公开(公告)号：US07364915B2

公开(公告)日：2008-04-29

申请号：US11617804

申请日：2006-12-29

Applicant: Steven A. Sundberg ,  J. Wallace Parce ,  Calvin Y. H. Chow

Inventor： Steven A. Sundberg ,  J. Wallace Parce ,  Calvin Y. H. Chow

IPC: G01N1/10 ,  B01L3/02

CPC classification number: G01N27/44791 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00853 ,  B01J2219/00891 ,  B01J2219/00909 ,  B01L3/0244 ,  B01L3/0262 ,  B01L3/5025 ,  B01L3/50255 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502753 ,  B01L2200/027 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0487 ,  B01L2400/0688 ,  G01N27/44743 ,  G01N2035/00237 ,  G01N2035/1037 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: Fluid introduction is facilitated through the use of a port which extends entirely through a microfluidic substrate. Capillary forces can be used to retain the fluid within the port, and a series of samples or other fluids may be introduced through a single port by sequentially blowing the fluid out through the substrate and replacing the removed fluid with an alternate fluid, or by displacing the fluid in part with additional fluid. In another aspect, microfluidic substrates have channels which varying in cross-sectional dimension so that capillary action spreads a fluid only within a limited portion of the channel network. In yet another aspect, the introduction ports may include a multiplicity of very small channels leading from the port to a fluid channel, so as to filter out particles or other contaminants which might otherwise block the channel at the junction between the channel and the introduction port.

公开(公告)号：US20070102297A1

公开(公告)日：2007-05-10

申请号：US11617800

申请日：2006-12-29

Applicant: Steven Sundberg ,  J. Parce ,  Calvin Chow

Inventor： Steven Sundberg ,  J. Parce ,  Calvin Chow

IPC: G01N27/00

CPC classification number: G01N27/44791 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00853 ,  B01J2219/00891 ,  B01J2219/00909 ,  B01L3/0244 ,  B01L3/0262 ,  B01L3/5025 ,  B01L3/50255 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502753 ,  B01L2200/027 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0487 ,  B01L2400/0688 ,  G01N27/44743 ,  G01N2035/00237 ,  G01N2035/1037 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: Fluid introduction is facilitated through the use of a port which extends entirely through a microfluidic substrate. Capillary forces can be used to retain the fluid within the port, and a series of samples or other fluids may be introduced through a single port by sequentially blowing the fluid out through the substrate and replacing the removed fluid with an alternate fluid, or by displacing the fluid in part with additional fluid. In another aspect, microfluidic substrates have channels which varying in cross-sectional dimension so that capillary action spreads a fluid only within a limited portion of the channel network. In yet another aspect, the introduction ports may include a multiplicity of very small channels leading from the port to a fluid channel, so as to filter out particles or other contaminants which might otherwise block the channel at the junction between the channel and the introduction port.

公开(公告)号：US20070102296A1

公开(公告)日：2007-05-10

申请号：US11617799

申请日：2006-12-29

Applicant: Steven Sundberg ,  J. Parce ,  Calvin Chow

Inventor： Steven Sundberg ,  J. Parce ,  Calvin Chow

IPC: G01N27/00

CPC classification number: G01N27/44791 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00853 ,  B01J2219/00891 ,  B01J2219/00909 ,  B01L3/0244 ,  B01L3/0262 ,  B01L3/5025 ,  B01L3/50255 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502753 ,  B01L2200/027 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0487 ,  B01L2400/0688 ,  G01N27/44743 ,  G01N2035/00237 ,  G01N2035/1037 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: Fluid introduction is facilitated through the use of a port which extends entirely through a microfluidic substrate. Capillary forces can be used to retain the fluid within the port, and a series of samples or other fluids may be introduced through a single port by sequentially blowing the fluid out through the substrate and replacing the removed fluid with an alternate fluid, or by displacing the fluid in part with additional fluid. In another aspect, microfluidic substrates have channels which varying in cross-sectional dimension so that capillary action spreads a fluid only within a limited portion of the channel network. In yet another aspect, the introduction ports may include a multiplicity of very small channels leading from the port to a fluid channel, so as to filter out particles or other contaminants which might otherwise block the channel at the junction between the channel and the introduction port.

Abstract translation: 通过使用完全延伸通过微流体衬底的端口来促进流体引入。 可以使用毛细管力将流体保持在端口内，并且可以通过单个端口引入一系列样品或其它流体，通过依次将流体通过基底吹出并用替代流体代替去除的流体，或通过置换 流体部分附加流体。 在另一方面，微流体衬底具有在横截面尺寸上变化的通道，使得毛细管作用仅在通道网络的有限部分内扩散流体。 在另一方面，引入端口可以包括从端口引导到流体通道的多个非常小的通道，以便过滤除了通道和引入端口之间的连接处可能阻挡通道的颗粒或其它污染物 。

公开(公告)号：US20060286000A1

公开(公告)日：2006-12-21

申请号：US11493996

申请日：2006-07-27

Applicant: Steven Sundberg ,  J. Parce ,  Calvin Chow

Inventor： Steven Sundberg ,  J. Parce ,  Calvin Chow

IPC: B01L3/02

CPC classification number: G01N27/44791 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00853 ,  B01J2219/00891 ,  B01J2219/00909 ,  B01L3/0244 ,  B01L3/0262 ,  B01L3/5025 ,  B01L3/50255 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502753 ,  B01L2200/027 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0487 ,  B01L2400/0688 ,  G01N27/44743 ,  G01N2035/00237 ,  G01N2035/1037 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: Fluid introduction is facilitated through the use of a port which extends entirely through a microfluidic substrate. Capillary forces can be used to retain the fluid within the port, and a series of samples or other fluids may be introduced through a single port by sequentially blowing the fluid out through the substrate and replacing the removed fluid with an alternate fluid, or by displacing the fluid in part with additional fluid. In another aspect, microfluidic substrates have channels which varying in cross-sectional dimension so that capillary action spreads a fluid only within a limited portion of the channel network. In yet another aspect, the introduction ports may include a multiplicity of very small channels leading from the port to a fluid channel, so as to filter out particles or other contaminants which might otherwise block the channel at the junction between the channel and the introduction port.

公开(公告)号：US20040179980A1

公开(公告)日：2004-09-16

申请号：US10742004

申请日：2003-12-19

Inventor： Ashish V. Pattekar ,  Mayuresh V. Kothare

IPC: B01J019/00

CPC classification number: C01B3/323 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/0081 ,  B01J2219/00826 ,  B01J2219/00828 ,  B01J2219/00835 ,  B01J2219/0086 ,  B01J2219/00869 ,  B01J2219/00873 ,  B01J2219/00909 ,  B01J2219/00961 ,  B01J2219/00984 ,  C01B2203/00 ,  C01B2203/0233 ,  C01B2203/0283 ,  C01B2203/066 ,  C01B2203/085 ,  C01B2203/1011 ,  C01B2203/1041 ,  C01B2203/1076 ,  C01B2203/1223 ,  C01B2203/1619 ,  C01B2203/1633 ,  C01B2203/1695 ,  Y02P20/52

Abstract: The microreactor consists of a network of catalyst-packed parallel microchannels of cross-sectional dimensions from 400 to 1000 micrometers with a catalyst particle filter near the outlet fabricated by micromachining techniques, e.g., using photolithography and deep-reactive ion etching (DRIE) on a silicon substrate. Microchannel and filter capping, on-chip heating and temperature sensing, introduction and trapping of catalyst particles in the microchannels, flow distribution, microfluidic interfacing and thermal insulation are features of the microreactor. Another microreactor consists of a radial-flow configuration utilizing a annular shaped catalyst zone for carrying out reactions between gases introduced into the microreactor as the gases flow from an inner circular boundary to an outer circular boundary in a radial direction. Methanol to hydrogen molar conversion of at least 85% to 90% at flow rates enough to supply hydrogen to an 8 to 10 Watt fuel cell have been achieved. Microreactors according to the invention can be achieved to produce hydrogen as required for up to a 25 Watt fuel cell. Several such microreactors can be used simultaneously to generate hydrogen for fuel cells with higher power capacities.

Abstract translation: 微反应器由横截面尺寸为400至1000微米的催化剂填充的平行微通道网络组成，在由微加工技术制成的出口附近具有催化剂颗粒过滤器，例如使用光刻和深反应离子蚀刻（DRIE） 硅衬底。 微通道和过滤器封盖，片上加热和温度检测，微通道中催化剂颗粒的引入和捕获，流动分布，微流体界面和隔热是微反应器的特征。 另一个微反应器包括利用环形催化剂区域的径向流动配置，用于当气体从径向方向从内圆形边界流到外圆形边界时，引入到微反应器中的气体之间的反应。 已经实现了甲醇至氢的摩尔转化率至少85％至90％，其流量足以将氢气供应至8至10瓦燃料电池。 根据本发明的微反应器可以实现以产生高达25瓦特燃料电池所需的氢。 可以同时使用若干这样的微反应器来产生具有较高功率容量的燃料电池的氢气。

公开(公告)号：US06709559B2

公开(公告)日：2004-03-23

申请号：US10209493

申请日：2002-07-30

Applicant: Steven A. Sundberg ,  J. Wallace Parce ,  Calvin Y. H. Chow

Inventor： Steven A. Sundberg ,  J. Wallace Parce ,  Calvin Y. H. Chow

IPC: G01N2726

CPC classification number: G01N27/44791 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00853 ,  B01J2219/00891 ,  B01J2219/00909 ,  B01L3/0244 ,  B01L3/0262 ,  B01L3/5025 ,  B01L3/50255 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502753 ,  B01L2200/027 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0487 ,  B01L2400/0688 ,  G01N27/44743 ,  G01N2035/00237 ,  G01N2035/1037 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: Fluid introduction is facilitated through the use of a port which extends entirely through a microfluidic substrate. Capillary forces can be used to retain the fluid within the port, and a series of samples or other fluids may be introduced through a single port by sequentially blowing the fluid out through the substrate and replacing the removed fluid with an alternate fluid, or by displacing the fluid in part with additional fluid. In another aspect, microfluidic substrates have channels which varying in cross-sectional dimension so that capillary action spreads a fluid only within a limited portion of the channel network. In yet another aspect, the introduction ports may include a multiplicity of very small channels leading from the port to a fluid channel, so as to filter out particles or other contaminants which might otherwise block the channel at the junction between the channel and the introduction port.

Abstract translation: 通过使用完全延伸通过微流体衬底的端口来促进流体引入。 可以使用毛细管力将流体保持在端口内，并且可以通过单个端口引入一系列样品或其它流体，通过依次将流体通过基底吹出并用替代流体代替去除的流体，或通过置换 流体部分附加流体。 在另一方面，微流体衬底具有在横截面尺寸上变化的通道，使得毛细管作用仅在通道网络的有限部分内扩散流体。 在另一方面，引入端口可以包括从端口引导到流体通道的多个非常小的通道，以便过滤除了通道和引入端口之间的连接处可能阻挡通道的颗粒或其它污染物 。

公开(公告)号：US20020187074A1

公开(公告)日：2002-12-12

申请号：US10164887

申请日：2002-06-07

Applicant: Nanostream, Inc.

Inventor： Stephen D. O'Connor ,  Christoph D. Karp ,  Marci Pezzuto ,  Courtney Coyne ,  Steven E. Hobbs ,  Eugene Dantsker

IPC: B01L003/00

CPC classification number: B01F5/0682 ,  B01F5/0688 ,  B01F13/0059 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/0081 ,  B01J2219/00822 ,  B01J2219/00833 ,  B01J2219/00837 ,  B01J2219/00867 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00909 ,  B01J2219/00916 ,  B01J2219/00934 ,  B01J2219/00961 ,  B01L3/5027 ,  B01L3/502707 ,  B01L3/502738 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2300/18 ,  B01L2400/0487 ,  B01L2400/0638 ,  B01L2400/084 ,  B82Y30/00 ,  G01N21/05 ,  G01N2021/0346 ,  G01N2021/056 ,  G01N2021/058 ,  Y10T137/0491 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

Abstract: Modular microfluidic systems includes a plurality of microfluidic modules, each capable of performing fluidic operations including, but not limited to, filtering, splitting, regulating pressure, mixing, metering, reacting, diverting, heating, cooling, and condensing are provided. The microfluidic modules are polymeric, stencil-based structures adapted to be coupled in sequence for performing biological or chemical synthesis, including, but not limited to, chemical and biological syntheses of organic, polymer, inorganic, oligonucleotide, peptide, protein, bacteria, and enzymatic products.

Abstract translation: 模块化微流体系统包括多个微流体模块，其各自能够执行流体操作，包括但不限于过滤，分离，调节压力，混合，计量，反应，转向，加热，冷却和冷凝。 微流体模块是适合于依次耦合以进行生物或化学合成的聚合物，基于蜡纸的结构，包括但不限于有机，聚合物，无机，寡核苷酸，肽，蛋白质，细菌和 酶产品。

公开(公告)号：US20020185377A1

公开(公告)日：2002-12-12

申请号：US10208297

申请日：2002-07-30

Applicant: Caliper Technologies Corp.

Inventor： Steven A. Sundberg ,  J. Wallace Parce ,  Calvin Y.H. Chow

IPC: G01N027/26 ,  G01N027/447

CPC classification number: G01N27/44791 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00853 ,  B01J2219/00891 ,  B01J2219/00909 ,  B01L3/0244 ,  B01L3/0262 ,  B01L3/5025 ,  B01L3/50255 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502753 ,  B01L2200/027 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0487 ,  B01L2400/0688 ,  G01N27/44743 ,  G01N2035/00237 ,  G01N2035/1037 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: Fluid introduction is facilitated through the use of a port which extends entirely through a microfluidic substrate. Capillary forces can be used to retain the fluid within the port, and a series of samples or other fluids may be introduced through a single port by sequentially blowing the fluid out through the substrate and replacing the removed fluid with an alternate fluid, or by displacing the fluid in part with additional fluid. In another aspect, microfluidic substrates have channels which varying in cross-sectional dimension so that capillary action spreads a fluid only within a limited portion of the channel network. In yet another aspect, the introduction ports may include a multiplicity of very small channels leading from the port to a fluid channel, so as to filter out particles or other contaminants which might otherwise block the channel at the junction between the channel and the introduction port.

公开(公告)号：US06440645B1

公开(公告)日：2002-08-27

申请号：US09445650

申请日：1999-12-09

Applicant: Bernadette Yon-Hin ,  James McCann ,  Saji Eapen ,  Christopher Robin Lowe

Inventor： Bernadette Yon-Hin ,  James McCann ,  Saji Eapen ,  Christopher Robin Lowe

IPC: G03F700

CPC classification number: B81C1/00119 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00891 ,  B01J2219/00909 ,  B01L7/525 ,  B41M1/12 ,  B41M3/00 ,  B81B2203/0338 ,  B81C2201/0184

Abstract: A process for the production of a device having a surface microstructure of wells or channels. In the process one or more steps of screen-printing the microstructure as a curable material onto a plastic substrate, and curing the material. Such a device is also obtained by applying onto a substrate a material that is polymerizable or depolymerizable by irradiation, applying a negative or positive resist photoresist respectively, irradiating the structure and removing the unpolymerized or depolymerized material.

Abstract translation: 用于生产具有孔或通道的表面微结构的装置的方法。 在该过程中，将微结构作为可固化材料丝网印刷到塑料基材上的一个或多个步骤，并固化该材料。 这样的器件也可以通过将通过照射可聚合或解聚的材料分别施加到衬底上，分别施加负极或正性抗蚀剂光刻胶，照射该结构并除去未聚合或解聚的材料而获得。

公开(公告)号：US06375901B1

公开(公告)日：2002-04-23

申请号：US09294867

申请日：1999-04-20

Applicant: Karla M. Robotti ,  Sally A. Swedberg ,  Hongfeng Yin

Inventor： Karla M. Robotti ,  Sally A. Swedberg ,  Hongfeng Yin

IPC: B01L1100

CPC classification number: B81B3/0035 ,  B01J19/0093 ,  B01J2219/00891 ,  B01J2219/00907 ,  B01J2219/00909 ,  B01L3/502738 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2400/0677 ,  F16K99/0001 ,  F16K99/0017 ,  F16K99/0025 ,  F16K99/0036 ,  F16K99/0044 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0078 ,  F16K2099/0084 ,  Y10T137/2082 ,  Y10T436/2575

Abstract: Micro-fluid devices and methods for their use are provided. The subject devices are characterized by the presence of at least one micro-valve comprising a phase reversible material, e.g. a reversible gel, that reversibly changes its physical state in response to an applied stimulus, e.g. a thermoreversible gel. In using the subject device, fluid flow along a flow path of the device is modulated by applying an appropriate stimulus, e.g. changing the temperature, to the microvalve. The subject devices find use in a variety of applications, including micro-analytical applications.