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公开(公告)号：US06924149B2
公开(公告)日：2005-08-02
申请号：US10229424
申请日：2002-08-28
申请人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. Van Beek , Damian A. Hajduk , Ralph B. Nielsen , William C. Rust
发明人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. Van Beek , Damian A. Hajduk , Ralph B. Nielsen , William C. Rust
IPC分类号： B01F15/00 , B01J19/00 , B01L3/00 , B01L7/00 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/10 , G01N7/00
CPC分类号： B01L3/50851 , B01F13/0818 , B01F13/0827 , B01F15/00201 , B01F15/00207 , B01F15/00246 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00736 , B01J2219/00738 , B01J2219/00745 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/1079 , Y10T436/11 , Y10T436/115831 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/25875
摘要： Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.
摘要翻译： 公开了用于控制和监测多个反应的进展和性质的装置和方法。 该方法和装置对于组合文库的合成，筛选和表征特别有用，但是与常规实验反应器相比也具有显着的优点。 该装置通常包括用于容纳反应混合物的多个容器和用于控制各个反应混合物或反应混合物组的搅拌速率和温度的系统。 此外，该装置可以包括用于独立地控制每个容器中的压力的装置，以及用于以不同于环境压力的压力将液体注入容器的系统。 单独反应混合物的原位监测为过程控制器提供反馈，并提供用于确定反应速率，产物产率和反应产物的各种性质（包括粘度和分子量）的数据。公开了基于计算机的方法用于过程监测和控制， 并进行数据显示和分析。
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公开(公告)号：US06890492B1
公开(公告)日：2005-05-10
申请号：US09724276
申请日：2000-11-28
申请人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. Van Beek , Damian A. Hajduk , Ralph B. Nielsen , Paul Mansky , Leonid Matsiev , Pei Wang , Eric McFarland
发明人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. Van Beek , Damian A. Hajduk , Ralph B. Nielsen , Paul Mansky , Leonid Matsiev , Pei Wang , Eric McFarland
IPC分类号： B01F15/00 , B01J19/00 , B01L3/00 , B01L7/00 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/10 , B01F7/00
CPC分类号： B01L3/50851 , B01F13/0818 , B01F13/0827 , B01F15/00201 , B01F15/00207 , B01F15/00246 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00736 , B01J2219/00738 , B01J2219/00745 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/1079 , Y10T436/11 , Y10T436/115831 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/25875
摘要： Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.
摘要翻译： 公开了用于控制和监测多个反应的进展和性质的装置和方法。 该方法和装置对于组合文库的合成，筛选和表征特别有用，但是与常规实验反应器相比也具有显着的优点。 该装置通常包括用于容纳反应混合物的多个容器和用于控制各个反应混合物或反应混合物组的搅拌速率和温度的系统。 此外，该装置可以包括用于独立地控制每个容器中的压力的装置，以及用于以不同于环境压力的压力将液体注入容器的系统。 单独反应混合物的原位监测为过程控制器提供反馈，并提供了确定反应速率，产物产率和反应产物各种性质（包括粘度和分子量）的数据。 公开了基于计算机的方法，用于过程监控和控制，以及数据显示和分析。
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公开(公告)号：US06787112B1
公开(公告)日：2004-09-07
申请号：US09724275
申请日：2000-11-28
申请人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. VanBeek , Damian A. Hajduk , Ralph B. Nielsen , William C. Rust
发明人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. VanBeek , Damian A. Hajduk , Ralph B. Nielsen , William C. Rust
IPC分类号： B01J1900
CPC分类号： B01L3/50851 , B01F13/0818 , B01F13/0827 , B01F15/00201 , B01F15/00207 , B01F15/00246 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00736 , B01J2219/00738 , B01J2219/00745 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/1079 , Y10T436/11 , Y10T436/115831 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/25875
摘要： Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.
摘要翻译： 公开了用于控制和监测多个反应的进展和性质的装置和方法。 该方法和装置对于组合文库的合成，筛选和表征特别有用，但是与常规实验反应器相比也具有显着的优点。 该装置通常包括用于容纳反应混合物的多个容器和用于控制各个反应混合物或反应混合物组的搅拌速率和温度的系统。 此外，该装置可以包括用于独立地控制每个容器中的压力的装置，以及用于以不同于环境压力的压力将液体注入容器的系统。 单独反应混合物的原位监测为过程控制器提供反馈，并提供了确定反应速率，产物产率和反应产物各种性质（包括粘度和分子量）的数据。 公开了基于计算机的方法，用于过程监控和控制，以及数据显示和分析。
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公开(公告)号：US06864092B1
公开(公告)日：2005-03-08
申请号：US09723926
申请日：2000-11-28
申请人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. VanBeek , Damian A. Hajduk , Ralph B. Nielsen , Paul Mansky , Leonid Matsiev , Pei Wang , Eric McFarland
发明人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. VanBeek , Damian A. Hajduk , Ralph B. Nielsen , Paul Mansky , Leonid Matsiev , Pei Wang , Eric McFarland
IPC分类号： B01F15/00 , B01J19/00 , B01L3/00 , B01L7/00 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/10 , G01N31/10
CPC分类号： B01L3/50851 , B01F13/0818 , B01F13/0827 , B01F15/00201 , B01F15/00207 , B01F15/00246 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00736 , B01J2219/00738 , B01J2219/00745 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/1079 , Y10T436/11 , Y10T436/115831 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/25875
摘要： Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.
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公开(公告)号：US06455316B1
公开(公告)日：2002-09-24
申请号：US09548848
申请日：2000-04-13
申请人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. VanBeek , Damian A. Hajduk , Ralph B. Nielsen , Paul Mansky , Leonid Matsiev , Pei Wang , Eric McFarland
发明人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. VanBeek , Damian A. Hajduk , Ralph B. Nielsen , Paul Mansky , Leonid Matsiev , Pei Wang , Eric McFarland
IPC分类号： G01N3110
CPC分类号： B01F15/00207 , B01F13/065 , B01F13/08 , B01F15/00357 , B01F15/00396 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00745 , B01L3/50851 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , F28F27/00 , G01K13/00 , G01N21/253 , G01N35/1079 , Y10T436/11
摘要： Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.
摘要翻译： 公开了用于控制和监测多个反应的进展和性质的装置和方法。 该方法和装置对于组合文库的合成，筛选和表征特别有用，但是与常规实验反应器相比也具有显着的优点。 该装置通常包括用于容纳反应混合物的多个容器和用于控制各个反应混合物或反应混合物组的搅拌速率和温度的系统。 此外，该装置可以包括用于独立地控制每个容器中的压力的装置，以及用于以不同于环境压力的压力将液体注入容器的系统。 单独反应混合物的原位监测为过程控制器提供反馈，并提供了确定反应速率，产物产率和反应产物各种性质（包括粘度和分子量）的数据。 公开了基于计算机的方法，用于过程监控和控制，以及数据显示和分析。
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公开(公告)号：US07288229B2
公开(公告)日：2007-10-30
申请号：US09850916
申请日：2001-05-08
CPC分类号： G01N21/253 , B01F13/065 , B01F13/08 , B01F15/00207 , B01F15/00357 , B01F15/00396 , B01F15/00454 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00745 , B01L3/50851 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , F28F27/00 , G01K13/00 , Y10T436/11
摘要： An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.
摘要翻译： 公开了一种用于实施和监测多重反应的进展和性质的装置和方法。 该方法和装置对于组合文库的合成，筛选和表征特别有用，但是与常规实验反应器相比也具有显着的优点。 该装置通常包括用于容纳反应混合物的多个容器和用于控制各个反应混合物或反应混合物组的搅拌速率和温度的系统。 此外，该装置可以包括用于独立地控制每个容器中的压力的装置，以及用于以不同于环境压力的压力将液体注入容器的系统。 单独反应混合物的原位监测为过程控制器提供反馈，并提供了确定反应速率，产物产率和反应产物各种性质（包括粘度和分子量）的数据。
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7.发明授权Combinatorial synthesis and screening of organometallic compounds and catalysts 有权组合合成和筛选有机金属化合物和催化剂公开(公告)号：US06440745B1
公开(公告)日：2002-08-27
申请号：US09337048
申请日：1999-06-21
申请人： W. Henry Weinberg , Eric W. McFarland , Isy Goldwasser , Thomas Boussie , Howard Turner , Johannes A. M. van Beek , Vince Murphy , Tim Powers
发明人： W. Henry Weinberg , Eric W. McFarland , Isy Goldwasser , Thomas Boussie , Howard Turner , Johannes A. M. van Beek , Vince Murphy , Tim Powers
IPC分类号： G01N3300
CPC分类号： B01J19/0046 , B01J2219/00313 , B01J2219/00317 , B01J2219/00378 , B01J2219/0043 , B01J2219/00432 , B01J2219/00436 , B01J2219/00441 , B01J2219/00443 , B01J2219/00475 , B01J2219/005 , B01J2219/00511 , B01J2219/00515 , B01J2219/0052 , B01J2219/00527 , B01J2219/00531 , B01J2219/00533 , B01J2219/00536 , B01J2219/0054 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00644 , B01J2219/00646 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00691 , B01J2219/00711 , B01J2219/0072 , B01J2219/00722 , B01J2219/00736 , B01J2219/00745 , B01J2219/00747 , B01J2219/00752 , B01J2219/00754 , B82Y25/00 , B82Y30/00 , C01G51/006 , C01P2002/34 , C01P2002/72 , C01P2002/89 , C01P2004/41 , C01P2004/61 , C01P2004/84 , C01P2006/40 , C01P2006/42 , C04B35/01 , C04B35/16 , C04B35/4508 , C04B35/4521 , C04B35/4525 , C04B35/62218 , C04B2235/3206 , C04B2235/3208 , C04B2235/3213 , C04B2235/3215 , C04B2235/3224 , C04B2235/3225 , C04B2235/3227 , C04B2235/3262 , C04B2235/327 , C04B2235/3275 , C04B2235/3284 , C04B2235/3286 , C04B2235/3296 , C04B2235/3298 , C04B2235/3418 , C04B2235/3463 , C04B2235/656 , C04B2235/761 , C04B2235/762 , C04B2235/768 , C04B2235/96 , C23C14/042 , C23C14/087 , C23C16/042 , C40B30/08 , C40B40/14 , C40B40/18 , C40B60/08 , C40B60/14 , C40B70/00 , G01R33/16 , H01F1/401 , H01F1/407 , H01F10/007 , H01F10/193 , H01F41/18 , H01F41/34 , H01L43/10
摘要： The present invention relates, inter alia, to methodologies for the synthesis, screening and characterization of organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention provide for the combinatorial synthesis, screening and characterization of libraries of supported and unsupported organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (e.g., homogeneous catalysts), but also as additives and therapeutic agents.
摘要翻译： 本发明尤其涉及有机金属化合物和催化剂（例如均相催化剂）的合成，筛选和表征的方法。 本发明的方法提供了负载和未负载的有机金属化合物和催化剂（例如均相催化剂）的文库的组合合成，筛选和表征。 本发明的方法可用于大量有机金属化合物的制备和筛选，所述有机金属化合物不仅可用作催化剂（例如均相催化剂），而且可用作添加剂和治疗剂。
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公开(公告)号：US06419881B1
公开(公告)日：2002-07-16
申请号：US09337043
申请日：1999-06-21
申请人： W. Henry Weinberg , Isy Goldwasser , Thomas Boussie , Howard Turner , Johannes A. M. van Beek , Vince Murphy , Tim Powers
发明人： W. Henry Weinberg , Isy Goldwasser , Thomas Boussie , Howard Turner , Johannes A. M. van Beek , Vince Murphy , Tim Powers
IPC分类号： G01N2100
CPC分类号： C07F15/045 , C07F15/006 , C08F110/02 , C40B40/16 , G01N21/21 , G01N21/47 , G01N21/59 , C08F10/00 , C08F4/7006
摘要： The present invention relates, inter alia, to methodologies for the synthesis, screening and characterization of organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention provide for the combinatorial synthesis, screening and characterization of libraries of supported and unsupported organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (e.g., homogeneous catalysts), but also as additives and therapeutic agents.
摘要翻译： 本发明尤其涉及有机金属化合物和催化剂（例如均相催化剂）的合成，筛选和表征的方法。 本发明的方法提供了负载和未负载的有机金属化合物和催化剂（例如均相催化剂）的文库的组合合成，筛选和表征。 本发明的方法可用于大量有机金属化合物的制备和筛选，所述有机金属化合物不仅可用作催化剂（例如均相催化剂），而且可用作添加剂和治疗剂。
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公开(公告)号：US6030917A
公开(公告)日：2000-02-29
申请号：US898715
申请日：1997-07-22
申请人： W. Henry Weinberg , Eric McFarland , Isy Goldwasser , Thomas Boussie , Howard Turner , Johannes A. M. Van Beek , Vince Murphy , Timothy Powers
发明人： W. Henry Weinberg , Eric McFarland , Isy Goldwasser , Thomas Boussie , Howard Turner , Johannes A. M. Van Beek , Vince Murphy , Timothy Powers
IPC分类号： B01J19/00 , C07B61/00 , C07F15/00 , C07F15/04 , C08F4/70 , C08F10/00 , C40B30/08 , C40B40/14 , C40B40/18 , C40B50/14 , C40B60/14 , G01J4/00 , G01N21/64 , G01N29/036 , G01N29/24 , G01N29/34 , G01N29/44 , B01J31/00 , B01J37/00 , C08F4/02
CPC分类号： G01N21/6402 , B01J19/0046 , B82Y30/00 , C07F15/0066 , C07F15/045 , C08F10/00 , G01J4/00 , G01N29/036 , G01N29/2425 , G01N29/348 , G01N29/4427 , B01J2219/00315 , B01J2219/00317 , B01J2219/00364 , B01J2219/00378 , B01J2219/0043 , B01J2219/00443 , B01J2219/00497 , B01J2219/005 , B01J2219/00511 , B01J2219/00515 , B01J2219/0052 , B01J2219/00527 , B01J2219/00536 , B01J2219/00583 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00702 , B01J2219/00722 , B01J2219/00738 , B01J2219/00745 , B01J2219/00747 , B01J2219/0075 , B01J2219/00754 , C40B30/08 , C40B40/14 , C40B40/18 , C40B50/14 , C40B60/14 , G01N2291/02818 , G01N2291/0423 , G01N2291/106
摘要： The present invention relates, inter alia, to methodologies for the synthesis, screening and characterization of organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention provide for the combinatorial synthesis, screening and characterization of libraries of supported and unsupported organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (e.g., homogeneous catalysts), but also as additives and therapeutic agents.
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10.发明授权Polymerization method from the combinatorial synthesis and analysis of organometallic compounds and catalysts 有权从组合合成和分析有机金属化合物和催化剂的聚合方法公开(公告)号：US06756195B2
公开(公告)日：2004-06-29
申请号：US09235368
申请日：1999-01-21
申请人： W. Henry Weinberg , Eric McFarland , Isy Goldwasser , Thomas Boussie , Howard Turner , Johannes A. M. Van Beek , Vince Murphy , Timothy Powers
发明人： W. Henry Weinberg , Eric McFarland , Isy Goldwasser , Thomas Boussie , Howard Turner , Johannes A. M. Van Beek , Vince Murphy , Timothy Powers
IPC分类号： C12Q100
CPC分类号： G01N21/6402 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00364 , B01J2219/00378 , B01J2219/0043 , B01J2219/00443 , B01J2219/00497 , B01J2219/005 , B01J2219/00511 , B01J2219/00515 , B01J2219/0052 , B01J2219/00527 , B01J2219/00536 , B01J2219/00583 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00702 , B01J2219/00722 , B01J2219/00738 , B01J2219/00745 , B01J2219/00747 , B01J2219/0075 , B01J2219/00754 , B82Y30/00 , C07F15/0066 , C07F15/045 , C08F10/00 , C40B30/08 , C40B40/14 , C40B40/18 , C40B50/14 , C40B60/14 , G01J4/00 , G01N29/036 , G01N29/2425 , G01N29/348 , G01N29/4427 , G01N2291/02818 , G01N2291/0423 , G01N2291/106 , C08F4/7006 , C08F4/7081
摘要： The present invention relates, inter alia, to methodologies for the synthesis, screening and characterization of organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention provide for the combinatorial synthesis, screening and characterization of libraries of supported and unsupported organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (e.g., homogeneous catalysts), but also as additives and therapeutic agents.
摘要翻译： 本发明尤其涉及有机金属化合物和催化剂（例如均相催化剂）的合成，筛选和表征的方法。 本发明的方法提供了负载和未负载的有机金属化合物和催化剂（例如均相催化剂）的文库的组合合成，筛选和表征。 本发明的方法可用于大量有机金属化合物的制备和筛选，所述有机金属化合物不仅可用作催化剂（例如均相催化剂），而且可用作添加剂和治疗剂。
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