公开(公告)号：US10006083B2

公开(公告)日：2018-06-26

申请号：US15320730

申请日：2015-06-19

Applicant: BIOLOGICAL DYNAMICS, INC.

Inventor： Rajaram Krishnan ,  David J. Charlot ,  Eugene Tu ,  James McCanna ,  Lucas Kumosa ,  Paul D. Swanson ,  Robert Turner ,  Kai Yang ,  Irina Dobrovolskaya ,  David Liu ,  Juan Pablo Hinestrosa Salazar ,  Juscilene Menezes

IPC: C12Q1/68 ,  C12Q1/6825 ,  C12Q1/6806 ,  C12Q1/6869 ,  C12N13/00 ,  G01N27/447

CPC classification number: C12Q1/6825 ,  B03C5/005 ,  B03C5/026 ,  B03C2201/18 ,  B03C2201/26 ,  C12N15/1003 ,  C12N15/101 ,  C12Q1/6806 ,  C12Q1/6869 ,  G01N27/447

Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.

公开(公告)号：US20180149574A1

公开(公告)日：2018-05-31

申请号：US15825965

申请日：2017-11-29

Applicant: SYSMEX CORPORATION

Inventor： Yasuko KAWAMOTO ,  Ayato TAGAWA

IPC: G01N15/14 ,  B03C1/28

CPC classification number: G01N15/1404 ,  B01L3/50273 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/027 ,  B01L2200/0647 ,  B01L2200/0673 ,  B01L2400/0487 ,  B03C1/288 ,  B03C2201/18 ,  G01N15/1459 ,  G01N15/1484 ,  G01N33/54326 ,  G01N35/00069 ,  G01N35/0098 ,  G01N35/085 ,  G01N2015/1006 ,  G01N2015/1409 ,  G01N2015/1415 ,  G01N2015/1486 ,  G01N2035/00158 ,  G01N2035/00237 ,  G01N2035/1034

Abstract: Disclosed is a method of processing a specimen in which a target component in a specimen is processed using a specimen processing chip provided with a flow-path, the method including: introducing a fluid into a flow-path to form an interface that divides the fluid from a process liquid used for the processing of the target component with a rim of the interface on an inner wall of the flow-path, the process liquid containing particles including the target component; and moving the formed interface along the flow-path with the rim of the interface on the inner wall so as to force out the particles retained in the process liquid by the fluid.

公开(公告)号：US09975790B2

公开(公告)日：2018-05-22

申请号：US15033486

申请日：2014-09-30

Applicant: Maersk Olie og Gas A/S

Inventor： Martin Vad Bennetzen ,  Kristian Mogensen

IPC: E21B43/20 ,  C02F1/48 ,  B03C1/01 ,  C02F1/68 ,  B03C1/033 ,  B03C1/28 ,  B03C1/02 ,  C02F3/34 ,  C02F103/02 ,  C02F103/08

CPC classification number: C02F1/488 ,  B03C1/01 ,  B03C1/02 ,  B03C1/0332 ,  B03C1/288 ,  B03C2201/18 ,  C02F1/683 ,  C02F3/345 ,  C02F2103/02 ,  C02F2103/08 ,  C02F2303/08 ,  C02F2303/16 ,  C02F2303/20 ,  C02F2305/08 ,  E21B43/20

Abstract: A method of depleting the bacterial content in a water source is provided. The method involves depleting the bacterial content in a water source for a water flooding process, said method comprising contacting a water source with a superparamagnetic or paramagnetic nanoparticle; complexing the bacteria with the particle; and removing the bacteria-particle complex by applying a magnetic field so as to provide a water source with depleted bacterial content. The depleted water can then be pumped into one or more connecting injection well(s) in an oil field pushing the crude oil towards one or more production well(s) thereby allowing for enhanced oil recovery from the production wells.

公开(公告)号：US20180127742A1

公开(公告)日：2018-05-10

申请号：US15807029

申请日：2017-11-08

Applicant: AXAGARIUS GMBH & CO. KG

Inventor： Thomas PRANGENBERG ,  Helmut RIERING

IPC: C12N15/10 ,  C08G18/34 ,  C08G18/48 ,  C08G18/32 ,  C08G18/76 ,  C08G18/75 ,  C08G18/73 ,  B03C1/01 ,  B03C1/32

CPC classification number: C12N15/1013 ,  B03C1/01 ,  B03C1/32 ,  B03C2201/18 ,  C08G18/0823 ,  C08G18/3206 ,  C08G18/3215 ,  C08G18/348 ,  C08G18/4233 ,  C08G18/4238 ,  C08G18/4277 ,  C08G18/48 ,  C08G18/6677 ,  C08G18/6681 ,  C08G18/73 ,  C08G18/755 ,  C08G18/7621

Abstract: Particulate solid composite material for purifying nucleic acids containing magnetic nanoparticles embedded in a carrier matrix based on at least one polymer that is obtained by polyaddition of a) at least one isocyanate-reactive monomer A, selected from compounds containing at least two functional groups, each having at least one Zerewitinoff-reactive hydrogen atom, and in addition to these at least two functional groups, carry at least one anionic or potentially anionic residue, preferably selected from the group consisting of carboxylate, sulfonate or combinations thereof, with b) at least one polyisocyanate monomer B with the provisio that said polyaddition occurs in the presence of magnetic nanoparticles, is particularly suitable as carrier material for purification of nucleic acids. Said composite material is easy to prepare, is stable, and magnetic and has outstanding application properties in the bind-wash-elute purification of nucleic acids using magnetic separation.

公开(公告)号：US20180127741A1

公开(公告)日：2018-05-10

申请号：US15345271

申请日：2016-11-07

Applicant: WAVESENSE, INC.

Inventor： CHRISTOPHER FEISTEL

IPC: C12N15/10 ,  G01N1/40 ,  B01L3/00 ,  B03C1/28

CPC classification number: C12N15/1013 ,  B01L3/508 ,  B01L3/50825 ,  B01L2200/0668 ,  B01L2300/042 ,  B01L2300/046 ,  B01L2300/0832 ,  B01L2400/043 ,  B03C1/01 ,  B03C1/288 ,  B03C1/30 ,  B03C2201/18 ,  B03C2201/26 ,  G01N1/405

Abstract: Systems and methods for detecting and sequestering target analytes in a fluid sample. The system comprises a bulk specimen reservoir for receiving a liquid sample, along with paramagnetic materials operative to selectively bind to the target analyte of interest. A vertex is interconnected with the bulk specimen reservoir to define a specimen chamber assembly to which a magnetic chamber is deployed about the vertex portion thereof and operative to sequester the magnetic particles, as well as any analyte of interest bound thereto, within the interior of the vertex. Once sufficient time is allowed for mixing and allowing the magnetic capsule to sufficiently retain the magnetic particles within the vertex, the vertex is disconnected from the specimen reservoir and the paramagnetic materials retained therein analyzed to determine the presence of the analyte of interest.

公开(公告)号：US09962714B2

公开(公告)日：2018-05-08

申请号：US14797168

申请日：2015-07-12

Applicant: International Business Machines Corporation

Inventor： Jaione Tirapu Azpiroz ,  Emmanuel Delamarche ,  Claudius Feger ,  Yuksel Temiz

IPC: B03C5/00 ,  B01L3/00 ,  B03C5/02

CPC classification number: B03C5/005 ,  B01L3/502746 ,  B01L3/502761 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2200/0684 ,  B01L2400/0424 ,  B01L2400/084 ,  B03C5/026 ,  B03C2201/18 ,  B03C2201/26

Abstract: A microchannel for processing microparticles in a fluid flow comprises a first and second pairs of electrodes. The first pair of electrodes is configured for generating an asymmetric first electric field and for sorting the microparticles to provide sorted microparticles. The second pair of electrodes is configured for generating an asymmetric second electric field and for trapping at least some of the sorted microparticles.

公开(公告)号：US09962705B2

公开(公告)日：2018-05-08

申请号：US14669419

申请日：2015-03-26

Applicant: GEN-PROBE INCORPORATED

Inventor： Norbert D. Hagen ,  Byron J. Knight ,  David Opalsky

IPC: B01L3/00 ,  B01L9/00 ,  G01N35/00 ,  B03C1/033 ,  B03C1/28 ,  B65B3/04 ,  B03C1/12 ,  B03C1/14 ,  B25J11/00 ,  C12N15/10

CPC classification number: B01L3/52 ,  B01L3/561 ,  B01L9/52 ,  B01L2300/0609 ,  B01L2300/12 ,  B03C1/0332 ,  B03C1/12 ,  B03C1/14 ,  B03C1/28 ,  B03C1/286 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  B25J11/00 ,  B65B3/04 ,  C12N15/1013 ,  G01N35/0098 ,  Y10T29/49815

Abstract: Methods, systems, and apparatus are provided for automated isolation of selected analytes, to which magnetically-responsive solid supports are bound, from other components of a sample. An apparatus for performing an automated magnetic separation procedure includes a mechanism for effecting linear movement of a magnet between operative and non-operative positions with respect to a receptacle device. A receptacle holding station within which a receptacle device may be temporarily stored prior to moving the receptacle to the apparatus for performing magnetic separation includes magnets for applying a magnetic field to the receptacle device held therein, thereby drawing at least a portion of the magnetically-responsive solid supports out of suspension before the receptacle device is moved to the magnetic separation station. An automated receptacle transport mechanism moves the receptacle devices between the apparatus for performing magnetic separation and the receptacle holding station.

公开(公告)号：USD812724S1

公开(公告)日：2018-03-13

申请号：US29560419

申请日：2016-04-06

Applicant: Adey Holdings (2008) Limited

Designer： Christopher Adey ,  Matthew Taylor ,  Simon Downie

CPC classification number: B04C5/14 ,  B01D21/0009 ,  B01D21/0042 ,  B01D21/2411 ,  B01D21/2483 ,  B01D21/26 ,  B01D21/267 ,  B01D29/908 ,  B01D35/06 ,  B01D35/303 ,  B01D2201/302 ,  B01D2201/4023 ,  B01D2221/02 ,  B03C1/02 ,  B03C1/0355 ,  B03C1/14 ,  B03C1/286 ,  B03C1/288 ,  B03C1/30 ,  B03C2201/18 ,  B03C2201/20 ,  B03C2201/28 ,  B04C3/06 ,  B04C5/185 ,  B21D39/044 ,  C02F1/488 ,  C02F2101/203 ,  C02F2201/48 ,  C02F2303/22 ,  E03B7/074 ,  F16L21/00 ,  F16L29/007 ,  F16L55/24 ,  F17D3/16 ,  F24D19/0092 ,  Y10T137/794

Abstract: A separator device for removing particles from suspension in a liquid comprises: a housing (12), having first (19) and second (40) chambers with apertures (98) for ingress and egress of liquid into the first chamber (19); means (100) for setting up a swirl of liquid within the first chamber (19); apertures enabling flow of liquid between the first chamber (19) and the second chamber (40); means for setting up a swirl of liquid within the second chamber (40), the swirl in the second chamber (40) being in substantially the opposite direction to the swirl in the first chamber, and there being no substantial flow in the second chamber (40) which is in the same direction as the swirl in the first chamber (19).

公开(公告)号：US20180056306A1

公开(公告)日：2018-03-01

申请号：US15689025

申请日：2017-08-29

Applicant: MAGNETIC PRODUCTS, INC.

Inventor： Ronald Kwasniewicz

IPC: B03C1/03 ,  B03C1/247 ,  B03C1/033 ,  B03C1/06

CPC classification number: B03C1/03 ,  B03C1/0332 ,  B03C1/06 ,  B03C1/247 ,  B03C1/26 ,  B03C1/284 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/28

Abstract: A magnetic separator includes a housing defining a product flow path through which material may pass. The magnetic separator further includes a drawer moveable between a first position and a second position and at least one magnet operatively connected to the drawer. The at least one magnet is positioned within the product flow path in the first position of the drawer. The at least one magnet is withdrawn from the flow path when in the second position.

公开(公告)号：US09901931B2

公开(公告)日：2018-02-27

申请号：US14583464

申请日：2014-12-26

Applicant: Kosky Yen ,  Peter Wu ,  Michael Lee ,  Charles Chen

Inventor： Kosky Yen ,  Peter Wu ,  Michael Lee ,  Charles Chen

IPC: B03C1/032 ,  B03C1/033 ,  B03C1/28

CPC classification number: B03C1/032 ,  B03C1/0332 ,  B03C1/0335 ,  B03C1/284 ,  B03C1/286 ,  B03C2201/18

Abstract: A high capacity magnetic filter for separating magnetic and non-magnetic contaminants from contaminated liquid streams includes a housing having (i) an interior region between the inlet and outlet for a process stream, (ii) a plurality of vertically oriented, elongated non-magnetic holder sleeves positioned within the interior region (iii) paramagnetic metal packing material that is randomly distributed in the interior region to form a packed compartment that has a void volume which is above 95 percent, and (iv) a device to generate a magnetic field within the interior region. Generation of a uniform magnetic field within the packed compartment magnetizes the holder sleeves and matrix of packing materials. The holder sleeves and matrix create a large surface area for collecting the contaminants.