Alfavbeta3 and alfavbet6 integrin antagonists as antifibrotic agents
    72.
    发明申请
    Alfavbeta3 and alfavbet6 integrin antagonists as antifibrotic agents 审中-公开
    Alfavbeta3和alfavbet6整合素拮抗剂作为抗纤维化剂

    公开(公告)号:US20070117849A1

    公开(公告)日:2007-05-24

    申请号:US10574215

    申请日:2004-09-16

    IPC分类号: A61K31/4439 A61K31/44

    CPC分类号: A61K31/00

    摘要: This invention relates to inhibition of αv integrins, especially αvβ3 and αvβ6 integrins, by specific antagonists, preferably non-peptidic antagonists, related compounds and compounds with comparable specificity, that downregulate fibrogenesis by inhibiting cell migration and production of pro-fibrogenic molecules (e.g., collagens, TIMP-1) and cytokines (e.g., CTGF) by activated hepatic stellate cells/myofibroblasts, activated epithelia and endothelia. These antagonists alone or in combination with other agents can effectively prevent, mitigate or even reverse development of advanced fibrosis, such as fibrosis/cirrhosis of the liver and fibrosis of other organs, such as lungs, kidneys, intestine, pancreas, skin and arteries.

    摘要翻译: 本发明涉及通过特异性拮抗剂,优选非肽拮抗剂,相关化合物和具有相当特异性的化合物抑制alphav整合素,特别是alphavbeta3和alphavbeta6整联蛋白,通过抑制细胞迁移和产生促纤维化分子来下调纤维发生(例如, 胶原,TIMP-1)和活化的肝星状细胞/肌成纤维细胞,活化的上皮细胞和内皮细胞因子(例如CTGF)。 这些单独的或与其它药剂组合的拮抗剂可以有效地预防,减轻或甚至逆转晚期纤维化的发展,例如肝纤维化/肝硬化和其他器官如肺,肾,肠,胰腺,皮肤和动脉的纤维化。

    Laminin-5 modulators and uses thereof
    75.
    发明申请
    Laminin-5 modulators and uses thereof 审中-公开
    层粘连蛋白-5调节剂及其用途

    公开(公告)号:US20070014788A1

    公开(公告)日:2007-01-18

    申请号:US11451583

    申请日:2006-06-12

    IPC分类号: A61K48/00 A61K39/395

    CPC分类号: A61K39/395

    摘要: Described herein are methods of treating or preventing various diseases and disorders using modulators of laminin-5. Exemplary diseases and disorders are inflammatory bowel disease, including ulcerative colitis and Crohn's disease, as well as polycystic kidney disease and cancers associated with one or more of the aforementioned conditions. Exemplary laminin-5 modulators include monoclonal antibodies against the laminin-5 gamma2 chain and short interfering RNA (siRNA) sequences against nucleotide sequences encoding the laminin-5 gamma2 chain. Described are also combination treatments based on the administration of a laminin-5 modulator and at least one other therapeutic agent.

    摘要翻译: 本文描述的是使用层粘连蛋白-5的调节剂治疗或预防各种疾病和病症的方法。 示例性疾病和病症是炎性肠病,包括溃疡性结肠炎和克罗恩病,以及与一种或多种上述病症相关的多囊肾病和癌症。 示例性的层粘连蛋白-5调节剂包括针对层粘连蛋白-5γ2链的单克隆抗体和针对编码层粘连蛋白-5γ2链的核苷酸序列的短干扰RNA(siRNA)序列。 还描述了基于施用层粘连蛋白-5调节剂和至少一种其它治疗剂的组合治疗。

    System and method for mining and searching localized business-marketing and informational data
    79.
    发明申请
    System and method for mining and searching localized business-marketing and informational data 审中-公开
    用于挖掘和搜索本地化的商业营销和信息数据的系统和方法

    公开(公告)号:US20050278309A1

    公开(公告)日:2005-12-15

    申请号:US10858947

    申请日:2004-06-02

    IPC分类号: G06F7/00 G06F17/30

    CPC分类号: G06F16/9537

    摘要: A system and method for searching records. One embodiment includes a method for searching comprising: receiving a search a term comprising a product term and a geography limitation; identifying a normalized term corresponding to the product term; identify a first set of records corresponding to the normalized term; sorting the first set of records according to the geography limitation; returning at least some of the first set of records according to the sort; identifying navigation links corresponding to the normalized term; identifying a second set of records corresponding to at least one of the navigation links; and returning at least some of the second set of records.

    摘要翻译: 用于搜索记录的系统和方法。 一个实施例包括一种用于搜索的方法,包括:接收搜索包括产品项和地理限制的术语; 识别对应于产品项的标准化术语; 识别与归一化术语相对应的第一组记录; 根据地理限制对第一组记录进行排序; 根据排序返回至少一些第一组记录; 识别与归一化术语相对应的导航链接; 识别对应于所述导航链路中的至少一个的第二组记录; 并返回至少一些第二组记录。