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公开(公告)号：US20170182113A1
公开(公告)日：2017-06-29
申请号：US15398379
申请日：2017-01-04
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Wei Yang Seow
CPC classification number: A61L27/3804 , A61K9/06 , A61K35/33 , A61K38/02 , A61K47/42 , A61L26/0028 , A61L26/0061 , A61L26/008 , A61L27/22 , A61L27/38 , A61L27/50 , A61L27/52 , A61L2300/412 , A61L2300/426 , A61L2400/06 , A61L2430/00 , A61L2430/06 , A61L2430/38 , C12N5/0018 , C12N5/0062 , C12N5/0068 , C12N5/0671 , C12N5/0691 , C12N2513/00 , C12N2533/50 , C12N2533/54 , C12N2537/10
Abstract: The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.
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12.发明申请公开(公告)号：US20150320908A1
公开(公告)日：2015-11-12
申请号：US14639035
申请日：2015-03-04
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Wei Yang Seow
CPC classification number: A61L27/52 , A61L26/0028 , A61L26/0061 , A61L26/008 , A61L27/22 , A61L27/38 , A61L27/50 , A61L27/60 , A61L2430/06 , A61L2430/16 , C12N5/0068 , C12N2533/50 , C12N2533/54 , C12N2537/10
Abstract: The present invention relates to hydrogel membranes comprising a hydrogel, said hydrogel comprising a plurality of tetramer amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of tetramer amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to stratisfied biostructures and devices comprising at least two hydrogel membranes of the invention, which can be used e.g. to rebuild human skin and for tissue engineering of organs and tissues. The present invention further relates to corneal implants and devices comprising a hydrogel membrane of the invention.
Abstract translation: 本发明涉及包含水凝胶的水凝胶膜，所述水凝胶包括能够自组装成三维大分子纳米纤维网络的多个四聚体两亲肽和/或拟肽，其捕获水并形成所述水凝胶，其中至少一部分 的所述多个四聚体两亲肽和/或拟肽化学交联。 本发明还涉及包含本发明的至少两种水凝胶膜的粘合生物结构和装置，其可以例如使用。 重建人体皮肤和器官和组织的组织工程。 本发明还涉及角膜植入物和包含本发明的水凝胶膜的装置。
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公开(公告)号：US09120841B2
公开(公告)日：2015-09-01
申请号：US13731525
申请日：2012-12-31
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Yihua Loo
IPC: A61K31/74 , A61K47/48 , A01N63/00 , A01N65/00 , C12N5/00 , C12N5/02 , A61K38/08 , A61K38/07 , A61K38/04 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , A61K38/06 , C07K7/06 , C07K5/08 , C07K5/10 , A61K9/06 , C07K5/103 , C07K5/083 , A61K47/42 , A61L27/22 , A61L27/52 , A61L27/54 , A61L31/04 , A61L31/14 , A61L31/16 , A61L15/32 , A61L15/44 , A61L15/60 , A61K9/00 , A61K9/70
CPC classification number: C07K7/06 , A61K9/0019 , A61K9/06 , A61K9/7023 , A61K38/06 , A61K38/07 , A61K38/08 , A61K47/42 , A61L15/32 , A61L15/44 , A61L15/60 , A61L27/22 , A61L27/52 , A61L27/54 , A61L31/043 , A61L31/145 , A61L31/16 , A61L2300/25 , A61L2400/06 , C07K5/08 , C07K5/0808 , C07K5/10 , C07K5/101 , C07K7/00
Abstract: The present invention provides an amphiphilic linear peptide and/or peptoid as well as a hydrogel that includes the amphiphilic linear peptide/peptoid.
Abstract translation: 本发明提供两亲性线性肽和/或拟肽以及包含两亲性线性肽/拟肽的水凝胶。
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公开(公告)号：US20150038428A1
公开(公告)日：2015-02-05
申请号：US14380615
申请日：2013-02-22
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Archana Mishra
IPC: C07K7/06 , A61K38/06 , A61K45/06 , H01L51/00 , A61K8/64 , A61Q19/00 , A61K8/04 , A61K9/107 , A61K38/08 , C07K5/083
CPC classification number: C07K7/06 , A61K8/042 , A61K8/64 , A61K9/06 , A61K9/107 , A61K38/06 , A61K38/08 , A61K45/06 , A61K47/34 , A61K2800/10 , A61K2800/48 , A61Q19/00 , C07K5/06034 , C07K5/0808 , H01L51/0093
Abstract: The present invention relates to organogels and emulsions based on ultrasmall self-assembling peptides. It further relates to methods for producing such organogels and emulsions as well as to the use of the organogels and emulsions in biological and non-biological applications.
Abstract translation: 本发明涉及基于超小型自组装肽的有机凝胶和乳液。 它还涉及生产这种有机凝胶和乳液的方法以及在生物和非生物应用中使用有机凝胶和乳液。
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公开(公告)号：US10179194B2
公开(公告)日：2019-01-15
申请号：US15039952
申请日：2014-12-01
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Yihua Loo
IPC: A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , A61L27/52 , A61K38/06 , A61K38/07 , A61K38/08 , C07K5/062 , C07K5/083 , C07K5/103 , C07K7/06 , A61L27/38 , A61L27/50 , A61L27/54 , B33Y10/00
Abstract: The present invention relates to the use of peptides, peptoids and/or peptidomimetics capable of self-assembling and forming a (nanofibrous) hydrogel in biofabrication. The present invention further relates to methods for preparing hydrogels and to methods for preparing continuous fibres and to methods for obtaining multi-cellular constructs with defined, precise geometrics. The present invention further relates to various uses of such hydrogels for obtaining mini-hydrogel arrays and 3D organoid structures or 3D macromolecular biological constructs.
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Patent Agency Ranking
公开(公告)号：US10105454B2
公开(公告)日：2018-10-23
申请号：US15324144
申请日：2015-07-08
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Ming Ni
Abstract: Various aspects of the present invention relate to a peptide based biomaterial for visualization by SHG microscopy. In particular the invention relates to the use of short peptides as a non-linear optical (NLO) material for second harmonic generation (SHG) microscopy. A preferred short peptide comprises LIVAGK (LK6) and contains a non-polar aliphatic tail (with decreasing hydrophobicity) and a polar head; and can self-assemble into hydrogels; wherein which the peptide forms a tunable fibrous structure for in vitro and in vivo imaging applications and is suitable in disease diagnostics such as amyloidosis, including 1) neuro-degenerative amyloidosis, e.g. Alzheimer's (AD), Parkinson's, Huntington's (PD), 2) non-neuropathic localized amyloidosis such as in Type II Diabetes, and 3) systemic amyloidosis that occurs in multiple tissues, e.g. cataracts and lattice corneal dystrophy (LCD), as well as drug delivery and/or wound dressings.
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公开(公告)号：US09925307B2
公开(公告)日：2018-03-27
申请号：US14634559
申请日：2015-02-27
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Wei Yang Seow
IPC: A61K38/00 , A61P43/00 , A01N25/00 , A61K47/00 , C12N5/00 , C12N5/02 , A61L27/52 , A61K47/42 , A61K38/02 , A61L27/22 , A61L27/38 , A61L27/50 , A61L26/00 , A61K9/06
CPC classification number: A61L27/3804 , A61K9/06 , A61K35/33 , A61K38/02 , A61K47/42 , A61L26/0028 , A61L26/0061 , A61L26/008 , A61L27/22 , A61L27/38 , A61L27/50 , A61L27/52 , A61L2300/412 , A61L2300/426 , A61L2400/06 , A61L2430/00 , A61L2430/06 , A61L2430/38 , C12N5/0018 , C12N5/0062 , C12N5/0068 , C12N5/0671 , C12N5/0691 , C12N2513/00 , C12N2533/50 , C12N2533/54 , C12N2537/10
Abstract: The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.
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公开(公告)号：US20180036432A9
公开(公告)日：2018-02-08
申请号：US15324144
申请日：2015-07-08
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Ming Ni
CPC classification number: A61K49/00 , A61K9/14 , A61K47/42 , A61L26/0047 , A61L26/008 , A61L27/227 , A61L27/52 , C07K5/06034 , C07K5/0808 , C07K5/101 , C07K14/78 , C12Q1/02
Abstract: Various aspects of the present invention relate to a peptide based biomaterial for visualization by SHG microscopy. In particular the invention relates to the use of short peptides as a non-linear optical (NLO) material for second harmonic generation (SHG) microscopy. A preferred short peptide comprises LIVAGK (LK6) and contains a non-polar aliphatic tail (with decreasing hydrophobicity) and a polar head; and can self-assemble into hydrogels; wherein which the peptide forms a tunable fibrous structure for in vitro and in vivo imaging applications and is suitable in disease diagnostics such as amyloidosis, including 1) neuro-degenerative amyloidosis, e.g. Alzheimer's (AD), Parkinson's, Huntington's (PD), 2) non-neuropathic localized amyloidosis such as in Type II Diabetes, and 3) systemic amyloidosis that occurs in multiple tissues, e.g. cataracts and lattice corneal dystrophy (LCD), as well as drug delivery and/or wound dressings.
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19.发明申请NOVEL ULTRASHORT HYDROPHOBIC PEPTIDES THAT SELF-ASSEMBLE INTO NANOFIBROUS HYDROGELS AND THEIR USES 审中-公开自组装成NANOFIBROUS HYDROGELS及其用途的新型超声波疏水性肽公开(公告)号：US20170002041A1
公开(公告)日：2017-01-05
申请号：US15039922
申请日：2014-11-28
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Charlotte Hauser , Yihua Loo
CPC classification number: C07K7/06 , A61K38/00 , A61L26/0047 , A61L26/008 , A61L27/227 , A61L27/38 , A61L27/52 , A61L31/047 , A61L31/145 , A61L2400/06 , A61L2400/12 , A61L2430/34 , C07K5/06034 , C07K5/06052 , C07K5/0808 , C07K5/101 , C12N5/0062 , C12N5/0068 , C12N2533/50
Abstract: The present invention relates to hydrophobic peptides and/or peptidomimetics capable of forming a (nanofibrous) hydrogel and hydrogels comprising said hydrophobic peptides and/or peptidomimetics and to various uses, such as in regenerative medicine, injectable therapies, delivery of bioactive moieties, wound healing, 2D and 3D synthetic cell culture substrate, biosensor development, biofunctionalized surfaces, and biofabrication.
Abstract translation: 本发明涉及能够形成（纳米纤维）水凝胶的疏水肽和/或肽模拟物和包含所述疏水性肽和/或肽模拟物的水凝胶以及各种用途，例如再生医学，可注射治疗，递送生物活性部分，伤口愈合 2D和3D合成细胞培养基质，生物传感器开发，生物功能化表面和生物制造。
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公开(公告)号：US10449257B2
公开(公告)日：2019-10-22
申请号：US14356116
申请日：2012-11-05
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Yihua Loo , Andrew C. A. Wan , Michael Reithofer
IPC: A61K47/36 , A61K31/7088 , A61K35/28 , A61K35/51 , A61K35/545 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/18 , A61K38/19 , A61K47/18 , A61L26/00 , A61L27/26 , A61L27/38 , A61L27/48 , A61L27/52 , A61L27/54 , C08L5/00 , C08L5/04 , C08L5/08 , C08L5/10 , C08L5/16 , C08L71/02 , C08L89/00 , C12N5/00 , C12N15/113
Abstract: The present invention relates to composite hydrogels comprising at least one non-peptidic polymer and at least one peptide having the general formula: Z—(X)m—(Y)n—Z′p, wherein Z is an N-terminal protecting group; X is, at each occurrence, independently selected from an aliphatic amino acid, an aliphatic amino acid derivative and a glycine; Y is, at each occurrence, independently selected from a polar amino acid and a polar amino acid derivative; Z′ is a C-terminal protecting group; m is an integer selected from 2 to 6; n is selected from 1 or 2; and p is selected from 0 or 1. The present invention further relates to methods of producing the composite hydrogels, to uses of the composite hydrogels for the delivery of drugs and other bioactive agents/moieties, as an implant or injectable agent that facilitates tissue regeneration, and as a topical agent for wound healing. The present invention further relates to devices and pharmaceutical or cosmetic compositions comprising the composite hydrogels and to medical uses of the composite hydrogels.
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