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    Device incorporating a microfluidic chip for separating analyte from a sample
    8.
    发明授权
    Device incorporating a microfluidic chip for separating analyte from a sample 有权
    装有微流体芯片以用于从样品中分离分析物的装置

    公开(公告)号：US06664104B2

    公开(公告)日：2003-12-16

    申请号：US10006850

    申请日：2001-11-07

    申请人： Farzad Pourahmadi ,  William A. McMillan ,  Jesus Ching ,  Ronald Chang ,  Lee A. Christel ,  Gregory T. A. Kovacs ,  M. Allen Northrup ,  Kurt E. Petersen

    发明人： Farzad Pourahmadi ,  William A. McMillan ,  Jesus Ching ,  Ronald Chang ,  Lee A. Christel ,  Gregory T. A. Kovacs ,  M. Allen Northrup ,  Kurt E. Petersen

    IPC分类号： C12M134

    CPC分类号： C12M47/06 ,  B01L2400/0622 ,  B01L2400/0644

    摘要： A device for separating an analyte from a fluid sample comprises a cartridge incorporating a flow-through microfluidic chip. The microfluidic chip includes an extraction chamber having an array of microstructures for capturing the analyte and for subsequently releasing the captured analyte into an elution fluid. Each of the microstructures has an aspect ratio of at least 2:1. The cartridge also includes channels and at least one low controller (e.g., one or more valves) for directing the flow of the sample and elution fluid through the microfluidic chip. The cartridge may optionally include a lysing region for lysing sample components (e.g., cells spores, or microorganisms), a waste chamber for storing waste fluid, and reaction or detection chambers for amplifying or detecting the analyte.

    摘要翻译： 用于从流体样品分离分析物的装置包括结合流过微流控芯片的盒。 微流体芯片包括具有用于捕获分析物的微结构阵列并用于随后将捕获的分析物释放到洗脱流体中的提取室。 每个微结构具有至少2:1的纵横比。 墨盒还包括通道和至少一个低控制器（例如，一个或多个阀），用于引导样品流和洗脱流体通过微流体芯片。 筒可任选地包括用于裂解样品组分（例如细胞孢子或微生物）的裂解区，用于储存废液的废物室和用于扩增或检测分析物的反应或检测室。