公开(公告)号：US20230133011A1

公开(公告)日：2023-05-04

申请号：US17816980

申请日：2022-08-02

申请人： MONTEFIORE MEDICAL CENTER

发明人： Richard M. LOPACHIN ,  Terrence GAVIN ,  Brian GEOHAGEN

IPC分类号： A61K31/12 ,  A61K31/167 ,  A61K31/495 ,  A61K31/05 ,  A61K31/095 ,  A61K31/36 ,  A61P39/06 ,  A01N1/02 ,  A61K31/381 ,  A61K31/402 ,  A61K31/5375 ,  C07C49/80 ,  C07C49/807 ,  C07C49/825 ,  C07C49/84 ,  C07C233/33 ,  C07C323/22 ,  C07D207/04 ,  C07D207/325 ,  C07D295/112 ,  C07D333/22

摘要： Methods, filters and compositions are disclosed for treating toxicity due to oxidative stress and toxic electrophiles.

公开(公告)号：US10543481B2

公开(公告)日：2020-01-28

申请号：US15019673

申请日：2016-02-09

申请人： The Trustees of Princeton University

发明人： John T. Groves ,  Xiongyi Huang

IPC分类号： B01J31/18 ,  C07C49/80 ,  C07D319/20 ,  A61K51/04 ,  C07C41/22 ,  C07D209/48 ,  C07D213/643

摘要： Methods of preparing fluorinated compounds by carboxylative fluorination using fluoride are contained herein. Fluorinated compounds are provided. Methods of using fluorinated compounds are contained herein.

公开(公告)号：US10538509B2

公开(公告)日：2020-01-21

申请号：US15301692

申请日：2015-03-27

申请人： THE TRUSTEES OF PRINCETON UNIVERSITY

发明人： David W. C. MacMillan ,  Zhiwei Zuo

IPC分类号： C07C269/06 ,  C07C29/62 ,  C07C41/22 ,  C07C45/65 ,  C07C29/00 ,  C07C319/20 ,  C07C17/363 ,  C07C22/08 ,  C07C23/10 ,  C07C23/18 ,  C07C271/24 ,  C07C271/18 ,  C07C271/22 ,  C07C323/43 ,  C07C49/80 ,  C07C49/807 ,  C07C49/784 ,  C07C49/84 ,  C07C49/792 ,  C07C49/813 ,  C07C33/46 ,  C07C43/225 ,  C07D307/12 ,  C07D403/04 ,  C07D401/04 ,  C07D265/30 ,  C07D211/08 ,  C07D209/14 ,  C07D207/08 ,  C07D207/06 ,  C07C211/27

摘要： Methods described herein enable the production of numerous molecular species through decarboxylative cross-coupling via use of photoredox and transition metal catalysts. A method described herein, in some embodiments, comprises providing a reaction mixture including a photoredox catalyst, a transition metal catalyst, a coupling partner and a substrate having a carboxyl group. The reaction mixture is irradiated with a radiation source resulting in cross-coupling of the substrate and coupling partner via a mechanism including decarboxylation, wherein the coupling partner is selected from the group consisting of a substituted aromatic compound and a substituted aliphatic compound.

公开(公告)号：US20190315892A1

公开(公告)日：2019-10-17

申请号：US16455040

申请日：2019-06-27

申请人： Sirrus, Inc.

发明人： Bernard M. Malofsky ,  Adam G. Malofsky ,  Tanmoy Dey ,  Jeffrey M. Sullivan

IPC分类号： C08F20/28 ,  C08F24/00 ,  C07C67/333 ,  C07D333/24 ,  C09D129/12 ,  C08F128/06 ,  C08F116/36 ,  C07D333/22 ,  C09D141/00 ,  C07D307/46 ,  C09J133/06 ,  C08F20/68 ,  C07C67/343 ,  C08F20/14 ,  C09D4/00 ,  C09J4/00 ,  C08K3/013 ,  C08K5/00 ,  C07C67/30 ,  C07C49/80 ,  C09J133/16 ,  C09J135/02 ,  C09D135/02 ,  C09D133/16 ,  C09D133/14 ,  C08F20/30 ,  C07C69/738 ,  C08F28/06 ,  C08F222/14 ,  C08L35/02 ,  C08L33/16 ,  C08L33/14 ,  C08L21/00 ,  C08F22/20 ,  C08F20/38 ,  C07D307/54 ,  C09J133/14 ,  C07C45/75 ,  C07C49/798 ,  C07C49/796 ,  C07C49/794 ,  C07C67/03 ,  C07C69/604

摘要： The present teachings are directed at 1,1-di substituted alkene monomers (e.g., methylene beta-ketoester monomers), methods for producing the same, polymerizable compositions including a methylene beta-ketoester monomer, and polymers, compositions and products formed therefrom. The monomer preferably is a high purity monomer. In the method for producing the methylene beta-ketoesters of the invention, a beta-ketoester may be reacted with a source of formaldehyde. The methylene beta-ketoester monomers may be used in monomer-based products (e.g., inks, adhesives, coatings, sealants or reactive molding) and polymer-based products (e.g., fibers, films, sheets, medical polymers, composite polymers and surfactants).

公开(公告)号：US20180346615A1

公开(公告)日：2018-12-06

申请号：US15978923

申请日：2018-05-14

申请人： Sirrus, Inc.

发明人： Bernard M. Malofsky ,  Adam G. Malofsky ,  Tanmoy Dey ,  Matthew M. Ellison ,  Larry Hines

IPC分类号： C08F20/28 ,  C09D4/00 ,  C07D307/54 ,  C08K3/013 ,  C08F20/14 ,  C09J133/14 ,  C08F20/30 ,  C08F20/38 ,  C08F22/20 ,  C08K5/00 ,  C08L21/00 ,  C08L33/14 ,  C08L33/16 ,  C08L35/02 ,  C09D133/14 ,  C09D135/02 ,  C09J135/02 ,  C09J133/16 ,  C09D133/16 ,  C07C49/80 ,  C07C67/03 ,  C07C69/604

CPC分类号： C08F20/28 ,  C07C45/75 ,  C07C49/794 ,  C07C49/796 ,  C07C49/798 ,  C07C49/80 ,  C07C67/03 ,  C07C67/30 ,  C07C69/604 ,  C07C69/738 ,  C07D307/46 ,  C07D307/54 ,  C07D333/22 ,  C07D333/24 ,  C08F20/14 ,  C08F20/30 ,  C08F20/38 ,  C08F20/68 ,  C08F22/20 ,  C08F24/00 ,  C08F28/06 ,  C08F116/36 ,  C08F128/06 ,  C08F222/1006 ,  C08F222/14 ,  C08K3/013 ,  C08K5/0008 ,  C08L21/00 ,  C08L33/14 ,  C08L33/16 ,  C08L35/02 ,  C09D4/00 ,  C09D129/12 ,  C09D133/14 ,  C09D133/16 ,  C09D135/02 ,  C09D141/00 ,  C09J133/06 ,  C09J133/14 ,  C09J133/16 ,  C09J135/02 ,  Y02P20/127

摘要： The present invention provides multifunctional monomers, including, but not limited to include multifunctional methylene malonate and methylene beta-ketoester monomers; methods for producing the same; and compositions and products formed therefrom. The multifunctional monomers of the invention may be produced by transesterification or by direct synthesis from monofunctional methylene malonate monomers or methylene beta-ketoester monomers. The present invention further compositions and products formed from methylene beta-ketoester monomers of the invention, including monomer-based products (e.g., inks, adhesives, coatings, sealants or reactive molding) and polymer-based products (e.g., fibers, films, sheets, medical polymers, composite polymers and surfactants).

公开(公告)号：US20170355789A1

公开(公告)日：2017-12-14

申请号：US15661893

申请日：2017-07-27

申请人： SIRRUS, INC.

发明人： Bernard M. Malofsky ,  Adam G. Malofsky ,  Tanmoy Dey ,  Jeffrey M. Sullivan

IPC分类号： C08F20/28 ,  C09D135/02 ,  C07C67/30 ,  C08L33/14 ,  C08F24/00 ,  C08F20/68 ,  C07C69/604 ,  C09J133/16 ,  C07C49/794 ,  C09D133/16 ,  C08F20/38 ,  C07C49/80 ,  C08F20/30 ,  C07D307/54 ,  C08K3/00 ,  C08K5/00 ,  C08F128/06 ,  C07C49/798 ,  C07D333/22 ,  C07C49/796 ,  C09J133/06 ,  C07C69/738 ,  C07C67/03 ,  C09J133/14 ,  C07C45/75 ,  C08F28/06 ,  C09D141/00 ,  C09D129/12 ,  C08F116/36 ,  C08L21/00 ,  C08F22/20 ,  C07D307/46 ,  C08L33/16 ,  C08L35/02 ,  C09J135/02 ,  C07D333/24 ,  C09D133/14 ,  C08F222/14 ,  C08F222/10

CPC分类号： C08F20/28 ,  C07C45/75 ,  C07C49/794 ,  C07C49/796 ,  C07C49/798 ,  C07C49/80 ,  C07C67/03 ,  C07C67/30 ,  C07C67/333 ,  C07C67/343 ,  C07C69/604 ,  C07C69/738 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07D307/46 ,  C07D307/54 ,  C07D333/22 ,  C07D333/24 ,  C08F20/14 ,  C08F20/30 ,  C08F20/38 ,  C08F20/68 ,  C08F22/20 ,  C08F24/00 ,  C08F28/06 ,  C08F116/36 ,  C08F128/06 ,  C08F222/1006 ,  C08F222/14 ,  C08K3/013 ,  C08K5/0008 ,  C08K5/005 ,  C08K5/08 ,  C08K5/13 ,  C08L21/00 ,  C08L33/14 ,  C08L33/16 ,  C08L35/02 ,  C09D4/00 ,  C09D129/12 ,  C09D133/14 ,  C09D133/16 ,  C09D135/02 ,  C09D141/00 ,  C09J4/00 ,  C09J133/06 ,  C09J133/14 ,  C09J133/16 ,  C09J135/02 ,  Y02P20/127 ,  C07C69/716

摘要： The present teachings are directed at 1,1-disubstituted alkene monomers (e.g., methylene beta-ketoester monomers), methods for producing the same, polymerizable compositions including a methylene beta-ketoester monomer, and polymers, compositions and products formed therefrom. The monomer preferably is a high purity monomer. In the method for producing the methylene beta-ketoesters of the invention, a beta-ketoester may be reacted with a source of formaldehyde. The methylene beta-ketoester monomers may be used in monomer-based products (e.g., inks, adhesives, coatings, sealants or reactive molding) and polymer-based products (e.g., fibers, films, sheets, medical polymers, composite polymers and surfactants).

公开(公告)号：US09828324B2

公开(公告)日：2017-11-28

申请号：US14868795

申请日：2015-09-29

申请人： Sirrus, Inc.

发明人： Jeffrey M. Sullivan ,  Adam G. Malofsky ,  Bernard M. Malofsky ,  Tanmoy Dey

IPC分类号： C07C45/00 ,  C07C49/00 ,  C08L27/12 ,  B03D1/016 ,  C08F214/06 ,  C08L27/00 ,  C07C49/84 ,  C07C45/75 ,  C07C49/203 ,  C07C49/794 ,  C07C49/796 ,  C07D333/22 ,  C07C49/557 ,  C07C49/227 ,  C07D307/46 ,  C07C49/80

CPC分类号： C07C49/84 ,  C07C45/75 ,  C07C49/203 ,  C07C49/227 ,  C07C49/557 ,  C07C49/794 ,  C07C49/796 ,  C07C49/80 ,  C07C2601/14 ,  C07D307/46 ,  C07D333/22

摘要： The present teachings are directed at 1,1-disubstituted alkene monomers (e.g., methylene beta-diketone monomers), methods for producing the same, and compositions and products formed therefrom. In the method for producing the monomer, a beta-diketone is preferably reacted with a source of formaldehyde in a modified Knoevenagel reaction optionally in the presence of an acidic or basic catalyst, and optionally in the presence of an acidic or non-acidic solvent, to form reaction complex. The reaction complex may be an oligomeric complex. The reaction complex is subjected to vaporization in order to isolate the monomer. The monomer(s) may be employed in compositions and products, including monomer-based products (e.g., inks, adhesives, coatings, sealants or reactive molding) and polymer-based products (e.g., fibers, films, sheets, medical polymers, composite polymers and surfactants).

公开(公告)号：US09783476B2

公开(公告)日：2017-10-10

申请号：US15126692

申请日：2015-09-07

申请人： Toray Fine Chemicals Co., Ltd.

发明人： Jiro Nakatani ,  Tatsuhiro Nozoe

IPC分类号： C07C45/42 ,  C07C49/80

CPC分类号： C07C45/42 ,  C07C45/455 ,  C07C49/80

摘要： A method produces a 2′-trifluoromethyl-substituted aromatic ketone and includes reacting a 2-halogen-substituted benzotrifluoride compound with magnesium metal to convert the compound to a Grignard reagent; and reacting the Grignard reagent with an acid anhydride; and then hydrolyzing the resultant to produce a 2′-trifluoromethyl-substituted aromatic ketone. The method of producing a 2′-trifluoromethyl-substituted aromatic ketone enables 2′-trifluoromethyl-substituted aromatic ketone to be produced without using expensive raw materials by generating a Grignard reagent as an intermediate and reacting this Grignard reagent with an acid anhydride in an efficient productivity. The 2′-trifluoromethyl-substituted aromatic ketone that is produced by the method of producing a 2′-trifluoromethyl-substituted aromatic ketone can be used as fine chemicals, raw materials for pharmaceuticals and agrochemicals, raw materials for resins and plastics, electronics and information related materials, optical materials, and the like.

公开(公告)号：US20170204041A1

公开(公告)日：2017-07-20

申请号：US15430786

申请日：2017-02-13

申请人： Karos Pharmaceuticals, Inc.

发明人： Stéphane De Lombaert ,  Daniel R. Goldberg

IPC分类号： C07C49/80

CPC分类号： C07C29/32 ,  C07B2200/07 ,  C07C29/143 ,  C07C45/455 ,  C07C49/80 ,  C07C259/10 ,  C07C33/46

摘要： The present invention relates to processes for the preparation of (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol, 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone, and intermediates thereof, which are useful in the preparation of inhibitors of TPH1 for the treatment of, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, low bone mass diseases, serotonin syndrome, and cancer.

公开(公告)号：US09611231B2

公开(公告)日：2017-04-04

申请号：US14683423

申请日：2015-04-10

申请人： E.I. du Pont de Nemours and Company

发明人： Gary David Annis

IPC分类号： C07D261/04 ,  C07C49/80 ,  C07C49/813 ,  C07D231/12 ,  C07C231/12 ,  C07D249/08 ,  C07D231/14 ,  C07D231/16 ,  C07C67/343 ,  C07C231/14 ,  C07C17/35 ,  C07C25/13 ,  C07C205/45 ,  C07D213/40 ,  C07D249/10 ,  C07D277/28 ,  C07C209/74 ,  C07C45/45 ,  C07C45/70

CPC分类号： C07D261/04 ,  C07C17/35 ,  C07C25/13 ,  C07C45/455 ,  C07C45/70 ,  C07C49/80 ,  C07C49/813 ,  C07C67/343 ,  C07C205/45 ,  C07C209/74 ,  C07C231/12 ,  C07C231/14 ,  C07C235/84 ,  C07D213/40 ,  C07D231/12 ,  C07D231/14 ,  C07D231/16 ,  C07D249/08 ,  C07D249/10 ,  C07D277/28 ,  C07C69/94 ,  C07C69/76 ,  C07C211/56

摘要： Disclosed is a method for preparing a compound of Formula 1 wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture comprising a compound of Formula 2, a compound of Formula 3, a base comprising at least one compound selected from the group consisting of alkaline earth metal hydroxides of Formula 4 wherein M is Ca, Sr or Ba, alkali metal carbonates of Formula 4a wherein M1 is Li, Na or K, 1,5-diazabicyclo[4.3.0]non-5-ene and 1,8-diazabicyclo[5.4.0]undec-7-ene, and an aprotic solvent capable of forming a low-boiling azeotrope with water. Also disclosed is a method for preparing a compound of Formula 2 comprising (1) forming a reaction mixture comprising a Grignard reagent derived from contacting a compound of Formula 5 wherein X is Cl, Br or I with magnesium metal or an alkylmagnesium halide in the presence of an ethereal solvent, and then (2) contacting the reaction mixture with a compound of Formula 6 wherein Y is OR11 or NR12R13, and R11, R12 and R13 are as defined in the disclosure. Further disclosed is a method for preparing a compound of Formula 7 wherein Q and Z are as defined in the disclosure, using a compound of Formula 1 characterized by preparing the compound of Formula 1 by the method disclosed above or using a compound of Formula 1 prepared by the method disclosed above.