for forming arrays. According to one aspect of the invention, a computer system (100) is used to select probes and design the layout of an array of DNA or other polymers with certain beneficial characteristics. According to another aspect of the invention, a computer system uses chip design files (104) to design and/or generate lithographic masks (110).
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公开(公告)号：US07736906B2
公开(公告)日：2010-06-15
申请号：US10172939
申请日：2002-06-17
申请人： James L. Winkler , Stephen P. A. Fodor , Christopher J. Buchko , Debra A. Ross , Lois Aldwin , Douglas N. Modlin
发明人： James L. Winkler , Stephen P. A. Fodor , Christopher J. Buchko , Debra A. Ross , Lois Aldwin , Douglas N. Modlin
IPC分类号： G01N1/28
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00364 , B01J2219/00367 , B01J2219/00369 , B01J2219/00378 , B01J2219/00389 , B01J2219/00416 , B01J2219/0043 , B01J2219/00432 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00686 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07H21/00 , C07K1/045 , C07K1/047 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1072 , Y10S436/809 , Y10T436/143333 , Y10T436/25 , Y10T436/255 , Y10T436/2575
摘要： A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodologies.
摘要翻译： 一种用于在基底（401）上形成大量聚合物阵列的方法和装置。 根据本发明的优选方面，衬底与其中具有通道（409）的通道块（407）接触。 所选择的试剂通过通道输送，基底通过旋转阶段（403）旋转，并且重复该过程以在基底上形成聚合物阵列。 该方法可以与光定向方法组合。
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公开(公告)号：US07691330B1
公开(公告)日：2010-04-06
申请号：US09579982
申请日：2000-05-26
申请人： James L. Winkler , Stephen P. A. Fodor , Christopher J. Buchko , Debra A. Ross , Lois Aldwin , Douglas N. Modlin
发明人： James L. Winkler , Stephen P. A. Fodor , Christopher J. Buchko , Debra A. Ross , Lois Aldwin , Douglas N. Modlin
IPC分类号： B01L3/02
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00364 , B01J2219/00367 , B01J2219/00369 , B01J2219/00378 , B01J2219/00389 , B01J2219/00416 , B01J2219/0043 , B01J2219/00432 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00686 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07H21/00 , C07K1/045 , C07K1/047 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1072 , Y10S436/809 , Y10T436/143333 , Y10T436/25 , Y10T436/255 , Y10T436/2575
摘要： A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.
摘要翻译： 一种用于在基底（401）上形成大量聚合物阵列的方法和装置。 根据本发明的优选方面，衬底与其中具有通道（409）的通道块（407）接触。 所选择的试剂通过通道输送，基底通过旋转阶段（403）旋转，并且重复该过程以在基底上形成聚合物阵列。 该方法可以与光导方法组合。
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公开(公告)号：US06705754B2
公开(公告)日：2004-03-16
申请号：US10062431
申请日：2002-01-30
申请人： James L. Winkler , Mark Chee , David Lockhart
发明人： James L. Winkler , Mark Chee , David Lockhart
IPC分类号： B01F1100
CPC分类号： B01J19/28 , B01F9/0021 , B01J2219/00488 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/00659 , B01J2219/00722 , C40B40/06 , C40B60/14 , Y10S435/809
摘要： The invention provides exemplary devices, systems and methods for mixing of fluids, such as biological fluids. One exemplary device comprises is particularly adapted for holding at least one cartridge having a chamber containing a biological fluid, with the chamber having a generally planar face. The device comprises a rotatable body having a rotational axis. The rotatable body includes at least one mounting element which is adapted to mount the rotatable body such that the face of the chamber is generally perpendicular to the rotational axis.
摘要翻译： 本发明提供了用于混合流体例如生物流体的示例性装置，系统和方法。 一个示例性装置包括特别适用于保持具有包含生物流体的腔室的至少一个筒，该腔室具有大致平坦的面。 该装置包括具有旋转轴线的可转动体。 可旋转主体包括至少一个安装元件，该安装元件适于安装可旋转主体，使得腔室的表面大致垂直于旋转轴线。
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公开(公告)号：US5489678A
公开(公告)日：1996-02-06
申请号：US390272
申请日：1995-02-16
申请人： Stephen P. A. Fodor , Lubert Stryer , James L. Winkler , Christopher P. Holmes , Dennis W. Solas
发明人： Stephen P. A. Fodor , Lubert Stryer , James L. Winkler , Christopher P. Holmes , Dennis W. Solas
IPC分类号： B01J19/00 , C07B61/00 , C07C229/14 , C07C229/16 , C07D263/44 , C07D317/62 , C07H19/04 , C07H19/10 , C07H21/00 , C07K1/04 , C07K1/06 , C07K7/06 , C07K17/06 , C07K17/14 , C08F2/46 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/14 , G01N21/25 , G01N21/64 , G03F7/00 , G03F7/004 , G03F7/26 , G03F7/38 , G11C13/02 , C07H21/02 , C07H21/04
CPC分类号： G01N21/6452 , B01J19/0046 , B82Y10/00 , B82Y30/00 , C07C229/14 , C07C229/16 , C07D263/44 , C07D317/62 , C07H19/04 , C07H19/10 , C07H21/00 , C07K1/042 , C07K1/045 , C07K1/047 , C07K1/062 , C07K17/06 , C07K17/14 , C07K7/06 , C12Q1/6809 , C12Q1/6816 , C12Q1/6837 , C12Q1/6874 , C40B80/00 , G01N21/253 , G01N21/6428 , G03F7/00 , G03F7/0045 , G03F7/265 , G03F7/38 , G11C13/0014 , G11C13/0019 , B01J2219/00315 , B01J2219/00432 , B01J2219/00434 , B01J2219/00436 , B01J2219/00459 , B01J2219/00468 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1475 , G01N21/6458 , Y02P20/55 , Y10S435/969 , Y10S435/973 , Y10S436/807 , Y10S436/809
摘要： A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
摘要翻译： 创造大规模化学多样性的综合战略。 使用固相化学，光不稳定保护基团和光刻法来实现光定向空间可寻址并行化学合成。 在一个实施例中使用二进制掩蔽技术。 还公开了反应器系统，可光除保护组和改进的数据收集和处理技术。 还提供了筛选接头分子的技术。
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8.发明授权Very large scale immobilized polymer synthesis using mechanically directed flow paths 失效使用机械定向流动路径的非常大规模的固定化聚合物合成
公开(公告)号：US5384261A
公开(公告)日：1995-01-24
申请号：US796243
申请日：1991-11-22
IPC分类号： B01J19/00 , C07B61/00 , C07H21/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/10 , G01N33/543
CPC分类号： B82Y30/00 , B01J19/0046 , C07H21/00 , C07K1/045 , C07K1/047 , G01N35/1072 , B01J2219/00364 , B01J2219/00367 , B01J2219/00369 , B01J2219/00378 , B01J2219/00389 , B01J2219/00416 , B01J2219/0043 , B01J2219/00432 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00686 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B60/14 , Y10S435/968 , Y10S435/969 , Y10S435/97 , Y10S435/973 , Y10S436/807 , Y10S436/809 , Y10T436/143333
摘要： A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are flowed through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.
摘要翻译： 一种用于在基底（401）上形成大量聚合物阵列的方法和装置。 根据本发明的优选方面，衬底与其中具有通道（409）的通道块（407）接触。 选定的试剂流过通道，衬底通过旋转阶段（403）旋转，并重复该过程以在衬底上形成聚合物阵列。 该方法可以与光导方法组合。
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公开(公告)号：US06864101B1
公开(公告)日：2005-03-08
申请号：US09579949
申请日：2000-05-26
申请人： James L. Winkler , Stephen P. A. Fodor , Christopher J. Buchko , Debra A. Ross , Lois Aldwin , Douglas N. Modlin
发明人： James L. Winkler , Stephen P. A. Fodor , Christopher J. Buchko , Debra A. Ross , Lois Aldwin , Douglas N. Modlin
IPC分类号： B01J19/00 , C07B61/00 , C07H21/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/10 , G01N1/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00364 , B01J2219/00367 , B01J2219/00369 , B01J2219/00378 , B01J2219/00389 , B01J2219/00416 , B01J2219/0043 , B01J2219/00432 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00686 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07H21/00 , C07K1/045 , C07K1/047 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1072 , Y10S436/809 , Y10T436/143333 , Y10T436/2575
摘要： A method for producing polymer arrays by spacing a dispenser a distance from a surface of a support, dispensing a volume containing a monomer in a single coupling step of less than 5 nl to occupy a localized area of less than 1 cm2 of the surface of the support, allowing the monomer to bind directly or indirectly to the support and repeating the steps to produce an array of at least 100 polymer ligands at a density of 1000 per cm2 or greater.
摘要翻译： 一种通过将分配器与支撑体的表面间隔一定距离来制备聚合物阵列的方法，在单个耦合步骤中分配含有单体的体积小于5nl以占据小于1cm 2的局部区域 表面，允许单体直接或间接地结合到载体上并重复步骤以产生密度为1000 / cm 2或更大的至少100个聚合物配体的阵列。
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公开(公告)号：US06780301B1
公开(公告)日：2004-08-24
申请号：US09677203
申请日：2000-10-02
申请人： Michael J. Natan , Thomas E. Mallouk , Benjamin R. Martin , Brian D. Reiss , Louis J. Dietz , James L. Winkler
发明人： Michael J. Natan , Thomas E. Mallouk , Benjamin R. Martin , Brian D. Reiss , Louis J. Dietz , James L. Winkler
IPC分类号： C25D502
摘要： Synthetic methods for the manufacture of segmented nanoparticles are described.
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