公开(公告)号：US20110016955A1

公开(公告)日：2011-01-27

申请号：US12919555

申请日：2009-02-25

申请人： Sylvain Cormier

发明人： Sylvain Cormier

IPC分类号： G01N30/16 ,  G01N35/10

CPC分类号： G01N30/20 ,  G01N1/38 ,  G01N30/34 ,  G01N35/1097 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/207 ,  G01N2030/347

摘要： A method of liquid chromatography includes providing an injection valve, drawing a sample and a diluent while mixing, pushing the mixed sample and diluent onto a sample loop of the injection valve, and injecting the mixed sample and diluent. An analytical apparatus includes a proportioning unit, an injection valve having a sample loop, and a sample pump. The injection valve has a draw state and a load state, and has a port in fluidic communication with an outlet port of the proportioning unit. The sample pump is in fluidic communication with the outlet port of the proportioning unit, if the injection valve is in the draw state, to draw both a sample and a diluent through the proportioning unit and the injection valve, and in fluidic communication with the sample loop, if the injection valve is in the load state, to push the drawn sample and diluent onto the sample loop.

摘要翻译： 液相色谱法包括提供注射阀，在混合时抽取样品和稀释剂，将混合的样品和稀释剂推入注射阀的样品环上，并注入混合的样品和稀释剂。 分析装置包括配料单元，具有样品环的注射阀和样品泵。 注射阀具有抽出状态和负载状态，并且具有与配比单元的出口流体连通的端口。 样品泵与配比单元的出口流体连通，如果喷射阀处于拉伸状态，则通过比例单元和喷射阀将样品和稀释剂抽出，并与样品流体连通 循环，如果进样阀处于负载状态，将抽出的样品和稀释剂推到样品环上。

公开(公告)号：US20100139367A1

公开(公告)日：2010-06-10

申请号：US12529741

申请日：2008-03-07

申请人： Jan Blomberg ,  Patricia Lecoutaller ,  Francois Julien Raoul Deygout

发明人： Jan Blomberg ,  Patricia Lecoutaller ,  Francois Julien Raoul Deygout

IPC分类号： G01N30/16

CPC分类号： G01N30/463 ,  G01N33/28 ,  G01N2030/127 ,  G01N2030/8854 ,  G01N2030/8886

摘要： A method of analysing the hydrocarbon compounds in a bituminous material by means of comprehensive multi-dimensional gas chromatography is disclosed. The method may be used to measure the quantity of polycyclic aromatic compounds (PACs) in a bituminous material and may be used to determine the mutagenic tendency of a bituminous material.

摘要翻译： 公开了通过全面的多维气相色谱分析沥青材料中的烃化合物的方法。 该方法可以用于测量沥青材料中的多环芳族化合物（PAC）的量，并且可以用于确定沥青材料的诱变趋势。

公开(公告)号：US20090266143A1

公开(公告)日：2009-10-29

申请号：US11988997

申请日：2006-07-05

申请人： Matthias Rebhan ,  Daniel Sickert

发明人： Matthias Rebhan ,  Daniel Sickert

IPC分类号： G01N30/16

CPC分类号： B01J20/282 ,  B01J20/205 ,  B01J20/28007 ,  B01J2220/54 ,  B01J2220/84 ,  B82Y30/00 ,  G01N30/6043 ,  G01N30/6078 ,  G01N30/64 ,  G01N2030/525

摘要： In a chromatograph, a separation column is disposed between an injection system and a detector. The separation column includes a bundle of capillaries which are formed of carbon nanotubes with a typical diameter of 0.5 nm to 5 nm and may number in the several hundreds.

摘要翻译： 在色谱仪中，分离柱设置在注射系统和检测器之间。 分离柱包括一束毛细管，其由典型直径为0.5nm至5nm的碳纳米管形成，并且数量可以为几百个。

公开(公告)号：US07500386B2

公开(公告)日：2009-03-10

申请号：US12068202

申请日：2008-02-04

申请人： Yuki Togashi ,  Osamu Shirota ,  Aya Ohkubo

发明人： Yuki Togashi ,  Osamu Shirota ,  Aya Ohkubo

IPC分类号： G01N30/16

CPC分类号： G01N35/1004 ,  B01L99/00 ,  G01N30/18 ,  G01N2035/00554

摘要： A sample injection apparatus and a liquid chromatography apparatus including the sample injection apparatus are provided. The sample injection apparatus includes a sampling vessel into which a sample is supplied, a sampling needle for aspirating and ejecting the sample, a cleaning part into which a cleaning liquid for cleaning at least the sampling needle is supplied, a sample injection part for injecting the sample ejected from the sampling needle into a moving liquid, and a needle transfer part for transferring the sampling needle among the sampling vessel, the cleaning part and the sample injection part, wherein the cleaning part includes an ultrasonic vibrator for generating an ultrasonic wave in the cleaning liquid.

摘要翻译： 提供了一种样品注射装置和包括样品注射装置的液相色谱装置。 样品注入装置包括：供给样品的取样容器，吸取和排出样品的取样针;至少提供采样针的清洗用清洗液的清洗部，将注射了样品的样品注入部， 从采样针喷射到移动液体中的样品和用于在采样容器，清洁部分和样品注入部分中传送采样针的针转移部分，其中清洁部分包括用于在所述采样管中产生超声波的超声波振动器 清洗液体。

公开(公告)号：US07337653B2

公开(公告)日：2008-03-04

申请号：US10556391

申请日：2004-05-14

申请人： Yuki Togashi ,  Osamu Shirota ,  Aya Ohkubo

发明人： Yuki Togashi ,  Osamu Shirota ,  Aya Ohkubo

IPC分类号： G01N30/16

CPC分类号： G01N35/1004 ,  B01L99/00 ,  G01N30/18 ,  G01N2035/00554

摘要： A sample injection apparatus and sample injection method capable of sufficiently reducing carry-over, having simple cleaning means for a short cleaning time period, a small influence of vibration of the cleaning means, and a small error in the amount of injected sample and preventing the durability of a sampling needle from being lowered, and a liquid chromatography apparatus having the sample injection apparatus are provided. The sample injection apparatus has a sampling vessel 14 into which a sample is supplied, a sampling needle 10 for aspirating and ejecting the sample, a cleaning part 17 into which a cleaning liquid for cleaning at least the sampling needle 10 is supplied, a sample injection part 15 for injecting the sample ejected from the sampling needle 10 into a moving liquid, and needle transfer means for transferring the sampling needle 10 among the sampling vessel 4, the cleaning part 17 and the sample injection part 15, wherein the cleaning part 17 has an ultrasonic vibrator for generating an ultrasonic wave in the cleaning liquid.

摘要翻译： 一种能够充分降低携带量的样品注射装置和样品注射方法，具有清洁时间短的简单清洁装置，清洁装置的振动的小影响，以及注射的样品量的小误差，并防止 提供采样针的耐久性降低，并且提供具有样品注射装置的液相色谱装置。 样品注射装置具有供给样品的取样容器14，用于抽吸和抽出试样的取样针10，至少提供用于清洗的清洗液的清洗部17，样品注入 用于将从采样针10喷射的样品注入到移动液体中的部分15以及用于在取样容器4，清洁部17和样品注入部15中传送采样针10的针传送装置，其中清洁部17具有 用于在清洗液中产生超声波的超声波振动器。

公开(公告)号：US06955709B2

公开(公告)日：2005-10-18

申请号：US10450165

申请日：2002-12-19

申请人： Paolo Magni

发明人： Paolo Magni

IPC分类号： G01N30/02 ,  G01N30/12 ,  G01N30/16 ,  B01D15/08

CPC分类号： G01N30/16 ,  G01N30/12 ,  G01N2030/025 ,  G01N2030/127 ,  G01N2030/165 ,  G01N2030/167

摘要： This invention concerns a method and apparatus for vaporization injection of large volumes of liquid sample (substance to be analysed+solvent) introduced by a syringe needle into a heated vaporization chamber which is part of an injector coupled operatively to a device for gas chromatographic analysis. The sample is sent in the form of a liquid band traveling through the vaporization chamber at high speed until it reaches a stopping and vaporization device positioned adjacent to the inlet of a capillary to collect the vapors. In order to inject large volumes without modifying the vaporization chamber and without partial losses of the samples, the sample vapors, in splitless mode, are drawn up from the vaporization chamber into the capillary by virtue of the local action of volume contraction caused by recondensation of at least the solvent vapors in the capillary.

摘要翻译： 本发明涉及一种用于将大量体积的待注射针引入的液体样品（待分析物质+溶剂）蒸发注入加热的蒸发室的方法和装置，所述加热蒸发室是可操作地连接到用于气相色谱分析的装置的喷射器的一部分。 样品以以高速行进通过蒸发室的液体带的形式发送，直到其到达位于毛细管入口附近的停止和蒸发装置以收集蒸气。 为了注入大量而不改变蒸发室并且没有样品的部分损失，样品蒸汽以不分流模式从蒸发室通过由缩合引起的体积收缩引起的局部作用从气化室中吸入毛细管中 至少毛细管中的溶剂蒸气。

公开(公告)号：US06941825B2

公开(公告)日：2005-09-13

申请号：US10440246

申请日：2003-05-19

申请人： Janusz B. Pawliszyn

发明人： Janusz B. Pawliszyn

IPC分类号： G01N1/34 ,  G01N1/40 ,  G01N13/00 ,  G01N30/00 ,  G01N30/04 ,  G01N30/16

CPC分类号： G01N30/00 ,  G01N1/40 ,  G01N1/405 ,  G01N2013/003 ,  G01N2030/009 ,  Y10T436/255

摘要： A method and device for determining the concentration of analytes in a sample. The device has a surface with an extraction coating thereon. The method is carried out while the sample is highly agitated to maintain a substantially constant boundary layer. The sample is brought into contact with the coating for a limited time so that all the analytes that pass through the boundary layer are adsorbed by the coating. The amount of analytes in the coating is determined and the concentration of those same analytes in the sample is then calculated from the diffusion coefficient of the analytes. The device is first calibrated using analytes of known concentration.

摘要翻译： 用于测定样品中分析物浓度的方法和装置。 该装置具有其上具有提取涂层的表面。 该方法在样品被高度搅拌以保持基本恒定的边界层的同时进行。 使样品与涂层接触一段有限的时间，使得通过边界层的所有分析物被涂层吸附。 确定涂层中分析物的量，然后根据分析物的扩散系数计算样品中相同分析物的浓度。 首先使用已知浓度的分析物对装置进行校准。

公开(公告)号：US06932939B2

公开(公告)日：2005-08-23

申请号：US10855198

申请日：2004-05-27

申请人： Can Özbal ,  Ian W. Hunter ,  John Linton

发明人： Can Özbal ,  Ian W. Hunter ,  John Linton

IPC分类号： G01N27/62 ,  B01F13/00 ,  B01J19/00 ,  B01L3/00 ,  B01L3/02 ,  C40B60/14 ,  G01N1/00 ,  G01N1/36 ,  G01N21/33 ,  G01N21/64 ,  G01N21/65 ,  G01N21/77 ,  G01N21/78 ,  G01N30/16 ,  G01N30/24 ,  G01N30/46 ,  G01N30/62 ,  G01N30/72 ,  G01N30/84 ,  G01N35/00 ,  G01N35/10 ,  B01D15/08

CPC分类号： G01N30/466 ,  B01F5/0085 ,  B01F13/0059 ,  B01J19/0046 ,  B01J2219/0036 ,  B01J2219/00387 ,  B01J2219/00414 ,  B01J2219/00418 ,  B01J2219/00479 ,  B01J2219/00495 ,  B01J2219/00515 ,  B01J2219/00518 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00657 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/0072 ,  B01L3/0262 ,  B01L3/0268 ,  B01L3/505 ,  B01L3/5085 ,  B01L2300/0812 ,  B01L2300/0845 ,  C40B60/14 ,  G01N30/24 ,  G01N30/7233 ,  G01N30/7266 ,  G01N30/84 ,  G01N35/00009 ,  G01N35/1095 ,  G01N2030/628 ,  G01N2030/8417 ,  G01N2035/1037 ,  G01N2035/1046 ,  Y10T436/115831 ,  G01N30/18

摘要： A system and method high throughput sample preparation and analysis using column chromatography. Each port in a plurality of ports has a port input that interfaces with a first fluid source and a port output. A fluidic circuit is coupled to each port output and to a second fluid source, the fluidic circuit for controlling fluid flow from the plurality of ports and the second fluid source. The fluidic circuit is also coupled to a plurality of chromatography columns. An interface to an analyzer receives output from at least one of the plurality of chromatography columns. The plurality of chromatography columns is moved relative to the analyzer via a translation stage, such that sample output from one of the plurality of chromatography columns can be selectively presented to the analyzer.

摘要翻译： 一种使用柱色谱法的高通量样品制备和分析的系统和方法。 多个端口中的每个端口具有与第一流体源和端口输出接口的端口输入。 流体回路耦合到每个端口输出端和第二流体源，流体回路用于控制来自多个端口和第二流体源的流体流。 流体回路还耦合到多个色谱柱。 分析仪的界面接收至少一个色谱柱的输出。 多个色谱柱经由平移台相对于分析器移动，使得从多个色谱柱中的一个色谱柱输出的样品可以选择性地呈现给分析器。

公开(公告)号：US20050043522A1

公开(公告)日：2005-02-24

申请号：US10499883

申请日：2002-12-17

申请人： Jean-Luc Maloisel

发明人： Jean-Luc Maloisel

IPC分类号： G01N30/88 ,  B01D15/08 ,  B01D15/36 ,  B01J20/281 ,  B01J20/285 ,  B01J20/32 ,  C07K1/16 ,  G01N30/02 ,  G01N30/16 ,  G01N30/26 ,  G01N30/34 ,  C07K1/10

CPC分类号： B01J20/262 ,  B01D15/368 ,  B01D15/3847 ,  B01J20/265 ,  B01J20/285 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3246 ,  B01J20/3248 ,  B01J20/3253 ,  B01J20/3255 ,  C07K1/16

摘要： The present invention relates to a method of separating a compound from a liquid, which method comprises providing a separation matrix comprising at least one uncharged ligand; providing a liquid wherein the compound to be separated is present in a positively charged state; contacting said matrix with said liquid to adsorb the compound; and removing the liquid. The uncharged ligands possess a quadrupole or dipole moment, allowing for a cation-π interaction between the compound and the ligand. The present invention also encompasses the use of a separation matrix, which comprises an uncharged group that possesses a quadrupole or dipole moment, in said method.

摘要翻译： 本发明涉及从液体中分离化合物的方法，该方法包括提供包含至少一种不带电配位体的分离基质; 提供其中待分离的化合物以带正电的状态存在的液体; 使所述基质与所述液体接触以吸附化合物; 并除去液体。 不带电荷的配体具有四极或偶极矩，允许化合物和配体之间的阳离子-Ip相互作用。 本发明还包括在所述方法中使用分离基质，其包含具有四极或偶极矩的不带电荷的基团。

公开(公告)号：US6156195A

公开(公告)日：2000-12-05

申请号：US48327

申请日：1998-03-26

申请人： Kenji Nakamura ,  Shinji Satomura ,  Masayoshi Hayashi ,  Hideyoshi Arashima ,  Tetsushi Okuyama ,  Nobuhiro Hanafusa ,  Koji Tanimizu

发明人： Kenji Nakamura ,  Shinji Satomura ,  Masayoshi Hayashi ,  Hideyoshi Arashima ,  Tetsushi Okuyama ,  Nobuhiro Hanafusa ,  Koji Tanimizu

IPC分类号： B01D15/08 ,  G01N30/16 ,  G01N30/24 ,  G01N30/40 ,  G01N30/88

CPC分类号： G01N30/40 ,  B01D15/1807 ,  B01D15/14 ,  G01N2030/402 ,  G01N2030/407 ,  G01N30/16 ,  G01N30/24 ,  G01N30/88

摘要： The object of the present invention is to provide a method for separating components in a liquid specimen and an apparatus used in said method, by which it is possible to avoid carryover even when the specimen injector is not washed using washing solution and also to avoid the increase of inner pressure in column of the separation device or ineffective separating operation even when many liquid specimens are separated by many times using the same separation device. In the present invention, the liquid specimen is introduced into the separation device from a direction opposite to eluting direction of the separation device which retains an adsorbent, and by separating and eluting the specimen from eluting outlet together with the eluant, trace quantity of insoluble substances and the specimen remained on the specimen introducing passage can be removed by elution procedure. As a result, it is possible to avoid carryover, to prevent the increase of inner pressure in the column of the separation device and to prevent ineffective separating operation caused by clogging of the column.