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    Anti-Viral Azide Containing Compounds
    422.
    发明申请
    Anti-Viral Azide Containing Compounds 有权
    抗病毒叠氮化合物

    公开(公告)号：US20150374723A1

    公开(公告)日：2015-12-31

    申请号：US14831220

    申请日：2015-08-20

    Applicant: Life Technologies Corporation ,  The Johns Hopkins University

    Inventor： Brian Agnew ,  David Graham ,  Upinder Singh ,  Scott Grecian

    IPC: A61K31/655 ,  A61K38/21 ,  A61K31/7088 ,  A61K45/06

    CPC classification number: A61K31/655 ,  A61K31/7024 ,  A61K31/7088 ,  A61K38/212 ,  A61K38/215 ,  A61K45/06 ,  A61K2300/00

    Abstract: Methods of using azide-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to inhibit infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. Also, provided are methods of tracking a virus in vivo, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. The azide-modified biomolecules may be combined with a pharmaceutically acceptable excipient to produce a pharmaceutical composition, optionally containing another anti-viral agent and/or a delivery agent, such as a liposome.

    Abstract translation: 提供了使用叠氮化物修饰的生物分子如脂肪酸，碳水化合物和脂质来治疗植物，昆虫或感染病毒的动物或抑制病毒如人类免疫缺陷病毒的感染性的方法。 还提供了用叠氮化物修饰的生物分子如脂肪酸，碳水化合物或类异戊二烯脂质来标记病毒（例如人类免疫缺陷病毒）的方法。 此外，提供了利用叠氮化物修饰的生物分子如脂肪酸，碳水化合物或类异戊二烯脂质体内追踪病毒的方法。 叠氮化物修饰的生物分子可以与药学上可接受的赋形剂组合以产生药物组合物，任选地含有另一种抗病毒剂和/或递送剂，例如脂质体。

    System and Method Incorporating Solid Buffer
    423.
    发明申请
    System and Method Incorporating Solid Buffer 审中-公开
    系统和方法结合固体缓冲液

    公开(公告)号：US20150369828A1

    公开(公告)日：2015-12-24

    申请号：US14741084

    申请日：2015-06-16

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： James A. BALL ,  Jonathan SCHULTZ

    IPC: G01N33/84 ,  C12Q1/68

    CPC classification number: G01N33/84 ,  B01J19/0086 ,  C12Q1/6869 ,  C12Q2527/119 ,  C12Q2527/125 ,  C12Q2565/607

    Abstract: A buffered suspension includes a surfactant and a solid buffer particulate having a point of zero charge at least 1.2 pH units different that the pH of the buffered suspension. The buffered suspension can be prepared by mixing a stock solution with the solid buffer particulate and titrating. A method of preforming a pH sensitive process includes drawing the buffered suspension from a reservoir, filtering the solid buffer particulate from the buffered suspension, and applying the filtered solution to a sensor.

    Abstract translation: 缓冲悬浮液包括表面活性剂和具有零电荷点的固体缓冲颗粒，其pH值不小于缓冲悬浮液的pH至少1.2pH单位。 缓冲悬浮液可以通过将储备溶液与固体缓冲颗粒混合并滴定来制备。 预处理pH敏感过程的方法包括从储存器中抽出缓冲的悬浮液，从缓冲的悬浮液中过滤固体缓冲颗粒，以及将过滤的溶液施加到传感器。

    SYSTEMS AND METHODS FOR IDENTIFYING AN INDIVIDUAL
    424.
    发明申请
    SYSTEMS AND METHODS FOR IDENTIFYING AN INDIVIDUAL 审中-公开
    用于识别个体的系统和方法

    公开(公告)号：US20150363586A1

    公开(公告)日：2015-12-17

    申请号：US14415952

    申请日：2013-07-22

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Leonard Klevan ,  Hugh Pasika ,  Ravi Gupta ,  Allan Minn ,  Philip McClurg

    IPC: G06F21/32 ,  G06F17/30

    CPC classification number: G06F21/32 ,  G06F21/6245 ,  G06Q50/265

    Abstract: The present application relates to systems and methods using biometric data of an individual for identifying the individual and/or verifying the identity of an individual. These systems and methods are useful for, amongst many applications, more secure identification of high-risk individuals attempting to gain access to an entity, transport, information, location, security organization, law enforcement organization, transaction, services, authorized status, and/or funds.

    Abstract translation: 本申请涉及使用个体的生物特征数据来识别个体和/或验证个体身份的系统和方法。 这些系统和方法在许多应用中对于尝试访问实体，运输，信息，位置，安全组织，执法组织，交易，服务，授权状态和/ 或资金。

    Systems and Methods for Substrate Enrichment
    425.
    发明申请
    Systems and Methods for Substrate Enrichment 有权
    基质富集系统与方法

    公开(公告)号：US20150361418A1

    公开(公告)日：2015-12-17

    申请号：US14736734

    申请日：2015-06-11

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Brian REED

    IPC: C12N15/10 ,  C12Q1/68

    CPC classification number: C12N15/1013 ,  C07H1/06 ,  C12Q1/6806 ,  C12Q1/6844 ,  C12Q2563/143 ,  C12Q2563/157 ,  C12Q2565/519

    Abstract: A method of separating bead substrates includes applying an emulsion to an emulsion-breaking solution. A dispersed phase of the emulsion includes an unbound polynucleotide, a first set of bead substrates and a second set of bead substrates. The unbound polynucleotide includes a segment complementary to a coupling oligonucleotide. The first set of bead substrates includes the coupling oligonucleotide extended to include a segment complementary to a portion of the unbound polynucleotide. The second set of bead substrates includes the coupling oligonucleotide. The emulsion-breaking solution includes an interference probe having a sequence similar to the coupling oligonucleotide or complementary to the coupling oligonucleotide. The method further includes binding beads of the first set of bead substrates to separation substrates and separating unbound beads of the second set of bead substrates from the beads of the first set of bead substrates bound to the separation substrates.

    Abstract translation: 分离珠粒基材的方法包括将乳液施加到破乳溶液中。 乳液的分散相包括未结合的多核苷酸，第一组珠粒基质和第二组珠粒基底。 未结合的多核苷酸包括与偶联寡核苷酸互补的区段。 第一组珠底物包括扩增为包含与未结合多核苷酸的一部分互补的区段的偶联寡核苷酸。 第二组珠底物包括偶联寡核苷酸。 破乳溶液包括具有与偶联寡核苷酸相似的序列或与偶联寡核苷酸互补的序列的干扰探针。 该方法还包括将第一组胎圈衬底的珠粒与分离衬底结合，并将第二组胎圈衬底的未结合的珠粒与与分离衬底结合的第一组胎圈衬底的珠粒分离。

    METHOD AND APPARATUS FOR IDENTIFYING DEFECTS IN A CHEMICAL SENSOR ARRAY
    427.
    发明申请
    METHOD AND APPARATUS FOR IDENTIFYING DEFECTS IN A CHEMICAL SENSOR ARRAY 审中-公开
    用于识别化学传感器阵列缺陷的方法和装置

    公开(公告)号：US20150355265A1

    公开(公告)日：2015-12-10

    申请号：US14830391

    申请日：2015-08-19

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Mark BEAUCHEMIN

    IPC: G01R31/26 ,  G01N27/414 ,  G01R31/28

    CPC classification number: G01R31/2851 ,  G01N27/414 ,  G01N27/4145 ,  G01N27/416 ,  G01R31/2621

    Abstract: An apparatus including an array of sensors including a plurality of chemical sensors and a plurality of reference sensors, each chemical sensor coupled to a corresponding reaction region for receiving at least one reactant, and each reference sensor comprising a field effect transistor having a gate coupled to a corresponding reference line and an access circuit for accessing the chemical sensors and the reference sensors and a controller to apply bias voltages to the reference lines to select corresponding reference sensors, acquire output signals from the selected reference sensors, and identify one or more defects in the access circuit based on differences between the acquired output signals and expected output signals.

    Abstract translation: 一种包括传感器阵列的设备，包括多个化学传感器和多个参考传感器，每个化学传感器耦合到对应的反应区域以接收至少一个反应物，每个参考传感器包括场效应晶体管，栅极耦合到 相应的参考线和用于访问化学传感器和参考传感器的访问电路以及用于向参考线施加偏置电压以选择相应的参考传感器的控制器，从所选择的参考传感器获取输出信号，以及识别一个或多个缺陷 基于所获取的输出信号和预期输出信号之间的差异的存取电路。

    COMPOSITIONS, METHODS, SYSTEMS AND KITS FOR TARGET NUCLEIC ACID ENRICHMENT
    430.
    发明申请
    COMPOSITIONS, METHODS, SYSTEMS AND KITS FOR TARGET NUCLEIC ACID ENRICHMENT 有权
    靶核酸成分的组成，方法，系统和工具

    公开(公告)号：US20150353993A1

    公开(公告)日：2015-12-10

    申请号：US14829297

    申请日：2015-08-18

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Mark ANDERSEN ,  Steven ROMAN

    IPC: C12Q1/68

    CPC classification number: C12Q1/6806 ,  C07H21/00 ,  C12Q1/6853 ,  C12Q2525/301 ,  C12Q2527/107 ,  C12Q2563/131 ,  C12Q2563/149

    Abstract: The present invention provides methods, compositions, kits, systems and apparatus that are useful for isolating nucleic acid molecules from a sample. In particular, the methods generally relate to normalizing the concentration of target nucleic acid molecules from a sample. In one aspect, the invention relates to purifying a primer extension product from a primer extension reaction mixture. In some aspects, nucleic acid molecules obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing.

    Abstract translation: 本发明提供了可用于从样品中分离核酸分子的方法，组合物，试剂盒，系统和装置。 特别地，所述方法通常涉及从样品归一化靶核酸分子的浓度。 一方面，本发明涉及从引物延伸反应混合物中纯化引物延伸产物。 在一些方面，使用所公开的方法，试剂盒，系统和装置获得的核酸分子可以用于包括核酸测序在内的各种下游过程。

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