公开(公告)号：US09154235B2

公开(公告)日：2015-10-06

申请号：US14306813

申请日：2014-06-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Axel Scherer ,  Aditya Rajagopal ,  Seheon Kim ,  Andrew P. Homyk

IPC: H04B10/12 ,  H04B10/80 ,  G01J3/02 ,  H01L31/0352 ,  H03F3/08 ,  H03F3/45 ,  H02S40/38 ,  H01L31/0475 ,  H01L31/054 ,  A61B5/00

CPC classification number: H02J50/30 ,  A61B5/0017 ,  A61B5/6867 ,  A61B2560/0219 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0283 ,  G01N21/25 ,  H01L31/03529 ,  H01L31/0475 ,  H01L31/054 ,  H02J7/025 ,  H02J17/00 ,  H02J50/80 ,  H02S40/38 ,  H03F3/082 ,  H03F3/45183 ,  H03F2203/45702 ,  H04B10/807 ,  Y02E10/52

Abstract: The present disclosure describes an optically powered transducer with a photovoltaic collector. An optical fiber power delivery method and system and a free space power delivery method are also provided. A fabrication process for making an optically powered transducer is further described, together with an implantable transducer system based on optical power delivery.

Abstract translation: 本公开描述了具有光伏收集器的光学功率传感器。 还提供了光纤功率传递方法和系统以及自由空间功率传递方法。 进一步描述用于制造光学功率传感器的制造工艺，以及基于光功率传递的可植入传感器系统。

公开(公告)号：US08968585B2

公开(公告)日：2015-03-03

申请号：US14070469

申请日：2013-11-01

Applicant: California Institute of Technology

Inventor： Imran R. Malik ,  Axel Scherer ,  Erika F. Garcia ,  Xiomara L. Madero

IPC: B44C1/22 ,  B01L3/00 ,  B01L7/00

CPC classification number: B01L3/52 ,  B01L3/502707 ,  B01L7/52 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2200/0689 ,  B01L2300/0654 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2400/0478 ,  B33Y80/00 ,  Y10T156/10

Abstract: Methods to fabricate reaction cartridges for biological sample preparation and analysis are disclosed. A cartridge may have a reaction chamber and openings to allow fluids to enter the chamber. The cartridge may also have handles to facilitate its use. Such cartridges may be used for polymerase chain reaction.

Abstract translation: 公开了制备用于生物样品制备和分析的反应柱的方法。 墨盒可以具有反应室和开口以允许流体进入腔室。 墨盒也可以具有便于使用的手柄。 这种药盒可用于聚合酶链反应。

公开(公告)号：US08838394B2

公开(公告)日：2014-09-16

申请号：US13756760

申请日：2013-02-01

Applicant: California Institute of Technology

Inventor： Emil Kartalov ,  Aditya Rajagopal ,  Axel Scherer

IPC: G01N33/48 ,  G01N31/00 ,  G06F17/10 ,  G01N21/64 ,  G06F19/12 ,  C12Q1/68 ,  G06F19/24 ,  G06F17/11

CPC classification number: G06F19/20 ,  C12Q1/68 ,  C12Q1/6825 ,  C12Q1/6851 ,  G01N21/6486 ,  G06F17/10 ,  G06F17/11 ,  G06F19/12 ,  G06F19/24 ,  Y02A50/53 ,  C12Q2537/101 ,  C12Q2537/143 ,  C12Q2537/165 ,  C12Q2563/107

Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.

Abstract translation: 本公开提供了用于多个检测样品中多个分析物的方法，系统，组合物和试剂盒。 在一些实例中，本公开提供方法，系统，组合物和试剂盒，其中可以通过获取信号的至少一个可定量分量的累积测量或测量，在单个样品体积中检测多个分析物。 在某些情况下，信号的附加组件或附加信号（或其组件）也被量化。 信号的每个信号或分量可以用于构建编码方案，然后可以使用它来确定是否存在任何分析物。

公开(公告)号：US20140167257A1

公开(公告)日：2014-06-19

申请号：US14106701

申请日：2013-12-13

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Muhammad Mujeeb-U-Rahman ,  Axel Scherer

IPC: H01L21/285 ,  H01L29/41

CPC classification number: H01L21/285 ,  A61B2562/125 ,  B81C1/00111 ,  B81C1/0038 ,  H01L21/02425 ,  H01L21/28556 ,  H01L24/14 ,  H01L29/41 ,  H01L31/00 ,  H01L33/387 ,  H01L2224/1401 ,  H01L2924/11

Abstract: A method for fabricating three dimensional high surface electrodes is described. The methods including the steps: designing the pillars; selecting a material for the formation of the pillars; patterning the material; transferring the pattern to form the pillars; insulating the pillars and providing a metal layer for increased conductivity. Alternative methods for fabrication of the electrodes and fabrication of the electrodes using CMOS are also described.

Abstract translation: 描述了制造三维高表面电极的方法。 方法包括步骤：设计支柱; 选择用于形成支柱的材料; 图案化材料; 转移模式形成支柱; 绝缘柱并提供用于增加导电性的金属层。 还描述了用于制造电极和使用CMOS制造电极的替代方法。

公开(公告)号：US20140073013A1

公开(公告)日：2014-03-13

申请号：US13961752

申请日：2013-08-07

Applicant: California Institute of Technology

Inventor： John B. GORMAN ,  George Maltezos ,  Axel Scherer

IPC: B01L7/00

CPC classification number: B01L7/52 ,  B01L2200/025 ,  B01L2300/0816 ,  B01L2300/1827 ,  B01L2300/1844

Abstract: This disclosure provides thermal cyclers, systems, and methods of thermally cycling a sample.

Abstract translation: 本公开提供热循环仪，系统和热循环样品的方法。

公开(公告)号：US20130210646A1

公开(公告)日：2013-08-15

申请号：US13763536

申请日：2013-02-08

Applicant: University of Southern California ,  California Institute of Technology

Inventor： Emil P. Kartalov ,  Michael Kahn ,  Axel Scherer

IPC: C12Q1/68 ,  C12M1/12 ,  C12Q1/24

CPC classification number: C12Q1/686 ,  B01L3/502761 ,  B01L3/50851 ,  B01L7/52 ,  B01L2200/0642 ,  B01L2200/0668 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0864 ,  B01L2300/0874 ,  C12M25/00 ,  C12Q1/24 ,  G01N15/14 ,  G01N33/574 ,  G01N2015/1006

Abstract: Described microfluidic technology focused on: 1) direct integration of microfluidic devices with solidified liquid tissue samples, 2) subordination of architectural and operational principles of microfluidic devices specific tissue structure and needs and/or 3) on-chip sample acquisition integrated with the detection measurement within the same device. In contrast to conventional methods of off-chip sample prep and subsequent insertion into a detection device, new applications are possible on solidified liquid or solid tissue samples, such as in situ PCR.

Abstract translation: 描述的微流控技术主要集中在：1）将微流体装置与凝固的液体组织样品直接集成，2）微流体装置的特定组织结构和需要的结构和操作原理的从属性和/或3）集成了检测测量的片上样品采集 在同一设备内。 与片外样品制备和随后插入检测装置的常规方法相比，在固化液体或固体组织样品（例如原位PCR）上可能有新的应用。

公开(公告)号：US11969246B2

公开(公告)日：2024-04-30

申请号：US18319085

申请日：2023-05-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Samson Chen ,  Axel Scherer ,  Dvin I. Adalian ,  Peter Petillo ,  Muhammad Musab Jilani ,  Xiomara L. Madero ,  Deepan Kishore Kumar

IPC: C12N11/14 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1486 ,  C12N9/02 ,  C12N11/02 ,  G01N27/327

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/1459 ,  C12N9/0004 ,  C12N11/02 ,  C12N11/14 ,  G01N27/3272 ,  C12Y101/01001 ,  C12Y101/03003 ,  C12Y101/03005 ,  C12Y101/03007 ,  C12Y101/03008 ,  C12Y101/0301 ,  C12Y101/03011 ,  C12Y101/03012 ,  C12Y101/03015 ,  C12Y101/03016 ,  C12Y101/03018 ,  C12Y101/03019 ,  C12Y101/0302 ,  C12Y101/03023 ,  C12Y101/03027 ,  C12Y101/03029 ,  C12Y101/0303 ,  C12Y101/03037 ,  C12Y101/03038 ,  C12Y101/0304 ,  C12Y101/03041

Abstract: A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.

公开(公告)号：US11866768B2

公开(公告)日：2024-01-09

申请号：US16937464

申请日：2020-07-23

Applicant: California Institute of Technology

Inventor： Emil P. Kartalov ,  Aditya Rajagopal ,  Axel Scherer

IPC: G01N33/48 ,  G01N33/50 ,  C12Q1/6825 ,  G16B25/00 ,  G16B5/00 ,  C12Q1/6851 ,  G16B25/20 ,  G16B40/10 ,  C12Q1/68 ,  G01N21/64 ,  G06F17/10 ,  G06F17/11 ,  G16B40/00

CPC classification number: C12Q1/6825 ,  C12Q1/68 ,  C12Q1/6851 ,  G01N21/6486 ,  G16B5/00 ,  G16B25/00 ,  G16B25/20 ,  G16B40/10 ,  G06F17/10 ,  G06F17/11 ,  G16B40/00 ,  Y02A50/30 ,  C12Q1/6851 ,  C12Q2537/101 ,  C12Q2537/143 ,  C12Q2537/165 ,  C12Q2563/107

Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.

公开(公告)号：US11647922B2

公开(公告)日：2023-05-16

申请号：US17486660

申请日：2021-09-27

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Axel Scherer

IPC: A61B5/00 ,  A61F13/00 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/1473 ,  G01N27/414

CPC classification number: A61B5/14546 ,  A61B5/1486 ,  A61B5/445 ,  A61B5/4848 ,  A61B5/6833 ,  A61F13/00051 ,  G01N27/4148 ,  A61B5/14735 ,  A61F2013/00314

Abstract: A sensing chip attached to a bandage monitors the healing process of a wound by detecting growth factors, thrombin and fibrinogen. The complementary metal-oxide semiconductor includes a functionalized working electrode, functionalized counter electrode and functionalized reference electrode. The healing progress is stimulated by generating oxygen in the wound.

公开(公告)号：US10996185B2

公开(公告)日：2021-05-04

申请号：US15601503

申请日：2017-05-22

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Samson Chen ,  Axel Scherer ,  Muhammad M. Jilani

IPC: G01N27/30 ,  G01N27/327

Abstract: A cycle of positive and negative voltage pulses applied to an electrode sensor removes passivation of an electrode surface. The conditioned sensors have improved sensitivity to concentrations for analytes of interest. The electrode surfaces can also be passivated on purpose to reduce sensitivity. The voltages applied are varied according to the solution present.