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    INTRINSICALLY DISORDERED PROTEINS FOR EXTRACTION OF NUCLEIC ACIDS
    1.
    发明公开
    INTRINSICALLY DISORDERED PROTEINS FOR EXTRACTION OF NUCLEIC ACIDS 审中-公开

    公开(公告)号：US20230407367A1

    公开(公告)日：2023-12-21

    申请号：US18137921

    申请日：2023-04-21

    申请人： Gabriel P. Lopez ,  Nichlaus J. Carroll ,  Telmo Diez Perez ,  David S. Peabody

    发明人： Gabriel P. Lopez ,  Nichlaus J. Carroll ,  Telmo Diez Perez ,  David S. Peabody

    IPC分类号： C12Q1/6806

    CPC分类号： C12Q1/6806

    摘要： The present disclosure relates to compositions and methods for isolating nucleic acids from a sample comprising nucleic acids, such as physiologically relevant samples or environmental samples. The sample can be incubated with a population of polymers that bind the nucleic acids to form a coacervate in a liquid-liquid phase separated solution. Incubation can be performed at a temperature above a concentration dependent phase separation transition temperature of the polymers. The resulting coacervate can be decanted from the liquid-liquid phase separated solution. The nucleic acids can be separated from the polymers by adding a salt solution, adjusting the pH, or both to disrupt an electrostatic interaction between the nucleic acids and the polymers.

    Nanostructured separation and analysis devices for biological membranes
    6.
    再颁专利
    Nanostructured separation and analysis devices for biological membranes 有权
    用于生物膜的纳米结构分离和分析装置

    公开(公告)号：USRE42315E1

    公开(公告)日：2011-05-03

    申请号：US11825298

    申请日：2007-07-05

    申请人： Gabriel P. Lopez ,  Steven R. J. Brueck ,  Linnea K. Ista

    发明人： Gabriel P. Lopez ,  Steven R. J. Brueck ,  Linnea K. Ista

    IPC分类号： B01D15/34

    CPC分类号： G01N27/44773 ,  B82Y30/00 ,  G01N30/00 ,  G01N30/88 ,  G01N2030/8813 ,  Y10S977/717 ,  Y10S977/845 ,  Y10T436/25375 ,  Y10T436/255

    摘要： The present invention provides a nanostructured device comprising a substrate including nanotroughs therein; and a lipid bilayer suspended on or supported in the substrate. A separation method is also provided comprising the steps of supporting or suspending a lipid bilayer on a substrate; wherein the substrate comprises nanostructures and wherein the lipid bilayer comprises at least one membrane associated biomolecule; and applying a driving force to the lipid bilayer to separate the membrane associated biomolecule from the lipid bilayer and to drive the membrane associated biomolecule into the nanostructures.

    摘要翻译： 本发明提供一种纳米结构装置，其包括其中包括纳沟的基板; 和悬浮在或支撑在基底中的脂质双层。 还提供了一种分离方法，包括以下步骤：在基质上支持或悬浮脂质双层; 其中所述底物包含纳米结构，并且其中所述脂质双层包含至少一个膜缔合的生物分子; 并将驱动力施加到脂质双层以将膜相关生物分子与脂质双层分离并将膜相关联的生物分子驱动到纳米结构中。

    Fabrication of an anisotropic super hydrophobic/hydrophilic nanoporous membranes
    7.
    发明授权
    Fabrication of an anisotropic super hydrophobic/hydrophilic nanoporous membranes 有权
    各向异性超疏水/亲水纳米孔膜的制备

    公开(公告)号：US07393391B2

    公开(公告)日：2008-07-01

    申请号：US10969341

    申请日：2004-10-21

    申请人： Gabriel P. Lopez ,  Plamen B. Atanassov ,  Dmitri A. Brevnov ,  Marcos Barela

    发明人： Gabriel P. Lopez ,  Plamen B. Atanassov ,  Dmitri A. Brevnov ,  Marcos Barela

    IPC分类号： B01D53/22 ,  B01D71/06 ,  B01D67/00

    CPC分类号： B01D69/02 ,  B01D67/0065 ,  B01D67/0079 ,  B01D67/0088 ,  B01D69/127 ,  C25D11/045 ,  C25D11/12 ,  C25D11/24

    摘要： Anisotropic hydrophobic/hydrophilic nanoporous membranes and methods of forming anisotropic hydrophobic/hydrophilic nanoporous membranes are disclosed. The method of forming the nanoporous membrane includes growing a nanoporous oxide film on a substrate. A nanoporous membrane having a top side and a bottom side can then be formed by partially separating the nanoporous oxide film from the substrate. A fluorocarbon film can be deposited on the top side of the nanoporous membrane by plasma polymerization. The disclosed anisotropic hydrophobic/hydrophilic nanoporous membranes can have extremely different hydrophobicity between the top side and the bottom side of the nanoporous membrane.

    摘要翻译： 公开了各向异性疏水/亲水纳米多孔膜和形成各向异性疏水/亲水纳米多孔膜的方法。 形成纳米多孔膜的方法包括在衬底上生长纳米多孔氧化物膜。 然后可以通过从纳米孔氧化膜与基底部分分离而形成具有顶侧和底侧的纳米多孔膜。 氟碳膜可以通过等离子体聚合沉积在纳米多孔膜的顶侧。 所公开的各向异性疏水/亲水纳米孔膜可以在纳米多孔膜的顶侧和底侧之间具有非常不同的疏水性。