公开(公告)号：US20170320058A1

公开(公告)日：2017-11-09

申请号：US15655330

申请日：2017-07-20

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Qinghuang Lin ,  Gustavo A. Stolovitzky ,  Chao Wang ,  Deqiang Wang

IPC: B01L3/00 ,  G01N27/447 ,  G01N33/487

CPC classification number: G01N33/48721 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/0663 ,  B01L2200/12 ,  B01L2300/042 ,  B01L2300/0645 ,  B01L2300/0887 ,  B01L2300/0896 ,  B01L2300/161 ,  B01L2400/0415 ,  B01L2400/0421 ,  G01N27/447 ,  G01N27/44791 ,  Y10T29/49002

Abstract: A device for passing a biopolymer molecule includes a nanochannel formed between a surface relief structure, a patterned layer forming sidewalls of the nanochannel and a sealing layer formed over the patterned layer to encapsulate the nanochannel. The surface relief structure includes a three-dimensionally rounded surface that reduces a channel dimension of the nanochannel at a portion of nanochannel and gradually increases the dimension along the nanochannel toward an opening position, which is configured to receive a biopolymer.

公开(公告)号：US09795964B2

公开(公告)日：2017-10-24

申请号：US14947745

申请日：2015-11-20

Applicant: International Business Machines Corporation

Inventor： Joshua T. Smith ,  Cornelia K. Tsang ,  Chao Wang ,  Benjamin H. Wunsch

IPC: B29C65/00 ,  B31B1/60 ,  B32B37/00 ,  H01L21/20 ,  B01L3/00 ,  B81C1/00 ,  B81B7/00 ,  G01N15/10

CPC classification number: B01L3/502707 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/0652 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/0887 ,  B01L2300/0896 ,  B01L2300/12 ,  B01L2400/086 ,  B81B7/0061 ,  B81B2201/058 ,  B81B2203/0338 ,  B81C1/00309 ,  B81C2203/0118 ,  G01N15/0255 ,  G01N15/10 ,  G01N2015/0288 ,  G01N2015/1081

Abstract: Techniques for use of wafer bonding techniques for sealing of microfluidic chips are provided. In one aspect, a wafer bonding sealing method includes the steps of: forming a first oxide layer coating surfaces of a first wafer, the first wafer having at least one fluidic chip; forming a second oxide layer on a second wafer; and bonding the first wafer to the second wafer via an oxide-to-oxide bond between the first oxide layer and the second oxide layer to form a bonded wafer pair, wherein the second oxide layer seals the at least one fluidic chip on the first wafer. The second wafer can be at least partially removed after performing the bonding, and fluidic ports may be formed in the second oxide layer. A fluidic chip device is also provided.

公开(公告)号：US09733232B1

公开(公告)日：2017-08-15

申请号：US15005576

申请日：2016-01-25

Applicant: International Business Machines Corporation

Inventor： Gustavo A. Stolovitzky ,  Chao Wang

IPC: G01N21/64 ,  G01N1/16 ,  B01L3/00 ,  G01N33/487

CPC classification number: G01N33/48721 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/0663 ,  B01L2300/0816 ,  B01L2300/0896 ,  B01L2400/086

Abstract: A technique relates to stretching an extensible molecule. The molecule moves through an array of pillars in a flow direction, where the array has an interface connecting a first pillar region and a second pillar region. Stretching the molecule by traversing the molecule in the flow direction through the interface connecting the first pillar region to the second pillar region, such that a first end and a second end of the molecule straddle a straddle pillar, thereby causing the first end to extend along a first path in the second and the second end to extend along a second path. Traversing the molecule stretches the first end and the second end along two different paths. The molecule is further traversed through the array such that the second end follows the first end along the first path, where the stretching causes the molecule to be in an uncoiled state.

公开(公告)号：US20170205329A1

公开(公告)日：2017-07-20

申请号：US15474118

申请日：2017-03-30

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Yann A. Astier ,  Robert L. Bruce ,  Joshua T. Smith ,  Chao Wang ,  Benjamin H. Wunsch

IPC: G01N15/10 ,  B82B3/00 ,  B01L3/00 ,  G03F7/20 ,  G03F7/00

CPC classification number: G01N15/10 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502753 ,  B01L2200/0652 ,  B01L2200/12 ,  B01L2300/0809 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/12 ,  B01L2400/086 ,  B03B5/48 ,  B81B1/006 ,  B81B2201/058 ,  B81B2203/0361 ,  B81C1/00111 ,  B81C2201/0132 ,  B82B3/0014 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1081 ,  G03F7/0002 ,  G03F7/2037

Abstract: A technique related to sorting entities is provided. An inlet is configured to receive a fluid, and an outlet is configured to exit the fluid. A nanopillar array, connected to the inlet and the outlet, is configured to allow the fluid to flow from the inlet to the outlet. The nanopillar array includes nanopillars arranged to separate entities by size. The nanopillars are arranged to have a gap separating one nanopillar from another nanopillar. The gap is constructed to be in a nanoscale range.

公开(公告)号：US09658184B2

公开(公告)日：2017-05-23

申请号：US14271926

申请日：2014-05-07

Applicant: International Business Machines Corporation

Inventor： Binquan Luan ,  Gustavo A. Stolovitzky ,  Chao Wang ,  Deqiang Wang

IPC: G01N1/10 ,  G01N27/403 ,  B82Y30/00 ,  G01N33/487

CPC classification number: G01N27/44791 ,  B82Y30/00 ,  C12Q1/6869 ,  G01N27/403 ,  G01N33/48721

Abstract: Techniques for increasing the capture zone in nano and microchannel-based polymer testing structures using concentric arrangements of nanostructures, such as nanopillars are provided. In one aspect, a testing structure for testing polymers is provided that includes a first fluid reservoir and a second fluid reservoir formed in an electrically insulating substrate; at least one channel formed in the insulating substrate that interconnects the first fluid reservoir and the second fluid reservoir; and an arrangement of nanostructures within either the first fluid reservoir or the second fluid reservoir wherein the nanostructures are arranged so as to form multiple concentric circles inside either the first fluid reservoir or the second fluid reservoir with each of the concentric circles being centered at an entry point of the channel. A method of analyzing a polymer using the testing structure is also provided.

公开(公告)号：US09513220B1

公开(公告)日：2016-12-06

申请号：US14982740

申请日：2015-12-29

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Yann Astier ,  Stephen W. Bedell ,  Ning Li ,  Devendra K. Sadana ,  William T. Spratt ,  Chao Wang

IPC: G01N21/64 ,  H01L31/0216 ,  H01L31/0232

CPC classification number: G01N21/6428 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/12 ,  B01L2300/168 ,  G01N15/1436 ,  G01N15/1459 ,  G01N21/05 ,  G01N21/645 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2021/6439 ,  G01N2021/6471 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  H01L25/167 ,  H01L31/02162 ,  H01L31/02164 ,  H01L31/02322 ,  H01L31/03044 ,  H01L31/036 ,  H01L31/1856

Abstract: A semiconductor device used for fluorescent-based molecule detection and a method for manufacturing the same are provided. The semiconductor device has a fluid channel layer defining a fluid channel through which a sample stream flows. A target cell coupled with a fluorescent source is contained by the sample stream. The semiconductor device also has an excitation light source for generating excitation light that reaches the target cell coupled with the fluorescent source to generate fluorescent light. The semiconductor device also has a light filter layer for permitting the fluorescent light to pass through and to block the excitation light and a light detection layer for detecting the fluorescent light. The functional components of the device are highly integrated. Leakage of the excitation light and background noise into the light detection component can be minimized to improve the quality of detection.

Abstract translation: 提供了一种用于荧光基分子检测的半导体器件及其制造方法。 半导体器件具有限定流体通道的流体通道层，样品流通过该流体通道流动。 与荧光源耦合的靶细胞被样品流包含。 半导体器件还具有用于产生到与荧光源耦合的目标单元产生荧光的激发光的激发光源。 半导体器件还具有用于允许荧光通过并阻挡激发光的滤光层和用于检测荧光的光检测层。 设备的功能组件高度集成。 将激发光和背景噪声泄漏到光检测部件中可以最小化以提高检测质量。

公开(公告)号：US20160220996A1

公开(公告)日：2016-08-04

申请号：US15096933

申请日：2016-04-12

Applicant: International Business Machines Corporation

Inventor： Jingwei Bai ,  Qinghuang Lin ,  Gustavo A. Stolovitzky ,  Chao Wang

IPC: B01L3/00 ,  G01N33/487 ,  C12Q1/68

Abstract: A technique includes forming a gradient channel with width and depth gradients. A mask is disposed on top of a substrate. The mask is patterned with at least one elongated channel pattern having different elongated channel pattern widths. A channel is etched in the substrate in a single etching step, the channel having a width gradient and a corresponding depth gradient both simultaneously etched in the single etching step according to the different elongated channel pattern widths in the mask.

公开(公告)号：US20160209394A1

公开(公告)日：2016-07-21

申请号：US15085394

申请日：2016-03-30

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Qinghuang Lin ,  Gustavo A. Stolovitzky ,  Chao Wang ,  Deqiang Wang

IPC: G01N33/487 ,  B01L3/00

CPC classification number: G01N33/48721 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/0663 ,  B01L2200/12 ,  B01L2300/042 ,  B01L2300/0645 ,  B01L2300/0887 ,  B01L2300/0896 ,  B01L2300/161 ,  B01L2400/0415 ,  B01L2400/0421 ,  G01N27/447 ,  G01N27/44791 ,  Y10T29/49002

Abstract: A device for passing a biopolymer molecule includes a nanochannel formed between a surface relief structure, a patterned layer forming sidewalls of the nanochannel and a sealing layer formed over the patterned layer to encapsulate the nanochannel. The surface relief structure includes a three-dimensionally rounded surface that reduces a channel dimension of the nanochannel at a portion of nanochannel and gradually increases the dimension along the nanochannel toward an opening position, which is configured to receive a biopolymer.

公开(公告)号：US09364832B2

公开(公告)日：2016-06-14

申请号：US13944552

申请日：2013-07-17

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Qinghuang Lin ,  Gustavo A. Stolovitzky ,  Chao Wang ,  Deqiang Wang

IPC: G01N27/447 ,  B01L3/00 ,  G01N33/487

CPC classification number: G01N33/48721 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/0663 ,  B01L2200/12 ,  B01L2300/042 ,  B01L2300/0645 ,  B01L2300/0887 ,  B01L2300/0896 ,  B01L2300/161 ,  B01L2400/0415 ,  B01L2400/0421 ,  G01N27/447 ,  G01N27/44791 ,  Y10T29/49002

Abstract: A device for passing a biopolymer molecule includes a nanochannel formed between a surface relief structure, a patterned layer forming sidewalls of the nanochannel and a sealing layer formed over the patterned layer to encapsulate the nanochannel. The surface relief structure includes a three-dimensionally rounded surface that reduces a channel dimension of the nanochannel at a portion of nanochannel and gradually increases the dimension along the nanochannel toward an opening position, which is configured to receive a biopolymer.

Abstract translation: 用于通过生物聚合物分子的装置包括形成在表面起伏结构，形成纳米通道的侧壁的图案化层和形成在图案化层上以封装纳米通道的密封层之间的纳米通道。 表面浮雕结构包括三维圆形表面，其减小了在纳米通道的一部分处的纳米通道的通道尺寸，并且将纳米通道的尺寸逐渐增加到构造成接收生物聚合物的开口位置。

公开(公告)号：US20160144406A1

公开(公告)日：2016-05-26

申请号：US14749309

申请日：2015-06-24

Applicant: International Business Machines Corporation

Inventor： Yann A. Astier ,  Joshua T. Smith ,  Gustavo A. Stolovitzky ,  Chao Wang ,  Benjamin H. Wunsch

IPC: B07B13/04

CPC classification number: B07B13/04 ,  B07B1/4609 ,  B82Y30/00 ,  G01N15/02 ,  G01N2015/0065 ,  G01N2015/0288 ,  Y10S977/84

Abstract: A technique relates sorting entities. The entities are introduced into a nanopillar array. The entities include a first population and a second population, and the nanopillar array includes nanopillars arranged to have a gap separating one from another. The nanopillars are ordered to have an array angle relative to a fluid flow direction. The entities are sorted through the nanopillar array by transporting the first population of the entities less than a predetermined size in a first direction and by transporting the second population of the entities at least the predetermined size in a second direction different from the first direction. The nanopillar array is configured to employ the gap with a gap size less than 300 nanometers in order to sort the entities having a sub-100 nanometer size.

Abstract translation: 一种技术涉及排序实体。 实体被引入纳米柱阵列。 实体包括第一群体和第二群体，并且纳米柱阵列包括布置成具有彼此分离的间隙的纳米柱。 纳米柱被命令相对于流体流动方向具有阵列角度。 通过在第一方向上传送小于预定尺寸的实体的第一群体并且通过在与第一方向不同的第二方向上传送至少预定大小的至少预定大小的实体，通过纳米柱阵列排序实体。 纳米柱阵列被配置为采用具有小于300纳米的间隙尺寸的间隙，以便对具有亚100纳米尺寸的实体进行分类。