Human growth and differentiation factor GDF-5
    2.
    发明授权
    Human growth and differentiation factor GDF-5 有权
    人类生长和分化因子GDF-5

    公开(公告)号:US08361745B2

    公开(公告)日:2013-01-29

    申请号:US12374080

    申请日:2007-07-17

    摘要: This invention relates to the production and use of pharmaceutical growth factor compositions with novel characteristics, e.g., improved solubility and controlled release characteristics under physiological conditions. Compositions of one or more precursor proteins of growth factors of the GDF family provoke morphogenic effects, such as growth, differentiation, protection and regeneration of a variety of tissues and organs, e.g., bone, cartilage, tendons, ligaments, nerves and skin. These compositions can be advantageously used for the healing of tissue-destructive injuries and for the prevention or therapy of degenerative disorders.

    摘要翻译: 本发明涉及具有新特性的药物生长因子组合物的生产和使用,例如生理条件下溶解度和控制释放特性的改善。 GDF家族生长因子的一种或多种前体蛋白质的组成引起形态发生的作用,例如各种组织和器官(例如骨,软骨,腱,韧带,神经和皮肤)的生长,分化,保护和再生。 这些组合物可有利地用于组织破坏性损伤的愈合和用于预防或治疗退行性疾病。