中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

97 records (took 0.063 seconds)

    Heating element for a rotating multiplex fluorescence detection device
    27.
    发明申请
    Heating element for a rotating multiplex fluorescence detection device 审中-公开
    用于旋转多重荧光检测装置的加热元件

    公开(公告)号：US20070009382A1

    公开(公告)日：2007-01-11

    申请号：US11174691

    申请日：2005-07-05

    Applicant: William Bedingham ,  Peter Ludowise ,  Barry Robole

    Inventor： William Bedingham ,  Peter Ludowise ,  Barry Robole

    IPC: G01N35/00

    CPC classification number: G01N21/645 ,  B01L3/5027 ,  B01L7/52 ,  B01L7/54 ,  B01L2200/147 ,  B01L2300/0806 ,  B01L2300/1805 ,  B01L2300/1844 ,  B01L2300/1872 ,  G01N21/07 ,  G01N21/6428 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/04 ,  G01N2201/0407 ,  G01N2201/08 ,  G01N2201/10 ,  G01N2201/101

    Abstract: Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of removable optical modules that are optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of removable optical modules conveys the fluorescent light from the optical modules to a single detector. The device further includes a heating element for heating one or more process chambers on the disk. In addition, the device may control the flow of fluid in the disk by locating and selectively opening valves separating chambers by heating the valves with a laser.

    Abstract translation: 描述了用于在实时PCR（聚合酶链式反应）中检测多种靶物种的技术。 例如，系统包括数据采集装置和耦合到数据采集装置的检测装置。 检测装置包括具有多个处理室的旋转盘，该多个处理室具有发射不同波长的荧光的多种物质。 该装置还包括多个可移除的光学模块，其被光学配置为激发物种并捕获由不同波长的物质发射的荧光。 耦合到多个可移除光学模块的光纤束将来自光学模块的荧光传送到单个检测器。 该装置还包括用于加热盘上的一个或多个处理室的加热元件。 此外，该装置可以通过利用激光加热阀来定位和选择性地打开阀分离腔来控制盘中的流体流动。

    Portable and cartridge-based surface plasmon resonance sensing systems
    28.
    发明申请
    Portable and cartridge-based surface plasmon resonance sensing systems 有权
    便携式和基于盒式的表面等离子体共振传感系统

    公开(公告)号：US20060279737A1

    公开(公告)日：2006-12-14

    申请号：US11398964

    申请日：2006-04-05

    Applicant: Timothy Chinowsky ,  Scott Soelberg ,  Peter Kauffman ,  Clement Furlong ,  Jared Tritz ,  Michael Grow ,  Alexei Naimushin ,  Sinclair Yee

    Inventor： Timothy Chinowsky ,  Scott Soelberg ,  Peter Kauffman ,  Clement Furlong ,  Jared Tritz ,  Michael Grow ,  Alexei Naimushin ,  Sinclair Yee

    IPC: G01N21/55

    CPC classification number: G01N21/553 ,  G01N2201/04

    Abstract: This specification discloses various improvements in the field of SPR sensing systems. One improvement relates to a portable SPR sensing system, e.g., a system contained within a suitcase that can be hand-carried to a monitoring site. Another improvement relates to a portable, cartridge-based SPR sensing system. In this system, selected portions of the system's electrical and fluidics systems are allocated between a base unit and a removable/disposable cartridge. Other improvements relate to methods or protocols for operating an SPR sensing system. Such methods provide for the elimination of false positives and increased sensitivity, e.g., by using secondary antibodies with specificity for different target epitopes and by sensor element redundancy. In addition, protocols are provided for the detection of small molecules. Such protocols may employ a competition type assay where the presence of the analyte inhibits the binding of antibodies to surface immobilized analyte, or a displacement assay, where antibodies bound to the analyte on the sensor surface are displaced by free analyte.

    Abstract translation: 本说明书公开了SPR传感系统领域的各种改进。 一个改进涉及便携式SPR感测系统，例如，可以手提携带到监控地点的手提箱内的系统。 另一项改进涉及一种便携式，基于盒式SPR感测系统。 在该系统中，系统的电和流体系统的选定部分被分配在基本单元和可移动/一次性盒之间。 其他改进涉及用于操作SPR感测系统的方法或协议。 这样的方法提供消除假阳性和提高灵敏度，例如通过使用对不同靶标表位具有特异性的二级抗体以及通过传感器元件冗余。 此外，提供了用于检测小分子的方案。 这样的方案可以采用竞争型测定法，其中分析物的存在抑制抗体与表面固定化分析物的结合，或位移测定法，其中与传感器表面上的分析物结合的抗体被游离分析物置换。

    Arrayed sensor measurement system and method
    29.
    发明申请
    Arrayed sensor measurement system and method 失效
    阵列传感器测量系统及方法

    公开(公告)号：US20050099622A1

    公开(公告)日：2005-05-12

    申请号：US11019439

    申请日：2004-12-21

    Applicant: Stephen Caracci ,  Norman Fontaine ,  Eric Mozdy ,  Po Yuen

    Inventor： Stephen Caracci ,  Norman Fontaine ,  Eric Mozdy ,  Po Yuen

    IPC: G01N21/25 ,  G02B27/10 ,  G01J3/50

    CPC classification number: G01N21/253 ,  G01N2201/04 ,  G01N2201/10 ,  G02B27/1086

    Abstract: Optical interrogation systems and methods are described herein that are capable of measuring the angles (or changes in the angles) at which light reflects, transmits, scatters, or is emitted from an array of sensors or specimens that are distributed over a large area 2-dimensional array. In one embodiment of the present invention, the optical interrogation system has a far-field diffraction measurement configuration so it can simultaneously receive the light from sensors in all or a sub-section of a sensor array at a detector. In another embodiment of the present invention, the optical interrogation system incorporates an anamorphic optical receive system that enables parallel detection of angular responses from the sensors in the 2D array. In yet another embodiment of the present invention, the optical interrogation system incorporates an angular measurement system which measures the change in angular tilt of the sensor plane when the sensor array is moved or removed and then replaced in the measurement system. Several other embodiments of optical interrogation systems and methods are also described herein. A significant advantage of the present invention is that the system has no critical moving or scanning parts, which are frequently the source of measurement sensitivity limitations.

    Abstract translation: 本文描述了光学询问系统和方法，其能够测量光从其分布在大面积上的传感器或样本阵列2反射，透射，散射或发射的角度（或角度变化） 维数组。 在本发明的一个实施例中，光学询问系统具有远场衍射测量配置，因此它可以在检测器处同时从传感器阵列的全部或子部分接收来自传感器的光。 在本发明的另一实施例中，光学询问系统包括变形光学接收系统，其能够并行地检测来自2D阵列中的传感器的角度响应。 在本发明的另一个实施例中，光学询问系统包括角度测量系统，该系统测量当传感器阵列移动或移除并随后在测量系统中被更换时传感器平面的角度倾斜度的变化。 本文还描述了光询问系统和方法的其他几个实施例。 本发明的显着优点是该系统没有关键的移动或扫描部件，其经常是测量灵敏度限制的来源。

Patent Agency Ranking