Solid phase N-hydroxysuccinimide reagents
    25.
    发明授权
    Solid phase N-hydroxysuccinimide reagents 失效
    固相N-羟基琥珀酰亚胺试剂

    公开(公告)号:US4812362A

    公开(公告)日:1989-03-14

    申请号:US84325

    申请日:1987-08-10

    申请人: Mark L. Stolowitz

    发明人: Mark L. Stolowitz

    IPC分类号: B01J20/32 B32B5/16

    摘要: A solid phase N-hydroxysuccinimide reagent having the general formula: ##STR1## where X is particulate silica gel or controlled pore glass; n=3-7; Y is either (CH.sub.2).sub.n' or (CH.sub.2).sub.n' --NH--CO--CH.sub.2 wherein n'=2-6; Z may be in the form of OCOR, OSO.sub.2 R and OCO.sub.2 R, and Z' may be either Z or OH, wherein R is a chromophore, fluorophore or electrophore capable of detection in chromatographic separation technology is disclosed. Also disclosed is the method for making compounds of this type and the method for using these compounds to identify and quantitate analytes having primary or secondary amine or thiol functionalities.

    摘要翻译: 具有以下通式的固相N-羟基琥珀酰亚胺试剂:其中X是颗粒状硅胶或受控孔隙玻璃; n = 3-7; Y是(CH 2)n'或(CH 2)n'-NH-CO-CH 2,其中n'= 2-6; Z可以是OCOR,OSO2R和OCO2R的形式,Z'可以是Z或OH,其中R是在色谱分离技术中能够检测的发色团,荧光团或电泳。 还公开了制备这种化合物的方法以及使用这些化合物鉴定和定量具有伯胺或仲胺或硫醇官能团的分析物的方法。