摘要:
This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for the treatment of bone disorders including osteoporosis.
摘要:
Novel pharmaceutically/cosmetically-active adamantyl-substituted biaromatic compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a')-(f'): ##STR2## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular, bone and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.
摘要:
Di(aromatic) compounds corresponding to the following formula: ##STR1## in which: Ar represents either ##STR2## n=1 or 2 or: ##STR3## X represents a divalent radical, Z represents O, S or a divalent radical,and R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 represent a hydrogen atom or various organic radicals, and the salts of the compounds of formula (I) when R.sub.1 is a carboxylic acid function.Use in human and veterinary medicine and in cosmetics.
摘要:
The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
摘要:
Compounds of the formula ##STR1## as herein defined, have retinoid-like activity and are substantially non-teratogenic and non-irritating to the skin.
摘要:
There are disclosed compounds of the formula (I): ##STR1## in which the variables R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, and X are defined in the specification. The compounds are useful as pharmaceuticals, especially as anti-inflammatory agents.
摘要:
This invention relates to novel 3-substituted-2-oxindole derivatives which are inhibitors of prostaglandin H.sub.2 synthase, 5-lipoxygenase and interleukin-1 biosynthesis. The compounds of the invention are useful as inhibitors of prostaglandin H.sub.2 synthase and interleukin-1 biosynthesis, per se, and as analgesic, antiinflammatory and antiarthritic agents in the treatment of chronic inflammatory diseases This invention also relates to pharmaceutical compositions comprising said 3-substituted-2-oxindole derivatives; to methods of inhibiting prostaglandin H.sub.2 synthase and biosynthesis of interleukin-1; and to treating chronic inflammatory diseases in a mammal with said compounds. Further, this invention relates to certain novel carboxylic acids useful as intermediates in the preparation of the 3-substituted-2-oxindole derivatives of this invention and to a process for the preparation of the 3-substituted-2-oxindole derivatives.
摘要:
Dicarboximides of the general formulae Ia and Ib ##STR1## where X is oxygen or sulfur, R.sup.1 is hydrogen, cycloalkyl, alkyl, hydroxyl, alkoxy, cyanoalkyl, alkenyl, alkynyl, phenyl, naphthyl or a 5-membered or 6-membered heterocyclic structure, where the stated radicals may be substituted, andR.sup.2 and R.sup.3 are each nitro, cyano, halogen, amino, mono- or dialkylamino, alkylcarbonylamino, unsubstituted or halogen-substituted alkoxy or alkylthio, alkylsulfonyl, haloalkylsulfonyl, alkenyl, alkynyl, phenyl, phenoxy or phenylthio or one of the radicals R.sup.1, with the proviso that specific compounds named in the description are excluded.Processes for the preparation of the compounds Ia and Ib and herbicides containing them.
摘要:
A process for producing a carboxylic acid amide or ester, which comprises reacting an organic chloride having at least one chlorine atom on its ring of a substituted or unsubstituted, aromatic or heterocyclic hydrocarbon with carbon monoxide and an amine or an alcohol in the presence of a base by using as catalysts a palladium compound and a phosphine compound represented by the general formula (V):(R).sub.2 P--X--P(R).sub.2 (V)wherein R is an alkyl group or a substituted or unsubstituted phenyl group, and X is an alkylene group having 1 to 6 carbon atoms ##STR1## or a binaphthyl group.
摘要:
An electrophotographic photosensitive material is disclosed, wherein the electrophotographic photosensitive material comprises a photosensitive layer containing at least one thiophene compound selected from the group consisting of compounds having the general formulae (I) and (II): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6, and R.sup.21, R.sup.22, R.sup.23, R.sup.24, R.sup.25 ; and R.sup.26 each represents a hydrogen or halogen atom or a hydroxy group, an alkyl group, a hydroxyalkyl group, an alkoxy group, an allyl group, a vinyl group, an acyl group, a formylalkyl group, an acyloxy group, an alkoxycarbonyl group, an aryl group, a cyano group, a nitro group, an amino group, an alkylamino group or an arylamino group and n is an integer of 1, 2, 3, 4 or 5.
摘要翻译:公开了一种电子照相感光材料,其中电子照相感光材料包括含有至少一种选自具有通式(I)和(II)的化合物的噻吩化合物的感光层: (II)其中R1,R2,R3,R4,R5和R6,以及R21,R22,R23,R24,R25, R 26各自表示氢或卤素原子或羟基,烷基,羟基烷基,烷氧基,烯丙基,乙烯基,酰基,甲酰基,酰氧基,烷氧基羰基, 芳基,氰基,硝基,氨基,烷基氨基或芳基氨基,n为1,2,3,4或5的整数。