公开(公告)号：US12103000B2

公开(公告)日：2024-10-01

申请号：US17995842

申请日：2021-04-09

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Elliot En-Yu Hui ,  Hinesh Vipul Patel

IPC分类号： B01L3/00

CPC分类号： B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/0689 ,  B01L2300/0861 ,  B01L2400/0677

摘要： The present invention is directed to the fabrication and use of phase-change material (PCM) membranes in microvalves for microfluidic systems. The microvalve may be fabricated by using a tissue-sectioning instrument to slice a thin membrane of PCM off of a block of PCM. The membrane may then be sandwiched between a plurality of microfluidic flow sections to act as a microvalve. At room temperature, the membrane may exist in a solid state to act as a zero-leakage seal and microvalve. Applying heat to the membrane may bring the membrane to a melting point, causing it to reach a liquid state. The microvalve in the liquid state may experience a surface tension effect by a material of the microfluidic flow sections, causing it to displace from a flow path and allow a fluid to pass from one microfluidic flow section to another.

公开(公告)号：US12102999B2

公开(公告)日：2024-10-01

申请号：US17417537

申请日：2019-12-27

申请人： ASTRAVEUS

发明人： Jérémie Laurent ,  Vincent Thisse

IPC分类号： B01L3/00 ,  B01F23/00 ,  B01F23/41 ,  B01F101/23 ,  B01L3/02 ,  B23Q17/24 ,  C12M1/34 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/686 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/39 ,  G01N21/45 ,  G01N21/64 ,  G01N30/12 ,  G01N30/68 ,  G01N30/70 ,  G01N30/72 ,  G01N30/88 ,  G01N33/00 ,  G01N33/18 ,  G01N33/50 ,  G01N33/543 ,  G01N33/68 ,  G01N35/04 ,  G01N35/10

CPC分类号： B01L3/502715 ,  B01L3/0289 ,  B01L3/50273 ,  B01L2200/0673 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2300/028 ,  B01L2300/0681 ,  B01L2300/0883 ,  B01L2300/14 ,  B01L2300/1883

摘要： A device for handling a particle suspension, in particular a cell suspension, which includes at least one channel for flowing the particle suspension, a pumping unit configured to move a driving fluid and control element for controlling the pumping unit. Also, a method for handling a particle suspension, which includes flowing the particle suspension in or out of at least one channel using a driving fluid for driving the particle suspension in the channel.

公开(公告)号：US12102997B2

公开(公告)日：2024-10-01

申请号：US18007456

申请日：2021-07-30

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

发明人： Devasier Bennet ,  Frederic Zenhausern

IPC分类号： B01L3/00 ,  A01N1/02 ,  A01N59/04 ,  A01P1/00 ,  A61B5/097 ,  A61B10/00 ,  A61L2/00 ,  A61L2/24 ,  A61L101/02

CPC分类号： B01L3/502 ,  A01N59/04 ,  A01P1/00 ,  A61B5/097 ,  A61B10/0051 ,  A61B10/0096 ,  A61L2/0023 ,  A61L2/24 ,  A61L2101/02 ,  A61L2202/14 ,  A61L2202/18 ,  B01L2200/0678 ,  B01L2200/185 ,  B01L2300/042 ,  B01L2300/0681 ,  B01L2300/069 ,  B01L2300/14 ,  B01L2300/1894

摘要： Provided herein are portable biocontainment devices for safe and reliable collection of biological samples, including liquid and gas samples. A sample inlet for collecting fluids and/or gases, including oral fluids and expired breath samples, is connected to a container having a climate-controlled container reservoir. One or more sample containers are connected to the sample inlet for collection of samples. The devices are configured for safe transport and handling of samples, while maintaining sample viability, including for relatively long transport periods. Safety components integrated within the device facilitates safe and effective decontamination of contagious samples. In this manner, aborting the sample preservation by decontamination prior to a hazardous release is achieved within the same apparatus.

公开(公告)号：US20240319188A1

公开(公告)日：2024-09-26

申请号：US18580342

申请日：2022-07-19

申请人： NANOTIS CORPORATION

发明人： Jinsei MIYAZAKI ,  Yoko NAGAI ,  Teruyuki NAGAMUNE ,  Lisa KATO

IPC分类号： G01N33/569 ,  B01L3/00 ,  G01N33/53 ,  G01N33/543 ,  G01N33/561

CPC分类号： G01N33/56983 ,  B01L3/50273 ,  G01N33/5308 ,  G01N33/54373 ,  G01N33/561 ,  B01L2200/16 ,  B01L2300/0654 ,  B01L2300/168 ,  B01L2400/0418 ,  B01L2400/0424

摘要： The invention relates to a method for detecting a virus in a specimen, including: a step of preparing a test solution containing a specimen, a surfactant, and a fluorescently labeled anti-nucleocapsid protein antibody; a step of bringing the test solution into contact with a microelectrode and applying a voltage to the microelectrode so as to concentrate a fluorescently labeled anti-nucleocapsid protein antibody which is bound to a nucleocapsid protein of the virus in the specimen near the microelectrode; and a step of detecting the presence of the virus in the specimen by fluorescence observation, in which the nucleocapsid protein forms a complex with a nucleic acid.

公开(公告)号：US20240316560A1

公开(公告)日：2024-09-26

申请号：US18577435

申请日：2022-07-08

申请人： LIGHTCAST DISCOVERY LTD

发明人： Robert WOOTTON ,  Thomas Henry ISAAC ,  William DEACON ,  Richard Jeremy INGHAM ,  Timothy James PUCHTLER

IPC分类号： B01L3/00

CPC分类号： B01L3/502792 ,  B01L3/502715 ,  B01L2200/04 ,  B01L2200/0673 ,  B01L2200/16 ,  B01L2300/16 ,  B01L2400/0427 ,  B01L2400/0487

摘要： A device for manipulating a microdroplet using optically mediated electrowetting is provided. The device comprising a microfluidic space bounded by: a first composite wall comprising: a first substrate; a first conductor layer on the substrate; a photoactive layer on the first conductor layer; and a first continuous dielectric layer on the photoactive layer having thickness of less than 20 nm; a second composite wall comprising: a second substrate; and a second conductor layer on the substrate.

公开(公告)号：US20240316558A1

公开(公告)日：2024-09-26

申请号：US18678112

申请日：2024-05-30

申请人： Xilis, Inc.

发明人： Bradley Scott Thomas ,  Timothy A. Miller ,  Daniel Nelson ,  Raheel Samuel ,  George Robinson ,  Tyler Welder

IPC分类号： B01L3/00 ,  C12M1/00 ,  C12M1/12 ,  C12M1/34 ,  C12M3/06 ,  G01N15/14 ,  G01N15/1433 ,  G01N15/1434

CPC分类号： B01L3/502784 ,  B01L3/50273 ,  B01L3/502746 ,  C12M23/16 ,  C12M23/40 ,  C12M25/16 ,  C12M41/12 ,  C12M41/36 ,  C12M41/40 ,  G01N15/1433 ,  G01N15/1434 ,  G01N15/1459 ,  B01L2200/061 ,  B01L2200/0673 ,  B01L2300/0654 ,  B01L2300/0883 ,  B01L2300/14 ,  B01L2300/161 ,  B01L2300/1805 ,  B01L2400/082 ,  G01N2015/1493

摘要： A microfluidic apparatus includes a microfluidic chip for MicroOrganoSpheres (MOS) generation. A first channel is defined in a surface of the microfluidic chip and includes: a droplet generation portion including an inlet portion, a junction between the inlet portion and an emulsifying fluid channel, and a chamber downstream of the junction. A cross-sectional area of the chamber is larger than that of the inlet portion. The first channel includes a polymerization portion downstream of the droplet generation portion, the polymerization portion having a serpentine configuration. The apparatus includes a cartridge for MOS demulsification, including: a collection container; a substrate disposed on the collection container, and a membrane disposed between the collection container and the surface of the substrate. A second channel is defined in the surface of the substrate that faces the collection container and is fluidically connected to an output of the polymerization portion of the first channel.

公开(公告)号：US20240316549A1

公开(公告)日：2024-09-26

申请号：US18672675

申请日：2024-05-23

申请人： Redbud Labs, Inc. ,  THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

发明人： Richard Chasen Spero ,  Jay Kenneth Fisher ,  Richard Superfine

IPC分类号： B01L3/00 ,  G01N33/543

CPC分类号： B01L3/502715 ,  B01L3/502746 ,  B01L3/502761 ,  G01N33/54366 ,  G01N33/54373 ,  B01L2200/0631 ,  B01L2200/0647 ,  B01L2200/14 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2400/0415 ,  B01L2400/043 ,  B01L2400/0475

摘要： A flow cell is provided that includes surface-attached structures in a chamber. The structures are movable in response to an actuation force. The flow cell may be utilized to extract or isolate nucleic acids from a sample flowing through the flow cell, wherein some portion of the flow cell comprises nucleic acid adsorbant material (e.g. the outer surface of the surface-attached structures, an inside surface of the chamber of the flow cell, beads attached to the outer surface of the surface-attached structures, or beads integrated into the outer surface of the surface-attached structures). Further, systems and methods for extraction of nucleic acids using such flow cells are also provided.

公开(公告)号：US20240316547A1

公开(公告)日：2024-09-26

申请号：US18273542

申请日：2021-01-20

申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)

发明人： Fabien SORIN ,  Bastien SCHYRR

IPC分类号： B01L3/00 ,  D01F1/10 ,  D01F8/00

CPC分类号： B01L3/502707 ,  D01F1/10 ,  D01F8/00 ,  B01L2200/12 ,  B01L2300/0838 ,  B01L2300/0845 ,  B01L2300/12 ,  B01L2400/0406 ,  D10B2401/022 ,  D10B2509/00

摘要： One aspect of the present invention relates to a method of fabricating a chemically active fibre device (1) by thermal drawing. The method comprises the steps of providing a preform, the preform comprising a support element (3) at least partially made of a first polymeric material; and carrying out a thermal drawing process of the preform to produce a thermally drawn fibre. The preform comprises one or more chemically active agents and/or biological materials configured to react with a fluid sample when the one or more chemically active agents and/or biological materials are in contact with the fluid sample. In this manner miniaturised lab-in-fibre devices can be fabricated.

公开(公告)号：US20240315620A1

公开(公告)日：2024-09-26

申请号：US18680331

申请日：2024-05-31

申请人： Magnolia Medical Technologies, Inc.

发明人： Gregory J. BULLINGTON ,  Jay M. MIAZGA ,  Shan E. GAW ,  Timothy F. RAMSEY

IPC分类号： A61B5/15 ,  B01L3/00

CPC分类号： A61B5/150946 ,  A61B5/15003 ,  A61B5/150099 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150251 ,  A61B5/150992 ,  B01L3/502 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2300/0681 ,  B01L2300/14 ,  B01L2400/0478 ,  B01L2400/0487

摘要： A fluid control device includes an inlet configured to be placed directly or indirectly in fluid communication with a bodily fluid source and an outlet configured to be placed in fluid communication with a fluid collection device. The fluid control device has a first state in which a negative pressure differential produced from an external source such as the fluid collection device is applied to the fluid control device to draw an initial volume of bodily fluid from the bodily fluid source, through the inlet, and into a sequestration portion of the fluid control device. The fluid control device has a second state in which (1) the sequestration portion sequesters the initial volume, and (2) the negative pressure differential draws a subsequent volume of bodily fluid, being substantially free of contaminants, from the bodily fluid source, through the fluid control device, and into the fluid collection device.

公开(公告)号：US12099011B2

公开(公告)日：2024-09-24

申请号：US17083182

申请日：2020-10-28

申请人： PLEXBIO CO., LTD.

发明人： Cheng-Tse Lin ,  Yi-Ming Sun ,  Kuei-Shen Hsu ,  Liang-Han Chang ,  Yao-Kuang Chung ,  Chin-Yun Wu ,  Chin-Shiou Huang

IPC分类号： G01N21/64 ,  B01L3/00 ,  C08F20/18 ,  C08F120/14 ,  C08K5/357 ,  C09B69/10 ,  C09K11/02 ,  C09K11/06 ,  G01N21/27 ,  G01N21/93

CPC分类号： G01N21/6452 ,  B01L3/5085 ,  C08F20/18 ,  C08F120/14 ,  C08K5/357 ,  C09B69/101 ,  C09B69/103 ,  C09B69/105 ,  C09B69/109 ,  C09K11/02 ,  C09K11/06 ,  G01N21/278 ,  G01N21/6486 ,  B01L2200/12 ,  B01L2200/148 ,  B01L2300/0829 ,  C09K2211/1033 ,  G01N2201/127

摘要： The present invention relates to a fluorescent polymer cast on the surface of wells of a plate and a plate comprising the fluorescent polymer. The plate is used in a method for calibrating read-out values of plate readers. The method for calibrating the plate readers can effectively reduce the deviation of read-out values among different plate readers.