-
公开(公告)号：US09314460B1
公开(公告)日：2016-04-19
申请号：US14249150
申请日：2014-04-09
Applicant: Alexandre Chigaev , Larry A. Sklar , Dominique Perez
Inventor： Alexandre Chigaev , Larry A. Sklar , Dominique Perez
IPC: C07D309/00 , A61K31/47 , A61K31/122 , G01N33/50 , A61K31/4425 , A61K31/357 , A61K31/343 , A61K31/35 , A61K31/437
CPC classification number: A61K31/58 , A61K31/00 , A61K31/122 , A61K31/343 , A61K31/35 , A61K31/357 , A61K31/365 , A61K31/437 , A61K31/4425 , A61K31/47 , A61K45/06 , G01N33/5011 , G01N2500/10 , G01N2800/52
Abstract: In one embodiment, the invention provides a method of inhibiting cAMP efflux and increasing intracellular cAMP in a subject who suffers from, or who is at risk of developing, a cancer by administering to the subject a therapeutically-effective amount of a cAMP efflux inhibitor. Novel compounds, pharmaceutical compositions, diagnostics and screening methods are also provided.
Abstract translation: 在一个实施方案中，本发明提供了通过向受试者施用治疗有效量的cAMP外排抑制剂来抑制患有或有风险发展为癌症的受试者的cAMP外排和增加细胞内cAMP的方法。 还提供了新颖的化合物，药物组合物，诊断和筛选方法。
-
52.发明授权High-affinity small molecule formylpeptide receptor ligands from screening of combinatorial mixture-based libraries 有权高亲和力小分子甲酰肽受体配体筛选组合基于混合物的文库公开(公告)号：US09310364B1
公开(公告)日：2016-04-12
申请号：US14174564
申请日：2014-02-06
Applicant: STC. UNM , TORREY PINES INSTITUTE FOR MOLECULAR STUDIES
Inventor： Bruce S. Edwards , Larry A. Sklar , Clemencia Pinilla , Richard A. Houghten , Jon R. Appel , Marc A. Giulianotti , Jose Medina-Franco
IPC: A61K38/00 , A61K31/17 , C07D241/08 , C40B30/02 , G01N33/566 , C07D403/14 , A61K31/496 , A61K45/06 , C07C275/28 , C07K1/04
CPC classification number: G01N33/6845 , A61K31/17 , A61K31/496 , A61K38/00 , A61K45/06 , B01J2219/00585 , C07C275/28 , C07D241/08 , C07D403/14 , C07K1/047 , C40B30/02 , G01N33/74 , G01N2333/726 , A61K2300/00
Abstract: The present invention provides novel methods and assays for high-throughput screening of combinatorial libraries to identify FPR1 and/or FPR2 ligands (e.g., agonists and/or antagonists), preferably FPR1 agonists and/or FPR2 antagonists, by positional scanning deconvolution.The invention also provides novel FPR1 and FPR2 ligands (e.g, agonists and antagonists), related pharmaceutical compositions and methods of treating FPR1 and FPR2-related disorders.
Abstract translation: 本发明提供了用于通过位置扫描反卷积来组合文库以鉴定FPR1和/或FPR2配体（例如激动剂和/或拮抗剂），优选FPR1激动剂和/或FPR2拮抗剂的高通量筛选的新方法和测定法。 本发明还提供新的FPR1和FPR2配体（例如激动剂和拮抗剂），相关的药物组合物和治疗FPR1和FPR2相关疾病的方法。
-
53.发明授权Aerosol reduction/expansion synthesis (A-RES) for zero valent metal particles 有权用于零价金属颗粒的气溶胶还原/膨胀合成（A-RES）公开(公告)号：US09308585B2
公开(公告)日：2016-04-12
申请号：US13884746
申请日：2011-11-10
Applicant: Zayd Leseman , Claudia Luhrs , Jonathan Phillips , Haytham Soliman
Inventor： Zayd Leseman , Claudia Luhrs , Jonathan Phillips , Haytham Soliman
CPC classification number: B22F9/26 , B22F1/0018 , B22F1/0096 , B22F9/22 , B33Y40/00 , B82Y40/00
Abstract: Various embodiments provide methods of forming zero valent metal particles using an aerosol-reductive/expansion synthesis (A-RES) process. In one embodiment, an aerosol stream including metal precursor compound(s) and chemical agent(s) that produces reducing gases upon thermal decomposition can be introduced into a heated inert atmosphere of a RES reactor to form zero valent metal particles corresponding to metals used for the metal precursor compound(s).
Abstract translation: 各种实施方案提供了使用气溶胶 - 还原/扩展合成（A-RES）方法形成零价金属颗粒的方法。 在一个实施方案中，包含金属前体化合物和在热分解时产生还原气体的化学试剂的气溶胶流可引入到RES反应器的加热惰性气氛中，以形成对应于用于 金属前体化合物。
-
54.发明授权公开(公告)号：US09274042B2
公开(公告)日：2016-03-01
申请号：US13835108
申请日：2013-03-15
Applicant: Steven Wayde Graves , Pearlson Prashanth Austin Suthanthiraraj , Andrew P. Shreve , Gabriel P Lopez
Inventor： Steven Wayde Graves , Pearlson Prashanth Austin Suthanthiraraj , Andrew P. Shreve , Gabriel P Lopez
CPC classification number: G01N15/14 , G01N15/1404 , G01N15/1434 , G01N15/1459 , G01N15/1484 , G01N21/64 , G01N2015/142
Abstract: An affordable flow cytometry system with a significantly increased analytical rate, volumetric sample delivery and usable particle size including a light beam that interrogates multiple flow streams so as to provide excitation across all of the streams, and an optical objective configured to collect light from the sample streams and image the light onto an array detector.
Abstract translation: 具有显着增加的分析速率，体积样品递送和可用粒度的可负担的流式细胞计量系统，其包括询问多个流动流的光束，以便在所有流中提供激发;以及光学物镜，被配置为收集来自样品的光 流并将光成像到阵列检测器上。
-
55.发明授权公开(公告)号：US09270701B1
公开(公告)日：2016-02-23
申请号：US13871250
申请日：2013-04-26
Applicant: STC.UNM
Inventor： Christopher C. Lamb , Gregory L. Heileman
CPC classification number: H04L63/20 , H04L63/0227
Abstract: A system and methods for transferring information between two or more incompatible security domains or levels of classification by embedding policy-centric content management components into an information-centric network. Specifically, overlay architectures enable cloud computing for multi-level security environments.
Abstract translation: 通过将以策略为中心的内容管理组件嵌入到以信息为中心的网络中，在两个或多个不兼容的安全域或分级级别之间传送信息的系统和方法。 具体来说，覆盖架构可以实现多层次安全环境的云计算。
-
Patent Agency Ranking
56.发明授权Low defect density lattice-mismatched semiconductor devices and methods of fabricating same 有权低缺陷密度晶格失配的半导体器件及其制造方法公开(公告)号：US09269569B1
公开(公告)日：2016-02-23
申请号：US13444712
申请日：2012-04-11
Applicant: Sang M. Han , Darin Leonhardt
Inventor： Sang M. Han , Darin Leonhardt
IPC: H01L29/165 , H01L21/20 , H01L21/02
CPC classification number: H01L21/02381 , H01L21/02524 , H01L21/02636 , H01L21/02664
Abstract: Lattice-mismatched semiconductor devices having a substrate, a first epitaxial film disposed thereon, a dielectric material, and a second epitaxial film. The first epitaxial film contains etch pits that extend from the outer surface of the first epitaxial film into the first epitaxial film. The dielectric material is disposed within the etch pits and blocks at least some of the threading dislocations in the first epitaxial film from propagating into the second epitaxial film. Semiconductor devices containing a silicon (Si) substrate or a silicon germanium (SiGe) substrate, a germanium (Ge) film disposed over the substrate, and a dielectric material. Methods for producing such semiconductor devices.
Abstract translation: 具有衬底的晶格不匹配的半导体器件，设置在其上的第一外延膜，电介质材料和第二外延膜。 第一外延膜含有从第一外延膜的外表面延伸到第一外延膜的蚀刻凹坑。 介电材料设置在蚀刻凹坑内，并且阻挡第一外延膜中的至少一些穿透位错传播到第二外延膜。 包含硅（Si）衬底或硅锗（SiGe）衬底，设置在衬底上的锗（Ge）膜）和电介质材料的半导体器件。 用于制造这种半导体器件的方法。
-
公开(公告)号：US09267892B2
公开(公告)日：2016-02-23
申请号：US14134754
申请日：2013-12-19
Applicant: STC.UNM
Inventor： Larry A. Sklar , Bruce Edwards , Frederick Kuckuck
CPC classification number: G01N15/1436 , B01L3/5085 , G01N15/1404 , G01N15/1459 , G01N21/6428 , G01N21/6486 , G01N35/0099 , G01N35/085 , G01N35/1095 , G01N2015/0065 , G01N2015/1006 , G01N2015/1402 , G01N2015/1413 , G01N2015/1477 , G01N2015/149 , G01N2021/6439 , G01N2201/06113 , Y10T436/117497 , Y10T436/118339 , Y10T436/119163 , Y10T436/2575
Abstract: The present invention, provides a flow cytometry apparatus for the detection of particles from a plurality of samples comprising: means for moving a plurality of samples comprising particles from a plurality of respective source wells into a fluid flow stream; means for introducing a separation gas between each of the plurality of samples in the fluid flow stream; and means for selectively analyzing each of the plurality of samples for the particles. The present invention also provides a flow cytometry method employing such an apparatus.
-
公开(公告)号：US09187397B2
公开(公告)日：2015-11-17
申请号：US14449599
申请日：2014-08-01
Applicant: STC.UNM
Inventor： David L. Vander Jagt , Lorraine M. Deck , Steve F. Abcouwer , Robert A. Orlando , Robert E. Royer , Waylon M. Weber , Ekaterina V. Bobrovnikova-Marjon , Lucy A. Hunsaker
IPC: A61K31/44 , C07C49/255 , A61K31/12 , A61K31/137 , A61K31/235 , A61K31/277 , A61K31/282 , A61K31/336 , A61K31/337 , A61K31/704 , A61K45/06 , A61K31/121 , A61K31/444 , C07C49/235 , C07D213/50 , G01N33/50
CPC classification number: C07C49/255 , A61K31/12 , A61K31/121 , A61K31/137 , A61K31/235 , A61K31/277 , A61K31/282 , A61K31/336 , A61K31/337 , A61K31/444 , A61K31/704 , A61K45/06 , C07C49/235 , C07D213/50 , G01N33/5023 , G01N33/5058 , G01N2500/10 , A61K2300/00
Abstract: Curcumin analogues and methods are provided for treatment of disease.
Abstract translation: 提供姜黄素类似物和方法用于治疗疾病。
-
公开(公告)号：US09186317B2
公开(公告)日：2015-11-17
申请号：US12313847
申请日：2008-11-25
Applicant: Hugh D. Smyth , Marek Osinski , Shayna L. McGill
Inventor： Hugh D. Smyth , Marek Osinski , Shayna L. McGill
IPC: A61B5/055 , A61M37/00 , A61N2/00 , A61K9/00 , A61K41/00 , A61K47/48 , A61K9/50 , A61K9/51 , A61K9/70
CPC classification number: A61K9/0009 , A61K9/5094 , A61K9/5115 , A61K9/7023 , A61K41/0052 , A61K47/6921 , A61K47/6923
Abstract: Active multifunctional nanoparticles provide significant enhancement of the efficacy of model therapeutic and gene agents due to increased diffusion and penetration through mucus and biological barriers under the influence of a magnetic field.
-
公开(公告)号：US09153431B1
公开(公告)日：2015-10-06
申请号：US13670391
申请日：2012-11-06
Applicant: STC.UNM
Inventor： Seung-Chang Lee , Steven R. J. Brueck
CPC classification number: C30B25/04 , C30B25/18 , C30B25/186 , C30B29/406 , H01L21/02381 , H01L21/0243 , H01L21/02433 , H01L21/02458 , H01L21/0254 , H01L21/02609 , H01L21/02639 , H01L21/02647 , H01L27/1222 , H01L29/045 , H01L29/06 , H01L29/0657 , H01L29/16 , H01L29/2003
Abstract: A method of epitaxially growing nitrogen-based compound semiconductor thin films on a semiconductor substrate, which is periodically patterned with grooves. The method can provide an epitaxial growth of a first crystalline phase epitaxial film on the substrate, and block the growth of an initial crystalline phase with barrier materials prepared at the sides of the grooves. Semiconductor devices employing the epitaxial films are also disclosed.
Abstract translation: 在半导体衬底上外延生长氮基化合物半导体薄膜的方法，该半导体衬底周期性地形成凹槽。 该方法可以在衬底上提供第一结晶相外延膜的外延生长，并且阻挡初始结晶相的生长与在槽的侧面制备的阻挡材料的生长。 还公开了使用外延膜的半导体器件。
-
-
-
-
-
-
-
-
-
Search Results
714
records
(took 0.085 seconds)
