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公开(公告)号：US09371929B2
公开(公告)日：2016-06-21
申请号：US14053688
申请日：2013-10-15
Applicant: EMD Millipore Corporation
Inventor： Paul Ju-Sung Hung , Philip Janmin Lee
IPC: C12M1/34 , F16K27/02 , C12M1/32 , C12M3/06 , C12M1/00 , C12M1/36 , F16K99/00 , B29C65/00 , G01N33/543 , B01L3/00 , G01N35/00
CPC classification number: C12M23/12 , B01L3/5025 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2200/12 , B01L2300/0681 , B01L2300/0816 , B01L2300/0819 , B01L2300/10 , B01L2300/123 , B01L2300/14 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B29C65/002 , C12M23/16 , C12M29/10 , C12M29/14 , C12M41/00 , C12M41/48 , C12Q1/025 , F16K27/0236 , F16K99/0001 , F16K99/0015 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/0084 , G01N33/5008 , G01N33/54366 , G01N2035/00158 , Y10T137/2202
Abstract: A valved microfluidics device, microfluidics cell-culture device and system incorporating the devices are disclosed. The valved microfluidics device includes a substrate, a microchannel through which liquid can be moved from one station to another within the device, and a pneumatic microvalve adapted to be switched between open and closed states to control the flow of fluid through a microchannel. The microvalve is formed of three flexible membranes, one of which is responsive to pneumatic pressure applied to the valve and the other two of which deform to produce a more sealable channel cross-section. The cell culture device provides valving to allow controlled loading of cells into the individual well of the device, and exchange of cell-culture components in the wells.
Abstract translation: 公开了一种带阀的微流体装置，微流体细胞培养装置和结合装置的系统。 带阀的微流体装置包括基底，微通道，通过该微通道液体可以在装置内从一个站移动到另一个站;以及气动微型阀，其适于在打开和关闭状态之间切换以控制通过微通道的流体流动。 微型阀由三个柔性膜形成，其中一个柔性膜响应于施加到阀上的气压，另外两个变形以产生更可密封的通道横截面。 细胞培养装置提供阀门以允许将细胞控制加载到装置的个体井中，以及在孔中交换细胞培养组分。
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公开(公告)号：US09353343B2
公开(公告)日：2016-05-31
申请号：US14081314
申请日：2013-11-15
Applicant: EMD Millipore Corporation
Inventor： Ju-Sung Paul Hung , Philip J. Lee , Amedeo J. Cappione
CPC classification number: C12M23/16 , B01L3/502715 , B01L3/502753 , B01L2200/027 , B01L2200/0647 , B01L2200/0694 , B01L2300/0681 , B01L2300/0877 , B01L2300/14 , C12M23/34 , C12M23/40 , C12M27/18 , C12M29/10 , C12M41/46 , C12Q1/02 , C12Q1/025
Abstract: A number of novel improved microfluidic configurations and systems and methods of manufacture and operation for a microfluidic invasion assay system.
Abstract translation: 许多新颖的改进的微流体配置和用于微流体入侵测定系统的制造和操作的系统和方法。
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公开(公告)号：US09308308B2
公开(公告)日：2016-04-12
申请号：US14506018
申请日：2014-10-03
Inventor： Yuanpang Samuel Ding , Ying-Cheng Lo , Joshua James Miller , Justin Rohde , Sujatha Karoor , Stephane Dupont
CPC classification number: A61M1/1696 , A61M1/1674 , A61M1/28 , A61M1/284 , A61M1/287 , A61M2202/0014 , B01D61/243 , B01D61/44 , B01D61/58
Abstract: Systems and methods for hemodialysis or peritoneal dialysis having integrated electrodeionization capabilities are provided. In an embodiment, the dialysis system includes a carbon source, a urease source and an electrodeionization unit. The carbon source and urease source can be in the form of removable cartridges.
Abstract translation: 提供了具有集成的电去离子能力的用于血液透析或腹膜透析的系统和方法。 在一个实施方案中，透析系统包括碳源，脲酶源和电去离子单元。 碳源和脲酶源可以是可移除的盒的形式。
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公开(公告)号：US09259733B2
公开(公告)日：2016-02-16
申请号：US14413555
申请日：2013-07-18
Applicant: EMD Millipore Corporation
Inventor： Ronald Tuccelli , Sebastien Cirou , Virginie Buisson , Christine Abouayad El Idrissi , Jim Kelly
CPC classification number: B01L3/561 , B01L3/565 , B01L2200/0689 , B01L2300/0816 , B01L2300/0861 , B01L2300/0887 , B01L2300/123 , B01L2400/0655 , C12M47/12 , Y10T137/9029
Abstract: The invention concerns a device comprising a circuit comprising a bag (10) comprising two flexible films (65, 66), a press (9) comprising a first shell (16) disposed upright on a front face of a base of the device and a second shell (17) mounted on said first shell, which shells clamp said bag to form conduits (13); said press is provided with a system (170) for jamming at the location of a treatment zone (67) of the bag, which comprises a jamming member (171) provided with at least one jamming nipple (173) and a complementary jamming member (172) provided with a jamming channel (174) configured to receive said nipple; said jamming member (171) and complementary jamming member (172) and said bag (10) being configured in order for the latter to have a portion (175) in said treatment zone in which said films are jammed between said nipple and said channel.
Abstract translation: 本发明涉及一种包括电路的装置，该电路包括包括两个柔性膜（65,66）的袋（10），压力机（9），包括直立设置在设备的基座的前面上的第一壳体（16）和 第二壳体（17），其安装在所述第一壳体上，所述壳体将所述袋子夹紧以形成管道（13）; 所述压机设置有用于在所述袋的处理区域（67）的位置处卡住的系统（170），所述系统包括设置有至少一个干扰接头（173）和互补干扰构件（172）的干扰构件（171） 172），其配置有接收所述乳头的干扰通道（174） 所述干扰构件（171）和互补的卡住构件（172），并且所述袋（10）构造成使得所述袋（10）在所述处理区域中具有一部分（175），在所述处理区域中所述膜被卡在所述接头和所述通道之间。
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355.发明申请SELECTIVE REMOVAL OF A PROTEIN FROM A MIXTURE OF PROTEINS USING ACTIVATED CARBON BY ADJUSTING SOLUTION CONDITIONS 审中-公开通过调节溶液条件，使用活性炭从蛋白质混合物中选择性去除蛋白质公开(公告)号：US20150376232A1
公开(公告)日：2015-12-31
申请号：US14768267
申请日：2014-02-11
Applicant: EMD MILLIPORE CORPORATION
Inventor： Matthew T. Stone , Mikhail Kozlov
CPC classification number: C07K1/36 , C07K1/22 , C07K16/065 , C07K2317/14
Abstract: The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely effecting the yield of the desired protein product.
Abstract translation: 本发明提供新颖和改进的蛋白质纯化方法，其包含某些类型的碳质材料，并且导致有效和选择性地除去某些不需要的杂质，而不会不利地影响所需蛋白质产物的产率。
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Patent Agency Ranking
公开(公告)号：US20150346169A1
公开(公告)日：2015-12-03
申请号：US14819806
申请日：2015-08-06
Applicant: EMD Millipore Corporation
Inventor： Venkatesh Natarajan , Anthony Frederick Mann , Daniel Schubnel
CPC classification number: G01N30/56 , B01D15/206 , B01D15/3809 , G01N2030/565
Abstract: A method and device for packing a chromatography column formed of one or more vibration devices attached to top and/or bottom flanges of the column. Media is added in one or more steps to the column, allowed to settle under the effects of gravity and then subjected to one or more treatments of vibration from the vibration devices until a suitably packed column is obtained. Liquid used to suspend the media while being placed into the column may be at least partially removed before or during the vibration step(s). The remaining liquid is then removed or replaced after the packing has been obtained.
Abstract translation: 一种用于包装色谱柱的方法和装置，所述色谱柱由连接到所述塔的顶部和/或底部凸缘的一个或多个振动装置形成。 介质以一个或多个步骤添加到塔中，允许在重力作用下沉降，然后经受来自振动装置的一个或多个振动处理，直到获得适当填充的塔。 用于在放置到柱中时将介质悬浮的液体可以在振动步骤之前或期间至少部分地去除。 在获得包装后，剩余的液体被去除或更换。
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公开(公告)号：US20150252085A1
公开(公告)日：2015-09-10
申请号：US14683738
申请日：2015-04-10
Applicant: EMD Millipore Corporation
Inventor： Shari Spector , Robert Smith , Joe Orlando , Nanying Bian
CPC classification number: C07K14/31 , B01D15/3809 , B01J20/286 , B01J20/3272 , B01J20/3274 , C07K1/22 , C07K16/1271 , C07K2319/21
Abstract: The present invention relates to chromatography matrices including ligands based on one or more domains of immunoglobulin-binding proteins such as, Staphylococcus aureus Protein A (SpA), as well as methods of using the same.
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358.发明授权Module for purifying a fluid containing a cleaning agent, and methods of fabricating and using this kind of module 有权用于净化含有清洁剂的流体的模块，以及制造和使用这种模块的方法公开(公告)号：US09089818B2
公开(公告)日：2015-07-28
申请号：US14023543
申请日：2013-09-11
Applicant: EMD Millipore Corporation
Inventor： Yves Gaignet , Ichiro Kano
IPC: B08B3/00 , B01D65/06 , A61L2/18 , B01D61/04 , B01D61/10 , B01D61/16 , B01D61/20 , B01D65/00 , B01D65/02 , B01F1/00 , C02F5/14 , B01D29/62 , B01D61/02 , B01D61/14 , C02F1/28 , C02F1/44 , C02F1/50
CPC classification number: B01D65/06 , A61L2/186 , A61L2202/16 , B01D29/62 , B01D61/025 , B01D61/027 , B01D61/04 , B01D61/10 , B01D61/145 , B01D61/147 , B01D61/16 , B01D61/20 , B01D65/00 , B01D65/02 , B01D65/022 , B01D2311/04 , B01D2311/16 , B01D2321/168 , B01F1/0027 , C02F1/281 , C02F1/283 , C02F1/44 , C02F1/50 , C02F5/145 , C02F2201/006 , B01D2311/12 , B01D2311/2626
Abstract: The invention consists in a disposable module (31) for purifying a fluid, in particular water, adapted to form part of a thud purification system and comprising fluid purification means (25, 28), a housing (35) in which the purification means are housed, and means for removably connecting the purification module (31) to the purification system to establish fluid communication between the purification system and the purification module (31), characterized in that the housing (35) contains from the outset a cleaning agent (36) disposed to come into contact with the fluid caused to circulate inside the housing (35) to clean at least a portion of the purification system, it also consists in the purification system and corresponding fabrication and cleaning methods.
Abstract translation: 本发明包括用于净化流体（尤其是水）的一次性模块（31），该流体适于形成ud净化系统的一部分，并且包括流体净化装置（25,28），其中净化装置 以及用于将净化模块（31）可移除地连接到净化系统以建立净化系统和净化模块（31）之间的流体连通的装置，其特征在于，所述壳体（35）从一开始就包含清洁剂（36） ）设置成与所述流体接触以在所述壳体（35）内循环以清洁所述净化系统的至少一部分，其还包括所述净化系统和相应的制造和清洁方法。
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公开(公告)号：US20150166965A1
公开(公告)日：2015-06-18
申请号：US14382769
申请日：2013-03-13
Applicant: EMD Millipore Corporation
Inventor： Damon Asher , Anne Leahy
IPC: C12N7/00
CPC classification number: C12N7/00 , C12N2740/13051
Abstract: The invention relates to a process for increasing the observed titer of a virus stock for the purpose of increasing the calculated log reduction (LRV) in virus clearance studies. A tissue culture or assay plate is seeded with an indicator cell line and titrated with a virus stock followed, by a centrifugation step for about 5 minutes to about 24 hours at a g-force ranging from about 50×g to about 2400×g, and at a temperature from about 4° C. to about 39° C. The resulting calculated virus titer after undergoing the centrifugation step is 10-fold higher than the virus titer would be if determined in the absence of the centrifuging step.
Abstract translation: 本发明涉及增加病毒储存液观察滴度以增加病毒清除研究中计算的对数降低（LRV）的方法。 将组织培养物或测定板用指示细胞系接种，并用病毒原液滴定，然后通过离心步骤约50分钟至约2400×g的g-力进行约5分钟至约24小时， 并且在约4℃至约39℃的温度下进行。在经历离心步骤后得到的计算病毒滴度比不存在离心步骤时测定的病毒滴度高10倍。
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360.发明申请USE OF CHARGED FLUOROCARBON COMPOSITIONS IN METHODS FOR PURIFICATION OF BIOMOLECULES 审中-公开在生物分子纯化方法中使用充电氟化物组合物公开(公告)号：US20150125929A1
公开(公告)日：2015-05-07
申请号：US14362964
申请日：2013-03-18
Applicant: EMD Millipore Corporation
Inventor： Mikhail Kozlov , Wilson Moya , Jad Jaber , William Cataldo , Ajish Potty , Christopher Gillespie
Abstract: The present invention relates to novel and improved methods for the purification of biomolecules. In particular, the present invention relates to methods of protein purification which employ a porous solid support modified with a charged fluorocarbon composition.
Abstract translation: 本发明涉及用于纯化生物分子的新颖和改进的方法。 特别地，本发明涉及蛋白质纯化方法，该方法采用用带电的碳氟化合物组合物改性的多孔固体支持物。
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