公开(公告)号：US11239066B2

公开(公告)日：2022-02-01

申请号：US15555694

申请日：2016-03-07

Applicant: Micromass UK Limited

Inventor： Emrys Jones ,  Steven Derek Pringle ,  Keith Richardson ,  James Ian Langridge ,  Zoltan Takats

IPC: H01J49/04 ,  A61B10/02 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  G01N3/00 ,  G01N9/00 ,  G01N33/68 ,  H01J49/00 ,  H01J49/06 ,  H01J49/16 ,  G16B20/50 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B17/00 ,  A61B18/04 ,  A61B18/18 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/622 ,  G01N27/624 ,  G01N30/72 ,  G01N33/487 ,  G01N33/92 ,  H01J49/02 ,  H01J49/10 ,  H01J49/14 ,  H01J49/24 ,  H01J49/26 ,  G16B20/00 ,  A61B17/32 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145

Abstract: A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed comprising: (a) using a first device to generate smoke, aerosol or vapour from a target in vitro or ex vivo cell population; (b) mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and (c) analysing said spectrometric data in order to identify and/or characterise said target cell population or one or more cells and/or compounds present in said target cell population.

公开(公告)号：US20210215638A1

公开(公告)日：2021-07-15

申请号：US16093506

申请日：2017-04-13

Applicant: Micromass UK Limited

Inventor： Emrys Jones ,  Sara Stead ,  Julia Balog ,  Richard Schafer

IPC: G01N27/623 ,  H01J49/00 ,  G01N33/00 ,  G01N33/68 ,  G01N33/92

Abstract: A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed comprising: (a) using a first device to generate smoke, aerosol or vapour from a target plant material; (b) mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and (c) analysing said spectrometric data in order to identify and/or characterise said plant material.

公开(公告)号：US11031230B2

公开(公告)日：2021-06-08

申请号：US16306809

申请日：2017-06-05

Applicant: MICROMASS UK LIMITED

Inventor： Emrys Jones ,  Richard Chapman ,  Steven Derek Pringle

IPC: H01J49/28 ,  H01J49/16 ,  H01J49/00 ,  H01J49/14

Abstract: A method of analysing a sample is disclosed that comprises surveying a sample in a first mode of operation by directing a spray of charged droplets onto the sample, determining one or more regions of interest in the sample, and analysing the one or more regions of interest in a second different mode of operation by directing a spray of charged droplets onto the sample. The spot size of the spray of charged droplets at a point of impact with the sample may be varied.

公开(公告)号：US20200158706A1

公开(公告)日：2020-05-21

申请号：US16072623

申请日：2017-01-19

Applicant: Micromass UK Limited

Inventor： Steven Derek Pringle ,  Emrys Jones ,  Michael Raymond Morris ,  Zoltán Takáts

IPC: G01N33/00

Abstract: A method of analysing a sample is disclosed that comprises activating an electronic cigarette (“e-cigarette”) or other vaporising or atomising device such that the electronic cigarette or other device emits aerosol, smoke, vapour and/or droplets, mass analysing the aerosol, smoke, vapour and/or droplets, and characterising the aerosol, smoke, vapour and/or droplets based on the mass analysis.

公开(公告)号：US20190267221A1

公开(公告)日：2019-08-29

申请号：US16308214

申请日：2017-06-06

Applicant: Micromass UK Limited

Inventor： Steven Pringle ,  Emrys Jones ,  Mike Morris ,  Keith Richardson ,  Zoltan Takats

IPC: H01J49/00 ,  H01J49/16 ,  G01N21/71 ,  G01N27/62 ,  A61B5/00

Abstract: A method of analysing a target is disclosed comprising ablating a portion of a target so as to cause an aerosol plume to be produced and light or other electromagnetic radiation to be emitted. The aerosol plume is analysed using mass spectrometry and/or ion mobility spectrometry and the emitted light or other electromagnetic radiation is analysed using optical spectroscopy in order to determine one or more regions of interest of the target and/or one or more margins or bounds of a region of interest of the target.

公开(公告)号：US20240297032A1

公开(公告)日：2024-09-05

申请号：US18260285

申请日：2022-01-05

Applicant: Micromass UK Limited

Inventor： Emrys Jones ,  Steven Derek Pringle ,  Michael Raymond Morris

IPC: H01J49/16 ,  H01J49/00 ,  H01J49/02 ,  H01J49/04

CPC classification number: H01J49/167 ,  H01J49/0031 ,  H01J49/022 ,  H01J49/0445 ,  H01J49/049

Abstract: A method of analysing a sample is disclosed in which a solvent emitting capillary is brought into contact with, or proximate to, a sample such that analyte from the sample is absorbed by solvent emitted from the capillary. A voltage is applied to the such that charged droplets of the solvent comprising the analyte from the sample are emitted from the capillary. The charged droplets are caused to be drawn into one or more sampling conduits connected to an atmospheric interface of an analytical instrument.

公开(公告)号：US11710627B2

公开(公告)日：2023-07-25

申请号：US17558925

申请日：2021-12-22

Applicant: Micromass UK Limited

Inventor： Emrys Jones ,  Steven Derek Pringle ,  Keith Richardson ,  James Ian Langridge ,  Zoltan Takats

IPC: G01N30/72 ,  H01J49/04 ,  A61B10/02 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  G01N3/00 ,  G01N9/00 ,  G01N33/68 ,  H01J49/00 ,  H01J49/06 ,  H01J49/16 ,  G16B20/50 ,  G01N27/623 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B17/00 ,  A61B18/04 ,  A61B18/18 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/624 ,  G01N33/487 ,  G01N33/92 ,  H01J49/02 ,  H01J49/10 ,  H01J49/14 ,  H01J49/24 ,  H01J49/26 ,  G16B20/00 ,  A61B17/32 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145

CPC classification number: H01J49/049 ,  A61B1/041 ,  A61B1/2736 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/015 ,  A61B5/055 ,  A61B5/0507 ,  A61B6/032 ,  A61B6/037 ,  A61B8/13 ,  A61B10/00 ,  A61B10/0041 ,  A61B10/0233 ,  A61B10/0283 ,  A61B17/00 ,  A61B18/00 ,  A61B18/04 ,  A61B18/042 ,  A61B18/14 ,  A61B18/1445 ,  A61B18/1815 ,  A61B18/20 ,  A61B90/13 ,  A61F13/38 ,  C12Q1/025 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/2202 ,  G01N3/00 ,  G01N9/00 ,  G01N27/623 ,  G01N27/624 ,  G01N30/724 ,  G01N33/487 ,  G01N33/6848 ,  G01N33/6851 ,  G01N33/92 ,  G16B20/50 ,  H01J49/0004 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/025 ,  H01J49/044 ,  H01J49/0404 ,  H01J49/0409 ,  H01J49/0422 ,  H01J49/0445 ,  H01J49/0459 ,  H01J49/0463 ,  H01J49/0468 ,  H01J49/061 ,  H01J49/068 ,  H01J49/10 ,  H01J49/14 ,  H01J49/16 ,  H01J49/164 ,  H01J49/24 ,  H01J49/26 ,  A61B1/00013 ,  A61B1/31 ,  A61B5/14542 ,  A61B17/320068 ,  A61B2010/0083 ,  A61B2017/320069 ,  A61B2018/00577 ,  A61B2018/00589 ,  A61B2018/00994 ,  A61B2218/002 ,  A61B2218/008 ,  G01N33/48735 ,  G01N2001/2223 ,  G01N2333/195 ,  G01N2405/00 ,  G01N2405/04 ,  G01N2405/08 ,  G01N2570/00 ,  G01N2800/26 ,  G16B20/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20

Abstract: A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed comprising: (a) using a first device to generate smoke, aerosol or vapour from a target in vitro or ex vivo cell population; (b) mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and (c) analysing said spectrometric data in order to identify and/or characterise said target cell population or one or more cells and/or compounds present in said target cell population.

公开(公告)号：US20220367166A1

公开(公告)日：2022-11-17

申请号：US17746308

申请日：2022-05-17

Applicant: Micromass UK Limited

Inventor： Zoltan Takats ,  Emrys Jones ,  James Ian Langridge ,  Michael Raymond Morris ,  Tamas Karancsi ,  Steven Derek Pringle ,  Julia Balog ,  Daniel Simon ,  Lajos Godorhazy ,  Daniel Szalay ,  Keith Richardson ,  Phillip Robert Bennett ,  David Alan Macintyre ,  Pamela Pruski

IPC: H01J49/04 ,  A61B10/02 ,  A61B17/32 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  G01N3/00 ,  G01N9/00 ,  G01N33/68 ,  H01J49/00 ,  H01J49/06 ,  H01J49/16 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B17/00 ,  A61B18/04 ,  A61B18/18 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/622 ,  G01N27/624 ,  G01N30/72 ,  G01N33/487 ,  G01N33/92 ,  H01J49/02 ,  H01J49/10 ,  H01J49/14 ,  H01J49/24 ,  H01J49/26

Abstract: A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.

公开(公告)号：US20220115222A1

公开(公告)日：2022-04-14

申请号：US17558925

申请日：2021-12-22

Applicant: Micromass UK Limited

Inventor： Emrys Jones ,  Steven Derek Pringle ,  Keith Richardson ,  James Ian Langridge ,  Zoltan Takats

IPC: H01J49/04 ,  A61B10/02 ,  H01J49/16 ,  G01N1/22 ,  G01N3/00 ,  G01N33/92 ,  H01J49/10 ,  H01J49/14 ,  G16B20/50 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  H01J49/02 ,  H01J49/06 ,  A61B1/273 ,  A61B10/00 ,  C12Q1/04 ,  H01J49/00 ,  A61B5/01 ,  A61B5/055 ,  A61B17/00 ,  C12Q1/18 ,  G01N9/00 ,  A61B90/13 ,  A61B18/04 ,  C12Q1/24 ,  G01N33/68 ,  A61B5/00 ,  A61B6/03 ,  A61B8/13 ,  A61F13/38 ,  G01N30/72 ,  A61B5/0507 ,  G01N27/622 ,  H01J49/24 ,  H01J49/26 ,  A61B1/04 ,  A61B18/18 ,  G01N27/624 ,  G01N33/487 ,  C12Q1/02 ,  G16H15/00 ,  A61B1/31 ,  G16H50/20 ,  A61B17/32 ,  A61B1/00 ,  G16H10/40 ,  A61B5/145 ,  G16B20/00

Abstract: A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed comprising: (a) using a first device to generate smoke, aerosol or vapour from a target in vitro or ex vivo cell population; (b) mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and (c) analysing said spectrometric data in order to identify and/or characterise said target cell population or one or more cells and/or compounds present in said target cell population.

公开(公告)号：US20220037140A1

公开(公告)日：2022-02-03

申请号：US17277003

申请日：2019-09-17

Applicant: Micromass UK Limited

Inventor： Emrys Jones ,  Richard Chapman ,  Steven Derek Pringle ,  Michael Raymond Morris

IPC: H01J49/16 ,  G01N1/30 ,  G01N33/92 ,  G01N33/68 ,  H01J49/00 ,  G06T7/00 ,  H01J49/04 ,  G06N20/00 ,  G06T7/11 ,  G01N1/06 ,  G01N27/623

Abstract: Disclosed herein is a method of analysing a tissue sample. The method comprises identifying one or more regions of interest within the tissue sample based on a tissue stain that has been applied to the tissue sample. Analyte material is then generated from the one or more regions of interest identified based on the tissue stain using a direct surface sampling probe (10), which analyte material is then received at a sampling inlet (30) and passed towards a mass and/or ion mobility spectrometer (50) for analysis.