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公开(公告)号：US07364895B2
公开(公告)日：2008-04-29
申请号：US10639696
申请日：2003-08-11
CPC分类号： B01L3/502715 , B01F13/0054 , B01F13/0059 , B01F13/02 , B01F13/08 , B01F13/0818 , B01J19/0046 , B01J2219/00286 , B01J2219/00353 , B01J2219/00371 , B01J2219/00432 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/0054 , B01J2219/00547 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00662 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L3/5027 , B01L3/502707 , B01L9/52 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2200/12 , B01L2200/147 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2300/0825 , B01L2300/0877 , B01L2300/1805 , B01L2400/0439 , B01L2400/0442 , B01L2400/0487 , B01L2400/0611 , B01L2400/065 , B82Y30/00 , C07H21/00 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C40B70/00 , G01N2035/00158 , H01L21/67144 , Y10T436/25
摘要： A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the cavity to contact the probes. Accordingly, a commercially feasible device for use in high throughput assay systems is provided.
摘要翻译： 具有空腔310的主体300，其具有根据美国专利No. 提供了第5,143,854号和PCT WO 92/10092等。 空腔包括用于将选定流体引入空腔中以接触探针的入口350和360。 因此，提供了用于高通量测定系统的商业上可行的装置。
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公开(公告)号：US07045049B1
公开(公告)日：2006-05-16
申请号：US09677203
申请日：2000-10-02
申请人： Michael J. Natan , Thomas E. Mallouk , Benjamin R. Martin , Brian D. Reiss , Louis J. Dietz , James L. Winkler
发明人： Michael J. Natan , Thomas E. Mallouk , Benjamin R. Martin , Brian D. Reiss , Louis J. Dietz , James L. Winkler
IPC分类号： C25D5/02
CPC分类号： G01N33/54346 , B01J13/0047 , B01J13/0091 , B01J19/0046 , B01J19/10 , B01J2219/005 , B01J2219/00502 , B01J2219/00513 , B01J2219/00545 , B01J2219/00547 , B01J2219/00554 , B01J2219/00585 , B01J2219/00596 , B01J2219/00657 , B01J2219/0072 , B01J2219/00722 , B01L3/545 , B22F1/004 , B22F2999/00 , B82B1/00 , B82Y25/00 , B82Y30/00 , C25D1/00 , C25D1/006 , C25D1/04 , C40B40/06 , C40B70/00 , H01F1/0081 , B22F2207/01
摘要： Synthetic methods for the manufacture of segmented nanoparticles are described.
摘要翻译： 描述了制备分段纳米颗粒的合成方法。
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公开(公告)号：US06919009B2
公开(公告)日：2005-07-19
申请号：US09969518
申请日：2001-10-02
IPC分类号： B01J13/00 , B01J19/00 , B01J19/10 , B01L3/00 , B22F1/00 , B82B1/00 , C25D1/00 , C25D1/04 , C40B40/06 , C40B70/00 , G01N33/543 , H01F1/00 , C25D5/02
CPC分类号： G01N33/54346 , B01J13/0047 , B01J13/0091 , B01J19/0046 , B01J19/10 , B01J2219/005 , B01J2219/00502 , B01J2219/00513 , B01J2219/00545 , B01J2219/00547 , B01J2219/00554 , B01J2219/00585 , B01J2219/00596 , B01J2219/00657 , B01J2219/0072 , B01J2219/00722 , B01L3/545 , B22F1/004 , B22F2999/00 , B82B1/00 , B82Y25/00 , B82Y30/00 , C25D1/00 , C25D1/006 , C25D1/04 , C40B40/06 , C40B70/00 , H01F1/0081 , B22F2207/01
摘要： A method is disclosed for the manufacture of colloidal rod particles as nanobarcodes. Template membranes for the deposition of materials are prepared using photolithographic techniques.
摘要翻译： 公开了用于制造胶体棒粒子作为纳米棒的方法。 使用光刻技术制备用于沉积材料的模板膜。
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公开(公告)号：US06491871B1
公开(公告)日：2002-12-10
申请号：US08999188
申请日：1997-12-09
IPC分类号： G01N2164
CPC分类号： C08G69/00 , B01J19/0046 , B01J2219/00315 , B01J2219/00432 , B01J2219/00434 , B01J2219/00436 , B01J2219/00459 , B01J2219/00468 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00639 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01L7/52 , B82Y10/00 , B82Y30/00 , C07B2200/11 , C07C229/14 , C07C229/16 , C07D263/44 , C07D317/62 , C07H19/04 , C07H19/10 , C07H21/00 , C07K1/04 , C07K1/042 , C07K1/045 , C07K1/047 , C07K1/062 , C07K7/06 , C07K17/06 , C07K17/14 , C12Q1/6809 , C12Q1/6816 , C12Q1/6837 , C12Q1/6874 , C40B40/06 , C40B40/10 , C40B60/14 , C40B80/00 , G01N15/1475 , G01N21/253 , G01N21/6428 , G01N21/6452 , G03F7/00 , G03F7/26 , G03F7/265 , G03F7/38 , G11C13/0014 , G11C13/0019 , H01L25/50 , H01L2924/0002 , Y02P20/55 , Y10S435/961 , Y10S435/968 , Y10S435/969 , Y10S435/973 , Y10S436/807 , Y10S436/809 , Y10T428/31971 , Y10T436/2575 , H01L2924/00
摘要： A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
摘要翻译： 创造大规模化学多样性的综合战略。 使用固相化学，光不稳定保护基团和光刻法来实现光定向空间可寻址并行化学合成。 在一个实施例中使用二进制掩蔽技术。 还公开了反应器系统，可光除保护组和改进的数据收集和处理技术。 还提供了筛选接头分子的技术。
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公开(公告)号：US06287850B1
公开(公告)日：2001-09-11
申请号：US09302052
申请日：1999-04-29
IPC分类号： C12M300
CPC分类号： B01L3/502715 , B01F13/0054 , B01F13/0059 , B01F13/02 , B01F13/08 , B01F13/0818 , B01J19/0046 , B01J2219/00286 , B01J2219/00353 , B01J2219/00371 , B01J2219/00432 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/0054 , B01J2219/00547 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00662 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L3/5027 , B01L3/502707 , B01L9/52 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2200/12 , B01L2200/147 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2300/0825 , B01L2300/0877 , B01L2300/1805 , B01L2400/0439 , B01L2400/0442 , B01L2400/0487 , B01L2400/0611 , B01L2400/065 , B82Y30/00 , C07H21/00 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C40B70/00 , G01N2035/00158 , H01L21/67144 , Y10T436/25
摘要： Agitation systems for reversibly directing fluid samples flow back and forth across a nucleic acid array, thereby promoting hybridization between targets in the fluid sample and probes on the nucleic acid array.
摘要翻译： 用于可逆地引导流体样品的搅拌系统来回穿过核酸阵列来回流动，从而促进流体样品中的靶标和核酸阵列上的探针之间的杂交。
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公开(公告)号：US6140044A
公开(公告)日：2000-10-31
申请号：US528173
申请日：1995-09-14
IPC分类号： G01N33/543 , B01F13/00 , B01F13/02 , B01F13/08 , B01J19/00 , B01L3/00 , B01L9/00 , B81B1/00 , C07H21/00 , C12M1/00 , C12M1/34 , C12N15/09 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C40B70/00 , G01N21/03 , G01N21/78 , G01N33/53 , G01N35/00 , G01N37/00 , G01N21/00 , G01N21/01 , G01N21/29
CPC分类号： B01L3/502715 , B01J19/0046 , B01L3/5027 , B01L3/502707 , B01L9/527 , B82Y30/00 , C07H21/00 , G01N33/543 , G01N33/54366 , B01F13/0059 , B01F13/02 , B01F13/08 , B01J2219/00371 , B01J2219/00432 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/0054 , B01J2219/00547 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00662 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2200/12 , B01L2300/0636 , B01L2300/0816 , B01L2300/0825 , B01L2300/0877 , B01L2400/0487 , C12Q1/6874 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C40B70/00 , G01N2035/00158 , Y10S435/97 , Y10S435/973 , Y10S436/809 , Y10T436/112499
摘要： A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the cavity to contact the probes. Accordingly, a commercially feasible device for use in high throughput assay systems is provided.
摘要翻译： 具有空腔310的主体300，其具有根据美国专利No. 提供了第5,143,854号和PCT WO 92/10092等。 空腔包括用于将选定流体引入空腔中以接触探针的入口350和360。 因此，提供了用于高通量测定系统的商业上可行的装置。
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37.发明授权Computer-aided engineering system for design of sequence arrays and lithographic masks 失效用于设计序列阵列和光刻掩模的计算机辅助工程系统
公开(公告)号：US5856101A
公开(公告)日：1999-01-05
申请号：US721689
申请日：1996-09-27
IPC分类号： B01J19/00 , C07B61/00 , C07K1/04 , C40B40/06 , C40B60/14 , G03F1/00 , C12Q1/68 , C12M1/34 , C12M3/04
CPC分类号： B82Y30/00 , B01J19/0046 , C07K1/04 , C07K1/045 , B01J2219/00432 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00693 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , C40B40/06 , C40B60/14
摘要： An improved set of computer tools for forming arrays. According to one aspect of the invention, a computer system (100) is used to select probes and design the layout of an array of DNA or other polymers with certain beneficial characteristics. According to another aspect of the invention, a computer system uses chip design files (104) to design and/or generate lithographic masks (110).
摘要翻译： 一组改进的用于形成阵列的计算机工具。 根据本发明的一个方面，计算机系统（100）用于选择探针并设计具有某些有益特征的DNA或其它聚合物阵列的布局。 根据本发明的另一方面，计算机系统使用芯片设计文件（104）来设计和/或生成光刻掩模（110）。
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38.发明授权Computer-aided engineering system for design of sequence arrays and lithographic masks 失效用于设计序列阵列和光刻掩模的计算机辅助工程系统
公开(公告)号：US5593839A
公开(公告)日：1997-01-14
申请号：US460411
申请日：1995-06-02
IPC分类号： B01J19/00 , C07B61/00 , C07K1/04 , C40B40/06 , C40B60/14 , G03F1/00 , C12Q1/68 , C07H21/04 , G03F9/00
CPC分类号： B82Y30/00 , B01J19/0046 , C07K1/04 , C07K1/045 , B01J2219/00432 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00693 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , C40B40/06 , C40B60/14
摘要： An improved set of computer tools for forming arrays. According to one aspect of the invention, a computer system is used to select probes and design the layout of an array of DNA or other polymers with certain beneficial characteristics. According to another aspect of the invention, a computer system uses chip design files to design and/or generate lithographic masks.
摘要翻译： 一组改进的用于形成阵列的计算机工具。 根据本发明的一个方面，计算机系统用于选择探针并设计具有某些有益特征的DNA或其它聚合物阵列的布局。 根据本发明的另一方面，计算机系统使用芯片设计文件来设计和/或生成光刻掩模。
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公开(公告)号：US5571639A
公开(公告)日：1996-11-05
申请号：US249188
申请日：1994-05-24
IPC分类号： B01J19/00 , C07B61/00 , C07K1/04 , C40B40/06 , C40B60/14 , G03F1/00 , G03F7/26 , C12Q1/68 , G03C5/00
CPC分类号： B82Y30/00 , B01J19/0046 , C07K1/04 , C07K1/045 , B01J2219/00432 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00693 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , C40B40/06 , C40B60/14
摘要： An improved set of computer tools for forming arrays. According to one aspect of the invention, a computer system (100) is used to select probes and design the layout of an array of DNA or other polymers with certain beneficial characteristics. According to another aspect of the invention, a computer system uses chip design files (104) to design and/or generate lithographic masks (110).
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