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158 条记录 (耗时 0.057 秒)

    3-dimensional silk hydroxyapatite compositions
    72.
    发明授权
    3-dimensional silk hydroxyapatite compositions 有权
    三维丝羟基磷灰石组合物

    公开(公告)号：US09504575B2

    公开(公告)日：2016-11-29

    申请号：US12866256

    申请日：2009-02-06

    申请人： David L. Kaplan ,  Hyeon Joo Kim ,  Gerard Kugel

    发明人： David L. Kaplan ,  Hyeon Joo Kim ,  Gerard Kugel

    IPC分类号： A61F2/46 ,  A61F2/28 ,  A61L27/46 ,  A61L27/54

    CPC分类号： A61F2/2846 ,  A61F2002/2817 ,  A61F2310/00293 ,  A61F2310/00365 ,  A61L27/46 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/602 ,  A61L2300/64 ,  A61L2430/02 ,  C08L89/00

    摘要： Described herein are methods and compositions comprising a mixture of silk polymer and hydroxyapatite. The methods described herein can be used to prepare a mixture of silk polymer and hydroxyapatite and further provide mixtures that can be molded into a desired shape. Also encompassed herein are compositions comprising a mixture of silk polymer and hydroxyapatite having a desired shape, which can further be implanted, for example, to facilitate bone healing or tooth structure or support. Such compositions can also include agents, such as therapeutic agents, or cells.

    摘要翻译： 本文描述了包含丝聚合物和羟基磷灰石的混合物的方法和组合物。 本文所述的方法可用于制备丝聚合物和羟基磷灰石的混合物，并进一步提供可模塑成所需形状的混合物。 本文还包括包含丝状聚合物和具有所需形状的羟基磷灰石的混合物的组合物，其可以进一步植入，例如以促进骨愈合或牙齿结构或支撑。 这样的组合物还可以包括试剂，例如治疗剂或细胞。

    Covalently immobilized protein gradients in three-dimensional porous scaffolds
    73.
    发明授权
    Covalently immobilized protein gradients in three-dimensional porous scaffolds 有权
    在三维多孔支架中共价固定的蛋白质梯度

    公开(公告)号：US09290579B2

    公开(公告)日：2016-03-22

    申请号：US11407373

    申请日：2006-04-19

    申请人： Charu Vepari ,  David L. Kaplan ,  Gordana Vunjak-Novakovic

    发明人： Charu Vepari ,  David L. Kaplan ,  Gordana Vunjak-Novakovic

    IPC分类号： C07K17/02 ,  C12N11/02 ,  C07K17/04 ,  C12N11/04 ,  C12N11/06 ,  C12N11/10

    CPC分类号： C07K17/02 ,  C07K17/04 ,  C12N11/02 ,  C12N11/04 ,  C12N11/06 ,  C12N11/10

    摘要： The invention provides a method for forming an immobilized agent gradient within a 3-dimensional porous scaffold. A 3-dimensional scaffold formed from a biocompatible material is provided. The surface of the scaffold and/or the agent is activated so as to allow binding of the agent to the scaffold. The activated scaffold is contacted with a solution containing the agent. Contact with the solution is maintained for a sufficient period of time to allow diffusion of the solution through a portion of the scaffold, thereby forming a desired gradient of the agent through the 3-dimensional scaffold.

    摘要翻译： 本发明提供了在三维多孔支架内形成固定化剂梯度的方法。 提供由生物相容性材料形成的3维支架。 支架和/或试剂的表面被活化，以允许试剂与支架结合。 活化的支架与含有该试剂的溶液接触。 保持与溶液接触足够的时间以允许溶液扩散通过支架的一部分，从而通过3维支架形成所需试剂的梯度。

    Polysaccharide composition and methods of isolation of the emulsion stabilizing cationic polyelectrolytic polysaccharide
    77.
    发明授权
    Polysaccharide composition and methods of isolation of the emulsion stabilizing cationic polyelectrolytic polysaccharide 失效
    多糖组成和分离乳液稳定阳离子聚电解多糖的方法

    公开(公告)号：US08609835B2

    公开(公告)日：2013-12-17

    申请号：US12993711

    申请日：2009-05-28

    申请人： David L. Kaplan ,  Bruce Panilaitis ,  Michael Mercaldi ,  Hanna Dams-Kozlowska

    发明人： David L. Kaplan ,  Bruce Panilaitis ,  Michael Mercaldi ,  Hanna Dams-Kozlowska

    IPC分类号： C08B37/00 ,  A61K9/14 ,  A61K31/715 ,  C07H5/04

    CPC分类号： C12P19/04 ,  A61K9/1271 ,  A61K9/5123 ,  A61K47/36 ,  B82Y30/00 ,  C08B37/0003 ,  C08B37/0063

    摘要： The present invention relates to purification and use of a novel emulsion stabilizing polysaccharide. In particular, a polyelectrolyte exopolysaccharide with high molecular weight comprising a high molecular weight polymer with a tri-saccharide repeating unit is disclosed. In one aspect of the invention, methods are directed to isolating and purifying a high molecular weight exopolysaccharide (EPS) from a cell supernatant. In another aspect, methods are disclosed for isolating a lipopolysaccharide (LPS) and a high molecular weight Acinetobacter polyelectrolyte exopolysaccharide (APE) from Acinetobacter bacteria. Compositions are also directed to lipid nanoparticles comprising a therapeutic agent encapsulated by a high molecular weight polysaccharide and nanoparticles comprising a therapeutic agent bound to a cationic polysaccharide cross-linked with a polyanion.

    摘要翻译： 本发明涉及新型乳化稳定多糖的纯化和应用。 特别地，公开了具有高分子量的聚电解质外多糖，其包含具有三糖重复单元的高分子量聚合物。 在本发明的一个方面，方法涉及从细胞上清液中分离和纯化高分子量外多糖（EPS）。 在另一方面，公开了从不动细菌分离脂多糖（LPS）和高分子量不动杆菌聚电解质外多糖（APE）的方法。 组合物还涉及包含由高分子量多糖包封的治疗剂和包含与聚阴离子交联的阳离子多糖结合的治疗剂的纳米颗粒的脂质纳米颗粒。

    Vitamin C Composition for Use in the Prevention and Treatment of Stretch Marks, Radiation Dermatitis, and Other Skin Conditions and Methods of Using the Same
    79.
    发明申请
    Vitamin C Composition for Use in the Prevention and Treatment of Stretch Marks, Radiation Dermatitis, and Other Skin Conditions and Methods of Using the Same 审中-公开
    用于预防和治疗伸展标记，放射性皮炎和其他皮肤状况的维生素C组合物及其使用方法

    公开(公告)号：US20130131162A1

    公开(公告)日：2013-05-23

    申请号：US13738125

    申请日：2013-01-10

    申请人： David L. Kaplan

    发明人： David L. Kaplan

    IPC分类号： A61K31/341

    CPC分类号： A61K8/676 ,  A61K9/0014 ,  A61K31/34 ,  A61K31/341 ,  A61K47/10 ,  A61Q19/004 ,  A61Q19/06

    摘要： A formulation for a stable ascorbic acid composition which, in a simplified form, is comprised of ascorbic acid in solution with a hygroscopic compound (i.e., a substance with the ability to attract water molecules from the surrounding environment through either absorption or adsorption). Also disclosed herein are methods for the production of such compounds and methods of using such compounds in the prevention, inhibition and treatment of striae gravidarum, radiation dermatitis, rhytids, lentigoes, dyschromia, sun-damage induced hyperpigmentation, cellulite, scars and purpura, among other skin diseases or conditions.

    摘要翻译： 用于稳定的抗坏血酸组合物的制剂，其以简单的形式由溶液中的抗坏血酸与吸湿性化合物（即具有通过吸收或吸附从周围环境吸引水分子的能力的物质）组成。 本文还公开了生产这种化合物的方法和使用这些化合物在预防，抑制和治疗妊娠纹，放射性皮炎，ids ids，，，es，dys ia ia ia，，，damage damage ite，among among among among among among among among among among among among among among among among among among 其他皮肤病或病症。

    Functionalization of silk material by avidin-biotin interaction
    80.
    发明授权
    Functionalization of silk material by avidin-biotin interaction 有权
    丝素材料通过抗生物素蛋白 - 生物素相互作用进行功能化

    公开(公告)号：US08293486B2

    公开(公告)日：2012-10-23

    申请号：US13381687

    申请日：2010-07-20

    申请人： David L. Kaplan ,  Xiaoqin Wang ,  Monica A. Serban

    发明人： David L. Kaplan ,  Xiaoqin Wang ,  Monica A. Serban

    IPC分类号： G01N33/53 ,  C07K1/00

    CPC分类号： C07K14/43586 ,  A61K47/64 ,  A61K47/6903 ,  A61K47/6921

    摘要： The present invention provides for compositions and methods of linking silk fibroin to active agents through the specific interaction between avidin and biotin, providing for functionalization of silk-based protein biomaterials. An avidin- or biotin-modified silk is a biomaterial platform for functionalization with a variety of correspondingly linked active agents, such as antibodies and growth factors. A variety of functionalized silk materials, such as silk hydrogel, silk micro/nanoparticles and silk films, can be prepared by the methods of the present invention. The functionalization strategies of the present invention are relatively easy, fast and feasible, and are thus useful in many biomedical applications.

    摘要翻译： 本发明提供通过抗生物素蛋白和生物素之间的特异性相互作用将丝素蛋白与活性剂连接的组合物和方法，提供了基于丝的蛋白质生物材料的功能化。 抗生物素蛋白或生物素修饰的丝是用于与多种相应连接的活性剂如抗体和生长因子进行功能化的生物材料平台。 可以通过本发明的方法制备各种功能性丝绸材料，例如丝素水凝胶，丝微/纳米颗粒和丝膜。 本发明的功能化策略相对容易，快速和可行，因此在许多生物医学应用中是有用的。