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公开(公告)号：US06924149B2
公开(公告)日：2005-08-02
申请号：US10229424
申请日：2002-08-28
申请人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. Van Beek , Damian A. Hajduk , Ralph B. Nielsen , William C. Rust
发明人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. Van Beek , Damian A. Hajduk , Ralph B. Nielsen , William C. Rust
IPC分类号： B01F15/00 , B01J19/00 , B01L3/00 , B01L7/00 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/10 , G01N7/00
CPC分类号： B01L3/50851 , B01F13/0818 , B01F13/0827 , B01F15/00201 , B01F15/00207 , B01F15/00246 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00736 , B01J2219/00738 , B01J2219/00745 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/1079 , Y10T436/11 , Y10T436/115831 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/25875
摘要： Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.
摘要翻译： 公开了用于控制和监测多个反应的进展和性质的装置和方法。 该方法和装置对于组合文库的合成，筛选和表征特别有用，但是与常规实验反应器相比也具有显着的优点。 该装置通常包括用于容纳反应混合物的多个容器和用于控制各个反应混合物或反应混合物组的搅拌速率和温度的系统。 此外，该装置可以包括用于独立地控制每个容器中的压力的装置，以及用于以不同于环境压力的压力将液体注入容器的系统。 单独反应混合物的原位监测为过程控制器提供反馈，并提供用于确定反应速率，产物产率和反应产物的各种性质（包括粘度和分子量）的数据。公开了基于计算机的方法用于过程监测和控制， 并进行数据显示和分析。
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公开(公告)号：US06890492B1
公开(公告)日：2005-05-10
申请号：US09724276
申请日：2000-11-28
申请人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. Van Beek , Damian A. Hajduk , Ralph B. Nielsen , Paul Mansky , Leonid Matsiev , Pei Wang , Eric McFarland
发明人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. Van Beek , Damian A. Hajduk , Ralph B. Nielsen , Paul Mansky , Leonid Matsiev , Pei Wang , Eric McFarland
IPC分类号： B01F15/00 , B01J19/00 , B01L3/00 , B01L7/00 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/10 , B01F7/00
CPC分类号： B01L3/50851 , B01F13/0818 , B01F13/0827 , B01F15/00201 , B01F15/00207 , B01F15/00246 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00736 , B01J2219/00738 , B01J2219/00745 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/1079 , Y10T436/11 , Y10T436/115831 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/25875
摘要： Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.
摘要翻译： 公开了用于控制和监测多个反应的进展和性质的装置和方法。 该方法和装置对于组合文库的合成，筛选和表征特别有用，但是与常规实验反应器相比也具有显着的优点。 该装置通常包括用于容纳反应混合物的多个容器和用于控制各个反应混合物或反应混合物组的搅拌速率和温度的系统。 此外，该装置可以包括用于独立地控制每个容器中的压力的装置，以及用于以不同于环境压力的压力将液体注入容器的系统。 单独反应混合物的原位监测为过程控制器提供反馈，并提供了确定反应速率，产物产率和反应产物各种性质（包括粘度和分子量）的数据。 公开了基于计算机的方法，用于过程监控和控制，以及数据显示和分析。
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公开(公告)号：US06787112B1
公开(公告)日：2004-09-07
申请号：US09724275
申请日：2000-11-28
申请人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. VanBeek , Damian A. Hajduk , Ralph B. Nielsen , William C. Rust
发明人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. VanBeek , Damian A. Hajduk , Ralph B. Nielsen , William C. Rust
IPC分类号： B01J1900
CPC分类号： B01L3/50851 , B01F13/0818 , B01F13/0827 , B01F15/00201 , B01F15/00207 , B01F15/00246 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00736 , B01J2219/00738 , B01J2219/00745 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/1079 , Y10T436/11 , Y10T436/115831 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/25875
摘要： Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.
摘要翻译： 公开了用于控制和监测多个反应的进展和性质的装置和方法。 该方法和装置对于组合文库的合成，筛选和表征特别有用，但是与常规实验反应器相比也具有显着的优点。 该装置通常包括用于容纳反应混合物的多个容器和用于控制各个反应混合物或反应混合物组的搅拌速率和温度的系统。 此外，该装置可以包括用于独立地控制每个容器中的压力的装置，以及用于以不同于环境压力的压力将液体注入容器的系统。 单独反应混合物的原位监测为过程控制器提供反馈，并提供了确定反应速率，产物产率和反应产物各种性质（包括粘度和分子量）的数据。 公开了基于计算机的方法，用于过程监控和控制，以及数据显示和分析。
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公开(公告)号：US06864092B1
公开(公告)日：2005-03-08
申请号：US09723926
申请日：2000-11-28
申请人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. VanBeek , Damian A. Hajduk , Ralph B. Nielsen , Paul Mansky , Leonid Matsiev , Pei Wang , Eric McFarland
发明人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. VanBeek , Damian A. Hajduk , Ralph B. Nielsen , Paul Mansky , Leonid Matsiev , Pei Wang , Eric McFarland
IPC分类号： B01F15/00 , B01J19/00 , B01L3/00 , B01L7/00 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/10 , G01N31/10
CPC分类号： B01L3/50851 , B01F13/0818 , B01F13/0827 , B01F15/00201 , B01F15/00207 , B01F15/00246 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00736 , B01J2219/00738 , B01J2219/00745 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/1079 , Y10T436/11 , Y10T436/115831 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/25875
摘要： Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.
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公开(公告)号：US06455316B1
公开(公告)日：2002-09-24
申请号：US09548848
申请日：2000-04-13
申请人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. VanBeek , Damian A. Hajduk , Ralph B. Nielsen , Paul Mansky , Leonid Matsiev , Pei Wang , Eric McFarland
发明人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. VanBeek , Damian A. Hajduk , Ralph B. Nielsen , Paul Mansky , Leonid Matsiev , Pei Wang , Eric McFarland
IPC分类号： G01N3110
CPC分类号： B01F15/00207 , B01F13/065 , B01F13/08 , B01F15/00357 , B01F15/00396 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00745 , B01L3/50851 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , F28F27/00 , G01K13/00 , G01N21/253 , G01N35/1079 , Y10T436/11
摘要： Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.
摘要翻译： 公开了用于控制和监测多个反应的进展和性质的装置和方法。 该方法和装置对于组合文库的合成，筛选和表征特别有用，但是与常规实验反应器相比也具有显着的优点。 该装置通常包括用于容纳反应混合物的多个容器和用于控制各个反应混合物或反应混合物组的搅拌速率和温度的系统。 此外，该装置可以包括用于独立地控制每个容器中的压力的装置，以及用于以不同于环境压力的压力将液体注入容器的系统。 单独反应混合物的原位监测为过程控制器提供反馈，并提供了确定反应速率，产物产率和反应产物各种性质（包括粘度和分子量）的数据。 公开了基于计算机的方法，用于过程监控和控制，以及数据显示和分析。
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公开(公告)号：US06548026B1
公开(公告)日：2003-04-15
申请号：US09177170
申请日：1998-10-22
IPC分类号： B01J1900
CPC分类号： B01F15/00207 , B01F13/065 , B01F13/08 , B01F15/00357 , B01F15/00396 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00745 , B01L3/50851 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , F28F27/00 , G01K13/00 , G01N21/253
摘要： An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.
摘要翻译： 公开了一种用于实施和监测多重反应的进展和性质的装置和方法。 该方法和装置对于组合文库的合成，筛选和表征特别有用，但是与常规实验反应器相比也具有显着的优点。 该装置通常包括用于容纳反应混合物的多个容器和用于控制各个反应混合物或反应混合物组的搅拌速率和温度的系统。 此外，该装置可以包括用于独立地控制每个容器中的压力的装置。 单独反应混合物的原位监测为过程控制器提供反馈，并提供了确定反应速率，产物产率和反应产物各种性质（包括粘度和分子量）的数据。
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7.发明授权公开(公告)号：US06508984B1
公开(公告)日：2003-01-21
申请号：US09620310
申请日：2000-07-19
IPC分类号： G01N2100
CPC分类号： G01N35/1097 , B01D15/08 , B01D15/12 , B01D15/14 , B01D15/1871 , B01D15/26 , B01D15/265 , B01D15/325 , B01D15/34 , B01J19/0046 , B01J19/26 , B01J2219/00274 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00313 , B01J2219/00335 , B01J2219/00337 , B01J2219/00344 , B01J2219/00351 , B01J2219/00452 , B01J2219/00495 , B01J2219/00585 , B01J2219/00587 , B01J2219/0059 , B01J2219/00596 , B01J2219/00689 , B01J2219/00691 , B01J2219/00704 , B01J2219/00707 , B01J2219/00722 , B01J2219/00738 , B01J2219/00745 , C40B40/14 , C40B40/18 , G01N15/0205 , G01N30/02 , G01N30/16 , G01N30/24 , G01N30/30 , G01N30/461 , G01N30/466 , G01N30/54 , G01N30/60 , G01N30/6052 , G01N30/88 , G01N30/90 , G01N33/44 , G01N35/085 , G01N2015/0288 , G01N2015/0294 , G01N2030/324 , G01N2030/885 , G01N2030/8886 , G01N2035/1058 , Y10T436/11 , Y10T436/25
摘要： A method and system for researching and developing and/or optimizing new catalysts and products in a combinatorial manner is disclosed. The method begins with starting components or a ligand library and provides methods of creating catalyst or product libraries, which are then tested in a reaction of interest. The system uses methods of robotic handling for moving libraries from station to station. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial catalyst libraries, but also offer significant advantages over conventional experimental methods as well.
摘要翻译： 公开了以组合方式研究和/或优化新催化剂和产品的方法和系统。 该方法从起始组分或配体文库开始，并提供产生催化剂或产物文库的方法，然后在感兴趣的反应中进行测试。 该系统使用机器人处理方法来移动图书馆从站到站。 该方法和装置对于合成，筛选和表征组合催化剂文库是特别有用的，但是与常规实验方法相比也具有显着的优点。
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8.发明授权Apparatus and method of research for creating and testing novel catalysts, reactions and polymers 有权用于制备和测试新型催化剂，反应和聚合物的设备和方法公开(公告)号：US06653138B1
公开(公告)日：2003-11-25
申请号：US09728396
申请日：2000-11-28
IPC分类号： G01N3110
CPC分类号： G01N35/1097 , B01D15/08 , B01D15/12 , B01D15/14 , B01D15/1871 , B01D15/26 , B01D15/265 , B01D15/325 , B01D15/34 , B01J19/0046 , B01J19/26 , B01J2219/00274 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00313 , B01J2219/00335 , B01J2219/00337 , B01J2219/00344 , B01J2219/00351 , B01J2219/00452 , B01J2219/00495 , B01J2219/00585 , B01J2219/00587 , B01J2219/0059 , B01J2219/00596 , B01J2219/00689 , B01J2219/00691 , B01J2219/00704 , B01J2219/00707 , B01J2219/00722 , B01J2219/00738 , B01J2219/00745 , C40B40/14 , C40B40/18 , G01N15/0205 , G01N30/02 , G01N30/16 , G01N30/24 , G01N30/30 , G01N30/461 , G01N30/466 , G01N30/54 , G01N30/60 , G01N30/6052 , G01N30/88 , G01N30/90 , G01N33/44 , G01N35/085 , G01N2015/0288 , G01N2015/0294 , G01N2030/324 , G01N2030/885 , G01N2030/8886 , G01N2035/1058 , Y10T436/11 , Y10T436/25
摘要： A method and system for researching and developing and/or optimizing new catalysts and products in a combinatorial manner is disclosed. The method begins with starting components or a ligand library and provides methods of creating catalyst or product libraries, which are then tested in a reaction of interest. The system uses methods of robotic handling for moving libraries from station to station. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial catalyst libraries, but also offer significant advantages over conventional experimental methods as well.
摘要翻译： 公开了以组合方式研究和/或优化新催化剂和产品的方法和系统。 该方法从起始组分或配体文库开始，并提供产生催化剂或产物文库的方法，然后在感兴趣的反应中进行测试。 该系统使用机器人处理方法来移动图书馆从站到站。 该方法和装置对于合成，筛选和表征组合催化剂文库是特别有用的，但是与常规实验方法相比也具有显着的优点。
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公开(公告)号：US06528026B2
公开(公告)日：2003-03-04
申请号：US09417125
申请日：1998-11-19
申请人： Damian A. Hajduk , Ralph B. Nielsen , Adam Safir , Leonid Matsiev , Eric McFarland , Paul Mansky
发明人： Damian A. Hajduk , Ralph B. Nielsen , Adam Safir , Leonid Matsiev , Eric McFarland , Paul Mansky
IPC分类号： G01N3300
CPC分类号： B01F15/00207 , B01F13/065 , B01F13/08 , B01F15/00357 , B01F15/00396 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00745 , B01L3/50851 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , F28D15/00 , F28D2021/0077 , F28F27/00 , G01K13/00 , G01N21/253 , Y10T436/10 , Y10T436/11 , Y10T436/25
摘要： An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.
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公开(公告)号：US06818183B2
公开(公告)日：2004-11-16
申请号：US10134556
申请日：2002-04-29
申请人： Damian A. Hajduk , Ralph B. Nielsen , Adam Safir , Leonid Matsiev , Eric McFarland , Paul Mansky
发明人： Damian A. Hajduk , Ralph B. Nielsen , Adam Safir , Leonid Matsiev , Eric McFarland , Paul Mansky
IPC分类号： G01N3348
CPC分类号： B01F15/00207 , B01F13/065 , B01F13/08 , B01F15/00357 , B01F15/00396 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00745 , B01L3/50851 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , F28D15/00 , F28D2021/0077 , F28F27/00 , G01K13/00 , G01N21/253 , Y10T436/10 , Y10T436/11 , Y10T436/25
摘要： An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.
摘要翻译： 公开了一种用于实施和监测多重反应的进展和性质的装置和方法。 该方法和装置对于组合文库的合成，筛选和表征特别有用，但是与常规实验反应器相比也具有显着的优点。 该装置通常包括用于容纳反应混合物的多个容器和用于控制各个反应混合物或反应混合物组的搅拌速率和温度的系统。 此外，该装置可以包括用于独立地控制每个容器中的压力的装置。 单独反应混合物的原位监测为过程控制器提供反馈，并提供了确定反应速率，产物产率和反应产物各种性质（包括粘度和分子量）的数据。
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