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    Bacterial thioredoxin reductase inhibitors and methods for use thereof
    22.
    发明授权
    Bacterial thioredoxin reductase inhibitors and methods for use thereof 有权
    细菌硫氧还蛋白还原酶抑制剂及其使用方法

    公开(公告)号：US08592468B2

    公开(公告)日：2013-11-26

    申请号：US13070457

    申请日：2011-03-23

    Applicant: Arne Holmgren ,  Jun Lu ,  Alexios Vlamis-Gardikas ,  Rong Zhao ,  Karuppasamy Kandasamy ,  Lars Engman ,  Lars Engstrand ,  Sven Hoffner

    Inventor： Arne Holmgren ,  Jun Lu ,  Alexios Vlamis-Gardikas ,  Rong Zhao ,  Karuppasamy Kandasamy ,  Lars Engman ,  Lars Engstrand ,  Sven Hoffner

    IPC: A61K31/425

    CPC classification number: C07D421/04 ,  A61K31/381 ,  A61K31/41 ,  C07D293/12 ,  Y02A50/473

    Abstract: The mechanism of action of Ebselen differentiates between bacterial and mammalian thioredoxin reductase (TrxR). It displays fast oxidation of mammalian Trx and via the NADPH-TrxR catalyzed turnover of ebselen selenol with hydrogen peroxide, and therefore are mammalian antioxidants. Ebselen, and its diselenide, are strong competitive inhibitors of E. coli TrxR with Ki of 0.14 μM and 0.46 μM, respectively. E. coli mutants lacking glutathione reductase or glutathione were much more sensitive to inhibition by ebselen. Since either glutaredoxin or thioredoxin systems are electron donors to ribonucleotide reductase, ebselen targets primarily glutathione and glutaredoxin-negative bacteria, a class which includes major pathogens. Ebselen, and similar compounds are therefore useful as antibacterial agents, even for multiresistant strains. Two major pathogenic bacteria, which previously had not been known to be sensitive to ebselen, Mycobacterium tuberculosis (tuberculosis) and Helicobacter pylori (stomach ulcer and cancer), were shown to be excellent targets. Helicobacter pylori was also sensitive to ebsulfur.

    Abstract translation: Ebselen的作用机制区分细菌和哺乳动物硫氧还蛋白还原酶（TrxR）。 它显示哺乳动物Trx的快速氧化，并且通过NADPH-TrxR催化依次硒硒酚与过氧化氢的周转，因此是哺乳动物抗氧化剂。 依布硒及其二硒化物是大肠杆菌TrxR的强烈竞争抑制剂，Ki分别为0.14μM和0.46μM。 缺乏谷胱甘肽还原酶或谷胱甘肽的大肠杆菌突变体对依布硒林的抑制更敏感。 由于谷氧还蛋白或硫氧还蛋白系统是核糖核苷酸还原酶的电子供体，依普硒靶主要是谷胱甘肽和谷氧还蛋白阴性细菌，一类包括主要病原体。 因此，依布硒林和类似化合物可用作抗菌剂，即使对于多抗性菌株也是有用的。 以前不知道对ebselen，结核分枝杆菌（结核分枝杆菌）和幽门螺杆菌（胃溃疡和癌症）敏感的两种主要致病菌被证明是优异的靶标。 幽门螺杆菌对硫化硫也敏感。

    Information management systems and methods for heterogeneous data sources
    23.
    发明授权
    Information management systems and methods for heterogeneous data sources 有权
    用于异构数据源的信息管理系统和方法

    公开(公告)号：US08589798B2

    公开(公告)日：2013-11-19

    申请号：US12749862

    申请日：2010-03-30

    Applicant: Anand Prahlad ,  Parag Gokhale ,  Rajiv Kottomtharayil ,  Jun Lu ,  Rahul S. Pawar

    Inventor： Anand Prahlad ,  Parag Gokhale ,  Rajiv Kottomtharayil ,  Jun Lu ,  Rahul S. Pawar

    IPC: G06F17/30

    CPC classification number: G06F11/1451 ,  G06F11/1448 ,  G06F11/1458 ,  G06F11/1464 ,  G06F11/1469 ,  G06F17/30283 ,  G06F17/3056 ,  H04L63/102 ,  H04L67/1097

    Abstract: Systems and methods integrate disparate backup devices with a unified interface. In certain examples, a management console manages data from various backup devices, while retaining such data in its native format. The management console can display a hierarchical view the client devices and/or their data and can further provide utilities for processing the various data formats. A data structure including fields for storing both metadata common to the client device data and value-added metadata can be used to mine or process the data of the disparate client devices. The unified single platform and interface reduces the need for multiple data management products and/or customized data utilities for each individual client device and provides a single pane of glass view into data management operations. Integrating the various types of storage formats and media allows a user to retain existing storage infrastructures and further facilitates scaling to meet long-term management needs.

    Abstract translation: 系统和方法将不同的备份设备与统一的接口集成。 在某些示例中，管理控制台管理来自各种备份设备的数据，同时以其本机格式保留此类数据。 管理控制台可以显示客户端设备和/或其数据的分层视图，并且可以进一步提供用于处理各种数据格式的实用程序。 可以使用包括用于存储客户端设备数据和增值元数据共有的元数据的字段的数据结构来挖掘或处理不同客户端设备的数据。 统一的单一平台和接口减少了对每个单独的客户端设备的多个数据管理产品和/或定制数据实用程序的需求，并将单个窗格视图提供到数据管理操作中。 集成各种类型的存储格式和媒体允许用户保留现有的存储基础架构，并进一步促进扩展以满足长期管理需求。

    Process to form semiconductor packages with external leads
    24.
    发明授权
    Process to form semiconductor packages with external leads 有权
    与外部引线形成半导体封装的工艺

    公开(公告)号：US08575006B2

    公开(公告)日：2013-11-05

    申请号：US12592596

    申请日：2009-11-30

    Applicant: Yan Xun Xue ,  Jun Lu

    Inventor： Yan Xun Xue ,  Jun Lu

    IPC: H01L31/00

    CPC classification number: H01L23/49551 ,  H01L21/4842 ,  H01L21/561 ,  H01L23/4952 ,  H01L23/49562 ,  H01L24/45 ,  H01L24/48 ,  H01L24/49 ,  H01L24/97 ,  H01L2224/32245 ,  H01L2224/451 ,  H01L2224/48247 ,  H01L2224/49111 ,  H01L2224/73265 ,  H01L2224/97 ,  H01L2924/00014 ,  H01L2924/01033 ,  H01L2924/01082 ,  H01L2924/181 ,  H01L2224/85 ,  H01L2224/83 ,  H01L2924/00 ,  H01L2924/00015 ,  H01L2224/05599 ,  H01L2924/00012

    Abstract: This invention discloses a process for packaging semiconductor device with external leads. The process includes comprises Step 1: providing a lead frame comprising a plurality of lead frame units connected by a plurality of metal beams, each lead frame unit comprising a die pad and a plurality of leads located on opposite sides of the die pad; adhering a semiconductor chip onto each of the die pad, and providing a plurality of metal connections for electrically connecting each chip to its corresponding leads; Step 2 providing a plastic molding material to enclose the plurality of the lead frame units, the metal beams, the chips, and at least portions of the metal connections; Step 3 removing a portion of the plastic molding material above the metal beams to expose the metal beams and portions of the leads in connection with the metal beams; and Step 4 separating each lead frame unit, forming a plurality of individual semiconductor plastic package components with external leads.

    Abstract translation: 本发明公开了一种用外部引线封装半导体器件的方法。 该方法包括步骤1：提供引线框架，该引线框架包括由多个金属梁连接的多个引线框架单元，每个引线框架单元包括管芯焊盘和位于管芯焊盘的相对侧上的多个引线; 将半导体芯片粘附到每个芯片焊盘上，并且提供多个金属连接件，用于将每个芯片电连接到其相应的引线; 步骤2提供塑料模制材料以封闭多个引线框架单元，金属梁，芯片以及金属连接件的至少部分; 步骤3，移除金属梁上方的塑料成型材料的一部分，以暴露金属梁和引线的与金属梁相关的部分; 以及步骤4分离每个引线框架单元，用外部引线形成多个单独的半导体塑料封装部件。

    Wireless dual-function network device dynamically switching and reconfiguring from a wireless network router state of operation into a wireless network coordinator state of operation in a wireless communication network
    30.
    发明授权
    Wireless dual-function network device dynamically switching and reconfiguring from a wireless network router state of operation into a wireless network coordinator state of operation in a wireless communication network 有权
    无线双功能网络设备从无线网络路由器动态切换和重新配置运行状态到无线网络协调器在无线通信网络中的运行状态

    公开(公告)号：US08457013B2

    公开(公告)日：2013-06-04

    申请号：US12319905

    申请日：2009-01-13

    Applicant: Steven Essinger ,  Xiaoxun Zhu ,  Michael Schnee ,  JiBin Liu ,  Xin Shen ,  LiangLiang Chen ,  Jun Lu

    Inventor： Steven Essinger ,  Xiaoxun Zhu ,  Michael Schnee ,  JiBin Liu ,  Xin Shen ,  LiangLiang Chen ,  Jun Lu

    IPC: H04L12/28

    CPC classification number: H04W4/001 ,  H04W4/50 ,  H04W16/00 ,  H04W84/10 ,  H04W84/18 ,  H04W88/00

    Abstract: Various wireless network components that offer increased flexibility, ease of use, functionality and performance in many demanding applications in diverse fields of use, namely: a wireless multi-function network device for use on a wireless communication network, that can serve multiple functions and dynamically switch and reconfigure from a network router into a network coordinator in the event that the originally designated network coordinator is permanently or temporally disabled; a wireless mesh-type communication network, including a plurality of wireless network router devices, each capable of performing the functions of a network controller/coordinator; a wireless network router device for use on a wireless communication network, and employing an integrated phased-array antenna structure, supporting the spatial isolation of multi-regions, and utilizing beam steering principles of operation, for illuminating multiple wireless network end-devices over separate regions; a network gateway device that supports a USB-type communication interface and RF-based wireless communication interface; a network protocol translation (NPT) based gateway device for use in a wireless communication network; and wireless network coordinator device for automatically establishing a Personal Area Network (PAN) on a wireless communication network, and having a compact housing with an electrical wall plug integrated therein having electrical prongs for plugging into a standard electrical wall socket.

    Abstract translation: 各种无线网络组件在不同使用领域的许多苛刻应用中提供了增强的灵活性，易用性，功能性和性能，即：在无线通信网络上使用的无线多功能网络设备，可以提供多种功能和动态 在原始指定的网络协调器永久或暂时禁用的情况下，从网络路由器切换和重配置到网络协调器中; 无线网状通信网络，包括多个无线网络路由器设备，每个能够执行网络控制器/协调器的功能; 用于在无线通信网络上使用的无线网络路由器设备，以及采用集成的相控阵天线结构，支持多区域的空间隔离，以及利用波束操纵原理，用于单独地照射多个无线网络终端设备 区域; 支持USB型通信接口和基于RF的无线通信接口的网络网关设备; 基于网络协议转换（NPT）的网关设备，用于无线通信网络; 以及用于在无线通信网络上自动建立个人区域网络（PAN）的无线网络协调器设备，并且具有紧凑的壳体，其中集成有电壁插塞，其中具有用于插入标准电壁插座的电插脚。

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